Induction of myeloproliferative disease in mice by tyrosine kinase fusion oncogenes does not require granulocyte-macrophage colony-stimulating factor or interleukin-3

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

Involvement of Granulocyte-Macrophage Colony-Stimulating Factor in Pulmonary Homeostasis

1994 • 883 citations

Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology.

1994 • 866 citations

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.

1988 • 602 citations

The P190, P210, and P230 Forms of the BCR/ABL Oncogene Induce a Similar Chronic Myeloid Leukemia–like Syndrome in Mice but Have Different Lymphoid Leukemogenic Activity

1999 • 503 citations

Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage

1987 • 384 citations

Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice.

1990 • 338 citations

Long-Term Marrow Culture Reveals Chromosomally Normal Hematopoietic Progenitor Cells in Patients with Philadelphia Chromosome-Positive Chronic Myelogenous Leukemia

1983 • 335 citations

Neoplastic transformation of mast cells by Abelson-MuLV: abrogation of IL-3 dependence by a nonautocrine mechanism

1985 • 330 citations

Stat5 Is Essential for the Myelo- and Lymphoproliferative Disease Induced by TEL/JAK2

2000 • 310 citations

Bcr-Abl Efficiently Induces a Myeloproliferative Disease and Production of Excess Interleukin-3 and Granulocyte-Macrophage Colony-Stimulating Factor in Mice: A Novel Model for Chronic Myelogenous Leukemia

1998 • 284 citations

Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients.

1997 • 283 citations

Malignant transformation of a growth factor-dependent myeloid cell line by Abelson virus without evidence of an autocrine mechanism

1985 • 272 citations

Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice.

1996 • 262 citations

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

1998 • 261 citations

Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia

1999 • 243 citations

The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells

1997 • 228 citations

kat: a high-efficiency retroviral transduction system for primary human T lymphocytes

1994 • 225 citations

A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factor.

1989 • 198 citations

The Survival Function of the Bcr-Abl Oncogene Is Mediated by Bad-Dependent and -Independent Pathways: Roles for Phosphatidylinositol 3-Kinase and Raf

2000 • 188 citations

bcr-abl oncogene renders myeloid cell line factor independent: potential autocrine mechanism in chronic myeloid leukemia.

1988 • 177 citations

Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus.

1992 • 167 citations

Nf1 and Gmcsf Interact in Myeloid Leukemogenesis

2000 • 147 citations

Culture of human leukemia cells

1966 • 146 citations

The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway.

1996 • 146 citations

Expression of bcr-abl abrogates factor-dependent growth of human hematopoietic M07E cells by an autocrine mechanism

1994 • 140 citations

Effects of recombinant GM-CSF on the blast cells of acute myeloblastic leukemia

1986 • 139 citations

Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia

2000 • 107 citations

TEL/PDGFβR Induces Hematologic Malignancies in Mice That Respond to a Specific Tyrosine Kinase Inhibitor

1999 • 106 citations

Interleukin-3 and p210 BCR/ABL activate both unique and overlapping pathways of signal transduction in a factor-dependent myeloid cell line.

1993 • 89 citations

Bone Marrow Colony-Stimulating Activity of Serum From Mice With Viral-Induced Leukemia<xref ref-type="fn" rid="FN1">2</xref>

1967 • 81 citations

Interleukin 3 and granulocyte-macrophage colony-stimulating factor are not required for induction of chronic myeloid leukemia-like myeloproliferative disease in mice by BCR/ABL

2001 • 76 citations

Interleukin-6 and granulocyte-macrophage colony-stimulating factor are candidate growth factors for chronic myelomonocytic leukemia cells

1989 • 72 citations

Granulocyte-macrophage colony-stimulating factor is an endogenous regulator of cell proliferation in juvenile chronic myelogenous leukemia

1989 • 71 citations

Colony-stimulating Factor and Inhibitor Levels in Acute Granulocytic Leukemia

1971 • 69 citations

The role of monocyte-derived hemopoietic growth factors in the regulation of myeloproliferation in juvenile chronic myelogenous leukemia.

1991 • 54 citations

Bcr‐Abl kinase promotes cell cycle entry of primary myeloid CML cells in the absence of growth factors

1998 • 52 citations

Generation of an autocrine leukaemia using a retroviral expression vector carrying the interleukin-3 gene.

1986 • 51 citations

Stimulation by Leukaemic Sera of Colony Formation in Solid Agar Cultures by Proliferation of Mouse Bone Marrow Cells

1967 • 49 citations

Growth factor-mediated terminal differentiation of chronic myeloid leukemia.

1994 • 48 citations

The BCR-ABL oncogene requires both kinase activity and src-homology 2 domain to induce cytokine secretion

1996 • 47 citations

Production of colony-stimulating factor by leukemic leukocytes

1976 • 43 citations

Improved growth of in vitro colonies in human acute leukemia with the feeding culture method.

1977 • 37 citations

Lack of evidence for abnormal autocrine or paracrine mechanisms underlying the uncontrolled proliferation of primitive chronic myeloid leukemia progenitor cells.

1991 • 36 citations

The BCR-ABL oncogene requires both kinase activity and src-homology 2 domain to induce cytokine secretion

1996 • 35 citations

Ubiquitous expression of cytokines in diverse leukemias of lymphoid and myeloid lineage.

1993 • 35 citations

Role of granulocyte-macrophage colony-stimulating factor in Philadelphia (Ph1)-positive acute lymphoblastic leukemia: Studies on two newly established Ph1-positive acute lymphoblastic leukemia cell lines (Z-119 and Z-181)

1996 • 34 citations

Activation of multiple hemopoietic growth factor genes in Abelson virus-transformed myeloid cells.

1988 • 30 citations

Constitutive and induced expression of growth factors in normal and chronic phase chronic myelogenous leukemia Ph1 bone marrow stroma.

1990 • 17 citations

Autostimulatory mechanisms in myeloid leukemogenesis

1987 • 16 citations

Autocrine production of pre-B-cell stimulating activity by a variety of transformed murine pre-B-cell lines.

1988 • 12 citations

The role of interleukin-1 and granulocyte-macrophage colony-stimulating factor in the paracrine stimulation of an in vivo-derived murine myeloid leukemia

1991 • 9 citations

Constitutive expression of hematopoietic growth factor genes by acute myeloblastic leukemia cells.

1988 • 8 citations

Behavior of Human Leukemic Progenitor Populations in Long-Term Marrow Culture

1985 • 3 citations

Interruption of autocrine and paracrine growth-stimulatory mechanisms: a new therapeutic strategy for chronic myelogenous leukemia.

1993 • 3 citations