The Emerging Three‐Dimensional Structure of a Receptor

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

Structure of the protein subunits in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3Å resolution

1985 • 3,049 citations

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

1990 • 2,969 citations

Structure at 2.8 Å resolution of cytochrome c oxidase from Paracoccus denitrificans

1995 • 1,991 citations

Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

1987 • 1,621 citations

Handbook of experimental pharmacology

1984 • 1,599 citations

The Diversity of Neuronal Nicotinic Acetylcholine Receptors

1993 • 1,040 citations

Acetylcholine receptor channel imaged in the open state

1995 • 1,002 citations

α9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells

1994 • 869 citations

Nicotinic Acetylcholine Receptor an 9 Å Resolution

1993 • 822 citations

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

1988 • 798 citations

Structural homology of Torpedo californica acetylcholine receptor subunits

1983 • 798 citations

Fast events in single‐channel currents activated by acetylcholine and its analogues at the frog muscle end‐plate.

1985 • 768 citations

Primary structure of α-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence

1982 • 730 citations

Acetylcholine Receptor Channel Structure Probed in Cysteine-Substitution Mutants

1992 • 668 citations

Acetylcholine Receptor: An Allosteric Protein

1984 • 620 citations

Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins

1995 • 614 citations

Acetylcholine Receptor: Complex of Homologous Subunits

1980 • 594 citations

Primary structures of β- and δ-subunit precursors of Torpedo californica acetylcholine receptor deduced from cDNA sequences

1983 • 527 citations

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

1991 • 515 citations

Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor.

1984 • 513 citations

Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor

1991 • 463 citations

Monoclonal antibodies used to probe acetylcholine receptor structure: localization of the main immunogenic region and detection of similarities between subunits.

1980 • 452 citations

Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons

1993 • 446 citations

ON THE COOPERATIVITY OF BIOLOGICAL MEMBRANES

1967 • 439 citations

On the application of “a plausible model” of allosteric proteins to the receptor for acetylcholine

1967 • 425 citations

Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic

1992 • 420 citations

N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1

1994 • 419 citations

Nucleotide and deduced amino acid sequences of Torpedo californica acetylcholine receptor gamma subunit.

1983 • 412 citations

Identification of the alpha subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site.

1984 • 408 citations

Chimaeric nicotinic–serotonergic receptor combines distinct ligand binding and channel specificities

1993 • 401 citations

Ligand-gated ion channels in the brain: The amino acid receptor superfamily

1990 • 397 citations

Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica

1978 • 384 citations

Evidence That the M2 Membrane-Spanning Region Lines the Ion Channel Pore of the Nicotinic Receptor

1988 • 379 citations

Location of a δ-subunit region determining ion transport through the acetylcholine receptor channel

1986 • 315 citations

Amino acids of the Torpedo marmorata acetylcholine receptor .alpha. subunit labeled by a photoaffinity ligand for the acetylcholine binding site

1988 • 314 citations

The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits

1986 • 313 citations

Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure

1991 • 313 citations

The structure of porin from Rhodobacter capsulatus at 1.8 Å resolution

1991 • 303 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine.

1986 • 296 citations

Topology profile for a glutamate receptor: Three transmembrane domains and a channel-lining reentrant membrane loop

1995 • 293 citations

Glycine receptors: recent insights into their structural organization and functional diversity

2006 • 283 citations

Quaternary structure of the acetylcholine receptor

1985 • 281 citations

Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor

1989 • 279 citations

An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor

1990 • 275 citations

Progesterone modulates a neuronal nicotinic acetylcholine receptor.

1992 • 272 citations

d-Tubocurarine binding sites are located at alpha-gamma and alpha-delta subunit interfaces of the nicotinic acetylcholine receptor.

1990 • 256 citations

The acetylcholine receptor: an "allosteric" membrane protein.

1979 • 256 citations

Multiple sites of action for noncompetitive blockers on acetylcholine receptor rich membrane fragments from Torpedo marmorata

1983 • 250 citations

Identification of a novel amino acid alpha-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labeling. Additional evidence for a three-loop model of the cholinergic ligands-binding sites.

1990 • 247 citations

Equilibrium binding of [3H]tubocurarine and [3H]acetylcholine by torpedo postsynaptic membranes: stoichiometry and ligand interactions

1979 • 243 citations

Biochemical properties of acetylcholine receptor subunits from Torpedo californica

1979 • 239 citations

Pore loops: An emerging theme in ion channel structure

1995 • 237 citations

The postsynaptic 43k protein clusters muscle nicotinic acetylcholine receptors in xenopus oocytes

1990 • 237 citations

Structure of nicotinic acetylcholine receptors

1993 • 234 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: [3H]chlorpromazine labels homologous residues in the .beta. and .delta. chains

1987 • 228 citations

Presence of a lattice structure in membrane fragments rich in nicotinic receptor protein from the electric organ of Torpedo marmorata

1973 • 212 citations

Rapsyn may function as a link between the acetylcholine receptor and the agrin-binding dystrophin-associated glycoprotein complex

1995 • 209 citations

Refined structure of the pore-forming domain of colicin A at 2.4 Å resolution

1992 • 205 citations

Identifying the Lipid-Protein Interface of the Torpedo Nicotinic Acetylcholine Receptor: Secondary Structure Implications

1994 • 200 citations

Neurotransmitter-gated ion channels as unconventional allosteric proteins

1994 • 197 citations

Location of subunits within the acetylcholine receptor by electron image analysis of tubular crystals from Torpedo marmorata.

1987 • 195 citations

Studies of the composition of purified Torpedo californica acetylcholine receptor and of its subunits

1979 • 193 citations

Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of residues that determine curare selectivity.

1993 • 186 citations

The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel.

1990 • 186 citations

Molecular forms of acetylcholine receptor. Effects of calcium ions and a sulfhydryl reagent on the occurrence of oligomers

1977 • 185 citations

Mapping of the acetylcholine binding site of the nicotinic acetylcholine receptor: [3H]nicotine as an agonist photoaffinity label

1991 • 184 citations

Identification of Acetylcholine Receptor Channel-Lining Residues in the M1 Segment of the .alpha.-Subunit

1995 • 179 citations

Allosteric modulations of the nicotinic acetylcholine receptor

1993 • 179 citations

An Analog of Lophotoxin Reacts Covalently with Tyr190 in the α-Subunit of the Nicotinic Acetylcholine Receptor

1989 • 169 citations

The nicotinic acetylcholine receptor and its ion channel

1986 • 169 citations

Cloning, sequencing and expression of cDNA for a novel subunit of acetylcholine receptor from calf muscle

1985 • 169 citations

Functional significance of aromatic amino acids from three peptide loops of the α7 neuronal nicotinic receptor site investigated by site‐directed mutagenesis

1991 • 168 citations

Functional architecture of the nicotinic acetylcholine receptor: A prototype of ligand-gated ion channels

1993 • 168 citations

Arrangement of the acetylcholine receptor subunits in the resting and desensitized states, determined by cryoelectron microscopy of crystallized Torpedo postsynaptic membranes.

1988 • 167 citations

Molecular dissection of subunit interfaces in the acetylcholine receptor: Identification of determinants of α-Conotoxin M1 selectivity

1995 • 164 citations

Gamma- and delta-subunits regulate the affinity and the cooperativity of ligand binding to the acetylcholine receptor.

1991 • 163 citations

Affinity labeling of one of two α-neurotoxin binding sites in acetylcholine receptor from Torpedo californica

1978 • 163 citations

Spontaneous openings of the acetylcholine receptor channel.

1984 • 162 citations

The tryptophan synthase bienzyme complex transfers indole between the .alpha.- and .beta.-sites via a 25-30 .ANG. long tunnel

1990 • 162 citations

Genetic engineering of snake toxins. Role of invariant residues in the structural and functional properties of a curaremimetic toxin, as probed by site-directed mutagenesis.

1993 • 153 citations

Genetic Engineering of Snake Toxins

1995 • 151 citations

Interleukin-9 Induces Tyrosine Phosphorylation of Insulin Receptor Substrate-1 via JAK Tyrosine Kinases

1995 • 150 citations

The Nicotinic Acetylcholine Receptor: Structure and Autoimmune Pathology

1994 • 149 citations

In vitro synthesis, glycosylation, and membrane insertion of the four subunits of Torpedo acetylcholine receptor.

1981 • 147 citations

Identification of a New Component of the Agonist Binding Site of the Nicotinic α7 Homooligomeric Receptor

1995 • 147 citations

Agonist-induced changes in the structure of the acetylcholine receptor M2 regions revealed by photoincorporation of an uncharged nicotinic noncompetitive antagonist.

1992 • 145 citations

The Permeation Pathway of Neurotransmitter-Gated Ion Channels

1992 • 142 citations

The reversible cholinesterase inhibitor physostigmine has channel-blocking and agonist effects on the acetylcholine receptor-ion channel complex.

1985 • 130 citations

Analysis of ligand binding to the synthetic dodecapeptide 185-196 of the acetylcholine receptor alpha subunit.

1986 • 130 citations

Stabilization of acetylcholine receptor secondary structure by cholesterol and negatively charged phospholipids in membranes

1987 • 129 citations

Regulation of receptor function by protein phosphorylation

1987 • 128 citations

Selectivity of cations and nonelectrolytes for acetylcholine-activated channels in cultured muscle cells.

1978 • 127 citations

Ultrastructure of isolated membranes ofTorpedo electric tissue

1973 • 120 citations

Molecular properties of the cholinergic receptor purified from Electrophorus electricus

1973 • 120 citations

Structure of the agonist-binding site of the nicotinic acetylcholine receptor. [3H]acetylcholine mustard identifies residues in the cation-binding subsite.

1991 • 119 citations

Negatively charged amino acid residues in the nicotinic receptor delta subunit that contribute to the binding of acetylcholine.

1993 • 117 citations

The arrangement of the subunits of the acetylcholine receptor of Torpedo californica.

1983 • 115 citations

Binding of alpha-bungarotoxin to isolated alpha subunit of the acetylcholine receptor of Torpedo californica: quantitative analysis with protein blots.

1983 • 113 citations

Explorations of the nicotinic acetylcholine receptor.

1989 • 113 citations

Threonine in the selectivity filter of the acetylcholine receptor channel

1992 • 112 citations

Primary structure and functional expression of the α‐, β‐, γ‐, δ‐ and ɛ‐subunits of the acetylcholine receptor from rat muscle

1990 • 110 citations

A model for the structure of bacteriorhodopsin based on high resolution electron cryomicroscopy

1990 • 108 citations

Clustering and immobilization of acetylcholine receptors by the 43-kD protein: a possible role for dystrophin-related protein.

1993 • 107 citations

Mutational analysis of ligand-induced activation of the Torpedo acetylcholine receptor.

1992 • 106 citations

The reaction site of a non-competitive antagonist in the delta-subunit of the nicotinic acetylcholine receptor.

1986 • 104 citations

Mapping the alpha-subunit site photolabeled by the noncompetitive inhibitor [3H]quinacrine azide in the active state of the nicotinic acetylcholine receptor.

1990 • 104 citations

Evidence for unpredicted transmembrane domains in acetylcholine receptor subunits.

1985 • 103 citations

Specificity of α-Bungarotoxin binding to Torpedo californica electroplax

1972 • 102 citations

Allosteric transitions of the acetylcholine receptor probed at the amino acid level with a photolabile cholinergic ligand.

1991 • 101 citations

Structure of the Nicotinic Receptor Acetylcholine-binding Site

1995 • 100 citations

The noncompetitive blocker [³H]chlorpromazine labels segment M2 but not segment M 1 of the nicotinic acetylcholine receptor α‐subunit

1989 • 99 citations

Identification of the mouse muscle 43,000-dalton acetylcholine receptor-associated protein (RAPsyn) by cDNA cloning.

1988 • 98 citations

Glycosylation sites selectively interfere with alpha-toxin binding to the nicotinic acetylcholine receptor.

1994 • 97 citations

The transmembrane domains of the nicotinic acetylcholine receptor contain alpha-helical and beta structures.

1994 • 96 citations

The refined crystal structure of alpha-cobratoxin from Naja naja siamensis at 2.4-A resolution.

1991 • 95 citations

Intersubunit contacts governing assembly of the mammalian nicotinic acetylcholine receptor

1995 • 95 citations

Three-dimensional location of the main immunogenic region of the acetylcholine receptor

1995 • 94 citations

Nicotinic receptor: an allosteric protein specialized for intercellular communication

1995 • 93 citations

Molecular weight and quaternary structure of the cholinergic receptor protein extracted by detergents from Electrophorus electricus electric tissue

1973 • 92 citations

Mutagenesis of the 43-kD postsynaptic protein defines domains involved in plasma membrane targeting and AChR clustering.

1991 • 90 citations

Expression of fusion proteins of the nicotinic acetylcholine receptor from mammalian muscle identifies the membrane-spanning regions in the alpha and delta subunits.

1992 • 88 citations

Distance between the Agonist and Noncompetitive Inhibitor Sites on the Nicotinic Acetylcholine Receptor

1989 • 85 citations

Acetylcholine receptor: ‐SH group reactivity as indicator of conformational changes and functional states

1977 • 85 citations

The refined crystal structure of alpha-cobratoxin from Naja naja siamensis at 2.4-A resolution.

1991 • 84 citations

The transmembrane topology of the amino terminus of the alpha subunit of the nicotinic acetylcholine receptor

1991 • 84 citations

Snake acetylcholine receptor: cloning of the domain containing the four extracellular cysteines of the alpha subunit.

1989 • 84 citations

Transport Through Membranes: Carriers, Channels and Pumps

1988 • 84 citations

Transmembrane topology of acetylcholine receptor subunits probed with photoreactive phospholipids

1985 • 81 citations

Stratification of the channel domain in neurotransmitter receptors

1993 • 80 citations

Structure of the noncompetitive antagonist-binding site of the Torpedo nicotinic acetylcholine receptor. [3H]meproadifen mustard reacts selectively with alpha-subunit Glu-262.

1992 • 80 citations

Agonist binding site of Torpedo electric tissue nicotinic acetylcholine receptor. A negatively charged region of the delta subunit within 0.9 nm of the alpha subunit binding site disulfide.

1991 • 80 citations

Carbohydrate structures of acetylcholine receptor from Torpedo californica and distribution of oligosaccharides among the subunits

1986 • 80 citations

The Acetylcholine Receptor as Part of a Protein Complex in Receptor-Enriched Membrane Fragments from Torpedo californica Electric Tissue

1978 • 79 citations

Photoaffinity labeling of Torpedo acetylcholine receptor by physostigmine

1993 • 79 citations

Steroids inhibit nicotinic acetylcholine receptors

1991 • 72 citations

A Role for Cholesterol as a Structural Effector of the Nicotinic Acetylcholine Receptor

1994 • 71 citations

Functional Equivalence of Monomeric and Dimeric Forms of Purified Acetylcholine Receptors from Torpedo californica in Reconstituted Lipid Vesicles

1980 • 71 citations

Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.

1991 • 70 citations

A second pathway of activation of the Torpedo acetylcholine receptor channel

1991 • 70 citations

The sidedness of the COOH terminus of the acetylcholine receptor δ subunit

1989 • 69 citations

Transverse distance between the membrane and the agonist binding sites on the Torpedo acetylcholine receptor: a fluorescence study

1994 • 68 citations

Site-directed mutagenesis and single-channel currents define the ionic channel of the nicotinic acetylcholine receptor

1989 • 65 citations

On the conformation of the acetylcholine receptor protein from Torpedo nobiliana

1974 • 65 citations

Competitive antagonists bridge the alpha-gamma subunit interface of the acetylcholine receptor through quaternary ammonium-aromatic interactions

1994 • 63 citations

Secondary structure and temperature behavior of the acetylcholine receptor by Fourier transform infrared spectroscopy

1993 • 62 citations

Electron microscopy of complexes of isolated acetylcholine receptor, biotinyl-toxin, and avidin.

1982 • 61 citations

The hydrophobic photoreagent 3-(trifluoromethyl)-3-m-([125I] iodophenyl) diazirine is a novel noncompetitive antagonist of the nicotinic acetylcholine receptor.

1991 • 61 citations

Characterization of d-tubocurarine binding site of Torpedo acetylcholine receptor

1994 • 59 citations

Erabutoxin b

1986 • 59 citations

Interacting surfaces of neurotoxins and acetylcholine receptor

1982 • 58 citations

The Handedness of the Subunit Arrangement of the Nicotinic Acetylcholine Receptor from Torpedo californica

1995 • 56 citations

Recent Developments in the Structure and Function of the Acetylcholine Receptor

1983 • 54 citations

Dissection of the 66 000-dalton subunit of the acetylcholine receptor

1981 • 53 citations

The .alpha.-Conotoxins GI and MI Distinguish between the Nicotinic Acetylcholine Receptor Agonist Sites while SI Does Not

1994 • 53 citations

Photolabeling reveals the proximity of the alpha-neurotoxin binding site to the M2 helix of the ion channel in the nicotinic acetylcholine receptor.

1995 • 53 citations

Secondary structural analyses of the nicotinic acetylcholine receptor as a test of molecular models.

1988 • 51 citations

Erabutoxin b

1985 • 51 citations

The main immunogenic region of the nicotinic acetylcholine receptor. Identification of amino acid residues interacting with different antibodies.

1989 • 49 citations

A sequence in the main cytoplasmic loop of the α subunit is required for assembly of mouse muscle nicotinic acetylcholine receptor

1994 • 47 citations

Equilibrium Binding of Acetylcholine to the Membrane-Bound Acetylcholine Receptor

1982 • 46 citations

Ligand-mediated Changes in the Tryptophan Synthase Indole Tunnel Probed by Nile Red Fluorescence with Wild Type, Mutant, and Chemically Modified Enzymes

1995 • 46 citations

Structure, oligosaccharide structures, and posttranslationally modified sites of the nicotinic acetylcholine receptor.

1989 • 44 citations

Crystal structures of methyltriphenylarsonium and methyltriphenylphosphonium bis-(ααα′α′-tetracyanoquinodimethanide){di-[3,6-bis(dicyanomethylene)cyclohexa-1,4-dienes]}

1971 • 44 citations

A Novel Agonist Binding Site on Nicotinic Acetylcholine Receptors

1993 • 44 citations

Relative locations of the beta and delta chains of the acetylcholine receptor determined by electron microscopy of isolated receptor trimer.

1981 • 44 citations

Monoclonal antibodies specific for each of the two toxin binding sites of Torpedo acetylcholine receptor

1987 • 43 citations

Two‐dimensional ¹H‐NMR study of the spatial structure of neurotoxin II from Naja naja oxiana

1993 • 42 citations

The selectivity filter of a ligand‐gated ion channel

1989 • 41 citations

FTIR analysis of nicotinic acetylcholine receptor secondary structure in reconstituted membranes

1993 • 38 citations

Arrangement of the subunits of the nicotinic acetylcholine receptor of Torpedo californica as determined by .alpha.-neurotoxin crosslinking

1985 • 38 citations

The Secondary Structure of Acetylcholine Receptor Reconstituted in a Single Lipid Component as Determined by Raman Spectroscopy

1984 • 37 citations

High‐resolution epitope mapping and fine antigenic characterization of the main immunogenic region of the acetylcholine receptor

1993 • 35 citations

Topography of toxin-acetylcholine receptor complexes by using photoactivatable toxin derivatives.

1990 • 33 citations

The nicotinic acetylcholine receptor; a glycoprotein

1975 • 33 citations

Investigation of ligand binding sites of the acetylcholine receptor using photoactivatable derivatives of neurotoxin II from Naja naja oxiana

1992 • 33 citations

Proteolytic fragments of the nicotinic acetylcholine receptor identified by mass spectrometry: implications for receptor topography

1989 • 31 citations

Relationship between the binding sites for an α-conotoxin and snake venom neurotoxins in the nicotinic acetylcholine receptor from Torpedo californica

1994 • 29 citations

Two forms of acetylcholine receptor gamma subunit in mouse muscle.

1995 • 27 citations

Localisation of the main immunogenic region of the nicotinic acetylcholine receptor

1986 • 25 citations

Detailed structural analysis of asparagine‐linked oligosaccharides of the nicotinic acetylcholine receptor from Torpedo californica

1992 • 25 citations

Rapid preparation of the nicotinic acetylcholine receptor for crystallization in detergent solution

1988 • 24 citations

On the Interaction between Cobra -Neurotoxin and the Acetylcholine Receptor

1976 • 24 citations

Agonist-induced photoincorporation of a p-benzoylphenylalanine derivative of substance P into membrane-spanning region 2 of the Torpedo nicotinic acetylcholine receptor delta subunit.

1994 • 24 citations

Molecular Determinants Conferring α-Toxin Resistance in Recombinant DNA-derived Acetylcholine Receptors

1995 • 24 citations

The Histrionicotoxin-Sensitive Ethidium Binding Site Is Located Outside of the Transmembrane Domain of the Nicotinic Acetylcholine Receptor: A Fluorescence Study

1994 • 23 citations

Conformation of acetylcholine receptor in the presence of agonists and antagonists

1990 • 18 citations

Raman spectroscopy of acetylcholine receptor‐rich membranes from Torpedo marmorata and of their isolated components

1983 • 18 citations

Interaction of protein ligands with receptor fragments

1994 • 15 citations

All potential glycosylation sites of the nicotinic acetylcholine receptor δ subunit from Torpedo californica are utilized

1994 • 15 citations

The transmembrane region of the nicotinic acetylcholine receptor: is it an all-helix bundle?

1994 • 14 citations

A high-affinity site for acetylcholine occurs close to the .alpha.-.gamma. subunit interface of Torpedo nicotinic acetylcholine receptor

1993 • 13 citations

The intactness and orientation of acetylcholine receptor-rich membrane from Torpedo californica electric tissue

1989 • 11 citations

Properties and Problems of the Helix-M2 model of the Acetylcholine Receptor-Ion Channel.

1988 • 6 citations

Deleted Work

1955 • 0 citations