Epithelial–mesenchymal transitions in tumour progression

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

2001 • 11,070 citations

Gene expression profiling predicts clinical outcome of breast cancer

2002 • 9,314 citations

The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

2000 • 3,504 citations

The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

2000 • 2,569 citations

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1991 • 2,230 citations

Molecular cloning and expression of human hepatocyte growth factor

1989 • 2,191 citations

WT-1 is required for early kidney development

1993 • 1,976 citations

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1991 • 1,686 citations

E-cadherin germline mutations in familial gastric cancer

1998 • 1,629 citations

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.

1991 • 1,592 citations

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

1997 • 1,508 citations

Morphogenetic roles of classic cadherins

1995 • 1,468 citations

A causal role for E-cadherin in the transition from adenoma to carcinoma

1998 • 1,415 citations

Scatter factor/hepatocyte growth factor is essential for liver development

1995 • 1,398 citations

The Two-Handed E Box Binding Zinc Finger Protein SIP1 Downregulates E-Cadherin and Induces Invasion

2001 • 1,351 citations

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

1987 • 1,333 citations

β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin

2001 • 1,304 citations

Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

1995 • 1,278 citations

Epithelial-Mesenchymal Interactions

1967 • 1,218 citations

A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.

1995 • 1,118 citations

Plexins Are a Large Family of Receptors for Transmembrane, Secreted, and GPI-Anchored Semaphorins in Vertebrates

1999 • 1,118 citations

Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4

1994 • 1,056 citations

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

1995 • 1,027 citations

Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

2001 • 1,020 citations

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

1994 • 1,018 citations

From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion

1993 • 997 citations

Transforming Growth Factor-β1 Mediates Epithelial to Mesenchymal Transdifferentiation through a RhoA-dependent Mechanism

2001 • 993 citations

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

1994 • 983 citations

Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.

1989 • 961 citations

Cytokeratin-Positive Cells in the Bone Marrow and Survival of Patients with Stage I, II, or III Breast Cancer

2000 • 927 citations

Molecular Predictors of Survival after Adjuvant Chemotherapy for Colon Cancer

2001 • 878 citations

Inactivation of the E-Cadherin-Mediated Cell Adhesion System in Human Cancers

1998 • 846 citations

Role of Src expression and activation in human cancer

2000 • 832 citations

Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex

2002 • 817 citations

E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.

1994 • 772 citations

E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.

1995 • 763 citations

Control of Cell Behavior During Vertebrate Development by Slug , a Zinc Finger Gene

1994 • 744 citations

Scatter-factor and semaphorin receptors: cell signalling for invasive growth

2002 • 734 citations

Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis

2002 • 693 citations

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells.

1996 • 680 citations

FGF Signaling Regulates Mesoderm Cell Fate Specification and Morphogenetic Movement at the Primitive Streak

2001 • 675 citations

Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.

1991 • 663 citations

Requirement for β-Catenin in Anterior-Posterior Axis Formation in Mice

2000 • 643 citations

Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells.

1982 • 642 citations

Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.

1995 • 635 citations

Interplay between Rac and Rho in the control of substrate contact dynamics

1999 • 623 citations

TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

1996 • 619 citations

The Mouse Snail Gene Encodes a Key Regulator of the Epithelial-Mesenchymal Transition

2001 • 611 citations

Mutations of the human E-cadherin (CDH1) gene

1998 • 598 citations

Inhibition of Myosin Light Chain Kinase by p21-Activated Kinase

1999 • 592 citations

Correlation of Snail expression with histological grade and lymph node status in breast carcinomas

2002 • 577 citations

twist and snail as positive and negative regulators during Drosophila mesoderm development.

1991 • 550 citations

E-Cadherin Suppresses Cellular Transformation by Inhibiting β-Catenin Signaling in an Adhesion-Independent Manner

2001 • 532 citations

Developmental Biology

2023 • 522 citations

The Zinc-Finger Protein Slug Causes Desmosome Dissociation, an Initial and Necessary Step for Growth Factor–induced Epithelial–Mesenchymal Transition

1997 • 515 citations

Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

1998 • 513 citations

Spatial and temporal expression pattern of N-cadherin cell adhesion molecules correlated with morphogenetic processes of chicken embryos

1987 • 510 citations

Detection and Clinical Importance of Micrometastatic Disease

1999 • 505 citations

Cadherins in embryonic and neural morphogenesis

2000 • 482 citations

The endophilin–CIN85–Cbl complex mediates ligand-dependent downregulation of c-Met

2002 • 468 citations

Cell contact during early morphogenesis in the chick embryo

1967 • 459 citations

Inhibition of Invasion of Epithelial Cells by Tiam1-Rac Signaling

1997 • 448 citations

Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer.

1995 • 447 citations

Quantitation of cell shedding into efferent blood of mammary adenocarcinoma.

1975 • 444 citations

Integrin-linked kinase (ILK) and its interactors

2001 • 441 citations

Nuclear β-catenin is required to specify vegetal cell fates in the sea urchin embryo

1999 • 440 citations

A New Role for E12/E47 in the Repression ofE-cadherin Expression and Epithelial-Mesenchymal Transitions

2001 • 439 citations

Mutation of the c-Cbl TKB Domain Binding Site on the Met Receptor Tyrosine Kinase Converts It into a Transforming Protein

2001 • 430 citations

Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways

1998 • 421 citations

The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells.

1993 • 409 citations

Met receptor tyrosine kinase: enhanced signaling through adapter proteins

2000 • 406 citations

Lack of Effect of Adjuvant Chemotherapy on the Elimination of Single Dormant Tumor Cells in Bone Marrow of High-Risk Breast Cancer Patients

2000 • 387 citations

Integrin β1 Signaling Is Necessary for Transforming Growth Factor-β Activation of p38MAPK and Epithelial Plasticity

2001 • 381 citations

shotgun encodes Drosophila E-cadherin and is preferentially required during cell rearrangement in the neurectoderm and other morphogenetically active epithelia.

1996 • 373 citations

An epithelial scatter factor released by embryo fibroblasts

1985 • 368 citations

Monoclonal Origins of Malignant Mixed Tumors (Carcinosarcomas)

1996 • 357 citations

E-Cadherin Gene Promoter Hypermethylation in Primary Human Gastric Carcinomas

2000 • 349 citations

Signalling by semaphorin receptors: cell guidance and beyond

2000 • 347 citations

Coupling of Gab1 to C-Met, Grb2, and Shp2 Mediates Biological Responses

2000 • 333 citations

Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas

2000 • 330 citations

A novel germ line juxtamembrane Met mutation in human gastric cancer

2000 • 330 citations

E-cadherin regulates cell growth by modulating proliferation-dependent β-catenin transcriptional activity

2001 • 328 citations

Germline E-cadherin Gene (CDH1) Mutations Predispose to Familial Gastric Cancer and Colorectal Cancer

1999 • 325 citations

Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas.

1992 • 317 citations

Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia

2001 • 311 citations

Snail/Slug family of repressors: slowly going into the fast lane of development and cancer

2000 • 297 citations

Diffuse Type Gastric and Lobular Breast Carcinoma in a Familial Gastric Cancer Patient with an E-Cadherin Germline Mutation

1999 • 294 citations

Adhesion molecules during somitogenesis in the avian embryo.

1987 • 293 citations

Raf induces TGFβ production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells

2000 • 292 citations

E-cadherin gene mutations in human gastric carcinomacell lines.

1994 • 288 citations

Phosphorylation and Free Pool of β-Catenin Are Regulated by Tyrosine Kinases and Tyrosine Phosphatases during Epithelial Cell Migration

1999 • 286 citations

E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer

1999 • 286 citations

Mutations of the E–cadherin gene in human gynecologic cancers

1994 • 280 citations

Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer.

1995 • 267 citations

Regulation of Rho GTPases by p120-catenin

2001 • 265 citations

Cytomechanics of cadherin-mediated cell—cell adhesion

1998 • 264 citations

Kidney morphogenesis: cellular and molecular regulation

2000 • 264 citations

IGF-II induces rapid β-catenin relocation to the nucleus during epithelium to mesenchyme transition

2001 • 260 citations

Role of Gab1 in Heart, Placenta, and Skin Development and Growth Factor- and Cytokine-Induced Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Activation

2000 • 258 citations

A role for the E-cadherin cell-cell adhesion molecule during tumor progression of mouse epidermal carcinogenesis.

1991 • 252 citations

Snail-Related Transcriptional Repressors Are Required in Xenopus for both the Induction of the Neural Crest and Its Subsequent Migration

2000 • 247 citations

Dynamic Behavior of the Cadherin-Based Cell–Cell Adhesion System duringDrosophilaGastrulation

1998 • 237 citations

Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion

1992 • 236 citations

Carcinosarcomas: current perspectives and an historical review of nosological concepts.

1993 • 235 citations

Desmosomes: Intercellular Adhesive Junctions Specialized for Attachment of Intermediate Filaments

1998 • 234 citations

Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.

2001 • 234 citations

Cell-cell contacts mediated by E-cadherin (uvomorulin) restrict invasive behavior of L-cells.

1991 • 232 citations

Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro

2001 • 212 citations

Overexpression of Snail family members highlights their ability to promote chick neural crest formation

2002 • 211 citations

The role of E-cadherin and integrins in mesoderm differentiation and migration at the mammalian primitive streak

1993 • 209 citations

Acidic fibroblast growth factor is a modulator of epithelial plasticity in a rat bladder carcinoma cell line.

1990 • 208 citations

Epithelial Mesenchymal Transition by c-Fos Estrogen Receptor Activation Involves Nuclear Translocation of β-Catenin and Upregulation of β-Catenin/Lymphoid Enhancer Binding Factor-1 Transcriptional Activity

2000 • 207 citations

Early epochal maps of two different cell adhesion molecules.

1983 • 204 citations

Overexpression of β-Catenin Induces Apoptosis Independent of Its Transactivation Function with LEF-1 or the Involvement of Major G1 Cell Cycle Regulators

2000 • 203 citations

N-Cadherin Extracellular Repeat 4 Mediates Epithelial to Mesenchymal Transition and Increased Motility

2000 • 201 citations

Epithelial cell plasticity in development and tumor progression.

1999 • 197 citations

Phenotypic characteristics of cell lines derived from disseminated cancer cells in bone marrow of patients with solid epithelial tumors: establishment of working models for human micrometastases.

1999 • 187 citations

Expression of the invasion factor laminin gamma2 in colorectal carcinomas is regulated by beta-catenin.

2001 • 180 citations

Slug is an Essential Target of TGFβ2 Signaling in the Developing Chicken Heart

2000 • 180 citations

Expression of Nuclear β-Catenin and c-myc Is Correlated with Tumor Size but Not with Proliferative Activity of Colorectal Adenomas

2000 • 166 citations

Desmosomes: differentiation, development, dynamics and disease

1996 • 165 citations

Sustained recruitment of phospholipase C-γ to Gab1 is required for HGF-induced branching tubulogenesis

2000 • 155 citations

Cell-cell interaction and polarity of epithelial cells: Specific perturbation using a monoclonal antibody

1983 • 153 citations

Inhibition of Neural Crest Migration in Xenopus Using Antisense Slug RNA

1999 • 152 citations

Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo.

1995 • 147 citations

Coupling Met to Specific Pathways Results in Distinct Developmental Outcomes

2001 • 144 citations

Mechanisms Identified in the Transcriptional Control of Epithelial Gene Expression

1996 • 142 citations

Src and Ras are involved in separate pathways in epithelial cell scattering

1997 • 141 citations

Regulation of the cytoskeleton by Rho-family GTPases: implications for tumour cell invasion

2001 • 134 citations

Role of morphogenetic factors in metastasis of mammary carcinoma cells

1998 • 122 citations

Src kinase contributes to the metastatic spread of carcinoma cells

2002 • 119 citations

The early steps of neural crest development

2001 • 119 citations

Extinction of E-cadherin expression in breast cancer via a dominant repression pathway acting on proximal promoter elements

1999 • 116 citations

The increasing complexity of the Snail gene superfamily in metazoan evolution

2001 • 110 citations

A large-scale analysis of mRNAs expressed by primary mesenchyme cells of the sea urchin embryo

2001 • 109 citations

Pathway specificity for Met signalling

2001 • 95 citations

Relationship between Gene Expression Domains of Xsnail, Xslug, and Xtwist and Cell Movement in the Prospective Neural Crest of Xenopus

2000 • 93 citations

Effect of epidermal growth factor receptor tyrosine kinase inhibition on epithelial proliferation in normal and premalignant breast.

2002 • 93 citations

Detection of isolated tumor cells in bone marrow in early-stage breast carcinoma patients: comparison with preoperative clinical parameters and primary tumor characteristics.

2001 • 91 citations

Ras induces NBT-II epithelial cell scattering through the coordinate activities of Rac and MAPK pathways

2002 • 88 citations

Different point mutations in the met oncogene elicit distinct biological properties

2000 • 88 citations

p53 immunostaining suggests that uterine carcinosarcomas are monoclonal

1994 • 85 citations

Development of the eye of the chick embryo.

1983 • 84 citations

Analysis by comparative genomic hybridization of epithelial and spindle cell components in sarcomatoid carcinoma and carcinosarcoma: histogenetic aspects

1999 • 80 citations

Developmentally regulated expression of the cell-cell adhesion glycoprotein cell-CAM in peri-implantation mouse embryos and extraembryonic membranes

1986 • 80 citations

Identification of genes involved in epithelial-mesenchymal transition and tumor progression

2001 • 76 citations

Osteopontin is an autocrine mediator of hepatocyte growth factor-induced invasive growth.

2001 • 74 citations

IGF-II Promotes Mesoderm Formation

2000 • 67 citations

Sequential Activation of ERK and Repression of JNK by Scatter Factor/Hepatocyte Growth Factor in Madin-Darby Canine Kidney Epithelial Cells

2000 • 65 citations

Distinct tyrosine autophosphorylation sites mediate induction of epithelial mesenchymal like transition by an activated ErbB-2/Neu receptor

2001 • 63 citations

The Multisubstrate Docking Site of the MET Receptor Is Dispensable for MET-mediated RAS Signaling and Cell Scattering

1999 • 63 citations

Regulation of E-Cadherin Gene Expression during Tumor Progression: The Role of a New Ets-Binding Site and the E-pal Element

1999 • 60 citations

Carcinosarcoma and Pseudosarcoma of the Esophagus: Two Names, One Disease—Comprehensive Review of the Literature

1999 • 60 citations

Atlas d'embryologie

1889 • 54 citations

Snail is an immediate early target gene of parathyroid hormone related peptide signaling in parietal endoderm formation.

2000 • 51 citations

Molecular characteristics of HGF-SF and its role in cell motility and invasion.

1993 • 51 citations

Biological characteristics of micrometastatic cancer cells in bone marrow.

1999 • 41 citations

The Role of a Single Formin Isoform in the Limb and Renal Phenotypes of Limb Deformity

1997 • 39 citations

Cbl-transforming Variants Trigger a Cascade of Molecular Alterations That Lead to Epithelial Mesenchymal Conversion

2000 • 35 citations

Relationship between E-cadherin and fibroblast growth factor receptor 2b expression in bladder carcinomas

1999 • 32 citations

The SFL activity secreted by metastatic carcinoma cells is related to laminin 5 and mediates cell scattering in an integrin-independent manner

1999 • 17 citations

The community effect in FGF-1 mediated tumor progression of a rat bladder carcinoma does not involve a direct paracrine signaling

1999 • 15 citations