Tumorigenic conversion of immortal human keratinocytes through stromal cell activation

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

1988 • 4,008 citations

Sunburn and p53 in the onset of skin cancer

1994 • 1,501 citations

Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.

1990 • 1,147 citations

The molecular and cellular biology of wound repair

1996 • 562 citations

p53 Mutations in human immortalized epithelial cell lines

1993 • 441 citations

Halting angiogenesis suppresses carcinoma cell invasion

1997 • 430 citations

PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors.

1994 • 428 citations

Fibroblast-mediated acceleration of human epithelial tumor growth in vivo.

1990 • 417 citations

cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.

1989 • 413 citations

Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.

1991 • 407 citations

Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter

1990 • 277 citations

Synthesis and secretion of platelet-derived growth factor by human breast cancer cell lines.

1987 • 266 citations

Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug resistance of small cell lung cancer cell lines.

1990 • 249 citations

Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB.

1993 • 238 citations

Extracellular matrix alters PDGF regulation of fibroblast integrins.

1996 • 225 citations

Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts.

1991 • 220 citations

Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression.

1991 • 217 citations

c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy.

1990 • 212 citations

Growth factor messenger RNA expression by human breast fibroblasts from benign and malignant lesions.

1991 • 204 citations

Large induction of keratinocyte growth factor expression by serum growth factors and pro-inflammatory cytokines in cultured fibroblasts.

1994 • 203 citations

Selective upregulation of platelet-derived growth factor alpha receptors by transforming growth factor beta in scleroderma fibroblasts.

1992 • 181 citations

Modulation of platelet-derived growth factor receptor expression in microvascular endothelial cells during in vitro angiogenesis.

1994 • 152 citations

Frequent expression of growth factors for mesenchymal cells in human mammary carcinoma cell lines.

1987 • 151 citations

Multiple Hormones Stimulate the Production of Somatomedin by Cultured Human Fibroblasts*

1984 • 143 citations

Sustained nontumorigenic phenotype correlates with a largely stable chromosome content during long-term culture of the human keratinocyte line HaCaT

1997 • 142 citations

Induction of platelet-derived growth factor receptor expression in smooth muscle cells and fibroblasts upon tissue culturing.

1988 • 135 citations

A novel mechanism regulating growth factor association with the cell surface: identification of a PDGF retention domain.

1991 • 131 citations

Elevated Levels of PDGF α Receptors in Keloid Fibroblasts Contribute to an Enhanced Response to PDGF

1994 • 126 citations

Expression of platelet-derived growth factor B-chain and the platelet-derived growth factor receptor beta subunit in human breast tissue and breast carcinoma.

1995 • 125 citations

The role of fibroblasts in tumor behavior

1995 • 125 citations

Tissue localization of beta receptors for platelet-derived growth factor and platelet-derived growth factor B chain during wound repair in humans.

1993 • 118 citations

Structure and sequence of the human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) transcriptional unit.

1986 • 117 citations

Decreased level of PDGF-stimulated receptor autophosphorylation by fibroblasts in mechanically relaxed collagen matrices

1993 • 105 citations

The Tumor-Promoting Effect of Wounding: A Possible Role for TGF-β-lnduced Stromal Alterations

1994 • 100 citations

Epithelial-Stromal Interactions in Basal Cell Cancer: The PDGF System

1994 • 90 citations

Platelet-derived growth factor in autocrine transformation.

1991 • 90 citations

The role of platelet-derived growth factor production by tumor-associated macrophages in tumor stroma formation in lung cancer

1995 • 79 citations

Practical aspects of radio-isotopic in situ hybridization on RNA

1993 • 79 citations

Platelet‐derived growth factor‐B increases colon cancer cell growth in vivo by a paracrine effect

1995 • 58 citations

Step-wise progression in human skin carcinogenesis in vitro involves mutational inactivation of p53, rasH oncogene activation and additional chromosome loss.

1995 • 51 citations

Transgenic models of epidermal neoplasia and multistage carcinogenesis.

1996 • 29 citations

Diagnostic Immunopathology

1996 • 23 citations