Structure of nicotinic acetylcholine receptors

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1991 • 2,613 citations

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

The Diversity of Neuronal Nicotinic Acetylcholine Receptors

1993 • 1,040 citations

Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

1986 • 979 citations

Primary Structure And Functional Expression of the 5HT ₃ Receptor, A Serotonin-gated Ion Channel

1991 • 976 citations

Nicotinic Acetylcholine Receptor an 9 Å Resolution

1993 • 822 citations

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

1988 • 798 citations

Structural homology of Torpedo californica acetylcholine receptor subunits

1983 • 798 citations

Acetylcholine Receptor Channel Structure Probed in Cysteine-Substitution Mutants

1992 • 668 citations

Acetylcholine Binding by a Synthetic Receptor: Implications for Biological Recognition

1990 • 608 citations

Phosphocholine binding immunoglobulin Fab McPC603

1986 • 576 citations

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

1991 • 515 citations

Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor

1991 • 463 citations

Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic

1992 • 420 citations

Nucleotide and deduced amino acid sequences of Torpedo californica acetylcholine receptor gamma subunit.

1983 • 412 citations

Identification of the alpha subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site.

1984 • 408 citations

Ligand-gated ion channels in the brain: The amino acid receptor superfamily

1990 • 397 citations

Location of functional regions of acetylcholine receptor α-subunit by site-directed mutagenesis

1985 • 390 citations

Evidence That the M2 Membrane-Spanning Region Lines the Ion Channel Pore of the Nicotinic Receptor

1988 • 379 citations

The structure of ion channels in membranes of excitable cells

1989 • 368 citations

Acetylcholine receptor binding site contains a disulfide cross-link between adjacent half-cystinyl residues.

1986 • 361 citations

Functional Architecture of the Nicotinic Acetylcholine Receptor: From Electric Organ to Brain

1991 • 327 citations

Location of a δ-subunit region determining ion transport through the acetylcholine receptor channel

1986 • 315 citations

Amino acids of the Torpedo marmorata acetylcholine receptor .alpha. subunit labeled by a photoaffinity ligand for the acetylcholine binding site

1988 • 314 citations

Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure

1991 • 313 citations

The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits

1986 • 313 citations

Neurons assemble acetylcholine receptors with as many as three kinds of subunits while maintaining subunit segregation among receptor subtypes

1993 • 303 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine.

1986 • 296 citations

Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor

1989 • 279 citations

An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor

1990 • 275 citations

Nicotinic acetylcholine receptor and superfamily of ligand-gated ion channels

1990 • 260 citations

d-Tubocurarine binding sites are located at alpha-gamma and alpha-delta subunit interfaces of the nicotinic acetylcholine receptor.

1990 • 256 citations

GABAA receptor channels: from subunits to functional entities

1992 • 255 citations

Identification of a novel amino acid alpha-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labeling. Additional evidence for a three-loop model of the cholinergic ligands-binding sites.

1990 • 247 citations

Equilibrium binding of [3H]tubocurarine and [3H]acetylcholine by torpedo postsynaptic membranes: stoichiometry and ligand interactions

1979 • 243 citations

Chemical Modification of the Active Site of the Acetylcholine Receptor

1969 • 235 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: [3H]chlorpromazine labels homologous residues in the .beta. and .delta. chains

1987 • 228 citations

Location of subunits within the acetylcholine receptor by electron image analysis of tubular crystals from Torpedo marmorata.

1987 • 195 citations

Diversity in primary structure and function of neuronal nicotinic acetylcholine receptor channels

1992 • 191 citations

The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel.

1990 • 186 citations

Mapping of the acetylcholine binding site of the nicotinic acetylcholine receptor: [3H]nicotine as an agonist photoaffinity label

1991 • 184 citations

An Analog of Lophotoxin Reacts Covalently with Tyr190 in the α-Subunit of the Nicotinic Acetylcholine Receptor

1989 • 169 citations

Functional significance of aromatic amino acids from three peptide loops of the α7 neuronal nicotinic receptor site investigated by site‐directed mutagenesis

1991 • 168 citations

Functional Contribution of Neuronal AChR Subunits Revealed by Antisense Oligonucleotides

1991 • 164 citations

Affinity labeling of one of two α-neurotoxin binding sites in acetylcholine receptor from Torpedo californica

1978 • 163 citations

Gamma- and delta-subunits regulate the affinity and the cooperativity of ligand binding to the acetylcholine receptor.

1991 • 163 citations

Location of a threonine residue in the α -subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel

1991 • 148 citations

Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor

1991 • 148 citations

Agonist-induced changes in the structure of the acetylcholine receptor M2 regions revealed by photoincorporation of an uncharged nicotinic noncompetitive antagonist.

1992 • 145 citations

Three subtypes of alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors are expressed in chick retina

1993 • 142 citations

The Permeation Pathway of Neurotransmitter-Gated Ion Channels

1992 • 142 citations

Expression of recombinant acetylcholinesterase in a baculovirus system: kinetic properties of glutamate 199 mutants

1992 • 136 citations

How the mongoose can fight the snake: the binding site of the mongoose acetylcholine receptor.

1992 • 130 citations

A ring of uncharged polar amino acids as a component of channel constriction in the nicotinic acetylcholine receptor

1991 • 127 citations

Rings of anionic amino acids as structural determinants of ion selectivity in the acetylcholine receptor channel

1991 • 127 citations

A molecular view of neurotransmitter receptors and ionic channels.

1987 • 121 citations

Structure of the agonist-binding site of the nicotinic acetylcholine receptor. [3H]acetylcholine mustard identifies residues in the cation-binding subsite.

1991 • 119 citations

Negatively charged amino acid residues in the nicotinic receptor delta subunit that contribute to the binding of acetylcholine.

1993 • 117 citations

The arrangement of the subunits of the acetylcholine receptor of Torpedo californica.

1983 • 115 citations

Native folding of an acetylcholine receptor alpha subunit expressed in the absence of other receptor subunits.

1988 • 114 citations

Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations.

1992 • 114 citations

Explorations of the nicotinic acetylcholine receptor.

1989 • 113 citations

Mutational analysis of ligand-induced activation of the Torpedo acetylcholine receptor.

1992 • 106 citations

Mapping the alpha-subunit site photolabeled by the noncompetitive inhibitor [3H]quinacrine azide in the active state of the nicotinic acetylcholine receptor.

1990 • 104 citations

Allosteric transitions of the acetylcholine receptor probed at the amino acid level with a photolabile cholinergic ligand.

1991 • 101 citations

The noncompetitive blocker [³H]chlorpromazine labels segment M2 but not segment M 1 of the nicotinic acetylcholine receptor α‐subunit

1989 • 99 citations

Functional properties of nicotinic acetylcholine receptor subunits expressed in various combinations

1987 • 95 citations

Properties of embryonic and adult muscle acetylcholine receptors transiently expressed in COS cells

1990 • 90 citations

Expression of fusion proteins of the nicotinic acetylcholine receptor from mammalian muscle identifies the membrane-spanning regions in the alpha and delta subunits.

1992 • 88 citations

The transmembrane topology of the amino terminus of the alpha subunit of the nicotinic acetylcholine receptor

1991 • 84 citations

Agonist binding site of Torpedo electric tissue nicotinic acetylcholine receptor. A negatively charged region of the delta subunit within 0.9 nm of the alpha subunit binding site disulfide.

1991 • 80 citations

Structure of the noncompetitive antagonist-binding site of the Torpedo nicotinic acetylcholine receptor. [3H]meproadifen mustard reacts selectively with alpha-subunit Glu-262.

1992 • 80 citations

Effects of substitution of putative transmembrane segments on nicotinic acetylcholine receptor function

1987 • 75 citations

The sidedness of the COOH terminus of the acetylcholine receptor δ subunit

1989 • 69 citations

Mapping and modification of an antibody hapten binding site: a site-directed mutagenesis study of McPC603

1991 • 68 citations

Transmembrane topography of the nicotinic acetylcholine receptor delta subunit.

1987 • 52 citations

Effects of agonists and antagonists on the reactivity of the binding site disulfide in acetylcholine receptor from Torpedo californica

1980 • 50 citations

Asymmetry of the rat acetylcholine receptor subunits in the narrow region of the pore

1992 • 50 citations

Coexpression of two distinct muscle acetylcholine receptor α-subunits during development

1990 • 49 citations

Monoclonal antibodies specific for each of the two toxin binding sites of Torpedo acetylcholine receptor

1987 • 43 citations

Role of a key cysteine residue in the gating of the acetylcholine receptor

1991 • 41 citations

Quinacrine binds to the lipid-protein interface of the Torpedo acetylcholine receptor: a fluorescence study.

1992 • 37 citations

Identification of a cytoplasmic region of the Torpedo nicotinic acetylcholine receptor alpha-subunit by epitope mapping.

1990 • 32 citations

Structure of the gamma-less nicotinic acetylcholine receptor: learning from omission.

1992 • 32 citations

The epsilon subunit confers fast channel gating on multiple classes of acetylcholine receptors

1993 • 31 citations

Expression of subunit‐omitted mouse nicotinic acetylcholine receptors in Xenopus laevis oocytes.

1993 • 31 citations

Substitution of Torpedo acetylcholine receptor .alpha.1-subunit residues with snake .alpha.1- and rat nerve .alpha.3-subunit residues in recombinant fusion proteins: effect on .alpha.-bungarotoxin binding

1992 • 31 citations

Influence of the γ subunit and expression system on acetylcholine receptor gating

1990 • 23 citations

Binding sites for .alpha.-bungarotoxin and the noncompetitive inhibitor phencyclidine on a synthetic peptide comprising residues 172-227 of the .alpha.-subunit of the nicotinic acetylcholine receptor

1991 • 17 citations

Subunit requirements for Torpedo AChR channel expression: A specific role for the ?-subunit in voltage-dependent gating

1992 • 11 citations

Contributions of the gamma and epsilon subunit family to nicotinic acetylcholine receptor function.

1993 • 4 citations