Photoaffinity labeling of Torpedo acetylcholine receptor by physostigmine

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii

2007 • 11,720 citations

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.

1987 • 5,066 citations

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1991 • 2,613 citations

The Pharmacological Basis for Therapeutics

1981 • 1,896 citations

Handbook of experimental pharmacology

1984 • 1,599 citations

A simple technique for eliminating interference by detergents in the Lowry method of protein determination

1975 • 962 citations

Primary structure of α-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence

1982 • 730 citations

Identification of the alpha subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site.

1984 • 408 citations

Amino acids of the Torpedo marmorata acetylcholine receptor .alpha. subunit labeled by a photoaffinity ligand for the acetylcholine binding site

1988 • 314 citations

The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits

1986 • 313 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine.

1986 • 296 citations

Oral physostigmine and lecithin improve memory in Alzheimer disease

1983 • 282 citations

Nicotinic acetylcholine receptor and superfamily of ligand-gated ion channels

1990 • 260 citations

Identification of a novel amino acid alpha-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labeling. Additional evidence for a three-loop model of the cholinergic ligands-binding sites.

1990 • 247 citations

Acetylcholinesterase

1975 • 243 citations

Mapping of the acetylcholine binding site of the nicotinic acetylcholine receptor: [3H]nicotine as an agonist photoaffinity label

1991 • 184 citations

An Analog of Lophotoxin Reacts Covalently with Tyr190 in the α-Subunit of the Nicotinic Acetylcholine Receptor

1989 • 169 citations

Plants in the Development of Modern Medicine

1972 • 136 citations

Conformations of Torpedo acetylcholine receptor associated with ion transport and desensitization

1982 • 135 citations

The TiPS lecture the nicotinic acetylcholine receptor: an allosteric protein prototype of ligand-gated ion channels

1990 • 133 citations

The reversible cholinesterase inhibitor physostigmine has channel-blocking and agonist effects on the acetylcholine receptor-ion channel complex.

1985 • 130 citations

Identification and functional characterization of a new agonist site on nicotinic acetylcholine receptors of cultured hippocampal neurons.

1993 • 122 citations

The Neuromuscular Junction

1988 • 116 citations

Allosteric transitions of the acetylcholine receptor probed at the amino acid level with a photolabile cholinergic ligand.

1991 • 101 citations

Direct spectroscopic studies of cation translocation by Torpedo acetylcholine receptor on a time scale of physiological relevance.

1980 • 101 citations

ACTIONS OF ANTI-CHOLINESTERASES ON ENDPLATE POTENTIAL OF FROG MUSCLE

1949 • 101 citations

Mapping of a cholinergic binding site by means of synthetic peptides, monoclonal antibodies, and .alpha.-bungarotoxin

1990 • 87 citations

The nature of the interactions of pyridostigmine with the nicotinic acetylcholine receptor-ionic channel complex. I. Agonist, desensitizing, and binding properties.

1984 • 78 citations

Oral physostigmine and lecithin improve memory in Alzheimer's disease.

1983 • 76 citations

A second pathway of activation of the Torpedo acetylcholine receptor channel

1991 • 70 citations

Fine localization of the major alpha-bungarotoxin binding site to residues alpha 189-195 of the Torpedo acetylcholine receptor. Residues 189, 190, and 195 are indispensable for binding.

1990 • 63 citations

Specific photoaffinity labeling induced by energy transfer: application to irreversible inhibition of acetylcholinesterase.

1980 • 61 citations

.alpha.-Bungarotoxin and the competing antibody WF6 interact with different amino acids within the same cholinergic subsite

1991 • 57 citations

Comparison of the toxin binding sites of the nicotinic acetylcholine receptor from Drosophila to human

1990 • 52 citations

Concentration-dependent effects of neostigmine on the endplate acetylcholine receptor channel complex

1985 • 39 citations

Effects of eserine and neostigmine on the interaction of alpha-bungarotoxin with Aplysia acetylcholine receptors.

1976 • 38 citations

Nicotinic acetylcholine receptor: A structural model for α‐subunit peptide 188–201, the putative binding site for cholinergic agents

1988 • 36 citations

Quinuclidinyl Benzilate Binding in House Fly Heads and Rat Brain

1981 • 33 citations

Desensitization is a property of the cholinergic binding region of the nicotinic acetylcholine receptor, not of the receptor‐integral ion channel

1991 • 31 citations

EFFECTS OF MORPHINE, PHYSOSTIGMINE AND RAPHE NUCLEI STIMULATION ON 5‐HYDROXYTRYPTAMINE RELEASE FROM THE CEREBRAL CORTEX OF THE CAT

1979 • 26 citations

The Molecular Basis of Anticholinesterase Actions on Nicotinic and Glutamatergic Synapses^a

1987 • 25 citations

Clinical Anesthesia in Neurosurgery

1991 • 25 citations

Selective changes in sensitivity to cholinergic agonists and receptor changes elicited by continuous physostigmine infusion.

1990 • 25 citations

Clinical Anesthesia in Neurosurgery

1985 • 22 citations

Physostigmine and Neuromuscular Transmissiona

1993 • 20 citations

Molecular Interactions of Organophosphates (OPs), Oximes and Carbamates at Nicotinic Receptors

1989 • 13 citations

Functional and structural analysis of acetylcholine receptor‐rich membranes after negative staining

1984 • 12 citations

Agonist and inhibitory effects of pyridostigmine at the neuromuscular junction

1986 • 9 citations

New Approaches to Covalent Sequence Analysis

1990 • 9 citations