S100 proteins structure functions and pathology

The versatility and universality of calcium signalling

2000 • 5,407 citations

RAGE Mediates a Novel Proinflammatory Axis

1999 • 1,807 citations

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

1989 • 1,752 citations

S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles

2001 • 1,555 citations

The S100 family of EF-hand calcium-binding proteins: functions and pathology

1996 • 1,002 citations

The biology of the receptor for advanced glycation end products and its ligands

2000 • 690 citations

Coregulation of Neurite Outgrowth and Cell Survival by Amphoterin and S100 Proteins through Receptor for Advanced Glycation End Products (RAGE) Activation

2000 • 566 citations

S-100 Protein and Neuron-Specific Enolase Concentrations in Blood as Indicators of Infarction Volume and Prognosis in Acute Ischemic Stroke

1997 • 457 citations

MRP-8 and MRP-14, two abundant Ca2+-binding proteins of neutrophils and monocytes

1993 • 388 citations

Classification and evolution of EF-hand proteins.

1998 • 345 citations

Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family

1995 • 332 citations

Structure of the negative regulatory domain of p53 bound to S100B(betabeta).

2000 • 311 citations

Structure of vitamin D-dependent calcium-binding protein from bovine intestine

1981 • 309 citations

The crystal structure of a complex of p11 with the annexin II N-terminal peptide.

1999 • 286 citations

New perspectives on S100 proteins: a multi-functional Ca(2+)-, Zn(2+)- and Cu(2+)-binding protein family.

1998 • 283 citations

Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9)

1998 • 276 citations

Neurite extension and neuronal survival activities of recombinant S100 beta proteins that differ in the content and position of cysteine residues.

1989 • 269 citations

Astroglial Protein S-100 Is an Early and Sensitive Marker of Hypoxic Brain Damage and Outcome After Cardiac Arrest in Humans

2001 • 243 citations

The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor

2001 • 242 citations

The Ca2+-binding Proteins S100A8 and S100A9 Are Encoded by Novel Injury-regulated Genes

2001 • 230 citations

Expression pattern of S100 calcium-binding proteins in human tumors

1996 • 224 citations

Titin–Actin Interaction in Mouse Myocardium: Passive Tension Modulation and Its Regulation by Calcium/S100A1

2001 • 221 citations

Increased S100β neurotrophic activity in Alzheimer's disease temporal lobe

1992 • 214 citations

Correlation of Astrocytic S100β Expression with Dystrophic Neurites in Amyloid Plaques of Alzheimerʼs Disease

1996 • 210 citations

S100A12 Is Expressed Exclusively by Granulocytes and Acts Independently from MRP8 and MRP14

1999 • 204 citations

S100β expression in Alzheimer's disease: Relation to neuropathology in brain regions

1994 • 193 citations

Interactions between the microtubule-associated tau proteins and S100b regulate tau phosphorylation by the Ca2+/calmodulin-dependent protein kinase II.

1988 • 189 citations

Structural basis of the Ca2+-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I

2000 • 182 citations

Expression of the calcium-binding protein S100A4 (p9Ka) in MMTV-neu transgenic mice induces metastasis of mammary tumours.

1996 • 182 citations

Differential expression patterns ofS100a2, S100a4 andS100a6 during progression of human malignant melanoma

1997 • 178 citations

Inverse expression of S100A4 and E-cadherin is associated with metastatic potential in gastric cancer.

2000 • 178 citations

The structure of calcyclin reveals a novel homodimeric fold for S100 Ca2+-binding proteins

1995 • 174 citations

Metastasis of mammary carcinomas in GRS/A hybrid mice transgenic for the mts1 gene.

1996 • 169 citations

Psoriasin (S100A7) Expression and Invasive Breast Cancer

1999 • 165 citations

Altered expression of the Ca2+-binding protein S100A1 in human cardiomyopathy

1996 • 165 citations

A Null Mutation in the Inflammation-Associated S100 Protein S100A8 Causes Early Resorption of the Mouse Embryo

1999 • 164 citations

Down-regulation of a member of the S100 gene family in mammary carcinoma cells and reexpression by azadeoxycytidine treatment.

1992 • 161 citations

Distinct subcellular localization of calcium binding S100 proteins in human smooth muscle cells and their relocation in response to rises in intracellular calcium

1998 • 159 citations

Human brain S100β and S100β mRNA expression increases with age: Pathogenic implications for Alzheimer's disease

1996 • 155 citations

Solution Structure of Calcium-Bound Rat S100B(ββ) As Determined by Nuclear Magnetic Resonance Spectroscopy^,

1998 • 154 citations

Increased S100B blood levels in unmedicated and treated schizophrenic patients are correlated with negative symptomatology

2001 • 149 citations

S100A1: A regulator of myocardial contractility

2001 • 146 citations

Calcium-binding protein S100A4 in health and disease

1998 • 139 citations

S100P calcium-binding protein overexpression is associated with immortalization of human breast epithelial cells in vitro and early stages of breast cancer development in vivo.

2000 • 138 citations

Expression of Ca²⁺‐binding proteins of the S100 family in malignant human breast‐cancer cell lines and biopsy samples

1994 • 134 citations

Life-long overexpression of S100β in Down’s syndrome: implications for Alzheimer pathogenesis

1998 • 131 citations

Expression of calcyclin in human melanoma cell lines correlates with metastatic behavior in nude mice.

1992 • 128 citations

S100A8: emerging functions and regulation

1999 • 125 citations

Overexpression of the Neurotrophic Cytokine S100β in Human Temporal Lobe Epilepsy

1995 • 125 citations

Liprin β1, a Member of the Family of LAR Transmembrane Tyrosine Phosphatase-interacting Proteins, Is a New Target for the Metastasis-associated Protein S100A4 (Mts1)

2002 • 124 citations

Solution Structure of Rat Apo-S100B(ββ) As Determined by NMR Spectroscopy^,

1996 • 122 citations

Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylation

1997 • 121 citations

Diminished expression of S100A2, a putative tumor suppressor, at early stage of human lung carcinogenesis.

2001 • 120 citations

A novel calcium-sensitive switch revealed by the structure of human S100B in the calcium-bound form

1998 • 118 citations

Interaction of S100A1 with the Ca²⁺ Release Channel (Ryanodine Receptor) of Skeletal Muscle

1997 • 117 citations

Disulfide-linked S100β dimers and signal transduction

1992 • 116 citations

Enhanced Calcium Transients in Glial Cells in Neonatal Cerebellar Cultures Derived from S100B Null Mice

2000 • 115 citations

The solution structure of the bovine S100B protein dimer in the calcium-free state

1996 • 114 citations

The three-dimensional structure of Ca2+-bound calcyclin: implications for Ca2+-signal transduction by S100 proteins

1998 • 113 citations

Supratentorial Pilocytic Astrocytomas, Astrocytomas, Anaplastic Astrocytomas and Glioblastomas are Characterized by a Differential Expression of S100 Proteins

1999 • 112 citations

The structure of S100A12 in a hexameric form and its proposed role in receptor signalling

2002 • 111 citations

Identification of Human Epidermal Differentiation Complex (EDC)-Encoded Genes by Subtractive Hybridization of Entire YACs to a Gridded Keratinocyte cDNA Library

2001 • 107 citations

Intracellular Ca2+ and Zn2+ Levels Regulate the Alternative Cell Density-dependent Secretion of S100B in Human Glioblastoma Cells

2001 • 105 citations

The crystal structure of human MRP14 (S100A9), a Ca2+-dependent regulator protein in inflammatory process

2002 • 101 citations

A novel mode of target recognition suggested by the 2.0 å structure of holo S100B from bovine brain

1998 • 100 citations

EF-hands at atomic resolution: the structure of human psoriasin (S100A7) solved by MAD phasing

1998 • 100 citations

Increased expression of S100A4 and its prognostic significance in esophageal squamous cell carcinoma

2001 • 100 citations

Human Gingival Crevicular Fluid Contains MRP8 (S100A8) and MRP14 (S100A9), Two Calcium-binding Proteins of the S100 Family

2000 • 99 citations

Brain S100A5 Is a Novel Calcium-, Zinc-, and Copper Ion-binding Protein of the EF-hand Superfamily

2000 • 98 citations

Molecular Cloning and Characterization of the Human S100A14 Gene Encoding a Novel Member of the S100 Family

2002 • 92 citations

The use of dipolar couplings for determining the solution structure of rat apo‐S100B(ββ)

1999 • 91 citations

Psoriasis and Altered Calcium Metabolism: Downregulated Capacitative Calcium Influx and Defective Calcium-Mediated Cell Signaling in Cultured Psoriatic Keratinocytes1

2000 • 88 citations

Comparison of the metastasis-inducing protein S100A4 (p9ka) with other prognostic markers in human breast cancer

2000 • 87 citations

Clustered organization of S100 genes in human and mouse

1998 • 85 citations

S100 beta is a more reliable tumor marker in peripheral blood for patients with newly occurred melanoma metastases compared with MIA, albumin and lactate-dehydrogenase.

2001 • 82 citations

Autoimmunity to a cornea-associated stromal antigen in patients with Mooren's ulcer.

1995 • 81 citations

Overexpression of the Neuritotrophic Cytokine S100β Precedes the Appearance of Neuritic β-Amyloid Plaques in APPV717F Mice

2000 • 80 citations

Subcellular distribution of S100 proteins in tumor cells and their relocation in response to calcium activation

1999 • 79 citations

Effects of S100A1 and S100B on microtubule stability. An in vitro study using triton-cytoskeletons from astrocyte and myoblast cell lines

2000 • 78 citations

The three-dimensional structure of human S100A12

2001 • 77 citations

A longitudinal study of the leukocyte protein L1 as an indicator of disease activity in patients with rheumatoid arthritis.

1989 • 73 citations

Three-Dimensional Solution Structure of the Calcium-Signaling Protein Apo-S100A1 As Determined by NMR^,

2001 • 72 citations

Prognostic significance of the Ca2+ binding protein S100A2 in laryngeal squamous-cell carcinoma

2000 • 69 citations

Calprotectin in patients with rheumatoid arthritis: relation to clinical and laboratory variables of disease activity.

1992 • 68 citations

Distribution of a specific calcium-binding protein of the S100 protein family, S100A6 (calcyclin), in subpopulations of neurons and glial cells of the adult rat nervous system

1999 • 66 citations

Decreased S100-beta protein in schizophrenia: preliminary evidence

2000 • 64 citations

Right ventricular upregulation of the Ca2+ binding protein S100A1 in chronic pulmonary hypertension

2000 • 62 citations

S100A1, a New Marker for Acute Myocardial Ischemia

2000 • 59 citations

Learning and Memory in S100-β Transgenic Mice: An Analysis of Impaired and Preserved Function

2001 • 59 citations

Human calgizzarin; one colorectal cancer-related gene selected by a large scale random cDNA sequencing and Northern blot analysis

1995 • 56 citations

High resolution solution structure of apo calcyclin and structural variations in the S100 family of calcium-binding proteins.

1999 • 54 citations

The Crystal Structure of Metal-free Human EF-hand Protein S100A3 at 1.7-Å Resolution

2002 • 54 citations

S100A13 and S100A6 exhibit distinct translocation pathways in endothelial cells

2002 • 53 citations

Molecular Characterization and Tissue Distribution of a Novel Member of the S100 Family of EF-Hand Proteins^,

2001 • 53 citations

Cytokine and S100B levels in paediatric patients undergoing corrective cardiac surgery with or without total circulatory arrest

1999 • 52 citations

Identification of a serum-inducible messenger RNA (5B10) as the mouse homologue of calcyclin: tissue distribution and expression in metastatic, ras-transformed NIH 3T3 cells.

1990 • 52 citations

Differential expression of S100 calcium‐binding proteins characterizes distinct clinical entities in both WHO grade II and III astrocytic tumours

2000 • 50 citations

Transcriptional regulation of S100A1 and expression during mouse heart development

2000 • 47 citations

Human S100A11 Exhibits Differential Steady-State RNA Levels in Various Tissues and a Distinct Subcellular Localization

1999 • 42 citations

Abnormal exploratory behavior in transgenic mice carrying multiple copies of the human gene for S100 beta.

1995 • 39 citations

S100A6, a calcium- and zinc-binding protein, is overexpressed in SOD1 mutant mice, a model for amyotrophic lateral sclerosis

2000 • 39 citations

Myeloid-related protein (MRP)-8 from cervico-vaginal secretions activates HIV replication

2001 • 38 citations

Acute exacerbation of multiple sclerosis increases plasma levels of S-100 protein

2009 • 33 citations

Identification of MRP-8 (calgranulin A) as a major responsive protein in chronic periodontitis

2000 • 31 citations

A new optical immunoassay for detection of S-100B protein in whole blood

1999 • 28 citations

Translocation of S100A1 Calcium Binding Protein during Heart Surgery

2001 • 19 citations

S100A1 modulates skeletal muscle contraction by desensitizing calcium activation of isometric tension, stiffness and ATPase

2001 • 19 citations

Characterization of a Splice Variant of Metastasis-Associatedh-mtsl (S100A4)Gene Expressed in Human Infiltrating Carcinomas of the Breast

1998 • 15 citations

Cloning and expression of bovine corneal antigen cDNA

1997 • 14 citations

A selective method for determining MRP8 and MRP14 homocomplexes and heterocomplexes by sandwich ELISA for the discrimination of active and non-active osteoarthritis from rheumatoid arthritis in sera and synovial fluids

1995 • 10 citations

A Unique Exon–Intron Organization of a Porcine S100C Gene: Close Evolutionary Relationship to Calmodulin Genes

1998 • 8 citations

[7] Calcium-binding proteins and their assessment in ocular diseases

2000 • 3 citations