Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

Metalloproteinases and their inhibitors in matrix remodeling

1990 • 1,627 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

1989 • 1,122 citations

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

1988 • 1,050 citations

Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas

1994 • 769 citations

Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

1986 • 764 citations

Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas.

1995 • 511 citations

Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages.

1993 • 479 citations

Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis

1995 • 429 citations

Urokinase and urokinase receptor: A paracrine/autocrine system regulating cell migration and invasiveness

1993 • 402 citations

Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones.

1994 • 391 citations

A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts.

1993 • 383 citations

Matrilysin: An epithelial matrix metalloproteinase with potentially novel functions

1996 • 370 citations

The collagenase gene family in humans consists of at least four members

1988 • 364 citations

Activity of type IV collagenases in benign and malignant breast disease

1993 • 337 citations

Immunohistochemical distribution of type IV collagenase in normal, benign, and malignant breast tissue.

1990 • 323 citations

cDNA Sequence and mRNA Tissue Distribution of a Novel Human Matrix Metalloproteinase with a Potential Transmembrane Segment

1995 • 319 citations

Expression and localization of the matrix metalloproteinase pump‐1 (MMP‐7) in human gastric and colon carcinomas

1991 • 288 citations

Primary structure and cDNA cloning of human fibroblast collagenase inhibitor.

1986 • 274 citations

Expression and localization of matrix‐degrading metalloproteinases during colorectal tumorigenesis

1994 • 256 citations

cDNA Sequence and mRNA Tissue Distribution of a Novel Human Matrix Metalloproteinase with a Potential Transmembrane Segment

1995 • 244 citations

Concanavalin A produces a matrix-degradative phenotype in human fibroblasts. Induction and endogenous activation of collagenase, 72-kDa gelatinase, and Pump-1 is accompanied by the suppression of the tissue inhibitor of matrix metalloproteinases.

1990 • 235 citations

Inhibition of Angiogenesis and Murine Hemangioma Growth by Batimastat, a Synthetic Inhibitor of Matrix Metalloproteinases

1995 • 234 citations

Transforming growth factor beta mediates the progesterone suppression of an epithelial metalloproteinase by adjacent stroma in the human endometrium.

1995 • 226 citations

Expression of metalloproteinase genes in human prostate cancer

1991 • 222 citations

Expression of collagenase‐related metalloproteinase genes in human lung or head and neck tumours

1991 • 210 citations

Stromelysin 3 belongs to a subgroup of proteinases expressed in breast carcinoma fibroblastic cells and possibly implicated in tumor progression.

1993 • 209 citations

Modulation of matrilysin levels in colon carcinoma cell lines affects tumorigenicity in vivo.

1994 • 189 citations

Inhibition of organ invasion by the matrix metalloproteinase inhibitor batimastat (BB-94) in two human colon carcinoma metastasis models.

1995 • 184 citations

Matrix Metalloproteinase Matrilysin Is Constitutively Expressed in Adult Human Exocrine Epithelium

1995 • 174 citations

Enhanced expression of tissue inhibitor of metalloproteinase‐2 (TIMP‐2) in the stroma of breast carcinomas correlates with tumor recurrence

1994 • 173 citations

Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family.

1994 • 162 citations

The basic region of AP-1 specifies glucocorticoid receptor activity at a composite response element.

1992 • 159 citations

Human Macrophage Metalloelastase. GENOMIC ORGANIZATION, CHROMOSOMAL LOCATION, GENE LINKAGE, AND TISSUE-SPECIFIC EXPRESSION

1995 • 156 citations

The metalloproteinase matrilysin is preferentially expressed by epithelial cells in a tissue-restricted pattern in the mouse.

1995 • 150 citations

Expression of the stromelysin-3 gene in fibroblastic cells of invasive carcinomas of the breast and other human tissues: a review

1993 • 123 citations

72 KD and 92 KD type IV collagenase, type IV collagen, and laminin mRNAs in breast cancer: a study by in situ hybridization.

1994 • 103 citations

Inhibition of bone resorption in vitro by selective inhibitors of gelatinase and collagenase

1995 • 95 citations

Gelatinase A expression and localization in human breast cancers. An in situ hybridization study and immunohistochemical detection using confocal microscopy

1994 • 82 citations

Correlation between stromelysin‐3 mRNA level and outcome of human breast cancer

1994 • 76 citations

Immunolocalization of matrix metallo-proteinases and their tissue inhibitor in human mammary pathology.

1992 • 63 citations

Expression of Matrilysin mRNA in Colorectal Adenomas and Its Induction by Truncated Fibronectin

1994 • 62 citations

Structure and expression of the cDNA encoding human neutrophil collagenase

1991 • 57 citations

Stromelysin‐3 expression in breast cancer biopsies: Clinico‐pathological correlations

1993 • 43 citations