Thrombopoietic Cells and the Bone Marrow Vascular Niche

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

2005 • 3,066 citations

Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets

1997 • 719 citations

Antimetastatic effects associated with platelet reduction.

1968 • 695 citations

Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes

2006 • 639 citations

The Bone Marrow Vascular Niche: Home of HSC Differentiation and Mobilization

2005 • 510 citations

Platelets secrete stromal cell–derived factor 1α and recruit bone marrow–derived progenitor cells to arterial thrombi in vivo

2006 • 415 citations

Platelet: transporter of vascular endothelial growth factor.

1997 • 374 citations

Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage

2006 • 342 citations

RETRACTED: Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis

2003 • 323 citations

Human bone marrow microvascular endothelial cells support long-term proliferation and differentiation of myeloid and megakaryocytic progenitors

1995 • 285 citations

Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias

2001 • 275 citations

Biosynthesis of major platelet proteins in human blood platelets

1987 • 225 citations

Structure and Function of Bone Marrow Hemopoiesis: Mechanisms of Response to Ionizing Radiation Exposure

2002 • 199 citations

Regulation of Hematopoiesis by Microvascular Endothelium

1997 • 166 citations

Angiogenesis in hematologic malignancies

2003 • 123 citations

Platelet and coagulation activation with vascular endothelial growth factor generation in soft tissue sarcomas.

2000 • 122 citations

Tie2 activation contributes to hemangiogenic regeneration after myelosuppression

2005 • 115 citations

Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization

2006 • 102 citations

Localization of megakaryocytes in the bone marrow.

1989 • 88 citations

Megakaryocytes require thrombospondin-2 for normal platelet formation and function

2003 • 47 citations

Shift in the balance between circulating thrombospondin-1 and vascular endothelial growth factor in cancer patients: Relationship to platelet a-granule content and primary activation

2004 • 28 citations

Shift in the Balance between Circulating Thrombospondin-1 and Vascular Endothelial Growth Factor in Cancer Patients: Relationship to Platelet α-Granule Content and Primary Activation

2004 • 7 citations