COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor–induced entry into the cell cycle from quiescence

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

MAP Kinases in the Immune Response

2002 • 1,620 citations

A Critical Role for Dnmt1 and DNA Methylation in T Cell Development, Function, and Survival

2001 • 1,215 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

2004 • 873 citations

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

2004 • 758 citations

Promotion of NEDD8-CUL1 Conjugate Cleavage by COP9 Signalosome

2001 • 687 citations

Role of Predicted Metalloprotease Motif of Jab1/Csn5 in Cleavage of Nedd8 from Cul1

2002 • 680 citations

S6K1- and ßTRCP-Mediated Degradation of PDCD4 Promotes Protein Translation and Cell Growth

2006 • 680 citations

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

1999 • 624 citations

Maintaining the norm: T-cell homeostasis

2002 • 608 citations

Pocket proteins and cell cycle control

2005 • 592 citations

The Many Faces of IL-7: From Lymphopoiesis to Peripheral T Cell Maintenance

2005 • 551 citations

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

2003 • 532 citations

Skp2 Regulates Myc Protein Stability and Activity

2003 • 492 citations

The COP9 Signalosome

2003 • 480 citations

The F-Box Protein Skp2 Participates in c-Myc Proteosomal Degradation and Acts as a Cofactor for c-Myc-Regulated Transcription

2003 • 466 citations

Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCF ^TIR1 in Mediating Auxin Response

2001 • 463 citations

Nedd8 on cullin: building an expressway to protein destruction

2004 • 423 citations

Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter

2001 • 334 citations

Cyclin C/Cdk3 Promotes Rb-Dependent G0 Exit

2004 • 300 citations

Homeostatic T Cell Proliferation

2000 • 279 citations

Ubiquitin Ligases and the Immune Response

2004 • 277 citations

Identification of pathways regulating cell size and cell-cycle progression by RNAi

2006 • 263 citations

Dynamics and Requirements of T Cell Clonal Expansion In Vivo at the Single-Cell Level: Effector Function Is Linked to Proliferative Capacity

1999 • 253 citations

The proteasome: a utility tool for transcription?

2006 • 243 citations

Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanisms

2003 • 199 citations

MAP kinases in immune responses.

2005 • 190 citations

COP9: a new genetic locus involved in light-regulated development and gene expression in arabidopsis.

1992 • 188 citations

Fission Yeast COP9/Signalosome Suppresses Cullin Activity through Recruitment of the Deubiquitylating Enzyme Ubp12p

2003 • 181 citations

Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels

2006 • 173 citations

The COP9 Signalosome Inhibits p27kip1 Degradation and Impedes G1-S Phase Progression via Deneddylation of SCF Cul1

2002 • 170 citations

Multiple Functions of Jab1 Are Required for Early Embryonic Development and Growth Potential in Mice

2004 • 158 citations

The COP9 signalosome: at the interface between signal transduction and ubiquitin-dependent proteolysis

2002 • 156 citations

Disruption of the COP9 Signalosome Csn2 Subunit in Mice Causes Deficient Cell Proliferation, Accumulation of p53 and Cyclin E, and Early Embryonic Death

2003 • 141 citations

COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways inDrosophila melanogaster

2002 • 132 citations

Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage

2007 • 116 citations

Deletion Mutants in COP9/Signalosome Subunits in Fission YeastSchizosaccharomyces pombeDisplay Distinct Phenotypes

2002 • 111 citations

The Mitogen-Induced Increase in T Cell Size Involves PKC and NFAT Activation of Rel/NF-κB-Dependent c-myc Expression

2004 • 109 citations

COP9 Signalosome Subunit 3 Is Essential for Maintenance of Cell Proliferation in the Mouse Embryonic Epiblast

2003 • 106 citations

Commitment Point during G₀→G₁ That Controls Entry into the Cell Cycle

2003 • 103 citations

Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3

2005 • 97 citations

CSN1 N-Terminal–dependent Activity Is Required for Arabidopsis Development But Not for Rub1/Nedd8 Deconjugation of Cullins: A Structure-Function Study of CSN1 Subunit of COP9 Signalosome

2002 • 75 citations

Characterization and Purification of the Mammalian COP9 Complex, a Conserved Nuclear Regulator Initially Identified as a Repressor of Photomorphogenesis in Higher Plants

1998 • 74 citations

The Jab1/COP9 signalosome subcomplex is a downstream mediator of Bcr-Abl kinase activity and facilitates cell-cycle progression

2004 • 74 citations

Characterization and Purification of the Mammalian COP9 Complex, a Conserved Nuclear Regulator Initially Identified as a Repressor of Photomorphogenesis in Higher Plants

1998 • 68 citations

The COP9 Signalosome Regulates Skp2 Levels and Proliferation of Human Cells

2006 • 68 citations

From antigen to activation: specific signal transduction pathways linking antigen receptors to NF-κB

2003 • 52 citations

Small Jab1‐containing subcomplex is regulated in an anchorage‐ and cell cycle‐dependent manner, which is abrogated by ras transformation

2005 • 50 citations

Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome

2008 • 47 citations

Retinoblastoma Protein Regulation by the COP9 Signalosome

2007 • 40 citations

The COP9 signalosome regulates cell proliferation of Dictyostelium discoideum

2006 • 34 citations

Analysis of Site-Specific Phosphorylation of the Retinoblastoma Protein during Cell Cycle Progression

1999 • 33 citations

The Role of Cyclin-Dependent Kinases in T-Cell Development, Proliferation, and Function

2006 • 32 citations