Migratory neighbors and distant invaders: tumor-associated niche cells

The Hallmarks of Cancer

2000 • 27,569 citations

Multilineage Potential of Adult Human Mesenchymal Stem Cells

1999 • 20,447 citations

Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin

2016 • 7,054 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Epithelial–mesenchymal transitions in tumour progression

2002 • 6,431 citations

Involvement of chemokine receptors in breast cancer metastasis

2001 • 5,203 citations

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

2002 • 5,109 citations

Fibroblasts in cancer

2006 • 4,177 citations

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

2005 • 3,543 citations

Tumour-educated macrophages promote tumour progression and metastasis

2004 • 3,259 citations

Mesenchymal stem cells within tumour stroma promote breast cancer metastasis

2007 • 3,082 citations

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

2005 • 3,066 citations

A multigenic program mediating breast cancer metastasis to bone

2003 • 2,539 citations

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

1996 • 2,374 citations

Stromal fibroblasts in cancer initiation and progression

2004 • 2,230 citations

Putting tumours in context

2001 • 2,145 citations

Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

2001 • 1,874 citations

Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma

2006 • 1,747 citations

Friends or foes — bipolar effects of the tumour stroma in cancer

2004 • 1,742 citations

Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration

2003 • 1,598 citations

Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy

2001 • 1,556 citations

Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

2007 • 1,446 citations

Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium

2000 • 1,445 citations

Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: Potential targets of anti-cancer therapy

2006 • 1,418 citations

Endothelial Cell Migration During Angiogenesis

2007 • 1,369 citations

Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1

1996 • 1,355 citations

Lysyl oxidase is essential for hypoxia-induced metastasis

2006 • 1,302 citations

Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors

2005 • 1,266 citations

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

2003 • 1,236 citations

Altered macrophage differentiation and immune dysfunction in tumor development

2007 • 1,196 citations

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

2003 • 1,172 citations

VEGF-Induced Adult Neovascularization: Recruitment, Retention, and Role of Accessory Cells

2006 • 1,122 citations

Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis

2004 • 1,111 citations

Progression to Malignancy in the Polyoma Middle T Oncoprotein Mouse Breast Cancer Model Provides a Reliable Model for Human Diseases

2003 • 1,049 citations

Macrophages Regulate the Angiogenic Switch in a Mouse Model of Breast Cancer

2006 • 1,020 citations

Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors

2007 • 1,011 citations

Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion

2007 • 970 citations

Tumor Induction of VEGF Promoter Activity in Stromal Cells

1998 • 964 citations

Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis

2006 • 959 citations

Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts

1999 • 919 citations

Intravital imaging of cell movement in tumours

2003 • 908 citations

Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis

2008 • 882 citations

MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis

2002 • 879 citations

In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

2005 • 860 citations

Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues

2004 • 853 citations

Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells

2007 • 831 citations

Antigen-Specific Inhibition of CD8+ T Cell Response by Immature Myeloid Cells in Cancer Is Mediated by Reactive Oxygen Species

2004 • 825 citations

PAR1 Is a Matrix Metalloprotease-1 Receptor that Promotes Invasion and Tumorigenesis of Breast Cancer Cells

2005 • 808 citations

Anti-PlGF Inhibits Growth of VEGF(R)-Inhibitor-Resistant Tumors without Affecting Healthy Vessels

2007 • 765 citations

Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells

2005 • 764 citations

Cellular abnormalities of blood vessels as targets in cancer

2004 • 753 citations

Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets

1997 • 719 citations

Macrophages Promote the Invasion of Breast Carcinoma Cells via a Colony-Stimulating Factor-1/Epidermal Growth Factor Paracrine Loop

2005 • 714 citations

S100 proteins structure functions and pathology

2002 • 702 citations

VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis

2005 • 678 citations

Identification of fibroblast heterogeneity in the tumor microenvironment

2006 • 657 citations

The biology of cell locomotion within three-dimensional extracellular matrix

2000 • 647 citations

Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis

2008 • 641 citations

Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes

2006 • 639 citations

A Proinflammatory Cytokine Inhibits P53 Tumor Suppressor Activity

1999 • 635 citations

Matrix Metalloproteinase Stromelysin-1 Triggers a Cascade of Molecular Alterations That Leads to Stable Epithelial-to-Mesenchymal Conversion and a Premalignant Phenotype in Mammary Epithelial Cells

1997 • 633 citations

Bone Marrow-Derived Cells Do Not Incorporate Into the Adult Growing Vasculature

2003 • 605 citations

The significance of hematogenous tumor cell clumps in the metastatic process.

1976 • 568 citations

Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells.

2000 • 537 citations

Human CD34+AC133+VEGFR-2+ cells are not endothelial progenitor cells but distinct, primitive hematopoietic progenitors

2007 • 526 citations

Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.

1996 • 515 citations

Bone Marrow Contribution to Tumor-Associated Myofibroblasts and Fibroblasts

2004 • 515 citations

Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas.

1995 • 511 citations

The multistep nature of cancer development.

1984 • 510 citations

VEGF-C–induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites

2006 • 506 citations

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

2003 • 481 citations

Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer

2007 • 479 citations

Reduction of Myeloid-Derived Suppressor Cells and Induction of M1 Macrophages Facilitate the Rejection of Established Metastatic Disease

2005 • 462 citations

Acceleration of human prostate cancer growth in vivo by factors produced by prostate and bone fibroblasts.

1991 • 449 citations

S100 proteins: structure, functions and pathology

2002 • 441 citations

Expression of CXCR4 and CXCL12 (SDF‐1) in human prostate cancers (PCa) in vivo

2003 • 440 citations

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

2003 • 436 citations

Nitric oxide and oxygen radicals in infection, inflammation, and cancer.

1998 • 425 citations

A Possible Role for CXCR4 and Its Ligand, the CXC Chemokine Stromal Cell-Derived Factor-1, in the Development of Bone Marrow Metastases in Neuroblastoma

2001 • 419 citations

Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization

2000 • 419 citations

Fibroblast-mediated acceleration of human epithelial tumor growth in vivo.

1990 • 417 citations

Platelets secrete stromal cell–derived factor 1α and recruit bone marrow–derived progenitor cells to arterial thrombi in vivo

2006 • 415 citations

Unopposed Production of Granulocyte-Macrophage Colony-Stimulating Factor by Tumors Inhibits CD8+ T Cell Responses by Dysregulating Antigen-Presenting Cell Maturation

1999 • 406 citations

Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization

2007 • 392 citations

Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas

2000 • 380 citations

Tumor-Induced Sentinel Lymph Node Lymphangiogenesis and Increased Lymph Flow Precede Melanoma Metastasis

2007 • 370 citations

The role of Osteopontin in tumor metastasis

2004 • 361 citations

Chemokine receptor CXCR4–dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells

2005 • 354 citations

Radiation to Stromal Fibroblasts Increases Invasiveness of Pancreatic Cancer Cells through Tumor-Stromal Interactions

2004 • 353 citations

Role Of Immature Myeloid Cells in Mechanisms of Immune Evasion In Cancer

2005 • 352 citations

Long-Term Hematopoietic Stem Cells Require Stromal Cell-Derived Factor-1 for Colonizing Bone Marrow during Ontogeny

2003 • 350 citations

Malignant transformation in a nontumorigenic human prostatic epithelial cell line.

2001 • 343 citations

Pericytes limit tumor cell metastasis

2006 • 336 citations

The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity.

2002 • 330 citations

VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization

2006 • 328 citations

Smooth‐muscle differentiation in stromal cells of malignant and non‐malignant breast tissues

1988 • 319 citations

Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer

2000 • 304 citations

Tumor-Associated CD8+ T Cell Tolerance Induced by Bone Marrow-Derived Immature Myeloid Cells

2005 • 302 citations

Mesenchymal progenitor cells as cellular vehicles for delivery of oncolytic adenoviruses

2006 • 300 citations

Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity

2003 • 300 citations

Induction of Hepatocyte Growth Factor in Fibroblasts by Tumor-derived Factors Affects Invasive Growth of Tumor Cells : In Vitro Analysis of Tumor-Stromal Interactions

1998 • 291 citations

Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium

2004 • 284 citations

The macrophage growth factor CSF-1 in mammary gland development and tumor progression.

2002 • 279 citations

Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction

2003 • 276 citations

Infiltration of COX-2–expressing macrophages is a prerequisite for IL-1β–induced neovascularization and tumor growth

2005 • 269 citations

PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE

2008 • 261 citations

Migration of coordinated cell clusters in mesenchymal and epithelial cancer explants in vitro.

1995 • 239 citations

Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-α and TGF-β

2005 • 229 citations

Anti-Colony-Stimulating Factor-1 Antibody Staining in Primary Breast Adenocarcinomas Correlates With Marked Inflammatory Cell Infiltrates and Prognosis

1994 • 226 citations

Contribution of endothelial progenitors and proangiogenic hematopoietic cells to vascularization of tumor and ischemic tissue

2006 • 224 citations

Suppression of Tumor Development and Metastasis Formation in Mice Lacking the S100A4(mts1) Gene

2005 • 218 citations

Tumor-Cell Homing to Lymph Nodes and Bone Marrow and CXCR4 Expression in Esophageal Cancer

2005 • 217 citations

Cytokine networks in solid human tumors: regulation of angiogenesis

1994 • 209 citations

Chemokine stimulation of monocyte matrix metalloproteinase-9 requires endogenous TNF-α

2002 • 200 citations

A reciprocal tensin-3–cten switch mediates EGF-driven mammary cell migration

2007 • 197 citations

The Participation of Mesenchymal Stem Cells in Tumor Stroma Formation and Their Application as Targeted-Gene Delivery Vehicles

2007 • 194 citations

Proangiogenic role of tumor-activated hepatic stellate cells in experimental melanoma metastasis

2003 • 189 citations

Preexisting Lymphatic Endothelium but not Endothelial Progenitor Cells Are Essential for Tumor Lymphangiogenesis and Lymphatic Metastasis

2004 • 187 citations

Analysis of the Gene Expression Profile Activated by the CC Chemokine Ligand 5/RANTES and by Lipopolysaccharide in Human Monocytes

2002 • 182 citations

Osteopontin Facilitates Angiogenesis, Accumulation of Osteoclasts, and Resorption in Ectopic Bone*

2001 • 180 citations

Regulation of Epithelial Cell Migration and Tumor Formation by β-Catenin Signaling

2002 • 162 citations

Macrophages in human breast disease: a quantitative immunohistochemical study

1988 • 160 citations

Thrombin Induces the Release of Angiopoietin-1 from Platelets

2001 • 147 citations

Tissue Inhibitor of Metalloproteinases-1 Promotes Liver Metastasis by Induction of Hepatocyte Growth Factor Signaling

2007 • 145 citations

What brings pericytes to tumor vessels?

2003 • 143 citations

Differentiation between High- and Low-Grade Astrocytoma Using a Human Recombinant Antibody to the Extra Domain-B of Fibronectin

2002 • 141 citations

The role of chemoattraction in cancer metastases

2001 • 138 citations

Tumor-dependent activation of rodent hepatic stellate cells during experimental melanoma metastasis

1997 • 135 citations

Vascular Endothelial Growth Factor Family and Receptor Expression in Human Choroidal Neovascular Membranes

2002 • 132 citations

Isolation of prostate-derived single cells and cell clusters from human peripheral blood.

1996 • 128 citations

Osteopontin-induced migration of human mammary epithelial cells involves activation of EGF receptor and multiple signal transduction pathways

2003 • 128 citations

Urokinase and macrophages in tumour angiogenesis

1995 • 121 citations

Chemokine modulation of matrix metalloproteinase and TIMP production in adult rat brain microglia and a human microglial cell line in vitro

1999 • 119 citations

Cell-adhesion-dependent influences on genomic instability and carcinogenesis

1998 • 101 citations

RANKL-induced CCL22/macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4

2006 • 99 citations

Membrane Conformations and Their Relation to Cytotoxicity of Asimicin and Its Analogues

1998 • 97 citations

Epigenetics and the plasticity of differentiation in normal and cancer stem cells

2006 • 91 citations

Deregulation of Alternative Splicing of Fibronectin Pre-mRNA in Malignant Human Liver Tumors

1989 • 89 citations

CXCR4 Activation Induces Epidermal Growth Factor Receptor Transactivation in an Ovarian Cancer Cell Line

2004 • 88 citations

Circulating Vascular Progenitor Cells Do Not Contribute to Compensatory Lung Growth

2003 • 86 citations

Induction of epithelial to mesenchymal transition in PMC42-LA human breast carcinoma cells by carcinoma-associated fibroblast secreted factors

2007 • 86 citations

Fibroblasts Can Modulate the Phenotype of Malignant Epithelial Cellsin Vitro

1997 • 79 citations

Hematopoietic cells regulate the angiogenic switch during tumorigenesis

2004 • 78 citations

Source of oncofetal ED-B-containing fibronectin: implications of production by both tumor and endothelial cells.

2000 • 67 citations

Migration-stimulating factor: a genetically truncated onco-fetal fibronectin isoform expressed by carcinoma and tumor-associated stromal cells.

2003 • 65 citations

The potential influence of radiation-induced microenvironments in neoplastic progression.

1998 • 62 citations

Osteopontin Facilitates Angiogenesis, Accumulation of Osteoclasts, and Resorption in Ectopic Bone

2001 • 54 citations

Identification of alterations in DNA copy number in host stromal cells during tumor progression

2006 • 51 citations

Autonomic neuropathy in extra-hepatic portal vein thrombosis: evidence for impaired autonomic reflex arc

1997 • 36 citations

Angiostatin inhibits monocyte/macrophage migrationviadisruption of actin cytoskeleton

2007 • 35 citations

Genetically modified CD34+ cells exert a cytotoxic bystander effect on human endothelial and cancer cells.

2000 • 33 citations

EB-D fibronectin expression in squamous cell carcinoma of the head and neck

2004 • 31 citations

Thrombopoietic Cells and the Bone Marrow Vascular Niche

2007 • 18 citations

Experimental lymphatic metastasis

1983 • 15 citations

Program outline for Melanoma Congress Program – November 1–4, 2007

2007 • 2 citations