A Potential Oncogenic Activity of Platelet-Derived Growth Factor D in Prostate Cancer Progression

Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor

1999 • 2,386 citations

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

1983 • 1,657 citations

Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor

1983 • 1,550 citations

Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

1994 • 1,211 citations

PDGF-C is a new protease-activated ligand for the PDGF α-receptor

2000 • 612 citations

High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20-69: an autopsy study of 249 cases.

1994 • 573 citations

PDGF-D is a specific, protease-activated ligand for the PDGF β-receptor

2001 • 542 citations

Use of a hybrid vaccinia virus-T7 RNA polymerase system for expression of target genes.

1987 • 409 citations

Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis.

2000 • 400 citations

PDGF-D, a new protease-activated growth factor

2001 • 389 citations

Polypeptide Growth Factors: Roles In Normal And Abnormal Cell Growth

1987 • 339 citations

The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB.

1999 • 284 citations

Effects of Blocking Platelet-Derived Growth Factor-Receptor Signaling in a Mouse Model of Experimental Prostate Cancer Bone Metastases

2003 • 275 citations

Neuropilin-1 Extracellular Domains Mediate Semaphorin D/III-Induced Growth Cone Collapse

1998 • 269 citations

Synthesis and secretion of platelet-derived growth factor by human breast cancer cell lines.

1987 • 266 citations

Platelet-derived Growth Factor Signaling and Human Cancer

2003 • 262 citations

Tumorigenic conversion of immortal human keratinocytes through stromal cell activation

1998 • 236 citations

Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor alpha receptor expression in human malignant gliomas.

1996 • 228 citations

Platelet-derived growth factor receptor-beta is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas.

1992 • 202 citations

Evidence for Distinct Signaling Properties and Biological Responses Induced by the PDGF Receptor α and β Subtypes

1999 • 197 citations

Platelet‐derived growth factor in human glioma

1995 • 196 citations

Comparison of Biological Properties and Transforming Potential of Human PDGF-A and PDGF-B Chains

1988 • 178 citations

PDGF-D is a potent transforming and angiogenic growth factor

2003 • 155 citations

A multi-institutional phase ii study of SU101, a platelet-derived growth factor receptor inhibitor, for patients with hormone-refractory prostate cancer.

2001 • 136 citations

Chromosomal Location, Exon Structure, and Vascular Expression Patterns of the Human PDGFC and PDGFD Genes

2001 • 132 citations

Molecular Dissection of the Intrinsic Factor-Vitamin B12 Receptor, Cubilin, Discloses Regions Important for Membrane Association and Ligand Binding

1999 • 129 citations

Expression of platelet-derived growth factor B-chain and the platelet-derived growth factor receptor beta subunit in human breast tissue and breast carcinoma.

1995 • 125 citations

Immunohistochemistry analysis of platelet-derived growth factor A and B chains and platelet-derived growth factor alpha and beta receptor expression in benign prostatic hyperplasias and Gleason-graded human prostate adenocarcinomas.

1994 • 122 citations

Growth-inhibitory effect of STI571 on cells transformed by theCOL1A1/PDGFB rearrangement

2001 • 116 citations

Expression in lung carcinomas of platelet-derived growth factor and its receptors.

1997 • 98 citations

Platelet-Derived Growth Factor-AA and -α Receptor Expression Suggests an Autocrine and/or Paracrine Loop in Osteosarcoma

2000 • 84 citations

Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells

2000 • 84 citations

Platelet-derived growth factor A and B chains and the α and β receptors in prostatic intraepithelial neoplasia

1996 • 81 citations

Positive immunostaining for platelet derived growth factor (PDGF) is an adverse prognostic factor in patients with advanced breast cancer

1994 • 74 citations

Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer.

2002 • 67 citations

Platelet-derived Growth Factor (PDGF) Receptor-α Activates c-Jun NH2-terminal Kinase-1 and Antagonizes PDGF Receptor-β-induced Phenotypic Transformation

2000 • 67 citations

Tumor cell and connective tissue cell interactions in human colorectal adenocarcinoma. Transfer of platelet-derived growth factor-AB/BB to stromal cells.

1997 • 62 citations

Platelet-derived growth factor receptor (beta-subunit) immunoreactivity in soft tissue tumors.

1992 • 58 citations

Complement components C1r/C1s, bone morphogenic protein 1 and Xenopus laevis developmentally regulated protein UVS.2 share common repeats

1991 • 47 citations

The v-sis oncogene product but not platelet-derived growth factor (PDGF) A homodimers activate PDGF alpha and beta receptors intracellularly and initiate cellular transformation.

1992 • 38 citations

Hormone-refractory prostate cancer: an evolving standard of care.

1999 • 37 citations

Structure and functions of the interaction domains of C1r and C1s: keystones of the architecture of the C1 complex

1999 • 28 citations

An in vitro model of cell migration: Evaluation of vascular endothelial cell migration

1990 • 21 citations

Expressions of Various Growth Factors and Their Receptors in Tissues from Neurofibroma

2000 • 16 citations

Pathogenesis of breast carcinoma

2004 • 10 citations

Natural Course of Localized Prostate Cancer. A Personal View With a Review of Published Papers

1998 • 9 citations

Pathogenesis of breast carcinoma. Immunohistochemical study.

1997 • 4 citations