Regulation of Epithelial Cell Migration and Tumor Formation by β-Catenin Signaling

The Hallmarks of Cancer

2000 • 27,569 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

1999 • 3,566 citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

1997 • 3,234 citations

Wnt signaling and cancer

2000 • 3,215 citations

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

β-catenin is a target for the ubiquitin–proteasome pathway

1997 • 2,461 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

1996 • 1,827 citations

A rapid in vitro assay for quantitating the invasive potential of tumor cells.

1987 • 1,787 citations

Linking Colorectal Cancer to Wnt Signaling

2000 • 1,507 citations

The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.

1989 • 1,393 citations

Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus

2000 • 1,253 citations

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin

1998 • 1,244 citations

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

1998 • 1,241 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

Use of dsRNA-Mediated Genetic Interference to Demonstrate that frizzled and frizzled 2 Act in the Wingless Pathway

1998 • 1,116 citations

Wound Macrophages Express TGF-α and Other Growth Factors in Vivo: Analysis by mRNA Phenotyping

1988 • 1,107 citations

Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

2001 • 1,020 citations

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

2000 • 943 citations

Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.

1993 • 912 citations

Nuclear localization of β-catenin by interaction with transcription factor LEF-1

1996 • 864 citations

MOLECULAR AND FUNCTIONAL ANALYSIS OF CADHERIN-BASED ADHERENS JUNCTIONS

1997 • 800 citations

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

1995 • 798 citations

E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.

1994 • 772 citations

Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex.

1995 • 739 citations

Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor.

1994 • 712 citations

Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin.

1995 • 651 citations

Large induction of keratinocyte growth factor expression in the dermis during wound healing.

1992 • 603 citations

Rho GTPases: Signaling, Migration, and Invasion

2000 • 584 citations

Two Distinct Osteoblast-Specific cis-Acting Elements Control Expression of a Mouse Osteocalcin Gene

1995 • 564 citations

WISP genes are members of the connective tissue growth factor family that are up-regulated in Wnt-1-transformed cells and aberrantly expressed in human colon tumors

1998 • 499 citations

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

1996 • 494 citations

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling

2000 • 491 citations

β-Catenin mutations in cell lines established from human colorectal cancers

1997 • 483 citations

Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling

1999 • 474 citations

Induction and regulation of epithelial–mesenchymal transitions

2000 • 434 citations

Tyrosine Phosphorylation of β-Catenin and Plakoglobin Enhanced by Hepatocyte Growth Factor and Epidermal Growth Factor in Human Carcinoma Cells

1994 • 421 citations

p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system.

1993 • 421 citations

The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila

1999 • 393 citations

Cadherins and catenins in development

1996 • 344 citations

Wnt-1 Regulates Free Pools of Catenins and Stabilizes APC-Catenin Complexes

1996 • 337 citations

Focalized proteolysis: spatial and temporal regulation of extracellular matrix degradation at the cell surface

1996 • 331 citations

Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis

1998 • 319 citations

Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo.

1995 • 313 citations

Neoplastic Transformation of RK3E by Mutant β-Catenin Requires Deregulation of Tcf/Lef Transcription but Not Activation of c-myc Expression

1999 • 313 citations

Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes.

2002 • 295 citations

Phosphorylation and Free Pool of β-Catenin Are Regulated by Tyrosine Kinases and Tyrosine Phosphatases during Epithelial Cell Migration

1999 • 286 citations

Exogenous Expression of β-Catenin Regulates Contact Inhibition, Anchorage-Independent Growth, Anoikis, and Radiation-Induced Cell Cycle Arrest

1999 • 278 citations

Regulation of β-Catenin Structure and Activity by Tyrosine Phosphorylation

2001 • 258 citations

Osteopontin Stimulates Tumor Growth and Activation of Promatrix Metalloproteinase-2 through Nuclear Factor-κB-mediated Induction of Membrane Type 1 Matrix Metalloproteinase in Murine Melanoma Cells

2001 • 253 citations

Acidic fibroblast growth factor is a modulator of epithelial plasticity in a rat bladder carcinoma cell line.

1990 • 208 citations

Association of Human Protein-tyrosine Phosphatase κ with Members of the Armadillo Family

1996 • 196 citations

WNT-1 and HGF Regulate GSK3β Activity and β-Catenin Signaling in Mammary Epithelial Cells

1998 • 187 citations

Down-regulation of beta-catenin TCF signaling is linked to colonic epithelial cell differentiation.

2001 • 174 citations

c-erbB-2 Gene Product Associates with Catenins in Human Cancer Cells

1994 • 162 citations

Frizzled and DFrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development

1999 • 161 citations

Cadherin Cell Adhesion Molecules in Differentiation and Embryogenesis

1996 • 148 citations

Oncogenic Mutants of RON and MET Receptor Tyrosine Kinases Cause Activation of the β-Catenin Pathway

2001 • 148 citations

Comparison of [3H]thymidine incorporation with MTT- and MTS-based bioassays for human and murine IL-2 and IL-4 analysis Tetrazolium assays provide markedly enhanced sensitivity

1995 • 145 citations

Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium.

1996 • 142 citations

Osteopontin-induced, integrin-dependent migration of human mammary epithelial cells involves activation of the hepatocyte growth factor receptor (Met)

2000 • 140 citations

Scatter factors and invasive growth

2001 • 122 citations

Cell surface expression of receptor protein tyrosine phosphatase RPTP mu is regulated by cell-cell contact.

1995 • 121 citations

Wingless signaling in the Drosophila embryo: zygotic requirements and the role of the frizzled genes

1999 • 114 citations

Differential MAPK Pathways Utilized for HGF- and EGF-dependent Renal Epithelial Morphogenesis

2001 • 98 citations

APC: the plot thickens

1999 • 97 citations

Chapter 16 Regulation of Protein Activities by Fusion to Steroid Binding Domains

1994 • 96 citations

Restoration of epithelial cell polarity in a colorectal cancer cell line by suppression of beta-catenin/T-cell factor 4-mediated gene transactivation.

2001 • 77 citations

Comprehensive gene expression profile of human activated Th1- and Th2-polarized cells

2001 • 76 citations

Osteopontin is an autocrine mediator of hepatocyte growth factor-induced invasive growth.

2001 • 74 citations

Cell Density and Phosphorylation Control the Subcellular Localization of Adenomatous Polyposis Coli Protein

2001 • 73 citations

Migration of breast epithelial cells on Laminin-5: differential role of integrins in normal and transformed cell types

1998 • 73 citations

Involvement of a Mitogen-activated Protein Kinase Signaling Pathway in the Regulation of Urokinase Promoter Activity by c-Ha-ras

1995 • 72 citations

Leukocyte common antigen-related receptor-linked tyrosine phosphatase. Regulation of mRNA expression.

1993 • 68 citations

METASTASIS-INDUCING DNA REGULATES THE EXPRESSION OF THE OSTEOPONTIN GENE BY BINDING THE TRANSCRIPTION FACTOR TCF-4

2002 • 62 citations

Tissue Culture of Urinary Bladder Tumor Induced in a Rat by <italic>N</italic>-Butyl-<italic>N</italic>-(-4-Hydroxybutyl) Nitrosamine: Establishment of Cell Line, Nara Bladder Tumor<xref ref-type="fn" rid="FN1">2</xref>

1971 • 62 citations

Receptor Tyrosine Kinases as Therapeutic Targets the Model of the MET Oncogene

2001 • 59 citations

Missing Links in GSK3 Regulation

2001 • 59 citations

E‐Cadherin as an Invasion Suppressor

2007 • 53 citations

FGF-2 and FGF-1 expressed in rat bladder carcinoma cells have similar angiogenic potential but different tumorigenic properties in vivo

1997 • 45 citations

Alternative patterns of mitogenesis and cell scattering induced by acidic FGF as a function of cell density in a rat bladder carcinoma cell line.

1990 • 44 citations

Growth Factor-Induced Cell Migration: Biology and Methods of Analysis

1994 • 44 citations

A basement‐membrane permeability assay which correlates with the metastatic potential of tumour cells

1992 • 39 citations

Novel Forms of epithelial cell motility on collagen and on glass surfaces

1982 • 35 citations

Protection against Anoikis and Down-regulation of Cadherin Expression by a Regulatable β-Catenin Protein

2002 • 34 citations

A high throughput colorimetric cell proliferation assay for the identification of human cytomegalovirus inhibitors

1999 • 30 citations

The epidermal growth factor-induced migration of rat liver epithelial cells is associated with a transient inhibition of DNA synthesis

1991 • 29 citations

Effect of MRC-5 fibroblast conditioned medium on breast cancer cell motility and invasion in vitro.

1997 • 20 citations

Enhanced gene expression of transforming growth factor-? and c-met in rat urinary bladder cancer

1996 • 19 citations

Epidermal Growth Factor Receptor as a Target: Recent Developments in the Search for Effective New Anti-Cancer Agents

2001 • 13 citations