A novel bipartite splicing enhancer modulates the differential processing of the human fibronectin EDA exon

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression

1987 • 2,333 citations

Splicing of Messenger RNA Precursors

1987 • 919 citations

Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing

1991 • 708 citations

ALTERNATIVE SPLICING IN THE CONTROL OF GENE EXPRESSION

1989 • 701 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene.

1985 • 659 citations

The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing

1987 • 594 citations

A role for exon sequences and splice-site proximity in splice-site selection

1986 • 494 citations

Distinct Functions of SR Proteins in Alternative pre-mRNA Splicing

1993 • 407 citations

α-Thalassaemia caused by a polyadenylation signal mutation

1983 • 407 citations

The role of exon sequences in splice site selection.

1993 • 367 citations

Transformed human cells produce a new fibronectin isoform by preferential alternative splicing of a previously unobserved exon.

1987 • 334 citations

A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA

1993 • 332 citations

Multiplex DNA deletion detection and exon sequencing of the hypoxanthine phosphoribosyltransferase gene in Lesch-Nyhan families

1990 • 328 citations

The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA

1993 • 309 citations

Multiple sites of alternative splicing of the rat fibronectin gene transcript.

1987 • 299 citations

DNA sequences necessary for transcription of the rabbit β-globin gene in vivo

1982 • 298 citations

Specific commitment of different pre-mRNAs to splicing by single SR proteins

1993 • 272 citations

U1 snRNP targets an essential splicing factor, U2AF65, to the 3' splice site by a network of interactions spanning the exon.

1992 • 225 citations

Human fibronectin: cell specific alternative mRNA splicing generates polypeptide chains dfffering in the number of internal repeats

1984 • 221 citations

The role of the mammalian branchpoint sequence in pre-mRNA splicing.

1988 • 215 citations

Effect of 5' splice site mutations on splicing of the preceding intron.

1990 • 200 citations

Control of Alternative Splicing by the Differential Binding of U1 Small Nuclear Ribonucleoprotein Particle

1991 • 191 citations

A functional association between the 5' and 3' splice site is established in the earliest prespliceosome complex (E) in mammals.

1993 • 173 citations

Regulation of tissue-specific alternative splicing: exon-specific cis-elements govern the splicing of leukocyte common antigen pre-mRNA.

1989 • 151 citations

Regulated Splicing of the Drosophila P Transposable Element Third Intron in Vitro: Somatic Repression

1990 • 149 citations

A role for exon sequences in alternative splicing of the human fibronection gene

1987 • 145 citations

Mechanism for cryptic splice site activation during pre-mRNA splicing.

1990 • 108 citations

Expression of a human alpha-globin/fibronectin gene hybrid generates two mRNAs by alternative splicing.

1984 • 101 citations

Nucleotide substitutions within the cardiac troponin T alternative exon disrupt pre-mRNA alternative splicing

1989 • 101 citations

Identification of two distinct intron elements involved in alternative splicing of beta-tropomyosin pre-mRNA.

1990 • 100 citations

Alternative splicing of beta-tropomyosin pre-mRNA: cis-acting elements and cellular factors that block the use of a skeletal muscle exon in nonmuscle cells.

1991 • 98 citations

Alternative processing of bovine growth hormone mRNA is influenced by downstream exon sequences.

1989 • 97 citations

In vitro splicing of mutually exclusive exons from the chicken beta-tropomyosin gene: role of the branch point location and very long pyrimidine stretch.

1990 • 97 citations

Exon as well as Intron Sequences Are cis-Regulating Elements for the Mutually Exclusive Alternative Splicing of the β Tropomyosin Gene

1990 • 87 citations

Effect of 5′ Splice Site Mutations on Splicing of the Preceding Intron

1990 • 83 citations

Alternative Processing of Bovine Growth Hormone mRNA Is Influenced by Downstream Exon Sequences

1989 • 50 citations

Cell type specific trans-acting factors are involved in alternative splicing of human fibronectin pre-mRNA.

1989 • 49 citations

Sequence analysis andin vivoexpression show that alternative splicing of ED-B and ED-A regions of the human fibronectin gene are independent events

1988 • 25 citations