Homeostasis of Naive and Memory T Cells

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

Lineage relationship and protective immunity of memory CD8 T cell subsets

2003 • 1,833 citations

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

2008 • 1,801 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

2000 • 1,596 citations

Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

2000 • 1,578 citations

Positive and Negative Selection of T Cells

2003 • 1,547 citations

SOCS proteins, cytokine signalling and immune regulation

2007 • 1,450 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

1998 • 1,316 citations

IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation

1998 • 1,293 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

2005 • 1,167 citations

miR-181a Is an Intrinsic Modulator of T Cell Sensitivity and Selection

2007 • 1,147 citations

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

2008 • 1,139 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

2008 • 946 citations

IL-7 is critical for homeostatic proliferation and survival of naïve T cells

2001 • 940 citations

Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells

2003 • 933 citations

Naive CD4+ T Cell Frequency Varies for Different Epitopes and Predicts Repertoire Diversity and Response Magnitude

2007 • 918 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

IL-15Rα Recycles and Presents IL-15 In trans to Neighboring Cells

2002 • 877 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells

2007 • 854 citations

Selective Stimulation of T Cell Subsets with Antibody-Cytokine Immune Complexes

2006 • 843 citations

DIVERSE FUNCTIONS OF IL-2, IL-15, AND IL-7 IN LYMPHOID HOMEOSTASIS

2006 • 816 citations

Massive Expansion of Antigen-Specific CD8+ T Cells during an Acute Virus Infection

1998 • 794 citations

Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells

2002 • 783 citations

Helping the CD8+ T-cell response

2004 • 775 citations

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1

2003 • 771 citations

Autophagy in metazoans: cell survival in the land of plenty

2005 • 752 citations

The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

1999 • 742 citations

Interleukin 15 Is Required for Proliferative Renewal of Virus-specific Memory CD8 T Cells

2002 • 671 citations

CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection

2004 • 653 citations

Maintaining the norm: T-cell homeostasis

2002 • 608 citations

Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory

2001 • 600 citations

CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death

2005 • 598 citations

Interleukin-7 receptor expression: intelligent design

2007 • 597 citations

Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells

2002 • 588 citations

Estimating the Precursor Frequency of Naive Antigen-specific CD8 T Cells

2002 • 584 citations

A critical role for the autophagy gene Atg5 in T cell survival and proliferation

2006 • 582 citations

Low-Affinity Ligands for the TCR Drive Proliferation of Mature CD8+ T Cells in Lymphopenic Hosts

1999 • 548 citations

Shaping and reshaping CD8+ T-cell memory

2008 • 537 citations

T Cell Memory

2002 • 529 citations

Kruppel-like factor 2 regulates thymocyte and T-cell migration

2006 • 527 citations

Suppression of IL7Rα Transcription by IL-7 and Other Prosurvival Cytokines

2004 • 472 citations

Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation

2006 • 463 citations

Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells

2003 • 454 citations

Interleukin 7 Regulates the Survival and Generation of Memory CD4 Cells

2003 • 449 citations

A Role for CD5 in TCR-Mediated Signal Transduction and Thymocyte Selection

1995 • 437 citations

Endogenous Naive CD8+ T Cell Precursor Frequency Regulates Primary and Memory Responses to Infection

2008 • 434 citations

Class II-Independent Generation of CD4 Memory T Cells from Effectors

1999 • 422 citations

Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes

2001 • 407 citations

Cytokines and immunodeficiency diseases

2001 • 380 citations

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1996 • 377 citations

Stat5a/b are essential for normal lymphoid development and differentiation

2006 • 369 citations

Coordinate Expression and Trans Presentation of Interleukin (IL)-15Rα and IL-15 Supports Natural Killer Cell and Memory CD8+ T Cell Homeostasis

2004 • 364 citations

Fatal Leukemia in Interleukin 15 Transgenic Mice Follows Early Expansions in Natural Killer and Memory Phenotype Cd8+ T Cells

2001 • 362 citations

Naïve and Memory CD4 ⁺ T Cell Survival Controlled by Clonal Abundance

2006 • 348 citations

T Cell Stimulation In Vivo by Lipopolysaccharide (LPS)

1997 • 335 citations

Interleukin 15 Controls both Proliferation and Survival of a Subset of Memory-Phenotype CD8+ T Cells

2002 • 332 citations

Designing and Maintaining the Mature TCR Repertoire

1999 • 323 citations

Stat5b Is Essential for Natural Killer Cell–mediated Proliferation and Cytolytic Activity

1998 • 323 citations

IL-15 Promotes the Survival of Naive and Memory Phenotype CD8+ T Cells

2003 • 323 citations

γ chain required for naïve CD4+ T cell survival but not for antigen proliferation

2000 • 314 citations

IL-7 Promotes the Transition of CD4 Effectors to Persistent Memory Cells

2003 • 307 citations

Negative Regulation of T Cell Homeostasis by Lymphocyte Activation Gene-3 (CD223)

2005 • 306 citations

Overexpression of Interleukin (IL)-7 Leads to IL-15–independent Generation of Memory Phenotype CD8+ T Cells

2002 • 291 citations

Neonates Support Lymphopenia-Induced Proliferation

2003 • 291 citations

Interleukin-7: master regulator of peripheral T-cell homeostasis?

2001 • 290 citations

An Indirect Effect of Stat5a in IL-2–Induced Proliferation: A Critical Role for Stat5a in IL-2–Mediated IL-2 Receptor α Chain Induction

1997 • 275 citations

Degenerative Disorders Caused by Bcl-2 Deficiency Prevented by Loss of Its BH3-Only Antagonist Bim

2001 • 270 citations

Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection

2007 • 260 citations

Requirement for Coronin 1 in T Lymphocyte Trafficking and Cellular Homeostasis

2006 • 252 citations

Cutting Edge: Recent Immune Status Determines the Source of Antigens That Drive Homeostatic T Cell Expansion

2005 • 243 citations

A Role for TCR Affinity in Regulating Naive T Cell Homeostasis

2004 • 235 citations

Antiviral CD4+ memory T cells are IL-15 dependent

2007 • 229 citations

How Much TCR Does a T Cell Need?

2001 • 224 citations

How αβ T cells deal with induced TCRα ablation

2001 • 224 citations

Memory CD8 T-cell compartment grows in size with immunological experience

2008 • 220 citations

Restoration of T-cell homeostasis after T-cell depletion

1997 • 218 citations

Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis

2007 • 215 citations

The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells

2006 • 209 citations

Spontaneous and Homeostatic Proliferation of CD4 T Cells Are Regulated by Different Mechanisms

2005 • 201 citations

IL-7 regulates basal homeostatic proliferation of antiviral CD4 ⁺ T cell memory

2004 • 197 citations

Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns

2008 • 194 citations

Regulation of mature T cell homeostasis

2005 • 191 citations

Autonomous activation of B and T cells in antigen-free mice

1986 • 184 citations

Impairment of immunological memory in the absence of MHC despite survival of memory T cells

2002 • 181 citations

The molecular program induced in T cells undergoing homeostatic proliferation

2004 • 176 citations

IL-2 negatively regulates IL-7 receptor α chain expression in activated T lymphocytes

2002 • 176 citations

Cutting Edge: Transpresentation of IL-15 by Bone Marrow-Derived Cells Necessitates Expression of IL-15 and IL-15Rα by the Same Cells

2004 • 175 citations

T Cell–Independent Interleukin 15rα Signals Are Required for Bystander Proliferation

2001 • 174 citations

Rapid Culling of the CD4+ T Cell Repertoire in the Transition from Effector to Memory

2008 • 170 citations

Suppressor of Cytokine Signaling-1 Is a Critical Regulator of Interleukin-7-Dependent CD8+ T Cell Differentiation

2003 • 169 citations

Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells

2003 • 163 citations

Lymphocide: cytokines and the control of lymphoid homeostasis

2002 • 161 citations

IL-15Rα expression on CD8⁺T cells is dispensable for T cell memory

2003 • 160 citations

TCR and IL-7 Receptor Signals Can Operate Independently or Synergize to Promote Lymphopenia-Induced Expansion of Naive T Cells

2002 • 160 citations

CD4+ T cell survival is not directly linked to self-MHC–induced TCR signaling

2000 • 156 citations

Regulation of T cell survival through coronin-1–mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering

2008 • 156 citations

Autologous Regulation of Naive T Cell Homeostasis Within the T Cell Compartment

2001 • 155 citations

Distinct Regions of the Interleukin-7 Receptor Regulate Different Bcl2 Family Members

2004 • 134 citations

Lymphocyte homeostasis

1997 • 133 citations

B and T lymphocyte attenuator regulates CD8+ T cell–intrinsic homeostasis and memory cell generation

2007 • 129 citations

Homeostatic Expansion Occurs Independently of Costimulatory Signals

2001 • 124 citations

Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells

2003 • 121 citations

TCR Signals Mediated by Src Family Kinases Are Essential for the Survival of Naive T Cells

2002 • 121 citations

An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2

2007 • 121 citations

CD24 Expression on T Cells Is Required for Optimal T Cell Proliferation in Lymphopenic Host

2004 • 114 citations

COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor–induced entry into the cell cycle from quiescence

2007 • 110 citations

The Lupus-Related Lmb3 Locus Contains a Disease-Suppressing Coronin-1A Gene Mutation

2008 • 102 citations

Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7Rα mutant mice

2007 • 100 citations

Suppression of CD4+ T Lymphocyte Effector Functions by CD4+CD25+ Cells In Vivo

2004 • 99 citations

Plasticity of T Cell Memory Responses to Viruses

2004 • 99 citations

Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis

2004 • 93 citations

SOCS-1 regulates IL-15–driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential

2005 • 87 citations

Cutting Edge: Secondary Lymphoid Organs Are Essential for Maintaining the CD4, But Not CD8, Naive T Cell Pool

2001 • 80 citations

Are Major Histocompatibility Complex Molecules Involved in the Survival of Naive CD4+ T Cells?

2003 • 76 citations

Regulation of T Cell Homeostasis by Heparan Sulfate-Bound IL-2

1999 • 75 citations

Do CD8 effector cells need IL-7R expression to become resting memory cells?

2006 • 63 citations

Soluble Interleukin (IL)-15Rα Is Generated by Alternative Splicing or Proteolytic Cleavage and Forms Functional Complexes with IL-15

2007 • 62 citations

On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4 ⁺ T cells

2003 • 60 citations

A major histocompatibility complex class I–dependent subset of memory phenotype CD8+ cells

2006 • 58 citations

A Role for CD28 in Lymphopenia-Induced Proliferation of CD4 T Cells

2004 • 57 citations

A role for “self” in T-cell activation

2007 • 53 citations

Suppressor of Cytokine Signaling 1 Stringently Regulates Distinct Functions of IL-7 and IL-15 In Vivo during T Lymphocyte Development and Homeostasis

2006 • 47 citations

Massive and destructive T cell response to homeostatic cue in CD24-deficient lymphopenic hosts

2006 • 44 citations

Non‐redundant role for IL‐7R signaling for the survival of CD8⁺ memory T cells

2007 • 44 citations

Not all CD4⁺ memory T cells are long lived

2006 • 42 citations

The Lymphopenic Environment of CD132 (Common γ-Chain)-Deficient Hosts Elicits Rapid Homeostatic Proliferation of Naive T Cells via IL-15

2008 • 41 citations

Mice deprived of exogenous antigenic stimulation develop a normal repertoire of functional T cells.

1992 • 35 citations

Evidence of a Novel IL-2/15Rβ-Targeted Cytokine Involved in Homeostatic Proliferation of Memory CD8+ T Cells

2004 • 25 citations

Regulation of T Cell Homeostasis by the Transmembrane Adaptor Protein SIT

2008 • 21 citations