KIT and Platelet-Derived Growth Factor Receptor Alpha Tyrosine Kinase Gene Mutations and KIT Amplifications in Human Solid Tumors

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia

2001 • 5,189 citations

Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors

2002 • 4,254 citations

PDGFRA Activating Mutations in Gastrointestinal Stromal Tumors

2003 • 2,224 citations

Kinase Mutations and Imatinib Response in Patients With Metastatic Gastrointestinal Stromal Tumor

2003 • 2,216 citations

Effect of the Tyrosine Kinase Inhibitor STI571 in a Patient with a Metastatic Gastrointestinal Stromal Tumor

2001 • 2,038 citations

A Tyrosine Kinase Created by Fusion of thePDGFRAandFIP1L1Genes as a Therapeutic Target of Imatinib in Idiopathic Hypereosinophilic Syndrome

2003 • 1,683 citations

Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

2002 • 1,349 citations

Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors.

2000 • 1,264 citations

KIT activation is a ubiquitous feature of gastrointestinal stromal tumors.

2001 • 964 citations

Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder.

1995 • 895 citations

Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product.

1993 • 835 citations

CD117: a sensitive marker for gastrointestinal stromal tumors that is more specific than CD34.

1998 • 788 citations

Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family-oncogenic activation of v-kit involves deletion of extracellular domain and C terminus.

1988 • 727 citations

Denaturing high-performance liquid chromatography: A review

2001 • 717 citations

Gain-of-function mutations of platelet-derived growth factor receptor α gene in gastrointestinal stromal tumors

2003 • 665 citations

Response to Imatinib Mesylate in Patients with Chronic Myeloproliferative Diseases with Rearrangements of the Platelet-Derived Growth Factor Receptor Beta

2002 • 642 citations

Inhibition of KIT Tyrosine Kinase Activity: A Novel Molecular Approach to the Treatment of KIT-Positive Malignancies

2002 • 582 citations

Activating and dominant inactivating c-KITcatalytic domain mutations in distinct clinical forms of human mastocytosis

1999 • 560 citations

Mutations in Exon 11 of c-Kit Occur Preferentially in Malignant versus Benign Gastrointestinal Stromal Tumors and Do Not Occur in Leiomyomas or Leiomyosarcomas

1999 • 555 citations

PDGF receptors as cancer drug targets

2003 • 462 citations

KIT Mutations Are Common in Incidental Gastrointestinal Stromal Tumors One Centimeter or Less in Size

2002 • 445 citations

Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy.

2002 • 431 citations

Activating c-kit Gene Mutations in Human Germ Cell Tumors

1999 • 414 citations

Molecular Targeting of Platelet-Derived Growth Factor B by Imatinib Mesylate in a Patient With Metastatic Dermatofibrosarcoma Protuberans

2002 • 373 citations

Blind Analysis of Denaturing High-Performance Liquid Chromatography as a Tool for Mutation Detection

1998 • 341 citations

Inhibition of KIT Tyrosine Kinase Activity: A Novel Molecular Approach to the Treatment of KIT-Positive Malignancies

2002 • 331 citations

KIT Mutations Are Common in Testicular Seminomas

2004 • 318 citations

KIT protein expression and analysis of c-kit gene mutation in adenoid cystic carcinoma.

1999 • 222 citations

Gain-of-function mutation at the extracellular domain of KIT in gastrointestinal stromal tumours

2001 • 221 citations

Identification of Activating c-kit Mutations in Adult-, but not in Childhood-Onset Indolent Mastocytosis: A Possible Explanation for Divergent Clinical Behavior

1998 • 212 citations

Preferential localization of c-kit product in tissue mast cells, basal cells of skin, epithelial cells of breast, small cell lung carcinoma and seminoma/dysgerminoma in human: immunohistochemical study on formalin-fixed, paraffin-embedded tissues

1994 • 209 citations

Amplification of erbB2 and erbB2 expression are superior to estrogen receptor status as risk factors for distant recurrence in pT1N0M0 breast cancer: a nationwide population-based study.

2003 • 209 citations

Expression of the c-kit protein is associated with certain subtypes of salivary gland carcinoma

2000 • 195 citations

Response of extraabdominal desmoid tumors to therapy with imatinib mesylate

2002 • 193 citations

Absence of c‐kit gene mutations in gastrointestinal stromal tumours from neurofibromatosis type 1 patients

2003 • 190 citations

Stem cell factor receptor (c-KIT) codon 816 mutations predict development of bilateral testicular germ-cell tumors.

2003 • 172 citations

Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model.

2003 • 157 citations

Effect of Imatinib Mesylate on Neuroblastoma Tumorigenesis and Vascular Endothelial Growth Factor Expression

2004 • 152 citations

STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptake.

2003 • 142 citations

Efficacy and safety of imatinib in adult patients with c-kit–positive acute myeloid leukemia

2004 • 141 citations

Improved technique for analysis of formalin‐fixed, paraffin‐embedded tumors by fluorescence in situ hybridization

1994 • 136 citations

A human brain tumor-derived PDGFR-α deletion mutant is transforming

2003 • 106 citations

Specific c-kit mutations in sinonasal natural killer/T-cell lymphoma in China and Japan.

2000 • 104 citations

Alterations of the c‐kit gene in testicular germ cell tumors

2003 • 104 citations

Targeting the Platelet-Derived Growth Factor Receptor in Antivascular Therapy for Human Ovarian Carcinoma

2004 • 102 citations

Imatinib mesylate (STI-571) reduces Bcr-Abl-mediated vascular endothelial growth factor secretion in chronic myelogenous leukemia.

2002 • 80 citations

A YAC Contig Spanning a Cluster of Human Type III Receptor Protein Tyrosine Kinase Genes (PDGFRA-KIT-KDR) in Chromosome Segment 4q12

1994 • 70 citations

Evaluation of denaturing high performance liquid chromatography (DHPLC) for the mutational analysis of the neurofibromatosis type 1 ( NF1 ) gene

2001 • 70 citations

Lack of c-kit exon 11 activating mutations in c-KIT/CD117-positive SCLC tumour specimens

2003 • 67 citations

Genomic organization of the human c-kit gene: evolution of the receptor tyrosine kinase subclass III.

1992 • 66 citations

Primary Mediastinal Seminomas: Evidence of Single and Multiple KIT Mutations

2002 • 65 citations

STI-571 inhibits in vitro angiogenesis

2003 • 19 citations