Cutting Edge: Secondary Lymphoid Organs Are Essential for Maintaining the CD4, But Not CD8, Naive T Cell Pool

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

2000 • 1,596 citations

Chemokines and Cell Migration in Secondary Lymphoid Organs

1999 • 1,046 citations

Visualizing the generation of memory CD4 T cells in the whole body

2001 • 1,029 citations

IL-7 is critical for homeostatic proliferation and survival of naïve T cells

2001 • 940 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

1999 • 742 citations

Persistence of Memory CD8 T Cells in MHC Class I-Deficient Mice

1999 • 738 citations

Selecting and maintaining a diverse T-cell repertoire

1999 • 712 citations

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

1997 • 603 citations

Low-Affinity Ligands for the TCR Drive Proliferation of Mature CD8+ T Cells in Lymphopenic Hosts

1999 • 548 citations

Antigen localisation regulates immune responses in a dose‐ and time‐dependent fashion: a geographical view of immune reactivity

1997 • 493 citations

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase

1999 • 448 citations

Immunologic ‘ignorance’ of vascularized organ transplants in the absence of secondary lymphoid tissue

2000 • 446 citations

Population Biology of Lymphocytes: The Flight for Survival

2000 • 439 citations

Class II-Independent Generation of CD4 Memory T Cells from Effectors

1999 • 422 citations

Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules

1997 • 419 citations

Lymphocyte life-span and memory

1994 • 405 citations

Survival of Mature CD4 T Lymphocytes Is Dependent on Major Histocompatibility Complex Class II–expressing Dendritic Cells

1997 • 402 citations

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1996 • 377 citations

A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice

1994 • 327 citations

Designing and Maintaining the Mature TCR Repertoire

1999 • 323 citations

The Role of the Thymus and Recent Thymic Migrants in the Maintenance of the Adult Peripheral Lymphocyte Pool

1998 • 294 citations

Homeostatic T Cell Proliferation

2000 • 279 citations

Homeostasis of αβ TCR+ T cells

2000 • 251 citations

Targeted Complementation of MHC Class II Deficiency by Intrathymic Delivery of Recombinant Adenoviruses

1997 • 204 citations

Effect of Thymectomy in Adult Mice on Immunological Responsiveness

1965 • 179 citations

Survival and Homeostatic Proliferation of Naive Peripheral CD4+ T Cells in the Absence of Self Peptide:MHC Complexes

2000 • 156 citations

CD4+ T cell survival is not directly linked to self-MHC–induced TCR signaling

2000 • 156 citations

Autologous Regulation of Naive T Cell Homeostasis Within the T Cell Compartment

2001 • 155 citations

The life span of naive alpha/beta T cells in secondary lymphoid organs.

1993 • 130 citations

The Effect of Thymectomy on the Lymphoid Tissues of the Mouse

1960 • 119 citations

Functional heterogeneity among the T-derived lymphocytes of the mouse. I. Analysis by adult thymectomy.

1974 • 105 citations

Functional Heterogeneity among the T-Derived Lymphocytes of the Mouse

1974 • 68 citations

On the Lifespan of Virgin T Lymphocytes

1999 • 57 citations

Functional heterogeneity among the T-derived lymphocytes of the mouse

1975 • 55 citations

Immunodeficiency of alymphoplasia mice (aly/aly)in vivo: structural defect of secondary lymphoid organs and functional B cell defect

2000 • 54 citations