A Role for Cholesterol as a Structural Effector of the Nicotinic Acetylcholine Receptor

Determination of protein secondary structure by Fourier transform infrared spectroscopy: A critical assessment

1993 • 1,489 citations

Quantitative studies of the structure of proteins in solution by fourier-transform infrared spectroscopy

1993 • 829 citations

Nicotinic Acetylcholine Receptor an 9 Å Resolution

1993 • 822 citations

Functional Architecture of the Nicotinic Acetylcholine Receptor: From Electric Organ to Brain

1991 • 327 citations

Correlation between acetylcholine receptor function and structural properties of membranes

1986 • 303 citations

FTIR difference spectroscopy of bacteriorhodopsin: Toward a molecular model

1992 • 291 citations

Nicotinic acetylcholine receptor and superfamily of ligand-gated ion channels

1990 • 260 citations

Annular and nonannular binding sites for cholesterol associated with the nicotinic acetylcholine receptor

1988 • 200 citations

Desensitization of the nicotinic acetylcholine receptor: Molecular mechanisms and effect of modulators

1989 • 198 citations

Effects of lipids on acetylcholine receptor. Essential need of cholesterol for maintenance of agonist-induced state transitions in lipid vesicles

1982 • 196 citations

Lipid-protein interactions in reconstituted membranes containing acetylcholine receptor

1983 • 189 citations

Arrangement of the acetylcholine receptor subunits in the resting and desensitized states, determined by cryoelectron microscopy of crystallized Torpedo postsynaptic membranes.

1988 • 167 citations

Variations of membrane cholesterol alter the kinetics of Ca2+-dependent K+ channels and membrane fluidity in vascular smooth muscle cells

1989 • 164 citations

Functional properties of the acetylcholine receptor incorporated in model lipid membranes. Differential effects of chain length and head group of phospholipids on receptor affinity states and receptor-mediated ion translocation.

1984 • 164 citations

The solution structure of concanavalin A probed by FT-IR spectroscopy

1988 • 157 citations

Biological membranes : a practical approach

1987 • 152 citations

Stabilization of acetylcholine receptor secondary structure by cholesterol and negatively charged phospholipids in membranes

1987 • 129 citations

Reconstitution of acetylcholine receptor function in lipid vesicles of defined composition

1983 • 127 citations

Fourier transform methods for spectral resolution enhancement

1988 • 114 citations

Role of membrane lipids in the interaction of daunomycin with plasma membranes from tumor cells: implications in drug-resistance phenomena

1990 • 103 citations

Lipid environment of acetylcholine receptor from Torpedo californica

1982 • 97 citations

Influence of Sterols and Phospholipids on Sarcolemmal and Sarcoplasmic Reticular Cation Transporters

1989 • 93 citations

The effect of cholesterol on agonist‐induced flux in reconstituted acetylcholine receptor vesicles

1980 • 91 citations

Lipid modulation of nicotinic acetylcholine receptor function: the role of neutral and negatively charged lipids

1992 • 83 citations

Structural and Functional Studies on the Interaction of Sodium Dodecyl Sulfate with β-Galactosidase

1993 • 74 citations

Secondary structure of streptokinase in aqueous solution: a Fourier transform infrared spectroscopic study

1992 • 73 citations

Infrared spectroscopic characterization of the structural changes connected with the E1→E2 transition in the Ca2+-ATPase of sarcoplasmic reticulum.

1987 • 73 citations

Fourier transform infrared investigation of the Escherichia coli methionine aporepressor

1987 • 66 citations

Incorporation of the nicotinic acetylcholine receptor into planar multilamellar films: characterization by fluorescence and Fourier transform infrared difference spectroscopy

1992 • 66 citations

Secondary structure and temperature behavior of the acetylcholine receptor by Fourier transform infrared spectroscopy

1993 • 62 citations

Fourier transform infrared difference spectroscopy of the nicotinic acetylcholine receptor: evidence for specific protein structural changes upon desensitization

1993 • 61 citations

Identification of subunits of acetylcholine receptor that interact with a cholesterol photoaffinity probe

1987 • 60 citations

Adenylate cyclase is inhibited upon depletion of plasma-membrane cholesterol

1983 • 58 citations

Correlation of phospholipid structure with functional effects on the nicotinic acetylcholine receptor. A modulatory role for phosphatidic acid

1993 • 56 citations

[9] Fourier resolution enhancement of infrared spectral data

1992 • 51 citations

Effect of local anaesthetics on steroid-nicotinic acetylcholine receptor interactions in native membranes of Torpedo marmorata electric organ

1990 • 42 citations

Probing conformational changes in the nicotinic acetylcholine receptor by Fourier transform infrared difference spectroscopy

1992 • 41 citations

Protein stability and interaction of the nicotinic acetylcholine receptor with cholinergic ligands studied by Fourier-transform infrared spectroscopy

1992 • 40 citations

Labeling of the nicotinic acetylcholine receptor by a photoactivatable steroid probe: effects of cholesterol and cholinergic ligands

1993 • 32 citations

Protein structural effects of agonist binding to the nicotinic acetylcholine receptor

1992 • 29 citations

Cholesterol stabilizes the structure of the nicotinic acetylcholine receptor reconstituted in lipid vesicles

1989 • 23 citations

Verapamil prevents the effects of daunomycin on the thermotropic phase transition of model lipid bilayers

1991 • 23 citations

Fourier transform infrared (FTIR) spectroscopic investigation of the nicotinic acetylcholine receptor (nAChR) Investigation of agonist binding and receptor conformational changes by flash‐induced release of ‘caged’ carbamoylcholine

1992 • 22 citations

5′‐Nucleotidase is activated upon cholesterol‐depletion of liver plasma membranes

1983 • 20 citations

Binding of anti-acetylcholine receptor antibodies inhibits the acetylcholine receptor mediated cation flux

1984 • 19 citations

Thermal perturbation studies of membrane-bound acetylcholine receptor from Torpedo: Effects of cholinergic ligands and membrane perturbants

1987 • 15 citations

Fourier transform infrared spectroscopy as a probe for the study of the structure of membrane proteins

1993 • 10 citations