Suppression of Tumor Development and Metastasis Formation in Mice Lacking the S100A4(mts1) Gene

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

2003 • 4,433 citations

Tumour-educated macrophages promote tumour progression and metastasis

2004 • 3,259 citations

QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES

1963 • 2,742 citations

The microenvironment of the tumour–host interface

2001 • 2,307 citations

Stromal fibroblasts in cancer initiation and progression

2004 • 2,230 citations

Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium

2000 • 1,445 citations

MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

2000 • 1,306 citations

Role of tissue stroma in cancer cell invasion

2003 • 1,021 citations

S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature)

2004 • 821 citations

S100 proteins structure functions and pathology

2002 • 702 citations

Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor

2001 • 463 citations

Early role of Fsp1 in epithelial-mesenchymal transformation

1997 • 433 citations

Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity

1994 • 431 citations

Radiation to Stromal Fibroblasts Increases Invasiveness of Pancreatic Cancer Cells through Tumor-Stromal Interactions

2004 • 353 citations

Isolation and characterization of a gene specifically expressed in different metastatic cells and whose deduced gene product has a high degree of homology to a Ca2+-binding protein family.

1989 • 302 citations

Experimental metastasis is suppressed in MMP-9-deficient mice.

1999 • 300 citations

Proteomic Characterization of the Interstitial Fluid Perfusing the Breast Tumor Microenvironment

2004 • 296 citations

In Vivo Evidence That the Stromelysin-3 Metalloproteinase Contributes in a Paracrine Manner to Epithelial Cell Malignancy

1998 • 290 citations

Tumor Suppressor p53 Protein Is a New Target for the Metastasis-associated Mts1/S100A4 Protein

2001 • 282 citations

Prognostic significance of the metastasis-inducing protein S100A4 (p9Ka) in human breast cancer.

2000 • 274 citations

Role of infiltrated leucocytes in tumour growth and spread

2004 • 271 citations

The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis.

2003 • 258 citations

The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor

2001 • 242 citations

Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1.

2000 • 220 citations

Extracellular S100A4(mts1) stimulates invasive growth of mouse endothelial cells and modulates MMP-13 matrix metalloproteinase activity

2004 • 195 citations

Expression of the calcium-binding protein S100A4 (p9Ka) in MMTV-neu transgenic mice induces metastasis of mammary tumours.

1996 • 182 citations

Non-muscle myosin heavy chain as a possible target for protein encoded by metastasis-related mts-1 gene.

1994 • 170 citations

Metastasis of mammary carcinomas in GRS/A hybrid mice transgenic for the mts1 gene.

1996 • 169 citations

S100A4 involvement in metastasis: deregulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti-S100A4 ribozyme.

1999 • 167 citations

Oligomeric Forms of the Metastasis-related Mts1 (S100A4) Protein Stimulate Neuronal Differentiation in Cultures of Rat Hippocampal Neurons

2000 • 153 citations

Clinical significance of S100A4 and E-cadherin-related adhesion molecules in non-small cell lung cancer.

2000 • 147 citations

Functional Significance of Metastasis-inducing S100A4(Mts1) in Tumor-Stroma Interplay

2004 • 141 citations

Prognostic significance of calcium-binding protein S100A4 in colorectal cancer

2002 • 134 citations

Liprin β1, a Member of the Family of LAR Transmembrane Tyrosine Phosphatase-interacting Proteins, Is a New Target for the Metastasis-associated Protein S100A4 (Mts1)

2002 • 124 citations

Expression of S100A4 protein is associated with metastasis and reduced survival in human bladder cancer

2002 • 117 citations

Growth and Dissemination of Lewis Lung Carcinoma in Plasminogen-Deficient Mice

1997 • 113 citations

S100A4 regulates cell motility and invasion in an in vitro model for breast cancer metastasis

2004 • 112 citations

Involvement of Sl00–related Calcium–binding Protein pEL98 (or mts1) in Cell Motility and Tumor Cell Invasion

1994 • 89 citations

Expression of S100A4 and <i>Met:</i> Potential Predictors for Metastasis and Survival in Early-Stage Breast Cancer

2004 • 82 citations

Extracellular S100A4 stimulates the migration rate of astrocytic tumor cells by modifying the organization of their actin cytoskeleton

2002 • 78 citations

Interaction of metastasis associated Mts1 protein with nonmuscle myosin.

1995 • 70 citations

Modulation of mts1 expression in mouse and human normal and tumor cells

1994 • 68 citations

Cancer predisposition in mice deficient for the metastasis-associated Mts1(S100A4) gene

2004 • 63 citations

Methionine Aminopeptidase 2 Is a New Target for the Metastasis-associated Protein, S100A4

2002 • 61 citations

Expression of Mts1, a metastasis-associated gene, increases motility but not invasion of a nonmetastatic mouse mammary adenocarcinoma cell line.

1995 • 55 citations

Involvement of S100A4 in Stromal Fibroblasts of the Regenerating Cornea

2003 • 53 citations

The Mts1/S100A4 protein is a neuroprotectant

2004 • 48 citations

Sensitization of interferon-γ induced apoptosis in human osteosarcoma cells by extracellular S100A4

2004 • 47 citations

Prognostic significance of S100A4 expression in gallbladder cancer

2002 • 45 citations

Plasminogen promotes sarcoma growth and suppresses the accumulation of tumor-infiltrating macrophages

2002 • 24 citations

Interleukin-1 alpha and basic fibroblast growth factor induction of matrix metalloproteinases and their inhibitors in osteosarcoma cells is modulated by the metastasis associated protein CAPL.

1998 • 21 citations

Growth and Dissemination of Lewis Lung Carcinoma in Plasminogen-Deficient Mice

1997 • 13 citations