Structure of the agonist-binding site of the nicotinic acetylcholine receptor. [3H]acetylcholine mustard identifies residues in the cation-binding subsite.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

1977 • 5,640 citations

Elution of proteins from sodium dodecyl sulfate-polyacrylamide gels, removal of sodium dodecyl sulfate, and renaturation of enzymatic activity: Results with sigma subunit of Escherichia coli RNA polymerase, wheat germ DNA topoisomerase, and other enzymes

1980 • 1,256 citations

A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX

1990 • 923 citations

Structural homology of Torpedo californica acetylcholine receptor subunits

1983 • 798 citations

Primary structure of α-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence

1982 • 730 citations

The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors

1987 • 730 citations

Acetylcholine Binding by a Synthetic Receptor: Implications for Biological Recognition

1990 • 608 citations

Acetylcholine Receptor: Complex of Homologous Subunits

1980 • 594 citations

Two novel GABAA receptor subunits exist in distinct neuronal subpopulations

1989 • 532 citations

Primary structures of β- and δ-subunit precursors of Torpedo californica acetylcholine receptor deduced from cDNA sequences

1983 • 527 citations

Cloning and sequence analysis of calf cDNA and human genomic DNA encoding α-subunit precursor of muscle acetylcholine receptor

1983 • 433 citations

Identification of the alpha subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site.

1984 • 408 citations

Ligand-gated ion channels in the brain: The amino acid receptor superfamily

1990 • 397 citations

Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica

1978 • 384 citations

Acetylcholine receptor binding site contains a disulfide cross-link between adjacent half-cystinyl residues.

1986 • 361 citations

Sequencing of Proteins and Peptides

1981 • 338 citations

Functional Architecture of the Nicotinic Acetylcholine Receptor: From Electric Organ to Brain

1991 • 327 citations

Amino acids of the Torpedo marmorata acetylcholine receptor .alpha. subunit labeled by a photoaffinity ligand for the acetylcholine binding site

1988 • 314 citations

The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits

1986 • 313 citations

Alpha 3, alpha 5, and beta 4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster.

1990 • 303 citations

Nicotinic acetylcholine receptor and superfamily of ligand-gated ion channels

1990 • 260 citations

d-Tubocurarine binding sites are located at alpha-gamma and alpha-delta subunit interfaces of the nicotinic acetylcholine receptor.

1990 • 256 citations

Identification of a novel amino acid alpha-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labeling. Additional evidence for a three-loop model of the cholinergic ligands-binding sites.

1990 • 247 citations

Equilibrium binding of [3H]tubocurarine and [3H]acetylcholine by torpedo postsynaptic membranes: stoichiometry and ligand interactions

1979 • 243 citations

Genes expressed in the brain define three distinct neuronal nicotinic acetylcholine receptors.

1988 • 232 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: [3H]chlorpromazine labels homologous residues in the .beta. and .delta. chains

1987 • 228 citations

Three-dimensional structure of the acetylcholine receptor by cryoelectron microscopy and helical image reconstruction.

1990 • 197 citations

Alpha 5, alpha 3, and non-alpha 3. Three clustered avian genes encoding neuronal nicotinic acetylcholine receptor-related subunits.

1990 • 191 citations

Mapping of the acetylcholine binding site of the nicotinic acetylcholine receptor: [3H]nicotine as an agonist photoaffinity label

1991 • 184 citations

Permeability control by cholinergic receptors in Torpedo postsynaptic membranes: agonist dose-response relations measured at second and millisecond times

1980 • 170 citations

An Analog of Lophotoxin Reacts Covalently with Tyr190 in the α-Subunit of the Nicotinic Acetylcholine Receptor

1989 • 169 citations

Isolation and characterization of a cDNA clone for the complete protein coding region of the delta subunit of the mouse acetylcholine receptor.

1984 • 155 citations

Formation of Isoaspartate at Two Distinct Sites during in vitro Aging of Human Growth Hormone

1989 • 145 citations

Conservation of neural nicotinic acetylcholine receptors from Drosophila to vertebrate central nervous systems.

1988 • 140 citations

Use of o-phthalaldehyde to reduce background during automated Edman degradation

1984 • 138 citations

Muscarinic acetylcholine receptors. Peptide sequencing identifies residues involved in antagonist binding and disulfide bond formation.

1990 • 138 citations

Kinetics of binding of [3H]acetylcholine and [3H]carbamoylcholine to Torpedo postsynaptic membranes: slow conformational transitions of the cholinergic receptor

1980 • 136 citations

Conformations of Torpedo acetylcholine receptor associated with ion transport and desensitization

1982 • 135 citations

Location of ligand-binding sites on the nicotinic acetylcholine receptor alpha-subunit.

1986 • 119 citations

Neurotransmitter Receptor Interactions

1972 • 115 citations

Three-dimensional structure of the nicotinic acetylcholine receptor and location of the major associated 43-kD cytoskeletal protein, determined at 22 A by low dose electron microscopy and x-ray diffraction to 12.5 A [published erratum appears in J Cell Biol 1989 Oct;109(4 Pt 1):1185]

1989 • 114 citations

Photolabeling of membrane-bound Torpedo nicotinic acetylcholine receptor with the hydrophobic probe 3-trifluoromethyl-3-(m-[125I]iodophenyl)diazirine

1988 • 87 citations

Mapping of a cholinergic binding site by means of synthetic peptides, monoclonal antibodies, and .alpha.-bungarotoxin

1990 • 87 citations

Nucleotide sequence of the mouse nicotinic acetylcholine receptor α subunit

1986 • 82 citations

A universal oligonucleotide probe for acetylcholine receptor genes. Selection and sequencing of cDNA clones for the mouse muscle beta subunit.

1986 • 81 citations

Mouse muscle nicotinic acetylcholine receptor γ subunit: cDNA sequence and gene expression

1986 • 72 citations

Mapping and modification of an antibody hapten binding site: a site-directed mutagenesis study of McPC603

1991 • 68 citations

On the specificity of antibody/antigen interactions: Phosphocholine binding to McPC603 and the correlation of three-dimensional structure and sequence data

1985 • 67 citations

The 43 kilodalton protein of Torpedo nicotinic postsynaptic membranes: purification and determination of primary structure

1987 • 59 citations

Coexpression of two distinct muscle acetylcholine receptor α-subunits during development

1990 • 49 citations

Reactions of dibenamine and some congeners with substances of biological interest in relation to the mechanism of adrenergic blockade.

1954 • 46 citations

Neurotoxin-Binding Site on The Acetylcholine Receptor

1988 • 45 citations

Quantitative analysis of resonance Raman spectra of purple membrane from Halobacterium halobium: L550 intermediate

1983 • 36 citations

Assessment of the number of free cysteines and isolation and identification of cystine-containing peptides from acetylcholine receptor

1989 • 35 citations

Localization of Sites Modified during Inactivation of the Bovine Heart Mitochondrial F1-ATPase by Quinacrine Mustard Using [3H]Aniline as a Probe

1989 • 32 citations

Reaction of [3H]meproadifen mustard with membrane-bound Torpedo acetylcholine receptor.

1986 • 28 citations

The reactivity of radiomimetic compounds II

1958 • 28 citations

Synthesis and pharmacological actions of 2-[(2-chloroethyl)methylamino]ethyl acetate and some of its derivatives on the isolated guinea pig ileum

1972 • 25 citations

THE IRREVERSIBLE BINDING OF ACETYLCHOLINE MUSTARD TO MUSCARINIC RECEPTORS IN INTESTINAL SMOOTH MUSCLE OF THE GUINEA‐PIG

1975 • 20 citations

Molecular forces acting between ammonium ions and acetylcholine receptor

1969 • 18 citations

A comparison of the action of acetylcholine and acetylcholine mustard (chloroethylmethylaminoethyl acetate) on muscarinic and nicotinic receptors.

1972 • 17 citations

AGONISTS OF TORPEDO NICOTINIC RECEPTORS: ESSENTIAL ROLE OF A POSITIVE CHARGE*

1980 • 5 citations

Interactions of Acetylcholine Mustard with Acetylcholinesterase

1975 • 4 citations