PDGF Receptors as Targets in Tumor Treatment

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor

1999 • 2,386 citations

PDGFRA Activating Mutations in Gastrointestinal Stromal Tumors

2003 • 2,224 citations

High interstitial fluid pressure — an obstacle in cancer therapy

2004 • 1,979 citations

A Tyrosine Kinase Created by Fusion of thePDGFRAandFIP1L1Genes as a Therapeutic Target of Imatinib in Idiopathic Hypereosinophilic Syndrome

2003 • 1,683 citations

Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

2002 • 1,349 citations

Gastrointestinal stromal tumors: The incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era

2005 • 1,251 citations

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

2003 • 1,236 citations

Lymphangiogenesis in development and human disease

2005 • 1,225 citations

Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

1994 • 1,211 citations

Biology of Gastrointestinal Stromal Tumors

2004 • 1,190 citations

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

2003 • 1,172 citations

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

1994 • 1,123 citations

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

1994 • 984 citations

PDGF-A Signaling Is a Critical Event in Lung Alveolar Myofibroblast Development and Alveogenesis

1996 • 867 citations

PDGFRA Mutations in Gastrointestinal Stromal Tumors: Frequency, Spectrum and In Vitro Sensitivity to Imatinib

2005 • 809 citations

Signal transduction via platelet-derived growth factor receptors

1998 • 735 citations

PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo

2001 • 708 citations

The PDGFα receptor is required for neural crest cell development and for normal patterning of the somites

1997 • 706 citations

Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops.

1992 • 689 citations

Response to Imatinib Mesylate in Patients with Chronic Myeloproliferative Diseases with Rearrangements of the Platelet-Derived Growth Factor Receptor Beta

2002 • 642 citations

Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall

2003 • 621 citations

Combined inhibition of VEGF‐ and PDGF‐signaling enforces tumor vessel regression by interfering with pericyte‐mediated endothelial cell survival mechanisms

2003 • 598 citations

PDGFRβ+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival

2005 • 538 citations

Deregulation of the platelet-derived growth factor β-chain gene via fusion with collagen gene COL1A1 in dermatof ibrosarcoma protuberans and giant-cell fibroblastoma

1997 • 518 citations

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis

2004 • 516 citations

Delivery of molecular and cellular medicine to solid tumors1PII of original article: S0169-409X(97)00027-6. The article was originally published in Advanced Drug Delivery Reviews 26 (1997) 71–90.1

2001 • 509 citations

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

2003 • 481 citations

A Multitargeted, Metronomic, and Maximum-Tolerated Dose “Chemo-Switch” Regimen is Antiangiogenic, Producing Objective Responses and Survival Benefit in a Mouse Model of Cancer

2004 • 479 citations

PDGF receptors as cancer drug targets

2003 • 462 citations

Molecular and Clinical Analysis of Locally Advanced Dermatofibrosarcoma Protuberans Treated With Imatinib: Imatinib Target Exploration Consortium Study B2225

2005 • 460 citations

Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors.

2001 • 444 citations

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

2003 • 436 citations

Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy.

2002 • 431 citations

Phase I/II Study of Imatinib Mesylate for Recurrent Malignant Gliomas: North American Brain Tumor Consortium Study 99-08

2006 • 423 citations

Insight into the physiological functions of PDGF through genetic studies in mice

2004 • 401 citations

Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II

2005 • 398 citations

Blocking Platelet-Derived Growth Factor-D/Platelet-Derived Growth Factor Receptor β Signaling Inhibits Human Renal Cell Carcinoma Progression in an Orthotopic Mouse Model

2005 • 398 citations

Platelet-derived growth factor BB for the treatment of chronic pressure ulcers

1992 • 389 citations

Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors.

1992 • 380 citations

Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy

2002 • 378 citations

Autocrine PDGFR signaling promotes mammary cancer metastasis

2006 • 352 citations

Role of Raf Kinase in Cancer: Therapeutic Potential of Targeting the Raf/MEK/ERK Signal Transduction Pathway

2006 • 346 citations

Platelet-Derived Growth Factor-B Enhances Glioma Angiogenesis by Stimulating Vascular Endothelial Growth Factor Expression in Tumor Endothelia and by Promoting Pericyte Recruitment

2003 • 340 citations

Pericytes limit tumor cell metastasis

2006 • 336 citations

Phase II Study of Imatinib Mesylate Plus Hydroxyurea in Adults With Recurrent Glioblastoma Multiforme

2005 • 333 citations

PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma

2004 • 320 citations

Clinical and Molecular Studies of the Effect of Imatinib on Advanced Aggressive Fibromatosis (desmoid tumor)

2006 • 314 citations

Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class.

2000 • 312 citations

FIP1L1-PDGFRA fusion: prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosinophilia

2004 • 311 citations

Platelet-derived Growth Factor-induced H2O2 Production Requires the Activation of Phosphatidylinositol 3-Kinase

2000 • 309 citations

Abnormal gastrointestinal development in PDGF-A and PDGFR-α deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis

2000 • 300 citations

VEGF-null cells require PDGFR α signaling-mediated stromal fibroblast recruitment for tumorigenesis

2004 • 287 citations

The TEL/platelet-derived growth factor β receptor (PDGFβR) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGFβR kinase-dependent signaling pathways

1996 • 285 citations

The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB.

1999 • 284 citations

Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis.

2001 • 276 citations

Platelet-Derived Growth Factor is AngiogenicIn Vivo

1992 • 276 citations

Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation.

1994 • 272 citations

PDGF alpha- and beta-receptors activate unique and common signal transduction pathways.

1992 • 259 citations

Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB.

1993 • 238 citations

Tumorigenic conversion of immortal human keratinocytes through stromal cell activation

1998 • 236 citations

Leydig Cell Loss and Spermatogenic Arrest in Platelet-Derived Growth Factor (Pdgf)-a–Deficient Mice

2000 • 234 citations

Angiogenesis stimulated by PDGF‐CC, a novel member in the PDGF family, involves activation of PDGFR‐aa and ‐ap receptors

2002 • 223 citations

New Members of the Platelet-Derived Growth Factor Family of Mitogens

2002 • 221 citations

A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFRbeta oncoprotein

1997 • 220 citations

A specific requirement for PDGF-C in palate formation and PDGFR-α signaling

2004 • 219 citations

PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling

2006 • 215 citations

Human breast carcinoma desmoplasia is PDGF initiated

2000 • 214 citations

Involvement of platelet-derived growth factor in disease: development of specific antagonists

2001 • 210 citations

A crucial function of PDGF in TGF-β-mediated cancer progression of hepatocytes

2006 • 205 citations

KIT and Platelet-Derived Growth Factor Receptor Alpha Tyrosine Kinase Gene Mutations and KIT Amplifications in Human Solid Tumors

2004 • 201 citations

Platelet-Derived Growth Factor Production by B16 Melanoma Cells Leads to Increased Pericyte Abundance in Tumors and an Associated Increase in Tumor Growth Rate

2004 • 196 citations

Delivery of molecular and cellular medicine to solid tumors

1998 • 190 citations

Platelet-derived growth factor β receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3′ kinase signaling

1999 • 185 citations

Novel PDGF family members: PDGF-C and PDGF-D

2003 • 184 citations

Tissue plasminogen activator is a potent activator of PDGF-CC

2004 • 184 citations

PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis

2004 • 179 citations

Imatinib and hydroxyurea in pretreated progressive glioblastoma multiforme: a patient series

2005 • 176 citations

Tumor-derived platelet-derived growth factor-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancer.

2002 • 170 citations

Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors

2004 • 166 citations

Blockade of Platelet-Derived Growth Factor Receptor-Beta by CDP860, a Humanized, PEGylated di-Fab', Leads to Fluid Accumulation and Is Associated With Increased Tumor Vascularized Volume

2004 • 161 citations

Identification of a Putative Syp Substrate, the PDGFβ Receptor

1995 • 158 citations

Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model.

2003 • 157 citations

Site-selective Dephosphorylation of the Platelet-derived Growth Factor β-Receptor by the Receptor-like Protein-tyrosine Phosphatase DEP-1

2000 • 150 citations

The Two PDGF Receptors Maintain Conserved Signaling In Vivo despite Divergent Embryological Functions

2001 • 147 citations

Microvascular pericytes express platelet-derived growth factor-beta receptors in human healing wounds and colorectal adenocarcinoma.

1993 • 144 citations

STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptake.

2003 • 142 citations

A novel physiological function for platelet‐derived growth factor‐BB in rat dermis.

1996 • 135 citations

Oncogenic protein tyrosine kinases

2004 • 133 citations

Antiangiogenic and Antitumor Activity of a Selective PDGFR Tyrosine Kinase Inhibitor, CP-673,451

2005 • 129 citations

PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors

2001 • 128 citations

Imatinib Mesylate (Gleevec) Inhibits Ovarian Cancer Cell Growth through a Mechanism Dependent on Platelet-Derived Growth Factor Receptor α and Akt Inactivation

2004 • 117 citations

Sunitinib malate for the treatment of solid tumours: a review of current clinical data

2006 • 116 citations

Identification of a novel imatinib responsive KIF5B-PDGFRA fusion gene following screening for PDGFRA overexpression in patients with hypereosinophilia

2006 • 114 citations

Platelet-Derived Growth Factor D Is Activated by Urokinase Plasminogen Activator in Prostate Carcinoma Cells

2005 • 114 citations

Transforming activity of the chimeric sequence formed by the fusion of collagen gene COL1A1 and the platelet derived growth factor b-chain gene in dermatofibrosarcoma protuberans

1998 • 114 citations

Targeting the platelet-derived growth factor receptor α with a neutralizing human monoclonal antibody inhibits the growth of tumor xenografts: Implications as a potential therapeutic target

2005 • 108 citations

TEL/PDGFβR Induces Hematologic Malignancies in Mice That Respond to a Specific Tyrosine Kinase Inhibitor

1999 • 106 citations

Activated platelet‐derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line

1994 • 105 citations

Targeting the Platelet-Derived Growth Factor Receptor in Antivascular Therapy for Human Ovarian Carcinoma

2004 • 102 citations

Site-Selective Regulation of Platelet-Derived Growth Factor β Receptor Tyrosine Phosphorylation by T-Cell Protein Tyrosine Phosphatase

2004 • 98 citations

Characterization of an imatinib-sensitive subset of high-grade human glioma cultures

2006 • 96 citations

A Potential Oncogenic Activity of Platelet-Derived Growth Factor D in Prostate Cancer Progression

2004 • 93 citations

Targeting Platelet-Derived Growth Factor Receptor on Endothelial Cells of Multidrug-Resistant Prostate Cancer

2006 • 93 citations

Inhibition of Platelet-Derived Growth Factor Receptor Signaling Restricts the Growth of Human Breast Cancer in the Bone of Nude Mice

2005 • 87 citations

Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-β

2005 • 84 citations

Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells

2000 • 84 citations

Platelet-derived growth factor receptor-β promotes early endothelial cell differentiation

2006 • 83 citations

Inhibition of Platelet-derived Growth Factor-BB-induced Receptor Activation and Fibroblast Migration by Hyaluronan Activation of CD44

2006 • 77 citations

Transient response to imatinib in a chronic eosinophilic leukemia associated with ins(9;4)(q33;q12q25) and a CDK5RAP2‐PDGFRA fusion gene

2006 • 73 citations

Bone-metastatic potential of human prostate cancer cells correlates with Akt/PKB activation by α platelet-derived growth factor receptor

2005 • 67 citations

Effect of Platelet-Derived Growth Factor Receptor-β Inhibition with STI571 on Radioimmunotherapy

2005 • 65 citations

Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or Ink4a-Arf deletion in a mouse glioma model.

2003 • 65 citations

Chronic myeloproliferative disorders with rearrangement of the platelet-derived growth factor α receptor: a new clinical target for STI571/Glivec

2003 • 63 citations

Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines

2002 • 56 citations

Growth factor receptors

1989 • 52 citations

Imatinib mesylate as a novel treatment option for hypereosinophilic syndrome: two case reports and a comprehensive review of the literature

2005 • 51 citations

Dermatofibrosarcoma protuberans: a surgical disease with a molecular savior

2006 • 48 citations

SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF β-receptor

2002 • 44 citations

Imatinib Mesylate Inhibits Leydig Cell Tumor Growth: Evidence for In vitro and In vivo Activity

2005 • 41 citations

Platelet-Derived Growth Factor BB–Mediated Normalization of Dermal Interstitial Fluid Pressure After Mast Cell Degranulation Depends on β3 but Not β1 Integrins

2006 • 40 citations

Characterization of the chronic myelomonocytic leukemia associated TEL-PDGFβR fusion protein

1999 • 37 citations

β PDGFR‐IgG chimera demonstrates that human β PDGFR Ig‐like domains 1 to 3 are sufficient for high affinity PDGF BB binding

1995 • 24 citations

Induction of myeloproliferative disease in mice by tyrosine kinase fusion oncogenes does not require granulocyte-macrophage colony-stimulating factor or interleukin-3

2001 • 20 citations

Predimerization of Recombinant Platelet-Derived Growth Factor Receptor Extracellular Domains Increases Antagonistic Potency

2000 • 8 citations