Lymphangiogenesis in development and human disease

Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis

2001 • 1,707 citations

A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.

1996 • 1,670 citations

Prox1 Function Is Required for the Development of the Murine Lymphatic System

1999 • 1,525 citations

Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.

1995 • 1,421 citations

Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins

2003 • 1,353 citations

Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice

1997 • 1,280 citations

Angiopoietin-1 protects the adult vasculature against plasma leakage

2000 • 1,271 citations

VEGF-D promotes the metastatic spread of tumor cells via the lymphatics

2001 • 1,217 citations

Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)

1998 • 1,192 citations

CCR7 Governs Skin Dendritic Cell Migration under Inflammatory and Steady-State Conditions

2004 • 997 citations

Angiopoietin-2 Is Required for Postnatal Angiogenesis and Lymphatic Patterning, and Only the Latter Role Is Rescued by Angiopoietin-1

2002 • 993 citations

VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment

2004 • 963 citations

Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis

2001 • 957 citations

Lymphatic Metastasis in the Absence of Functional Intratumor Lymphatics

2002 • 939 citations

An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype

2002 • 894 citations

Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3

1998 • 876 citations

Pathophysiological consequences of VEGF-induced vascular permeability

2005 • 848 citations

Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3

2001 • 816 citations

Lymphangiogenesis and cancer metastasis

2002 • 781 citations

Cancer cells compress intratumour vessels

2004 • 781 citations

Proteolytic processing regulates receptor specificity and activity of VEGF-C

1997 • 773 citations

Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3

2001 • 759 citations

VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis

2005 • 678 citations

Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice

2001 • 652 citations

Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth.

2001 • 648 citations

T1 /podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema

2003 • 640 citations

Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema

2000 • 625 citations

Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor

2002 • 622 citations

Abnormal lymphatic vessel development in neuropilin 2 mutant mice

2002 • 619 citations

A model for gene therapy of human hereditary lymphedema

2001 • 585 citations

Vascular endothelial growth factor C induces angiogenesis in vivo

1998 • 558 citations

Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis

2004 • 557 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor Induces Lymphangiogenesis as well as Angiogenesis

2002 • 552 citations

VEGFR-3 and Its Ligand VEGF-C Are Associated with Angiogenesis in Breast Cancer

1999 • 550 citations

Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity

2005 • 548 citations

Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation

2005 • 538 citations

Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate

2002 • 524 citations

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis

2004 • 516 citations

Isolation and Characterization of Dermal Lymphatic and Blood Endothelial Cells Reveal Stable and Functionally Specialized Cell Lineages

2001 • 516 citations

Suppression of Tumor Lymphangiogenesis and Lymph Node Metastasis by Blocking Vascular Endothelial Growth Factor Receptor 3 Signaling

2002 • 512 citations

Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation

2005 • 507 citations

VEGF and VEGF-C: Specific Induction of Angiogenesis and Lymphangiogenesis in the Differentiated Avian Chorioallantoic Membrane

1997 • 501 citations

Tumor Lymphangiogenesis

2003 • 478 citations

A tumor-homing peptide with a targeting specificity related to lymphatic vessels

2002 • 478 citations

Lymphatic Neoangiogenesis in Human Kidney Transplants Is Associated with Immunologically Active Lymphocytic Infiltrates

2004 • 469 citations

Molecular characterization of lymphatic endothelial cells

2002 • 461 citations

Kaposi sarcoma herpesvirus–induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma

2004 • 457 citations

PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature

2005 • 447 citations

Identification of Vascular Lineage-Specific Genes by Transcriptional Profiling of Isolated Blood Vascular and Lymphatic Endothelial Cells

2003 • 444 citations

Lymphatic vasculature development

2004 • 436 citations

VEGF-D Is the Strongest Angiogenic and Lymphangiogenic Effector Among VEGFs Delivered Into Skeletal Muscle via Adenoviruses

2003 • 431 citations

Lymphedema

2001 • 431 citations

Chylous ascites: A collective review

2000 • 425 citations

Regulation of Blood and Lymphatic Vascular Separation by Signaling Proteins SLP-76 and Syk

2003 • 417 citations

Proinflammatory Cytokines Regulate Expression of the Lymphatic Endothelial Mitogen Vascular Endothelial Growth Factor-C

1998 • 404 citations

Gene transfer as a tool to induce therapeutic vascular growth

2003 • 403 citations

Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells

2004 • 395 citations

Vascular Endothelial Cell Growth Factor Receptor 3–Mediated Activation of Lymphatic Endothelium Is Crucial for Tumor Cell Entry and Spread via Lymphatic Vessels

2005 • 393 citations

Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma–associated herpesvirus

2004 • 371 citations

Lymphangiogenesis and tumor metastasis: myth or reality?

2001 • 364 citations

Biosynthesis of Vascular Endothelial Growth Factor-D Involves Proteolytic Processing Which Generates Non-covalent Homodimers

1999 • 330 citations

Hepatocyte growth factor promotes lymphatic vessel formation and function

2005 • 312 citations

Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea

2002 • 302 citations

The lymphatic system in human embryos, with a consideration of the morphology of the system as a whole

1909 • 292 citations

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α

2000 • 291 citations

Vascular Endothelial Growth Factor D Is Dispensable for Development of the Lymphatic System

2005 • 288 citations

Fatal Bilateral Chylothorax in Mice Lacking the Integrin α9β1

2000 • 282 citations

Ligand-induced Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3) Heterodimerization with VEGFR-2 in Primary Lymphatic Endothelial Cells Regulates Tyrosine Phosphorylation Sites

2003 • 272 citations

Chemokines in neoplastic progression

2004 • 269 citations

Analysis of the phenotypic abnormalities in lymphoedema-distichiasis syndrome in 74 patients with FOXC2 mutations or linkage to 16q24

2002 • 266 citations

The β-Chemokine Receptor D6 Is Expressed by Lymphatic Endothelium and a Subset of Vascular Tumors

2001 • 264 citations

Intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinomas of the head and neck region.

2003 • 246 citations

Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation

2005 • 233 citations

Angiopoietin-1 promotes lymphatic sprouting and hyperplasia

2005 • 232 citations

A genetic Xenopus laevis tadpole model to study lymphangiogenesis

2005 • 231 citations

Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2

2005 • 227 citations

Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity

2004 • 220 citations

Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice

2000 • 214 citations

Biology of the lymphatic marker LYVE‐1 and applications in research into lymphatic trafficking and lymphangiogenesis

2004 • 201 citations

The Lymphangiogenic Vascular Endothelial Growth Factors VEGF-C and -D Are Ligands for the Integrin α9β1

2004 • 189 citations

Differential in vivo and in vitro expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in tumors and its relationship to lymphatic metastasis in immunocompetent rats.

2003 • 188 citations

Preexisting Lymphatic Endothelium but not Endothelial Progenitor Cells Are Essential for Tumor Lymphangiogenesis and Lymphatic Metastasis

2004 • 187 citations

FOXC2 haploinsufficient mice are a model for human autosomal dominant lymphedema-distichiasis syndrome

2003 • 187 citations

Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways

2005 • 170 citations

Lymphangiogenic Gene Therapy With Minimal Blood Vascular Side Effects

2002 • 166 citations

Eph Receptors and Ephrin Ligands Essential Mediators of Vascular Development

2000 • 161 citations

Mannose Receptor Is a Novel Ligand for L-Selectin and Mediates Lymphocyte Binding to Lymphatic Endothelium

2001 • 160 citations

Tumor-Secreted Vascular Endothelial Growth Factor-C Is Necessary for Prostate Cancer Lymphangiogenesis, but Lymphangiogenesis Is Unnecessary for Lymph Node Metastasis

2005 • 148 citations

Novel Expression of Vascular Endothelial Growth Factor Receptor (VEGFR)-3 and VEGF-C on Corneal Dendritic Cells

2003 • 137 citations

Molecular lymphangiogenesis: new players

2005 • 134 citations

Stimulation of β1 Integrin Induces Tyrosine Phosphorylation of Vascular Endothelial Growth Factor Receptor-3 and Modulates Cell Migration

2001 • 131 citations

CLEVER-1 mediates lymphocyte transmigration through vascular and lymphatic endothelium

2004 • 129 citations

Lymphangioblasts in the avian wing bud

1999 • 127 citations

Net-targeted mutant mice develop a vascular phenotype and up-regulate egr-1

2001 • 124 citations

Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema–distichiasis syndrome

2004 • 102 citations

Genesis and pathogenesis of lymphatic vessels

2003 • 93 citations

Proliferation of lymphatics in inflammation

1937 • 88 citations

Overexpression of vascular endothelial growth factor-A165 enhances tumor angiogenesis but not metastasis during beta-cell carcinogenesis.

2002 • 73 citations

Visualization of lymphatic vessels through NF-κB activity

2004 • 55 citations

Research Perspectives in Inherited Lymphatic Disease

2002 • 47 citations

Abnormal lymphatic development in trisomy 16 mouse embryos precedes nuchal edema

2004 • 45 citations

Kaposi's Sarcoma-associated Herpesvirus Activation of Vascular Endothelial Growth Factor Receptor 3 Alters Endothelial Function and Enhances Infection

2005 • 42 citations

New insights into the biology and pathology of the cutaneous lymphatic system

2003 • 39 citations