Coordinate Expression and Trans Presentation of Interleukin (IL)-15Rα and IL-15 Supports Natural Killer Cell and Memory CD8+ T Cell Homeostasis

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

2000 • 1,596 citations

Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

2000 • 1,578 citations

IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation

1998 • 1,293 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

1994 • 1,008 citations

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1995 • 881 citations

IL-15Rα Recycles and Presents IL-15 In trans to Neighboring Cells

2002 • 877 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

Interleukin 15 Is Required for Proliferative Renewal of Virus-specific Memory CD8 T Cells

2002 • 671 citations

Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.

1995 • 627 citations

Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells

2002 • 588 citations

In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells

2002 • 438 citations

The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

1994 • 417 citations

Functional Characterization of the Human Interleukin-15 Receptor αChain and Close Linkage of IL15RA and IL2RA Genes

1995 • 363 citations

Interleukin 15 Controls both Proliferation and Survival of a Subset of Memory-Phenotype CD8+ T Cells

2002 • 332 citations

Interleukin (IL)-15Rα–deficient Natural Killer Cells Survive in Normal but Not IL-15Rα–deficient Mice

2003 • 241 citations

The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases

2002 • 202 citations

T Cell–Independent Interleukin 15rα Signals Are Required for Bystander Proliferation

2001 • 174 citations

Transregulation of memory CD8 T-cell proliferation by IL-15Rα+ bone marrow–derived cells

2003 • 162 citations

IL-15Rα expression on CD8⁺T cells is dispensable for T cell memory

2003 • 160 citations

Death deflected: IL‐15 inhibits TNF‐α‐mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL‐15Rα chain

1999 • 155 citations

Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor α expression

2004 • 154 citations

Essential Role for IL-2 in the Regulation of Antiviral Extralymphoid CD8 T Cell Responses

2002 • 128 citations

The Long Signal Peptide Isoform and Its Alternative Processing Direct the Intracellular Trafficking of Interleukin-15

2000 • 103 citations

Dendritic cell‐derived IL‐15 controls the induction of CD8 T cell immune responses

2003 • 93 citations

Natural Splicing of Exon 2 of Human Interleukin-15 Receptor α-Chain mRNA Results in a Shortened Form with a Distinct Pattern of Expression

1999 • 92 citations

The IL-15Rα Chain Signals Through Association with Syk in Human B Cells

2001 • 84 citations

Interleukin-6 biology is coordinated by membrane bound and soluble receptors.

2003 • 76 citations

IL-15/IL-15Rα intracellular trafficking in human melanoma cells and signal transduction through the IL-15Rα

2000 • 72 citations

Differential Roles for IL-15R α-Chain in NK Cell Development and Ly-49 Induction

2003 • 60 citations

Regulation of Lymphoid Homeostasis by IL-2 Receptor Signals In Vivo

2000 • 60 citations

Mast Cells Express Novel Functional IL-15 Receptor α Isoforms

2003 • 44 citations

IL-2R alpha on one cell can present IL-2 to IL-2R beta/gamma(c) on another cell to augment IL-2 signaling.

1998 • 37 citations

IL-2Rα on One Cell Can Present IL-2 to IL-2Rβ/γc on Another Cell to Augment IL-2 Signaling

1998 • 32 citations