Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

A Laboratory manual

1989 • 6,833 citations

Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

1994 • 3,016 citations

Some new, simple and efficient stereological methods and their use in pathological research and diagnosis

1988 • 2,948 citations

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

2003 • 2,765 citations

Transplacental Carcinogenesis by Stilbestrol

1971 • 2,595 citations

The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis

1988 • 2,498 citations

Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor

1999 • 2,386 citations

Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment

1998 • 2,375 citations

Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice

1997 • 2,136 citations

Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model

1998 • 2,040 citations

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

1995 • 1,682 citations

Openings between Defective Endothelial Cells Explain Tumor Vessel Leakiness

2000 • 1,627 citations

Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse

1999 • 1,618 citations

Determinants of tumor blood flow: a review.

1988 • 1,362 citations

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

1999 • 1,248 citations

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

2003 • 1,236 citations

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

2003 • 1,172 citations

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

1994 • 1,123 citations

Lack of Pericytes Leads to Endothelial Hyperplasia and Abnormal Vascular Morphogenesis

2001 • 1,067 citations

Tumor Angiogenesis

1985 • 1,038 citations

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

1994 • 984 citations

Abnormalities in Pericytes on Blood Vessels and Endothelial Sprouts in Tumors

2002 • 955 citations

Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis

2002 • 892 citations

Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies.

2000 • 750 citations

Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall

2003 • 621 citations

The pericyte—A review

1986 • 563 citations

Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms

2002 • 492 citations

Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows.

1994 • 463 citations

Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors.

2001 • 444 citations

Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy

2002 • 378 citations

Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms

2002 • 347 citations

Platelet-Derived Growth Factor-B Enhances Glioma Angiogenesis by Stimulating Vascular Endothelial Growth Factor Expression in Tumor Endothelia and by Promoting Pericyte Recruitment

2003 • 340 citations

Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells

2002 • 279 citations

Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis.

2001 • 276 citations

Tumor Vessel Development and Maturation Impose Limits on the Effectiveness of Anti-Vascular Therapy

2003 • 240 citations

Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB.

1993 • 238 citations

Expression of the high molecular weight melanoma-associated antigen by pericytes during angiogenesis in tumors and in healing wounds.

1990 • 226 citations

Differential expression of markers for endothelial cells, pericytes, and basal lamina in the microvasculature of tumors and granulation tissue.

1991 • 222 citations

Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells

2002 • 220 citations

A High-Affinity Human Antibody That Targets Tumoral Blood Vessels

1999 • 209 citations

Analysis of Mural Cell Recruitment to Tumor Vessels

2002 • 181 citations

Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences.

1992 • 179 citations

Tyrosine kinase inhibition of multiple angiogenic growth factor receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms.

2001 • 165 citations

The Two PDGF Receptors Maintain Conserved Signaling In Vivo despite Divergent Embryological Functions

2001 • 147 citations

Early and Extensive Contribution of Pericytes/Vascular Smooth Muscle Cells to Microvascular Proliferation in Glioblastoma Multiforme

1995 • 145 citations

Identification of a cell retention signal in the B-chain of platelet-derived growth factor and in the long splice version of the A-chain.

1991 • 139 citations

A novel mechanism regulating growth factor association with the cell surface: identification of a PDGF retention domain.

1991 • 131 citations

Platelet-derived growth factor in autocrine transformation.

1991 • 90 citations

A novel transgenic marker for migrating limb muscle precursors and for vascular smooth muscle cells

2001 • 60 citations

Localization of platelet-derived growth factor (PDGF) in CHO cells transfected with PDGF A- or B-chain cDNA: Retention of PDGF-BB in the endoplasmic reticulum and Golgi complex

1990 • 57 citations

Regulation of the Spatial Organization of Mesenchymal Connective Tissue

1999 • 30 citations