Are Major Histocompatibility Complex Molecules Involved in the Survival of Naive CD4+ T Cells?

In search of the ‘missing self’: MHC molecules and NK cell recognition

1990 • 2,600 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1995 • 881 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

1999 • 742 citations

Persistence of Memory CD8 T Cells in MHC Class I-Deficient Mice

1999 • 738 citations

Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation

2000 • 644 citations

B Cells Turn Off Virgin But Not Memory T Cells

1992 • 578 citations

Homeostasis-Stimulated Proliferation Drives Naive T Cells to Differentiate Directly into Memory T Cells

2000 • 527 citations

Cutting Edge: Naive T Cells Masquerading as Memory Cells

2000 • 476 citations

MHC Class I Deficiency: Susceptibility to Natural Killer (NK) Cells and Impaired NK Activity

1991 • 474 citations

In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice.

1975 • 454 citations

Class II-Independent Generation of CD4 Memory T Cells from Effectors

1999 • 422 citations

Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules

1997 • 419 citations

Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice

1991 • 419 citations

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.

1994 • 418 citations

Survival of Mature CD4 T Lymphocytes Is Dependent on Major Histocompatibility Complex Class II–expressing Dendritic Cells

1997 • 402 citations

Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

2002 • 390 citations

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1996 • 377 citations

MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8

1992 • 368 citations

T cell memory is short-lived in the absence of antigen.

1991 • 367 citations

Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.

1994 • 353 citations

Homeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands

1999 • 341 citations

Designing and Maintaining the Mature TCR Repertoire

1999 • 323 citations

γ chain required for naïve CD4+ T cell survival but not for antigen proliferation

2000 • 314 citations

Neonates Support Lymphopenia-Induced Proliferation

2003 • 291 citations

H-2 haplotypes, genes, and antigens: Second listing

1982 • 283 citations

Homeostatic T Cell Proliferation

2000 • 279 citations

How αβ T cells deal with induced TCRα ablation

2001 • 224 citations

How Much TCR Does a T Cell Need?

2001 • 224 citations

Targeted Complementation of MHC Class II Deficiency by Intrathymic Delivery of Recombinant Adenoviruses

1997 • 204 citations

The peripheral T cell repertoire: independent homeostatic regulation of virgin and activated CD8⁺ T cell pools

1995 • 174 citations

TCR and IL-7 Receptor Signals Can Operate Independently or Synergize to Promote Lymphopenia-Induced Expansion of Naive T Cells

2002 • 160 citations

Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition.

1992 • 159 citations

Tetracycline-controllable Selection of CD4+ T Cells: Half-Life and Survival Signals in the Absence of Major Histocompatibility Complex Class II Molecules

2000 • 158 citations

Cd4+ T Cell Division in Irradiated Mice Requires Peptides Distinct from Those Responsible for Thymic Selection

1999 • 157 citations

Survival and Homeostatic Proliferation of Naive Peripheral CD4+ T Cells in the Absence of Self Peptide:MHC Complexes

2000 • 156 citations

CD4+ T cell survival is not directly linked to self-MHC–induced TCR signaling

2000 • 156 citations

Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection

1989 • 147 citations

Dependence of lymphopenia-induced T cell proliferation on the abundance of peptide/ MHC epitopes and strength of their interaction with T cell receptors

2001 • 133 citations

Dendritic Cells Permit Identification of Genes Encoding MHC Class II–Restricted Epitopes of Transplantation Antigens

2000 • 131 citations

Long-Term Survival But Impaired Homeostatic Proliferation of Naïve T Cells in the Absence of p56 ^lck

2000 • 120 citations

Involvement of both major histocompatibility complex class II alpha and beta chains in CD4 function indicates a role for ordered oligomerization in T cell activation.

1995 • 117 citations

Positive Selection of T Cells Induced by Viral Delivery of Neopeptides to the Thymus

1997 • 108 citations

Survival of Naive CD4 T Cells: Roles of Restricting Versus Selecting MHC Class II and Cytokine Milieu

1999 • 105 citations

The CD3 zeta cytoplasmic domain mediates CD2-induced T cell activation.

1992 • 82 citations

Naive CD4+ lymphocytes convert to anergic or memory-like cells in T cell-deprived recipients

2001 • 67 citations

Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage.

1996 • 63 citations

Acute Rejection in the Absence of Cognate Recognition of Allograft by T Cells

2001 • 62 citations

The mouse major histocompatibility complex: some assembly required

1999 • 62 citations

On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4 ⁺ T cells

2003 • 60 citations

On the Lifespan of Virgin T Lymphocytes

1999 • 57 citations

TCR-MHC class II interaction is required for peripheral expansion of CD4 cells in a T cell-deficient host

1998 • 56 citations

Mature CD4+ T Cells Perceive a Positively Selecting Class II MHC/Peptide Complex in the Periphery

2000 • 49 citations

Co‐Stimulation and Co‐Inhibition: Equal Partners in Regulation

1996 • 42 citations

"Anomalous" Thy-1+ killer cells in allogeneic and F1-anti-parental mixed leukocyte culture. Relation to natural killer cells and allospecific cytotoxic T lymphocytes.

1983 • 39 citations

The organization of mature T–cell pools

2000 • 35 citations

MHC-dependent survival of naïve T cells? A complicated answer to a simple question

2002 • 33 citations

Different cytoplasmic structure of the CD3ζ family dimer modulates the activation signal and function of T cells

1994 • 18 citations

Consequences of Self and Foreign Superantigen Interaction with Specific V Elements of the Murine TCR

1989 • 18 citations

CD2 Facilitates Differentiation of CD4 Th Cells Without Affecting Th1/Th2 Polarization

2002 • 13 citations

F1 hybrid-anti-parental H-2b cell-mediated lympholysis: genetic control of target antigens by the H-2D region.

1981 • 9 citations

Role of Self-Major Histocompatibility Complex/Peptide Ligands in Selection and Maintenance of a Diverse T Cell Repertoire

2000 • 9 citations