A G Protein Mutant That Inhibits Thrombin and Purinergic Receptor Activation of Phospholipase A₂

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

1983 • 1,937 citations

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

Functional inactivation of genes by dominant negative mutations

1987 • 1,174 citations

Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.

1987 • 751 citations

Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers

1988 • 512 citations

Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells.

1986 • 424 citations

Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins.

1987 • 359 citations

The G protein-gated atrial K+ channel is stimulated by three distinct GIα-subunits

1988 • 306 citations

Inhibition by islet-activating protein of a chemotactic peptide-induced early breakdown of inositol phospholipids and Ca2+ mobilization in guinea pig neutrophils.

1985 • 250 citations

Identification of receptor contact site involved in receptor–G protein coupling

1987 • 249 citations

Synthesis in Escherichia coli of GTPase-deficient mutants of Gsα

1989 • 247 citations

Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release in 3T3 fibroblasts. Selective susceptibility to islet-activating protein, pertussis toxin.

1985 • 245 citations

Mutations in the GTP-binding site of GSα alter stimulation of adenylyl cyclase

1989 • 209 citations

Evidence for involvement of guanine nucleotide‐binding regulatory proteins in the activation of phospholipases by hormones

1988 • 190 citations

Carboxyl Rerminal Domain of G _sα Specifies Coupling of Receptors to Stimulation of Adenylyl Cyclase

1988 • 174 citations

Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system.

1986 • 70 citations

Modulation of thrombin-stimulated lipid responses in cultured fibroblasts. Evidence for two coupling mechanisms

1987 • 48 citations

Expression of a Gαs/Gαi Chimera That Constitutively Activates Cyclic AMP Synthesis

1989 • 45 citations

Increased plasma membrane permeability to Ca2+ in anti-Ig-stimulated B lymphocytes is dependent on activation of phosphoinositide hydrolysis.

1988 • 36 citations

Mutation of the Gs protein alpha subunit NH2 terminus relieves an attenuator function, resulting in constitutive adenylyl cyclase stimulation.

1990 • 32 citations

Mutation of glycine 49 to valine in the .alpha. subunit of Gs results in the constitutive elevation of cyclic AMP synthesis

1989 • 24 citations

Enzymatic model for receptor activation of GTP-binding regulatory proteins

1987 • 23 citations

The G protein alpha o subunit alters morphology, growth kinetics, and phospholipid metabolism of somatic cells.

1989 • 21 citations