Recent Developments in the Structure and Function of the Acetylcholine Receptor

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Empirical Predictions of Protein Conformation

1978 • 3,167 citations

Single-channel currents recorded from membrane of denervated frog muscle fibres

1976 • 2,456 citations

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

Sodium and calcium channels in bovine chromaffin cells

1982 • 983 citations

The statistical nature of the acetylcholine potential and its molecular components

1972 • 960 citations

Local anaesthetics transiently block currents through single acetylcholine‐receptor channels.

1978 • 864 citations

Control of acetylcholine receptors in skeletal muscle

1979 • 770 citations

A study of supersensitivity in denervated mammalian skeletal muscle

1959 • 737 citations

Inward current channels activated by intracellular Ca in cultured cardiac cells

1981 • 687 citations

On the stochastic properties of single ion channels

1981 • 667 citations

Ca-dependent K channels with large unitary conductance in chromaffin cell membranes

1981 • 647 citations

Relaxation and fluctuations of membrane currents that flow through drug-operated channels

1977 • 630 citations

Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist

1980 • 608 citations

Acetylcholine Receptor: Complex of Homologous Subunits

1980 • 594 citations

The extracellular patch clamp: A method for resolving currents through individual open channels in biological membranes

1978 • 511 citations

Algorithms for prediction of α-helical and β-structural regions in globular proteins

1974 • 465 citations

Single Na+ channel currents observed in cultured rat muscle cells

1980 • 452 citations

Monoclonal antibodies used to probe acetylcholine receptor structure: localization of the main immunogenic region and detection of similarities between subunits.

1980 • 452 citations

ON THE COOPERATIVITY OF BIOLOGICAL MEMBRANES

1967 • 439 citations

Organization of acetylcholine receptors in quick-frozen, deep-etched, and rotary-replicated Torpedo postsynaptic membrane.

1979 • 429 citations

Mapping of surface structures of electrophorus acetylcholine receptor using monoclonal antibodies.

1981 • 412 citations

Single channel recordings of Ca2+-activated K+ currents in rat muscle cell culture

1981 • 408 citations

Biological Sciences: Isolation of the Cholinergic Receptor Protein of Torpedo Electric Tissue

1971 • 407 citations

Structural and Functional Properties of the Acetylcholine Receptor Protein in its Purified and Membrane-Bound States

1978 • 399 citations

Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica

1978 • 384 citations

Lateral motion of fluorescently labeled acetylcholine receptors in membranes of developing muscle fibers.

1976 • 383 citations

Rotational diffusion studied by passage saturation transfer electron paramagnetic resonance

1976 • 377 citations

Large‐Scale Purification of the Acetylcholine‐Receptor Protein in Its Membrane‐Bound and Detergent‐Extracted Forms from Torpedo marmorata Electric Organ

1977 • 375 citations

The control of gene expression in animal development

1974 • 369 citations

Membrane assembly in vitro : Synthesis, glycosylatio, and asymmetric insertion of a transmembrane protein

1977 • 366 citations

Fluctuations in the microsecond time range of the current through single acetylcholine receptor ion channels

1981 • 366 citations

Drug blockade of open end‐plate channels.

1976 • 352 citations

Acetylcholine and local anesthetic binding to Torpedo nicotinic postsynaptic membranes after removal of nonreceptor peptides.

1979 • 350 citations

CHARACTERIZATION OF A UNIQUE MUSCLE CELL LINE

1974 • 343 citations

Multiple conductance states of single acetylcholine receptor channels in embryonic muscle cells

1981 • 327 citations

The Mode of Neuromuscular Block Caused by Acetylcholine, Nicotine, Decamethonium and Suecinylcholine¹

1955 • 283 citations

Structure and function of an acetylcholine receptor

1982 • 281 citations

EXPERIMENTAL AUTOIMMUNE MYASTHENIA GRAVIS AND MYASTHENIA GRAVIS: BIOCHEMICAL AND IMMUNOCHEMICAL ASPECTS*

1976 • 275 citations

The acetylcholine receptor: an "allosteric" membrane protein.

1979 • 256 citations

Immunology of acetylcholine receptors in relation to myasthenia gravis.

1980 • 255 citations

In Vitro excitation of purified membrane fragments by cholinergic agonists

1971 • 250 citations

Structure and assembly of macromolecular lipid complexes composed of globular micelles

1964 • 250 citations

Change in synaptic channel gating during neuromuscular development

1978 • 249 citations

The Acetylcholine Receptor

1973 • 245 citations

Affinity-labeling of purified acetylcholine receptor from Torpedo californica

1974 • 243 citations

Equilibrium binding of [3H]tubocurarine and [3H]acetylcholine by torpedo postsynaptic membranes: stoichiometry and ligand interactions

1979 • 243 citations

Biochemical properties of acetylcholine receptor subunits from Torpedo californica

1979 • 239 citations

Purification and Properties of the Cholinergic Receptor Protein from Electrophorus electricus Electric Tissue

1974 • 238 citations

Voltage jump analysis of procaine action at frog end‐plate

1977 • 230 citations

Noise analysis of drug induced voltage clamp currents in denervated frog muscle fibres.

1976 • 226 citations

Properties of regenerating neuromuscular synapses in the frog

1960 • 223 citations

Acetylcholine receptor kinetics

1981 • 223 citations

Presence of a lattice structure in membrane fragments rich in nicotinic receptor protein from the electric organ of Torpedo marmorata

1973 • 212 citations

Purification and molecular properties of the acetylcholine receptor from Torpedo electroplax

1973 • 201 citations

Active multi-subunit ACh receptor assembled by translation of heterologous mRNA in Xenopus oocytes

1981 • 197 citations

Inhibition of glycosylation with tunicamycin blocks assembly of newly synthesized acetylcholine receptor subunits in muscle cells.

1982 • 193 citations

Studies of the composition of purified Torpedo californica acetylcholine receptor and of its subunits

1979 • 193 citations

Actin-binding proteins

1982 • 192 citations

Functional consequences of agonist-mediated state transitions in the cholinergic receptor. Studies in cultured muscle cells.

1979 • 191 citations

Sodium Uptake Associated with Activation of Action Potential Ionophores of Cultured Neuroblastoma and Muscle Cells

1973 • 188 citations

Molecular forms of acetylcholine receptor. Effects of calcium ions and a sulfhydryl reagent on the occurrence of oligomers

1977 • 185 citations

Life time and elementary conductance of the channels mediating the excitatory effects of acetylcholine in Aplysia neurones.

1978 • 184 citations

Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica

1977 • 183 citations

Fast Kinetic Studies on the Interaction of a Fluorescent Agonist with the Membrane‐Bound Acetylcholine Receptor from Torpedo marmorata

1979 • 183 citations

Single glutamate-activated channels in locust muscle

1979 • 182 citations

Immobilized lipid in acetylcholine receptor-rich membranes from Torpedo marmorata.

1978 • 182 citations

Purification of acetylcholine receptors, reconstitution into lipid vesicles, and study of agonist-induced cation channel regulation.

1980 • 182 citations

Purification of Torpedo californica post-synaptic membranes and fractionation of their constituent proteins

1980 • 176 citations

Purification of acetylcholine receptors from Torpedo claifornica electroplax by affinity chromatography

1973 • 176 citations

Generation of end-plate potentials

1976 • 176 citations

Studies on the cholinergic receptor protein from Electrophorus electricus Effect of detergents on some hydrodynamic properties of the receptor protein in solution

1972 • 172 citations

Permeability control by cholinergic receptors in Torpedo postsynaptic membranes: agonist dose-response relations measured at second and millisecond times

1980 • 170 citations

Proteins associated with cytoplasmic actin

1981 • 169 citations

Decamethonium both opens and blocks endplate channels.

1978 • 168 citations

5-[¹²⁵I]Iodonaphthyl azide, a reagent to determine the penetration of proteins into the lipid bilayer of biological membranes

1978 • 166 citations

Affinity labeling of one of two α-neurotoxin binding sites in acetylcholine receptor from Torpedo californica

1978 • 163 citations

Newly synthesized acetylcholine receptors are located in the Golgi apparatus.

1978 • 160 citations

On the excitability and cooperativity of the electroplax membrane.

1968 • 159 citations

Relationship between reversible antagonist occupancy and the functional capacity of the acetylcholine receptor.

1981 • 158 citations

Cholinergic receptor protein of Electrophorus electricus. II. Physical properties of the cholinergic receptor protein from Electrophorus electricus revealed by a tritiated α-toxin from Naja nigricollis venom

1972 • 158 citations

Monoclonal antibodies as probes of acetylcholine receptor structure. 2. Binding to native receptor

1981 • 157 citations

Single channel currents from excised patches of muscle membrane.

1980 • 157 citations

Immunospecific identification and three-dimensional structure of a membrane-bound acetylcholine receptor from Torpedo californica

1979 • 153 citations

Characterization of Torpedo californica Acetylcholine Receptor: Its Subunit Composition and Ligand-binding Properties

1976 • 153 citations

Functional acetylcholine receptor from Torpedo marmorata in planar membranes.

1980 • 151 citations

Distinct protein components from Torpedo marmorata membranes carry the acetylcholine receptor site and the binding site for local anesthetics and histrionicotoxin.

1978 • 150 citations

Binding of Naja nigricollis (3H)alpha-toxin to membrane fragments from Electrophorus and Torpedo electric organs. II. Effect of cholinergic agonists and antagonists on the binding of the tritiated alpha-neurotoxin.

1974 • 148 citations

In vitro synthesis, glycosylation, and membrane insertion of the four subunits of Torpedo acetylcholine receptor.

1981 • 147 citations

Cytoplasmic actin in postsynaptic structures at the neuromuscular junction.

1981 • 146 citations

Immunofluorescence localization at the mammalian neuromuscular junction of the Mr 43,000 protein of Torpedo postsynaptic membranes.

1981 • 144 citations

Kinetics of agonist-mediated transitions in state of the cholinergic receptor.

1977 • 143 citations

Alteration by Xylocaine (Lidocaine) and Its Derivatives of the Time Course of the End Plate Potential

1968 • 143 citations

Autoimmune Response to Acetylcholine Receptors in Myasthenia Gravis and Its Animal Model

1979 • 143 citations

Facets of the Structures of Acetylcholine Receptors from Electrophorus and Torpedo

1976 • 142 citations

Reconstitution of purified acetylcholine receptors with functional ion channels in planar lipid bilayers.

1980 • 141 citations

The relationship between agonist occupation and the permeability response of the cholinergic receptor revealed by bound cobra alpha-toxin.

1980 • 140 citations

Kinetics of biosynthesis of acetylcholine receptor and subsequent incorporation into plasma membrane of cultured chick skeletal muscle

1977 • 140 citations

Immunization of rats with polypeptide chains from torpedo acetylcholine receptor causes an autoimmune response to receptors in rat muscle.

1978 • 140 citations

Antibodies from patients with myasthenia gravis recognize determinants unique to extrajunctional acetylcholine receptors.

1979 • 139 citations

The localization of acetylcholine receptor clusters in areas of cell-substrate contact in cultures of rat myotubes

1980 • 136 citations

Single channel activity associated with the calcium dependent outward current inHelix pomatia

1981 • 134 citations

Acetylcholine receptors in normal and denervated rat diaphragm muscle. I. Purification and interaction with [¹²⁵I]-labeled α-bungarotoxin

1975 • 133 citations

The Affinity-Labeling of Partially Purified Acetylcholine Receptor from Electric Tissue of Electrophorus

1973 • 133 citations

Membranes Rich in Acetylcholine Receptor: Characterization and Reconstitution to Excitable Membranes from Exogenous Lipids

1978 • 132 citations

A morphological study of the cholinergic receptor protein from Torpedo marmorata in its membrane environment and in its detergent-extracted purified form

1978 • 130 citations

Formation of disulfide-linked oligomers of acetylcholine receptor in membrane from Torpedo electric tissue

1979 • 124 citations

Functional reassembly of membrane proteins in planar lipid bilayers

1981 • 123 citations

The effect of procaine on neuromuscular transmission

1970 • 122 citations

In vitro phosphorylation of the acetylcholine receptor

1977 • 122 citations

Acetylcholine receptor-controlled ion fluxes in membrane vesicles investigated by fast reaction techniques

1979 • 121 citations

Molecular properties of the cholinergic receptor purified from Electrophorus electricus

1973 • 120 citations

Transmembrane Orientation of Proteins Present in Acetylcholine Receptor‐Rich Membranes from Torpedo marmorata Studied by Selective Proteolysis

1980 • 120 citations

Ultrastructure of isolated membranes ofTorpedo electric tissue

1973 • 120 citations

Ligand-induced conformation changes in Torpedo californica membrane-bound acetylcholine receptor

1978 • 119 citations

Consequences of alkaline treatment for the ultrastructure of the acetylcholine-receptor-rich membranes from Torpedo marmorata electric organ.

1981 • 118 citations

Regulation of muscle acetylcoline receptor synthesis in vitro by cyclic nucleotide derivatives

1979 • 115 citations

Kinetic parameters for acetylcholine interaction in intact neuromuscular junction.

1981 • 115 citations

Cytoskeletal organization at the postsynaptic complex.

1981 • 115 citations

Monoclonal antibodies as probes of acetylcholine receptor structure. 1. Peptide mapping

1981 • 115 citations

Effects of inhibitors of the binding of iodinated alpha-bungarotoxin to acetylcholine receptors in rat muscle.

1976 • 115 citations

Comparison of the subunits of Torpedo californica acetylcholine receptor by peptide mapping

1979 • 114 citations

Rotational mobility of the membrane‐bound acetylcholine receptor of torpedo electric organ measured by phosphorescence depolarisation

1980 • 113 citations

Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ

1976 • 113 citations

Peptide extraction by alkaline treatment is accompanied by rearrangement of the membrane‐bound acetylcholine receptor from torpedo marmorata

1980 • 111 citations

Structure-function relation in the binding of snake neurotoxins to the Torpedo membrane receptor

1975 • 111 citations

Immunochemical similarities between subunits of acetylcholine receptors from Torpedo, Electrophorus, and mammalian muscle

1979 • 110 citations

Interaction of the Acetylcholine (Nicotinic) Receptor Protein from Torpedo marmorata Electric Organ with Monolayers of Pure Lipids

1978 • 109 citations

A study of desensitization using voltage clamp

1975 • 108 citations

Interaction of the cytoskeletal framework with acetylcholine receptor on th surface of embryonic muscle cells in culture.

1982 • 106 citations

Agonist-activated ionic channels in acetylcholine receptor reconstituted into planar lipid bilayers.

1981 • 106 citations

Perhydrohistrionicotoxin: a potential ligand for the ion conductance modulator of the acetylcholine receptor.

1977 • 105 citations

Effects of permeant monovalent cations on end‐plate channels.

1979 • 105 citations

Receptor stability and channel conversion in the subsynaptic membrane of the developing mammalian neuromuscular junction

1980 • 105 citations

Agonist-mediated changes of the acetylcholine receptor in its membrane environment

1978 • 104 citations

Dynamic properties of isolated acetylcholine receptor proteins: release of calcium ions caused by acetylcholine binding.

1976 • 103 citations

Specificity of α-Bungarotoxin binding to Torpedo californica electroplax

1972 • 102 citations

Molecular cloning of cDNA coding for the gamma subunit of Torpedo acetylcholine receptor.

1982 • 102 citations

Direct spectroscopic studies of cation translocation by Torpedo acetylcholine receptor on a time scale of physiological relevance.

1980 • 101 citations

Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ

1976 • 101 citations

Interaction of permeant ions with channels activated by acetylcholine in Aplysia neurones.

1979 • 101 citations

Interaction of [125I]-.alpha.-bungarotoxin with acetylcholine receptor from Torpedo californica

1979 • 100 citations

Junctional and extrajunctional acetylcholine receptors in normal and denervated frog muscle fibres

1976 • 100 citations

Some Structural Properties of the Cholinergic Receptor Protein in Its Membrane Environment Relevant to Its Function as a Pharmacological Receptor

1976 • 99 citations

Monoclonal antibodies against purified nicotinic acetylcholine receptor

1979 • 97 citations

Direct structural localization of two toxin-recognition sites on an ACh receptor protein

1982 • 95 citations

Demonstration of a specific α-bungarotoxin binding component in Electrophorus electricus electroplax membranes

1971 • 94 citations

Molecular weight and quaternary structure of the cholinergic receptor protein extracted by detergents from Electrophorus electricus electric tissue

1973 • 92 citations

Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ

1976 • 92 citations

Disulfide bond cross-linked dimer in acetylcholine receptor from Torpedo californica

1977 • 92 citations

STRUCTURE AND FUNCTION OF THE ACETYLCHOLINE RECEPTOR MOLECULE STUDIED USING MONOCLONAL ANTIBODIES

1981 • 90 citations

Proteolytic nicking of the acetylcholine receptor

1980 • 90 citations

Interaction of myasthenic serum globulin with the acetylcholine receptor

1975 • 90 citations

Subunit structure and peptide mapping of junctional and extrajunctional acetylcholine receptors from rat muscle

1979 • 90 citations

Immunological comparison of acetylcholine receptors and their subunits from species of electric ray

1977 • 89 citations

Stabilization of acetylcholine receptor channels by lipids in cholate solution and during reconstitution in vesicles.

1981 • 89 citations

Ligand specificity of state transitions in the cholinergic receptor: behavior of agonists and antagonists.

1979 • 89 citations

Crystalline arrays of membrane-bound acetylcholine receptor.

1981 • 89 citations

Studies of reversible and irreversible interactions of an alkylating agonist with Torpedo californica acetylcholine receptor in membrane-bound and purified states

1979 • 88 citations

Affinity labeling of the acetylcholine-receptor.

1967 • 87 citations

Rapid kinetics of single glutamate-receptor channels

1982 • 87 citations

Use of affinity chromatography for acetylcholine receptor purification

1972 • 87 citations

Reconstitution of a Chemically Excitable Membrane

1974 • 87 citations

Interconversion between Different States of Affinity for Acetylcholine of the Cholinergic Receptor Protein from Torpedo marmorata

1975 • 87 citations

Studies of the binding of α‐bungarotoxin to membrane‐bound and detergent‐dispersed acetylcholine receptors from Torpedo electric tissue

1972 • 86 citations

Subunit structure of the acetylcholine receptor from denervated rat skeletal muscle

1977 • 86 citations

Rapid lateral diffusion of functional ACh receptors in embryonic muscle cell membrane

1982 • 86 citations

Size of acetylcholine receptors in the membrane. An improved version of the radiation inactivation method

1982 • 86 citations

The rotational diffusion of the acetylcholine receptor in Torpeda marmorata membrane fragments studied with a spin-labelled alpha-toxin: importance of the 43 000 protein(s).

1982 • 85 citations

Phosphorylation in vitro of Membrane Fragments from Torpedo marmorata Electric Organ. Effect on Membrane Solubilization by Detergents

1980 • 85 citations

Kinetics of the Opening and Closing of Individual Excitability-Inducing Material Channels in a Lipid Bilayer

1974 • 85 citations

Phosphorylation of membrane proteins at a cholinergic synapse.

1977 • 83 citations

Synthesis of acetylcholine receptor by denervated rat diaphragm muscle.

1975 • 82 citations

The nicotinic cholinergic receptor protein: improved purification method, preliminary amino acid composition and observed auto‐immuno response

1974 • 82 citations

Single K+ channel currents of anomalous rectification in cultured rat myotubes.

1981 • 82 citations

Sodium transport by the acetylcholine receptor of cultured muscle cells.

1975 • 81 citations

Affinity partitioning of membranes. Cholinergic receptor-containing membranes from Torpedo californica.

1976 • 80 citations

Molecular mechanism of acetylcholine receptor-controlled ion translocation across cell membranes

1980 • 80 citations

Crosslinking of α‐bungarotoxin to the acetylcholine receptor from Torpedo marmorata by ultraviolet light irradiation

1982 • 79 citations

Appearance and disappearance of acetycholine receptor during differentiation of chick skeletal muscle in vitro

1976 • 78 citations

Single channel Ca2+ currents inHelix pomatia neurons

1981 • 77 citations

Nicotinic postsynaptic membranes from Torpedo: sidedness, permeability to macromolecules, and topography of major polypeptides.

1982 • 77 citations

Acetylcholine receptor subunits transit a precursor pool before acquiring alpha-bungarotoxin binding activity.

1981 • 76 citations

Reconstitution of a Functional Acetylcholine Receptor

1980 • 75 citations

Degradation of junctional and extrajunctional acetylcholine receptors by developing rat skeletal muscle.

1979 • 75 citations

Negative co-operativity in clustered receptors as a possible basis for membrane action

1974 • 74 citations

Influence of membrane lipids on acetylcholine receptor and lipid probe diffusion in cultured myotube membrane

1978 • 74 citations

In vitro excitation of purified membrane fragments by cholinergic agonists

1971 • 74 citations

Protease effects on the structure of acetylcholine receptor membranes from Torpedo californica.

1980 • 74 citations

Kinetics of agonist-induced intrinsic fluorescence changes in membrane-bound acetylcholine receptor

1976 • 73 citations

Acetylcholine receptors from Torpedo and Electrophorus have similar subunit structures

1980 • 73 citations

Structural stabilization of isolated acetylcholine receptor: specific interaction with phospholipids

1979 • 72 citations

Block of endplate channels by permeant cations in frog skeletal muscle.

1981 • 72 citations

The Non-Equilibrium Theory of Absolute Rates of Reaction¹

1947 • 72 citations

Single ionic channels observed in tissue-cultured muscle

1979 • 71 citations

An analysis by low-angle neutron scattering of the structure of the acetylcholine receptor from Torpedo californica in detergent solution

1979 • 71 citations

Mammalian muscle acetylcholine receptor purification and characterization

1982 • 68 citations

Binding of acetylcholine and related compounds to purified acetylcholine receptor from Torpedocalifornica electroplax

1973 • 68 citations

Affinity partitioning of membranes. Evidence for discrete membrane domains containing cholinergic receptor.

1981 • 68 citations

Purification and Characterization of Acetylcholine Receptor-I from Electrophorus electricus

1974 • 67 citations

Identification of exposed and buried determinants of the membrane-bound acetylcholine receptor from Torpedo californica

1981 • 67 citations

Topographic studies of Torpedo acetylcholine receptor subunits as a transmembrane complex.

1980 • 67 citations

Skeletal muscle acetylcholine receptor. Purification, characterization, and turnover in muscle cell cultures.

1978 • 67 citations

Photoaffinity labeling and quaternary structure of the acetylcholine receptor from Torpedo californica.

1976 • 66 citations

Kinetics of binding of [3H]acetylcholine to Torpedo postsynaptic membranes: association and dissociation rate constants by rapid mixing and ultrafiltration

1980 • 66 citations

Purification of an acetylcholine receptor from a nonfusing muscle cell line

1977 • 65 citations

Structural details of membrane-bound acetylcholine receptor from Tropedo marmorata.

1980 • 65 citations

Effects of thio-group modifications on the ion permeability control and ligand binding properties of Torpedo californica acetylcholine receptor

1981 • 64 citations

Synaptic membrane structure inTorpedo electric organ

1975 • 63 citations

Control of acetylcholine receptor mobility and distribution in cultured muscle membranes. A fluorescence study

1978 • 63 citations

Factors regulating the susceptibility of the acetylcholine receptor protein to heat inactivation

1979 • 62 citations

Cytoplasmic surface structure in postsynaptic membranes from electric tissue visualized by tannic-acid-mediated negative contrasting.

1982 • 62 citations

Structural heterogeneity and subcellular distribution of nicotinic synapse-associated proteins.

1981 • 62 citations

Electron microscopy of complexes of isolated acetylcholine receptor, biotinyl-toxin, and avidin.

1982 • 61 citations

Pyrenesulfonyl azide: a marker of acetylcholine receptor subunits in contact with membrane hydrophobic environment

1979 • 61 citations

Mechanism of inactivation (desensitization) of acetylcholine receptor. Investigations by fast reaction techniques with membrane vesicles

1981 • 60 citations

The molecular weight of an acetylcholine receptor isolated from Torpedo californica

1975 • 60 citations

Biology of Myasthenia Gravis

1980 • 60 citations

Postsynaptic membranes in the electric tissue of Narcine: IV. Isolation and characterization of the nicotinic receptor protein

1977 • 60 citations

Lateral segregation of proteins induced by cholesterol in bacteriorhodopsin-phospholipid vesicles

1980 • 58 citations

Ligand-induced changes in membrane-bound acetylcholine receptor observed by ethidium fluorescence. 2. Stopped-flow studies with agonists and antagonists

1979 • 58 citations

The amino‐terminal sequence of the 40 000 molecular weight subunit of the acetylcholine receptor protein from Torpedo marmorata

1979 • 58 citations

Quinacrine (mepacrine) action at frog end‐plate.

1980 • 57 citations

Single channel potassium currents of the anomalous rectifier

1981 • 57 citations

Endogenous Chemical Receptors: Some Physical Aspects

1979 • 57 citations

Ontogenesis and functional mechanisms of peripheral synapses

1982 • 57 citations

Change in state of phosphorylation of acetylcholine receptor during maturation of the electromotor synapse in Torpedo marmorata electric organ.

1981 • 56 citations

Isolation of cholinergic receptor protein(s) from Torpedo nobiliana by affinity chromatography

1974 • 56 citations

Molecular weight of the acetylcholine receptors of electric organs and the effect of Triton X-100.

1975 • 55 citations

Absence of filipin-sterol complexes from the membranes of active zones and acetylcholine receptor aggregates at frog neuromuscular junctions.

1981 • 54 citations

Purification and characterization of an acetylcholine receptor from mammalian skeletal muscle

1977 • 54 citations

Dissection of the 66 000-dalton subunit of the acetylcholine receptor

1981 • 53 citations

Comparison of acetylcholine receptor-controlled cation flux in membrane vesicles from Torpedo californica and Electrophorus electricus : Chemical kinetic measurements in the millisecond region

1982 • 53 citations

Affinity alkylation labels two subunits of the reduced acetylcholine receptor from mammalian muscle.

1977 • 52 citations

Dynamic properties of isolated acetylcholine receptor protein: kinetics of the binding of acetylcholine and Ca ions.

1976 • 52 citations

Voltage- and time-dependent action of histrionicotoxin on the endplate current of the frog muscle.

1978 • 51 citations

Quantitation of cation transport by reconstituted membrane vesicles containing purified acetylcholine receptor.

1981 • 50 citations

Acetylcholine receptor inactivation in torpedo californica electroplax membrane vesicles. Detection of two processes in the millisecond and second time regions

1981 • 50 citations

Localization of acetylcholine receptor in excitable membrane from the electric organ of Torpedo: Evidence for exposure of receptor antigenic sites on both sides of the membrane.

1978 • 49 citations

Mode of action of quinacrine on the acetylcholine receptor ionic channel complex.

1979 • 49 citations

Tryptophan and cysteine residues of the acetylcholine receptors of Torpedo species. Relation to binding of cholinergic ligands

1975 • 49 citations

SUBSTRUCTURE OF AMPHIBIAN MOTOR END PLATE

1974 • 49 citations

Demonstration of the transmembrane nature of the acetylcholine receptor by labeling with anti-receptor antibodies.

1979 • 49 citations

Functional acetylcholine receptor--electroplax membrane microsacs (vesicles): purification and characterization.

1977 • 49 citations

Comparison between the affinities for reversible cholinergic ligands of a purified and membrane bound state of the acetylcholine‐receptor protein from Electrophorus electricus

1973 • 49 citations

Binding of antibodies to acetylcholine receptors in Electrophorus and Torpedo electroplax membranes.

1978 • 48 citations

ANTIBODIES TO ACETYLCHOLINE RECEPTORS IN RABBITS: IMMUNOCHEMICAL AND ELECTROPHYSIOLOGICAL STUDIES*

1976 • 47 citations

The Isolation and Characterisation of the Nicotinic Acetylcholine Receptor from Human Skeletal Muscle

2005 • 47 citations

MOLECULAR AND FUNCTIONAL PROPERTIES OF THE ACETYLCHOLINE‐RECEPTOR

1975 • 46 citations

Cell-Free Synthesis of Acetylcholine Receptor Polypeptides

1980 • 45 citations

End‐plate channel opening and the kinetics of quinacrine (mepacrine) block.

1980 • 45 citations

Phospholipase A inhibition of acetylcholine receptor function in Torpedo californica membrane vesicles

1977 • 45 citations

Identification of the acetylcholine receptor subunit in the lipid bilayer of Torpedo electric organ excitable membranes.

1980 • 45 citations

Independent activation of the acetylcholine receptor from Torpedo californica at two sites

1980 • 45 citations

Oligomeric forms of the membrane-bound acetylcholine receptor disclosed upon extraction of the M(r) 43,000 nonreceptor peptide

1982 • 45 citations

Acetylcholine receptor oligomers from electroplax of Torpedo species

1976 • 45 citations

Relative locations of the beta and delta chains of the acetylcholine receptor determined by electron microscopy of isolated receptor trimer.

1981 • 44 citations

The biochemistry of an acetylcholine receptor

1974 • 44 citations

Rotational Molecular Dynamics of the Membrane-Bound Acetylcholine Receptor Revealed by Phosphorescene Spectroscopy

1981 • 44 citations

Acetylcholine receptor synthesis from membrane polysomes.

1981 • 44 citations

Saturation transfer electron paramagnetic resonance on membrane bound proteins. II-absence of rotational diffusion of the cholinergic receptor protein in torpedo marmorata membrane fragments

1977 • 43 citations

Acetylcholine-receptor-mediated ion flux in electroplax membrane preparations.

1975 • 43 citations

Permeant cations alter endplate channel characteristics

1977 • 43 citations

Binding Sites for Cholinergic Ligands in a Particulate Fraction of Electrophorus Electroplax

1971 • 42 citations

Composition of acetylcholine receptor protein from skeletal muscle

1978 • 42 citations

Functional stability of Torpedo acetylcholine receptor. Effects of protease treatment

1982 • 42 citations

Noise and relaxation studies of acetylcholine induced currents in the presence of procaine.

1978 • 42 citations

The characterization of actin associated with postsynaptic membranes from Torpedocalifornica

1980 • 41 citations

Dimeric arrangement and structure of the membrane-bound acetylcholine receptor studied by electron microscopy.

1982 • 41 citations

Intrinsic fluorescence of the membrane-bound acetylcholine receptor: Its quenching by suberyldicholine

1976 • 41 citations

Nuclear magnetic resonance studies of hemoglobins. VIII. Evidence for preferential ligand binding to β chains within deoxyhemoglobins

1971 • 40 citations

Correlation of polypeptide composition with functional events in acetylcholine receptor-enriched membranes from Torpedo californica.

1979 • 40 citations

Molecular Forms and Hydrodynamic Properties of Acetylcholine Receptor from Electric Tissue

1981 • 40 citations

Fast cation flux from membrane preparations: Implications for a functional role for acetylcholine receptor dimers

1978 • 40 citations

Active acetylcholine receptor fragment obtained by tryptic digestion of acetylcholine receptor from Torpedo californica

1979 • 38 citations

Modulation of acetylcholine receptor states by thiol modification

1980 • 37 citations

Isolation and Purification of the Nicotinic Acetylcholine Receptor and Its Functional Reconstitution into a Membrane Environment

1977 • 37 citations

Cooperativities in the binding of acetylcholine to its receptor

1973 • 36 citations

Specific reaction rate of acetylcholine receptor-controlled ion translocation: a comparison of measurements with membrane vesicles and with muscle cells.

1981 • 36 citations

Kinetic analysis of receptor-controlled tracer efflux from sealed membrane fragments

1978 • 35 citations

Photoaffinity derivatives of α‐Bungarotoxin and α‐Naja naja siamensis toxin

1979 • 35 citations

Characterization of the calcium-binding sites of the purified acetylcholine receptor and identification of the calcium-binding subunit

1978 • 35 citations

Multiple affinities for binding of cholinergic ligands to a particulate fraction of Torpedo electroplax.

1971 • 34 citations

Acetylcholine receptor-controlled ion flux in electroplax membrane vesicles: A minimal mechanism based on rate measurements in the millisecond to minute time region

1980 • 34 citations

Ryanodine alters the rate of acetylcholine receptor synthesis in chick skeletal muscle cell cultures.

1981 • 33 citations

The nicotinic acetylcholine receptor; a glycoprotein

1975 • 33 citations

Acetylcholine-receptor-mediated ion flux in electroplax membrane microsacs (vesicles): Change in mechanism produced by asymmetrical distribution of sodium and potassium ions

1978 • 33 citations

Evidence for separate initiation and inhibitory sites in the regulation of membrane potential of electroplax I. Kinetic studies with α-bungarotoxin

1973 • 32 citations

Immunology of the Nicotinic Acetylcholine Receptor

1979 • 32 citations

Ligand interactions with the acetylcholine receptor from Torpedo californica. Extensions of the allosteric model for cooperativity to half-of-site activity

1976 • 31 citations

Identification of the polypeptide chains in Torpedo californica electroplax membranes that interact with a local anesthetic analog.

1979 • 31 citations

Structure of acetylcholine receptor dimer determined by neutron scattering and electron microscopy.

1981 • 31 citations

Characterization of a nicotinic acetylcholine receptor from rabbit skeletal muscle and reconstitution in planar phospholipid bilayers

1976 • 30 citations

Membrane-bound protein kinase activity in acetylcholine receptor-enriched membranes

1980 • 29 citations

The effect of calcium on acetylcholine receptor synthesis

1981 • 29 citations

Presence of two forms of acetylcholine receptor with different isoelectric points in the electric organ of Electrophorus electricus and their catalytic interconversion in vitro

1976 • 29 citations

Effects of temperature, lipid modification and pH on the mobility of the major proteins of the receptor-rich membranes from Torpedo marmorata

1981 • 29 citations

Light and heavy forms of the acetylcholine receptor from Torpedo marmorata electric organ

1980 • 29 citations

Affinity directed crosslinking of acetylcholine receptor polypeptide components in post-synaptic membranes

1978 • 28 citations

Postsynaptic distribution of acetylcholine receptors in electroplax of the torpedine ray,Narcine brasiliensis

1980 • 28 citations

Amino terminal amino acid sequence of the major polypeptide subunit of Torpedocalifornica acetylcholine receptor

1979 • 28 citations

Conversion of high affinity acetylcholine receptor from Torpedo californica electroplax to an altered form

1975 • 26 citations

Interaction of a fluorescent probe with acetylcholine-activated synaptic membrane

1977 • 25 citations

Complete purification of the acetylcholine receptor protein from mammalian muscle

1975 • 25 citations

Characterization of acetylcholine receptor isolated from Torpedo californica electroplax through the use of an easily removable detergent, β-d-octylglucopyranoside

1981 • 24 citations

Identification of regions of high acetylcholine receptor density in tannic acid-fixed postsynaptic membranes from electric tissue

1980 • 23 citations

An acetylcholine receptor preparation lacking the 42,000 dalton component

1975 • 23 citations

Lactoperoxidase catalyzed membrane surface labeling of the acetylcholine receptor from Torpedo californica

1977 • 23 citations

Half-of-the-site reactivity of the membrane-bound Electrophorus electricus acetylcholine receptor

1974 • 23 citations

Rapid cation flux from Torpedo californica membrane vesicles: Comparison of acetylcholine receptor enriched and selectively extracted preparations

1979 • 22 citations

Reconstitution of acetylcholine receptors in model membranes

1981 • 21 citations

Fractionation by velocity sedimentation of Torpedo nicotinic post-synaptic membranes

1981 • 21 citations

Translational diffusion coefficient and molecular weight of the acetylcholine receptor from torpedo marmorata

1980 • 19 citations

Investigation of the Naja naja siamensis toxin binding site of the cholinergic receptor protein from Torpedo electric tissue

1974 • 18 citations

Lifetime and conductance of acetylcholine‐activated channels in normal and denervated toad sartorius muscle.

1980 • 17 citations

Transmembrane nature of acetylcholine receptor as evidenced by protease sensitivity

1979 • 17 citations

Acetylcholine-induced receptor-controlled ion flux investigated by flow quench techniques

1980 • 17 citations

Vidicon flame emission spectroscopy of Li+, Na+, and K+ fluxes mediated by acetylcholine receptor in Electrophorus electricus membrane vesicles

1981 • 16 citations

Binding of ?-bungarotoxin and cholinergic ligands to acetylcholine receptors in the membrane of skeletal muscle

1977 • 16 citations

Interrelationship of Concanavalin-A-Binding and Antigenic Sites on the Acetylcholine Receptor from Torpedo marmorata

1980 • 13 citations

Acetylcholine receptor-controlled ion flux in electroplax membrane vesicles: Identification and characterization of membrane properties that affect ion flux measurements

1981 • 13 citations

Polypeptide composition of acetylcholine receptor purified from teleost and Elasmobranch electroplax membranes

1979 • 12 citations

Structural models of the nicotinic acetylcholine receptor and its toxin-binding sites

1981 • 10 citations

Isolation and Characterization of a Lipid-Embedded Domain of the Acetylcholine Receptor from Torpedo calforrzica

1982 • 10 citations

Effects of periodate oxidation and glycosidases on structural and functional properties of the acetylcholine receptor and the non-receptor, peripheral ν-polypeptide (Mr 43,000)

1982 • 9 citations

Preparation of sealed Torpedo marmorata membrane fragments suitable for quantitative tracer flux studies

1981 • 8 citations

Physical factors determining gated flux from or into sealed membrane fragments

1980 • 7 citations

Analysis of gated flux from or into sealed membrane fragments

1980 • 7 citations

ACTION OF COLCHICINE AND CYTOCHALASIN B ON THE ACETYLCHOLINE RECEPTOR

1979 • 7 citations

Structural changes in alkaline-treated postsynaptic membranes from Torpedo marmorata are not due to lipid hydrolysis

1982 • 6 citations

On the kinetics of cholinergic excitation

1980 • 5 citations

The Use of Photochemical Probes for Studies of Structure and Function of Purified Acetylcholine Receptor Preparations *

1980 • 5 citations

Purification and Properties of the Acetylcholine Receptor Protein from Narke japonica1

1980 • 5 citations

A potpourri of plucked patches

1981 • 3 citations

Deleted Work

1955 • 0 citations