Stromal fibroblasts in cancer initiation and progression

Inflammation and cancer

2002 • 14,174 citations

Angiogenesis in cancer and other diseases

2000 • 8,734 citations

New functions for the matrix metalloproteinases in cancer progression

2002 • 5,937 citations

Cancer genes and the pathways they control

2004 • 4,172 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

Met, metastasis, motility and more

2003 • 2,526 citations

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

Evidence that fibroblasts derive from epithelium during tissue fibrosis

2002 • 1,792 citations

Basement membranes: structure, assembly and role in tumour angiogenesis

2003 • 1,652 citations

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

2001 • 1,584 citations

Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium

2000 • 1,445 citations

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

1997 • 1,444 citations

TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

2004 • 1,346 citations

Molecular characterization of the tumor microenvironment in breast cancer

2004 • 1,278 citations

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

2003 • 1,276 citations

Identification and characterization of a fibroblast marker: FSP1.

1995 • 1,050 citations

Reduced angiogenesis and tumor progression in gelatinase A-deficient mice.

1998 • 887 citations

Growth Inhibitor from BSC-1 Cells Closely Related to Platelet Type β Transforming Growth Factor

1984 • 779 citations

Reconstruction of functionally normal and malignant human breast tissues in mice

2004 • 777 citations

Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction

1996 • 772 citations

Scatter-factor and semaphorin receptors: cell signalling for invasive growth

2002 • 734 citations

TGF- β signaling in cancer – a double-edged sword

2001 • 734 citations

Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis

1997 • 561 citations

Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells.

2000 • 537 citations

The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells.

1995 • 425 citations

Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas

2002 • 424 citations

Know thy neighbor: stromal cells can contribute oncogenic signals

2001 • 422 citations

AUTOCRINE AND PARACRINE REGULATION BY CYTOKINES AND GROWTH FACTORS IN MELANOMA

2000 • 402 citations

Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis.

2000 • 400 citations

Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein

2003 • 385 citations

Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein

2003 • 382 citations

Matrix metalloproteinases in tumor–host cell communication

2002 • 376 citations

Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects

2002 • 375 citations

Role of the stromal microenvironment in carcinogenesis of the prostate

2003 • 362 citations

Radiation to Stromal Fibroblasts Increases Invasiveness of Pancreatic Cancer Cells through Tumor-Stromal Interactions

2004 • 353 citations

Malignant transformation in a nontumorigenic human prostatic epithelial cell line.

2001 • 343 citations

Stromal cell-derived factor 1alpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt.

2003 • 337 citations

Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects

2002 • 326 citations

The role for transforming growth factor-beta (TGF-beta) in human cancer.

1999 • 323 citations

Stromal-epithelial interactions in adult organs

1985 • 315 citations

Regulation of prostatic growth and function by peptide growth factors

1996 • 313 citations

Illegitimate WNT signaling promotes proliferation of multiple myeloma cells

2004 • 308 citations

Mammary tumor suppression by transforming growth factor beta 1 transgene expression.

1995 • 292 citations

Induction of Hepatocyte Growth Factor in Fibroblasts by Tumor-derived Factors Affects Invasive Growth of Tumor Cells : In Vitro Analysis of Tumor-Stromal Interactions

1998 • 291 citations

Heparin-binding keratinocyte growth factor is a candidate stromal-to-epithelial-cell andromedin.

1992 • 287 citations

Mammalian lung development: Interactions in formation and morphogenesis of tracheal buds

1970 • 284 citations

Targeting the tumor and its microenvironment by a dual-function decoy Met receptor

2004 • 280 citations

From developmental disorder to heritable cancer: it's all in the BMP/TGF-β family

2003 • 270 citations

Conditional inactivation of the TGF‐β type II receptor using Cre:Lox

2002 • 265 citations

The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis.

2003 • 258 citations

Preoperative Plasma Levels of Transforming Growth Factor Beta₁ (TGF-β₁) Strongly Predict Progression in Patients Undergoing Radical Prostatectomy

2001 • 211 citations

Large induction of keratinocyte growth factor expression by serum growth factors and pro-inflammatory cytokines in cultured fibroblasts.

1994 • 203 citations

Growth factor involvement in progression of prostate cancer.

1998 • 201 citations

THE PROSTATE: DEVELOPMENT AND PHYSIOLOGY

2000 • 201 citations

In vivo regeneration of murine prostate from dissociated cell populations of postnatal epithelia and urogenital sinus mesenchyme

2003 • 197 citations

Platelet-Derived Growth Factor Production by B16 Melanoma Cells Leads to Increased Pericyte Abundance in Tumors and an Associated Increase in Tumor Growth Rate

2004 • 196 citations

Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor beta receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene.

1997 • 195 citations

Fibroblast Growth Factor-10

1999 • 189 citations

Cross-talk between the proto-oncogenes Met and Ron

2000 • 180 citations

Growth factor involvement in progression of prostate cancer

1998 • 171 citations

Circulating transforming growth factor beta 1 as a predictor of liver metastasis after resection in colorectal cancer.

2001 • 150 citations

The Mouse Wnt-1 Gene Can Act Via a Paracrine Mechanism in Transformation of Mammary Epithelial Cells

1992 • 138 citations

Transgenic Mice Expressing a Dominant-Negative Mutant Type II Transforming Growth Factor-β Receptor Exhibit Impaired Mammary Development and Enhanced Mammary Tumor Formation

2003 • 129 citations

Anti-Vascular Endothelial Growth Factor Monoclonals in Non-Small Cell Lung Cancer

2004 • 125 citations

A juvenile polyposis tumor suppressor locus at 10q22 is deleted from nonepithelial cells in the lamina propria

1997 • 123 citations

Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development

1998 • 123 citations

Hamartomatous Polyposis Syndromes: Molecular Genetics, Neoplastic Risk, and Surveillance Recommendations

2001 • 123 citations

Adult, foetal and transformed fibroblasts display different migratory phenotypes on collagen gels: Evidence for an isoformic transition during foetal development

1985 • 114 citations

The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells.

1992 • 109 citations

Induction of Nuclear Androgen-Binding Sites in Epithelium of the Embryonic Urinary Bladder by Mesenchyme of the Urogenital Sinus of Embryonic Mice*

1980 • 91 citations

Preoperative plasma levels of transforming growth factor ?1 strongly predict clinical outcome in patients with bladder carcinoma

2001 • 88 citations

Tissue interactions in carcinogenesis

1972 • 83 citations

Tissue Interactions in Carcinogenesis

1973 • 79 citations

Fibroblasts from cancer patients display a mixture of both foetal and adult-like phenotypic characteristics

1988 • 73 citations

Directionally Specific Paracrine Communication Mediated by Epithelial FGF9 to Stromal FGFR3 in Two-Compartment Premalignant Prostate Tumors

2004 • 57 citations

Mesenchymal-Epithelial Interactions in the Growth and Development of the Prostate

1989 • 37 citations

Approaches to Modeling Stromal-Epithelial Interactions

2002 • 26 citations

Immediate Early Gene Responses of NIH 3T3 Fibroblasts and NMuMG Epithelial Cells to TGFβ-1

1991 • 21 citations

Deleted Work

1955 • 0 citations