Imatinib and hydroxyurea in pretreated progressive glioblastoma multiforme: a patient series

Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma

2005 • 18,835 citations

Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors

2002 • 4,254 citations

Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia

2003 • 3,532 citations

Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors.

2000 • 1,264 citations

Frequency of Major Molecular Responses to Imatinib or Interferon Alfa plus Cytarabine in Newly Diagnosed Chronic Myeloid Leukemia

2003 • 1,253 citations

Malignant glioma: genetics and biology of a grave matter

2001 • 1,229 citations

Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study

2002 • 1,195 citations

Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative.

1996 • 1,080 citations

Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study

2002 • 1,069 citations

A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse

2000 • 940 citations

Outcomes and Prognostic Factors in Recurrent Glioma Patients Enrolled Onto Phase II Clinical Trials

1999 • 911 citations

Glioblastoma multiforme: The terminator

2000 • 742 citations

Phase II Trial of Gefitinib in Recurrent Glioblastoma

2003 • 730 citations

PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo

2001 • 708 citations

Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops.

1992 • 689 citations

Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology.

1993 • 534 citations

PDGF receptors as cancer drug targets

2003 • 462 citations

Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors.

2002 • 432 citations

Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy.

2002 • 431 citations

Imatinib mesylate (STI-571 Glivec®, Gleevec™) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target

2003 • 399 citations

Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors.

1992 • 380 citations

Multicenter phase II trial of temozolomide in patients with glioblastoma multiforme at first relapse

2001 • 373 citations

High-Affinity Interaction of Tyrosine Kinase Inhibitors with the ABCG2 Multidrug Transporter

2004 • 338 citations

Imatinib Mesylate Is a Potent Inhibitor of the ABCG2 (BCRP) Transporter and Reverses Resistance to Topotecan and SN-38 in Vitro

2004 • 324 citations

PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma

2004 • 320 citations

P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate

2004 • 310 citations

Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop

1995 • 298 citations

Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus.

1998 • 290 citations

In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents

2001 • 274 citations

Genetic pathways to glioblastomas

2005 • 225 citations

Dose-Dependent Effects of Platelet-Derived Growth Factor-B on Glial Tumorigenesis

2004 • 224 citations

Platelet-derived growth factor receptor-beta is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas.

1992 • 202 citations

Platelet-derived growth factor receptors: A therapeutic target in solid tumors

2001 • 145 citations

Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 1: growth factor and Ras signaling pathways

2003 • 118 citations

Inhibition of glioma cell growth by a truncated platelet-derived growth factor-beta receptor.

1994 • 116 citations

A human brain tumor-derived PDGFR-α deletion mutant is transforming

2003 • 106 citations

Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors

2004 • 102 citations

Concomitant and adjuvant temozolomide (TMZ) and radiotherapy (RT) for newly diagnosed glioblastoma multiforme (GBM). Conclusive results of a randomized phase III trial by the EORTC Brain & RT Groups and NCIC Clinical Trials Group

2004 • 91 citations

Imatinib mesylate inhibits platelet-derived growth factor activity and increases chemosensitivity in feline vaccine-associated sarcoma

2004 • 86 citations

Multicentre phase II study of imatinib mesylate in patients with recurrent glioblastoma: An EORTC: NDDG/BTG Intergroup Study

2004 • 79 citations

Imatinib mesylate radiosensitizes human glioblastoma cells through inhibition of platelet-derived growth factor receptor

2005 • 79 citations

The Incidence and significance of thromboembolic complications in patients with high-grade gliomas

1991 • 75 citations

The prognostic impact of prior low grade histology in patients with anaplastic gliomas

1996 • 73 citations

Increasing tumor uptake of anticancer drugs with imatinib

2004 • 62 citations

Imatinib sensitizes CLL lymphocytes to chlorambucil

2003 • 59 citations

Venous thromboembolism after brain tumor surgery

1991 • 55 citations

Treatment of inoperable gastrointestinal stromal tumor (GIST) with Imatinib (Glivec, Gleevec).

2002 • 54 citations

Venous Thromboembolism after Brain Tumor Surgery: A Retrospective Review

1991 • 50 citations

Patupilone (epothilone B, EPO906) and imatinib (STI571, Glivec) in combination display enhanced antitumour activity in vivo against experimental rat C6 glioma

2004 • 30 citations

Hydroxyurea transport across the blood–brain and blood–cerebrospinal fluid barriers of the guinea‐pig

2003 • 28 citations

Platelet-derived growth factor receptors: A therapeutic target in solid tumors

2001 • 27 citations

Pharmacokinetics of Hydroxyurea in Plasma and Cerebrospinal Fluid of HIV‐1‐Infected Patients

2003 • 16 citations