Intravital imaging of cell movement in tumours

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1991 • 8,402 citations

Inflammation and cancer: back to Virchow?

2001 • 7,259 citations

Repeated observation of breast tumor subtypes in independent gene expression data sets

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Involvement of chemokine receptors in breast cancer metastasis

2001 • 5,203 citations

Rho GTPases in cell biology

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Dissemination and growth of cancer cells in metastatic sites

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Tumour-cell invasion and migration: diversity and escape mechanisms

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The microenvironment of the tumour–host interface

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Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

1995 • 1,682 citations

Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation

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Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy

2001 • 1,556 citations

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease.

1992 • 1,496 citations

Genomic analysis of metastasis reveals an essential role for RhoC

2000 • 1,449 citations

Cancer—Principles & Practice of Oncology

1983 • 1,403 citations

Compensation mechanism in tumor cell migration

2003 • 1,360 citations

RHO–GTPases and cancer

2002 • 1,355 citations

Lymphatic Metastasis in the Absence of Functional Intratumor Lymphatics

2002 • 939 citations

Adhesion assembly, disassembly and turnover in migrating cells – over and over and over again

2002 • 741 citations

Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis

2000 • 695 citations

Detection and characterization of carcinoma cells in the blood

1998 • 684 citations

Leaving the neighborhood: molecular mechanisms involved during epithelial‐mesenchymal transition

2001 • 673 citations

‘Hard’ and ‘soft’ principles defining the structure, function and regulation of keratin intermediate filaments

2002 • 670 citations

Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages

2000 • 656 citations

In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy

2001 • 603 citations

Dissecting tumour pathophysiology using intravital microscopy

2002 • 585 citations

Modeling tissue-specific signaling and organ function in three dimensions

2003 • 573 citations

Characterization of a β-Actin mRNA Zipcode-Binding Protein

1997 • 544 citations

Macrophage-Derived Metalloelastase Is Responsible for the Generation of Angiostatin in Lewis Lung Carcinoma

1997 • 537 citations

Bone Morphogenetic Protein-1: The Type I Procollagen C-Proteinase

1996 • 513 citations

Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling.

2002 • 419 citations

The organ microenvironment and cancer metastasis

2002 • 414 citations

A critical step in metastasis: in vivo analysis of intravasation at the primary tumor.

2000 • 400 citations

Temporal progression of metastasis in lung: cell survival, dormancy, and location dependence of metastatic inefficiency.

2000 • 400 citations

Multiphoton microscopy in biological research

2001 • 366 citations

Live Astrocytes Visualized by Green Fluorescent Protein in Transgenic Mice

1997 • 358 citations

Tumor-associated macrophages in breast cancer.

2002 • 346 citations

Persistence of Solitary Mammary Carcinoma Cells in a Secondary Site: A Possible Contributor to Dormancy

2002 • 337 citations

Lysophosphatidylcholine transcriptionally induces growth factor gene expression in cultured human endothelial cells.

1994 • 332 citations

The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5

2000 • 288 citations

Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression.

1997 • 284 citations

Steps in tumor metastasis: new concepts from intravital videomicroscopy

1995 • 268 citations

Development and Biologic Properties of Malignant Cell Sublines and Clones of a Spontaneously Metastasizing Rat Mammary Adenocarcinoma<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1982 • 253 citations

Pathogenesis of metastasis formation observed in vivo in the rabbit ear chamber.

1958 • 252 citations

Transgenic Polyoma middle-T mice model premalignant mammary disease.

2001 • 250 citations

Green fluorescent protein imaging of tumour growth, metastasis, and angiogenesis in mouse models

2002 • 243 citations

The physiological significance of β-actin mRNA localization in determining cell polarity and directional motility

2001 • 211 citations

Regulation of cadherin-mediated cell–cell adhesion by the Rho family GTPases

1999 • 204 citations

92 kDa type IV collagenase (MMP-9) is expressed in neutrophils and macrophages but not in malignant epithelial cells in human colon cancer

1996 • 175 citations

Critical determinants of cancer metastasis: rationale for therapy

1999 • 169 citations

Cell motility of tumor cells visualized in living intact primary tumors using green fluorescent protein.

1998 • 163 citations

The relationship between prognostic and predictive factors in the management of breast cancer

1998 • 157 citations

Regulation of Protrusion Shape and Adhesion to the Substratum during Chemotactic Responses of Mammalian Carcinoma Cells

1998 • 152 citations

T lymphocytes that infiltrate tumors and atherosclerotic plaques produce heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor: a potential pathologic role.

1995 • 146 citations

Detection of disseminated tumor cells in peripheral blood of colorectal cancer patients

1997 • 144 citations

New developments in multiphoton microscopy

2002 • 142 citations

Transgenic mouse models of human breast cancer

2000 • 141 citations

Detection and quantitation of circulating cancer cells in the peripheral blood of lung cancer patients.

1998 • 139 citations

Heparin-binding epidermal growth factor-like growth factor expression in cultured fetal human vascular smooth muscle cells. Induction of mRNA levels and secretion of active mitogen.

1993 • 134 citations

Stromal reaction in cancer tissue: Pathophysiologic significance of the expression of matrix-degrading enzymes in relation to matrix turnover and immune/inflammatory reactions

1998 • 131 citations

The collection of the motile population of cells from a living tumor.

2000 • 125 citations

Intravascular Location of Breast Cancer Cells after Spontaneous Metastasis to the Lung

2002 • 124 citations

Tumour‐associated leucocytes: Friends or foes in breast carcinoma

1994 • 121 citations

GFP expression in the mammary gland for imaging of mammary tumor cells in transgenic mice.

2002 • 108 citations

Immunohistochemical localization of urokinase-type plasminogen activator, type-1 plasminogen-activator inhibitor, urokinase receptor and α2-macroglobulin receptor in human breast carcinomas

1996 • 102 citations

Intravital videomicroscopic evidence for regulation of metastasis by the hepatic microvasculature: effects of interleukin-1alpha on metastasis and the location of B16F1 melanoma cell arrest.

1997 • 97 citations

Illuminating adhesion complexes in migrating cells: moving toward a bright future

2003 • 95 citations

A Rho-dependent signaling pathway operating through myosin localizes β-actin mRNA in fibroblasts

2001 • 93 citations

Epidermal Growth Factor Receptor Distribution during Chemotactic Responses

2000 • 91 citations

Real-time observation of micrometastasis formation in the living mouse liver using a green fluorescent protein gene-tagged rat tongue carcinoma cell line

2001 • 89 citations

Clinicopathological observations on metastasis in man studied in patients treated with peritoneovenous shunts.

1984 • 84 citations

Correlation of beta-actin messenger RNA localization with metastatic potential in rat adenocarcinoma cell lines.

1999 • 71 citations

Orthotopic transplant mouse models with green fluorescent protein-expressing cancer cells to visualize metastasis and angiogenesis.

1998 • 71 citations

Arrest of B16 Melanoma Cells in the Mouse Pulmonary Microcirculation Induces Endothelial Nitric Oxide Synthase-Dependent Nitric Oxide Release that Is Cytotoxic to the Tumor Cells

2003 • 71 citations

Brain tumor invasion model system using organotypic brain-slice culture as an alternative to in vivo model

2002 • 67 citations

GFP-transfected tumor cells are useful in examining early metastasis in vivo, but immune reaction precludes long-term tumor development studies in immunocompetent mice.

2003 • 65 citations

Colocalisation of matrix metalloproteinase-9-mRNA and protein in human colorectal cancer stromal cells

1996 • 61 citations

Ligand mediated activation of ectopic EGF receptor promotes matrix protein adhesion and lung colonization of rat mammary adenocarcinoma cells.

1995 • 53 citations

Blinded evaluation of reverse transcriptase-polymerase chain reaction prostate-specific antigen peripheral blood assay for molecular staging of prostate cancer

1999 • 49 citations

Novel Gliosarcoma Cell Line Expressing Green Fluorescent Protein: A Model for Quantitative Assessment of Angiogenesis

1998 • 48 citations

Molecular staging of prostate cancer: dream or reality?

1999 • 45 citations

Glioma cell migration is associated with glioma‐induced angiogenesis in vivo

1999 • 45 citations

Detection of Brain Tumor Invasion and Micrometastasis in Vivo by Expression of Enhanced Green Fluorescent Protein

1998 • 42 citations

Motility cues in the tumor microenvironment

2002 • 40 citations

Haematogenous cytokeratin 20 mRNA as a predictive marker for recurrence in oral cancer patients

1999 • 40 citations

Video microscopy of tumor metastasis: using the green fluorescent protein (GFP) gene as a cancer-cell-labeling system.

1999 • 31 citations

An in vivo rat model for visualizing glioma tumor cell invasion using stable persistent expression of the green fluorescent protein

1999 • 28 citations

Suppression of Ruffling by the EGF Receptor in Chemotactic Cells

1998 • 28 citations

Expression of epidermal growth factor, transforming growth factor-alpha and their receptor in the human oesophagus.

1997 • 28 citations

Induction of apoptosis by EGF receptor in rat mammary adenocarcinoma cells coincides with enhanced spontaneous tumour metastasis.

1996 • 26 citations

EXPRESSION OF EPIDERMAL GROWTH-FACTOR RECEPTOR CORRELATES WITH METASTATIC POTENTIAL OF 13762NF RAT MAMMARY ADENOCARCINOMA CELLS

1994 • 22 citations

Expression of Green Fluorescent Protein in Oligodendrocytes in a Time- and Level-Controllable Fashion with a Tetracycline-Regulated System

1999 • 22 citations

Usefulness of double gene construct for rapid identification of transgenic mice exhibiting tissue‐specific gene expression

2001 • 21 citations

Flow visualization of microcirculation in solid tumor tissues: intravital microscopic observation of blood circulation by use of a confocal laser scanning microscope.

1996 • 16 citations

A model of superficial bladder cancer using fluorescent tumour cells in an organ‐culture system

2000 • 13 citations

Detection of circulating metastatic cells.

1986 • 11 citations