Negatively charged amino acid residues in the nicotinic receptor delta subunit that contribute to the binding of acetylcholine.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1991 • 2,613 citations

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

1986 • 979 citations

Structural homology of Torpedo californica acetylcholine receptor subunits

1983 • 798 citations

Acetylcholine Receptor Channel Structure Probed in Cysteine-Substitution Mutants

1992 • 668 citations

Acetylcholine Binding by a Synthetic Receptor: Implications for Biological Recognition

1990 • 608 citations

Phosphocholine binding immunoglobulin Fab McPC603

1986 • 576 citations

Identification of the alpha subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site.

1984 • 408 citations

Location of functional regions of acetylcholine receptor α-subunit by site-directed mutagenesis

1985 • 390 citations

Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica

1978 • 384 citations

Acetylcholine receptor binding site contains a disulfide cross-link between adjacent half-cystinyl residues.

1986 • 361 citations

A general method of site-specific mutagenesis using a modification of the Thermus aquaticus polymerase chain reaction

1989 • 321 citations

Amino acids of the Torpedo marmorata acetylcholine receptor .alpha. subunit labeled by a photoaffinity ligand for the acetylcholine binding site

1988 • 314 citations

Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor

1989 • 279 citations

d-Tubocurarine binding sites are located at alpha-gamma and alpha-delta subunit interfaces of the nicotinic acetylcholine receptor.

1990 • 256 citations

Identification of a novel amino acid alpha-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labeling. Additional evidence for a three-loop model of the cholinergic ligands-binding sites.

1990 • 247 citations

Equilibrium binding of [3H]tubocurarine and [3H]acetylcholine by torpedo postsynaptic membranes: stoichiometry and ligand interactions

1979 • 243 citations

Mapping of the acetylcholine binding site of the nicotinic acetylcholine receptor: [3H]nicotine as an agonist photoaffinity label

1991 • 184 citations

An Analog of Lophotoxin Reacts Covalently with Tyr190 in the α-Subunit of the Nicotinic Acetylcholine Receptor

1989 • 169 citations

Functional significance of aromatic amino acids from three peptide loops of the α7 neuronal nicotinic receptor site investigated by site‐directed mutagenesis

1991 • 168 citations

Gamma- and delta-subunits regulate the affinity and the cooperativity of ligand binding to the acetylcholine receptor.

1991 • 163 citations

Affinity labeling of one of two α-neurotoxin binding sites in acetylcholine receptor from Torpedo californica

1978 • 163 citations

Isolation and characterization of a cDNA clone for the complete protein coding region of the delta subunit of the mouse acetylcholine receptor.

1984 • 155 citations

Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor

1991 • 148 citations

Expression of recombinant acetylcholinesterase in a baculovirus system: kinetic properties of glutamate 199 mutants

1992 • 136 citations

Structure linkage, and sequence of the two genes encoding the delta and gamma subunits of the nicotinic acetylcholine receptor.

1984 • 132 citations

A molecular view of neurotransmitter receptors and ionic channels.

1987 • 121 citations

Improved site-directed mutagenesis method using PCR

1991 • 120 citations

Structure of the agonist-binding site of the nicotinic acetylcholine receptor. [3H]acetylcholine mustard identifies residues in the cation-binding subsite.

1991 • 119 citations

The arrangement of the subunits of the acetylcholine receptor of Torpedo californica.

1983 • 115 citations

Native folding of an acetylcholine receptor alpha subunit expressed in the absence of other receptor subunits.

1988 • 114 citations

Mutational analysis of ligand-induced activation of the Torpedo acetylcholine receptor.

1992 • 106 citations

Allosteric transitions of the acetylcholine receptor probed at the amino acid level with a photolabile cholinergic ligand.

1991 • 101 citations

Regulation of acetylcholine receptor transcript expression during development in Xenopus laevis

1988 • 93 citations

Nucleotide sequence of the mouse nicotinic acetylcholine receptor α subunit

1986 • 82 citations

A universal oligonucleotide probe for acetylcholine receptor genes. Selection and sequencing of cDNA clones for the mouse muscle beta subunit.

1986 • 81 citations

Agonist binding site of Torpedo electric tissue nicotinic acetylcholine receptor. A negatively charged region of the delta subunit within 0.9 nm of the alpha subunit binding site disulfide.

1991 • 80 citations

Affinity Labeling of the Acetylcholine Receptor in the Electroplax: Electrophoretic Separation in Sodium Dodecyl Sulfate

1972 • 79 citations

Mouse muscle nicotinic acetylcholine receptor γ subunit: cDNA sequence and gene expression

1986 • 72 citations

Mapping and modification of an antibody hapten binding site: a site-directed mutagenesis study of McPC603

1991 • 68 citations

Multiple conductance classes of mouse nicotinic acetylcholine receptors expressed in Xenopus oocytes.

1990 • 52 citations

Effects of agonists and antagonists on the reactivity of the binding site disulfide in acetylcholine receptor from Torpedo californica

1980 • 50 citations

Structural and Functional Diversity in Vertebrate Skeletal Muscle Nicotinic Acetylcholine Receptors

1989 • 50 citations

Equilibrium properties of mouse-Torpedo acetylcholine receptor hybrids expressed in Xenopus oocytes.

1987 • 49 citations

Monoclonal antibodies specific for each of the two toxin binding sites of Torpedo acetylcholine receptor

1987 • 43 citations

Nucleotide sequence of human muscle acetylcholine receptor β-subunit

1989 • 37 citations

Structure of the gamma-less nicotinic acetylcholine receptor: learning from omission.

1992 • 32 citations

The epsilon subunit confers fast channel gating on multiple classes of acetylcholine receptors

1993 • 31 citations

Use of chemical modifications and site-directed mutagenesis to probe the functional role of thiol groups on the .gamma. subunit of Torpedo californica acetylcholine receptor

1989 • 29 citations

Nucleotide sequence of the rat muscle acetylcholine receptor -subunit

1988 • 23 citations

Influence of the γ subunit and expression system on acetylcholine receptor gating

1990 • 23 citations

Single-channel properties of mouse—Torpedo acetylcholine receptor hybrids expressed in Xenopus oocytes

1991 • 17 citations

Subunit requirements for Torpedo AChR channel expression: A specific role for the ?-subunit in voltage-dependent gating

1992 • 11 citations