Regulation of mature T cell homeostasis

Impaired immune and acute-phase responses in interleukin-6-deficient mice

1994 • 1,776 citations

The immunological and genetic basis of inflammatory bowel disease

2003 • 1,766 citations

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

2000 • 1,596 citations

Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

2000 • 1,578 citations

Positive and Negative Selection of T Cells

2003 • 1,547 citations

Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria

2004 • 1,520 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

Anatomical basis of tolerance and immunity to intestinal antigens

2003 • 1,365 citations

IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation

1998 • 1,293 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1994 • 1,129 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

Phenotypically distinct subsets of CD4⁺ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

1993 • 1,064 citations

IL-7 is critical for homeostatic proliferation and survival of naïve T cells

2001 • 940 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

IL-15Rα Recycles and Presents IL-15 In trans to Neighboring Cells

2002 • 877 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

Control of Homeostasis of CD8 ⁺ Memory T Cells by Opposing Cytokines

2000 • 847 citations

Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells

2002 • 783 citations

The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

1999 • 742 citations

Persistence of Memory CD8 T Cells in MHC Class I-Deficient Mice

1999 • 738 citations

Interleukin 15 Is Required for Proliferative Renewal of Virus-specific Memory CD8 T Cells

2002 • 671 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation

2000 • 644 citations

CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity

1998 • 643 citations

Maintaining the norm: T-cell homeostasis

2002 • 608 citations

Low-Affinity Ligands for the TCR Drive Proliferation of Mature CD8+ T Cells in Lymphopenic Hosts

1999 • 548 citations

Homeostasis-Stimulated Proliferation Drives Naive T Cells to Differentiate Directly into Memory T Cells

2000 • 527 citations

Cutting Edge: Requirement for IL-15 in the Generation of Primary and Memory Antigen-Specific CD8 T Cells

2002 • 519 citations

Increased production of IL-7 accompanies HIV-1–mediated T-cell depletion: implications for T-cell homeostasis

2001 • 519 citations

Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice

1997 • 503 citations

Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells

2003 • 454 citations

Interleukin 7 Regulates the Survival and Generation of Memory CD4 Cells

2003 • 449 citations

IL-7 Enhances the Survival and Maintains the Size of Naive T Cells

2001 • 437 citations

Class II-Independent Generation of CD4 Memory T Cells from Effectors

1999 • 422 citations

Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules

1997 • 419 citations

A potential role for interleukin-7 in T-cell homeostasis

2001 • 415 citations

Lymphocyte life-span and memory

1994 • 405 citations

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

2003 • 384 citations

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1996 • 377 citations

Fatal Leukemia in Interleukin 15 Transgenic Mice Follows Early Expansions in Natural Killer and Memory Phenotype Cd8+ T Cells

2001 • 362 citations

Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo

1989 • 351 citations

Homeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands

1999 • 341 citations

T Cell Stimulation In Vivo by Lipopolysaccharide (LPS)

1997 • 335 citations

Different Subsets of Enteric Bacteria Induce and Perpetuate Experimental Colitis in Rats and Mice

2001 • 334 citations

Interleukin 15 Controls both Proliferation and Survival of a Subset of Memory-Phenotype CD8+ T Cells

2002 • 332 citations

IL-15 Promotes the Survival of Naive and Memory Phenotype CD8+ T Cells

2003 • 323 citations

Designing and Maintaining the Mature TCR Repertoire

1999 • 323 citations

Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus

1997 • 318 citations

γ chain required for naïve CD4+ T cell survival but not for antigen proliferation

2000 • 314 citations

Interleukin 4 (IL-4) or IL-7 Prevents the Death of Resting T Cells: Stat6 Is Probably Not Required for the Effect of IL-4

1997 • 293 citations

Overexpression of Interleukin (IL)-7 Leads to IL-15–independent Generation of Memory Phenotype CD8+ T Cells

2002 • 291 citations

Homeostatic T Cell Proliferation

2000 • 279 citations

T Cell Regulation as a Side Effect of Homeostasis and Competition

2003 • 263 citations

Cutting Edge: Recent Immune Status Determines the Source of Antigens That Drive Homeostatic T Cell Expansion

2005 • 243 citations

CD25+CD4+ T cells contribute to the control of memory CD8+ T cells

2002 • 241 citations

A Role for TCR Affinity in Regulating Naive T Cell Homeostasis

2004 • 235 citations

Regulation of thymocyte differentiation: pre-TCR signals and β-selection

2002 • 225 citations

How αβ T cells deal with induced TCRα ablation

2001 • 224 citations

How Much TCR Does a T Cell Need?

2001 • 224 citations

Restoration of T-cell homeostasis after T-cell depletion

1997 • 218 citations

Distinct Effects of STAT5 Activation on CD4+ and CD8+ T Cell Homeostasis: Development of CD4+CD25+ Regulatory T Cells versus CD8+ Memory T Cells

2003 • 207 citations

Targeted Complementation of MHC Class II Deficiency by Intrathymic Delivery of Recombinant Adenoviruses

1997 • 204 citations

Intrathymic and extrathymic clonal deletion of T cells

1995 • 201 citations

IL-7 regulates basal homeostatic proliferation of antiviral CD4 ⁺ T cell memory

2004 • 197 citations

Impairment of immunological memory in the absence of MHC despite survival of memory T cells

2002 • 181 citations

Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype.

1991 • 180 citations

T Cell–Independent Interleukin 15rα Signals Are Required for Bystander Proliferation

2001 • 174 citations

The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells.

1987 • 173 citations

Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells

2003 • 163 citations

Sensory Adaptation in Naive Peripheral CD4 T Cells

2001 • 163 citations

Transregulation of memory CD8 T-cell proliferation by IL-15Rα+ bone marrow–derived cells

2003 • 162 citations

Lymphocide: cytokines and the control of lymphoid homeostasis

2002 • 161 citations

IL-15Rα expression on CD8⁺T cells is dispensable for T cell memory

2003 • 160 citations

CD4+ T cell survival is not directly linked to self-MHC–induced TCR signaling

2000 • 156 citations

Spontaneous proliferation, a response of naïve CD4 T cells determined by the diversity of the memory cell repertoire

2004 • 154 citations

Selection of the T-Cell Repertoire: Receptor-Controlled Checkpoints in T-Cell Development

2004 • 134 citations

Lymphocyte homeostasis

1997 • 133 citations

The life span of naive alpha/beta T cells in secondary lymphoid organs.

1993 • 130 citations

A Closer Look at Homeostatic Proliferation of CD4+ T Cells: Costimulatory Requirements and Role in Memory Formation

2001 • 130 citations

Different contributions of thymopoiesis and homeostasis-driven proliferation to the reconstitution of naive and memory T cell compartments

2002 • 129 citations

T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo

2001 • 128 citations

Positive selection of thymocytes bearing αβ T cell receptors

1997 • 124 citations

Homeostatic Expansion Occurs Independently of Costimulatory Signals

2001 • 124 citations

Cutting Edge: Homeostatic Proliferation of Peripheral T Lymphocytes Is Regulated by Clonal Competition

2003 • 123 citations

Loss of Bim Increases T Cell Production and Function in Interleukin 7 Receptor–deficient Mice

2004 • 121 citations

Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells

2003 • 121 citations

MHC class I is required for peripheral accumulation of CD8+ thymic emigrants.

1998 • 112 citations

An IFN-γ-Dependent Pathway Controls Stimulation of Memory Phenotype CD8+ T Cell Turnover In Vivo by IL-12, IL-18, and IFN-γ

2001 • 106 citations

Survival of Naive CD4 T Cells: Roles of Restricting Versus Selecting MHC Class II and Cytokine Milieu

1999 • 105 citations

The Involvement of the Intestinal Microflora in the Expansion of CD4+ T Cells with a-Naive Phenotype in the Periphery

1992 • 101 citations

MHC Class I Is Required for Peripheral Accumulation of CD8+ Thymic Emigrants

1998 • 100 citations

Normal Regulatory α/β T Cells Effectively Eliminate Abnormally Activated T Cells Lacking the Interleukin 2 Receptor β in Vivo

1999 • 99 citations

AUTORADIOGRAPHIC ANALYSIS OF LYMPHOPOIESIS AND LYMPHOCYTE MIGRATION IN MICE BEARING MULTIPLE THYMUS GRAFTS

1966 • 95 citations

Reduced Expression of Bcl-2 in CD8+ T Cells Deficient in the IL-15 Receptor α-Chain

2002 • 95 citations

IL-7 transgenic mice: analysis of the role of IL-7 in the differentiation of thymocytes in vivo and in vitro

1995 • 95 citations

T-cell survival

1998 • 90 citations

Monoassociation of SCID mice with Helicobacter muridarum, but not four other enterics, provokes IBD upon receipt of T cells

2002 • 88 citations

Are Major Histocompatibility Complex Molecules Involved in the Survival of Naive CD4+ T Cells?

2003 • 76 citations

Suppressor of Cytokine Signaling 1 Regulates IL-15 Receptor Signaling in CD8+CD44high Memory T Lymphocytes

2003 • 71 citations

Naive CD4+ lymphocytes convert to anergic or memory-like cells in T cell-deprived recipients

2001 • 67 citations

A Role for CD28 in Lymphopenia-Induced Proliferation of CD4 T Cells

2004 • 57 citations

Mice deprived of exogenous antigenic stimulation develop a normal repertoire of functional T cells.

1992 • 35 citations

Evidence of a Novel IL-2/15Rβ-Targeted Cytokine Involved in Homeostatic Proliferation of Memory CD8+ T Cells

2004 • 25 citations

Studies of hyperthymic mice. I. The influence of multiple thymus grafts on the size of the peripheral T cell pool and immunological performance.

1978 • 20 citations