Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-β

Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor

1999 • 2,386 citations

uPAR: a versatile signalling orchestrator

2002 • 1,175 citations

Regulation of Integrin Function by the Urokinase Receptor

1996 • 734 citations

Interleukin-1 Mitogenic Activity for Fibroblasts and Smooth Muscle Cells Is Due to PDGF-AA

1989 • 648 citations

Identification of the urokinase receptor as an adhesion receptor for vitronectin.

1994 • 593 citations

The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes.

1990 • 480 citations

Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.

1992 • 464 citations

Regulation of chemotaxis by the platelet-derived growth factor receptor-β

1994 • 441 citations

EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma

2002 • 386 citations

The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R

2002 • 356 citations

Smooth muscle cells express urokinase during mitogenesis and tissue-type plasminogen activator during migration in injured rat carotid artery.

1990 • 314 citations

Guidebook to Cytokines and Their Receptors

1995 • 273 citations

Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation.

1994 • 272 citations

Requirement of Receptor-bound Urokinase-type Plasminogen Activator for Integrin αvβ5-directed Cell Migration

1996 • 244 citations

Urokinase but Not Tissue Plasminogen Activator Mediates Arterial Neointima Formation in Mice

1997 • 222 citations

Cell‐induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH₂‐terminal domain of the urokinase receptor

1991 • 194 citations

Direct Binding of Occupied Urokinase Receptor (uPAR) to LDL Receptor-related Protein Is Required for Endocytosis of uPAR and Regulation of Cell Surface Urokinase Activity

2001 • 184 citations

The Jak/Stat Pathway and Urokinase Receptor Signaling in Human Aortic Vascular Smooth Muscle Cells

1998 • 179 citations

PDGF-Receptor Tyrosine Kinase Blocker AG1295 Selectively Attenuates Smooth Muscle Cell Growth In Vitro and Reduces Neointimal Formation After Balloon Angioplasty in Swine

1998 • 171 citations

Functional Blockade of Platelet-Derived Growth Factor Receptor-β but Not of Receptor-α Prevents Vascular Smooth Muscle Cell Accumulation in Fibrous Cap Lesions in Apolipoprotein E–Deficient Mice

2001 • 166 citations

Regulatory effects of platelet-derived growth factor-AA homodimer on migration of vascular smooth muscle cells

1992 • 119 citations

Epidermal growth factor-induced growth inhibition requires Stat1 activation.

1998 • 100 citations

Urokinase/urokinase receptor and vitronectin/αvβ3 integrin induce chemotaxis and cytoskeleton reorganization through different signaling pathways

2001 • 97 citations

Urokinase-induced mitogenesis is mediated by casein kinase 2 and nucleolin

1999 • 90 citations

Relative Platelet-derived Growth Factor Receptor Subunit Expression Determines Cell Migration to Different Dimeric Forms of PDGF

1990 • 87 citations

Urokinase Stimulates Human Vascular Smooth Muscle Cell Migration via a Phosphatidylinositol 3-Kinase-Tyk2 Interaction

2000 • 77 citations

Ser727/Tyr701-phosphorylated Stat1 is required for the regulation of c-Myc, cyclins, and p27Kip1 associated with ATRA-induced G0/G1 arrest of U-937 cells

2003 • 71 citations

Urokinase and Tissue-type Plasminogen Activator Are Required for the Mitogenic and Chemotactic Effects of Bovine Fibroblast Growth Factor and Platelet-derived Growth Factor-BB for Vascular Smooth Muscle Cells

1997 • 70 citations

Stem cell factor and c-kit are expressed by and may affect vascular SMCs through an autocrine pathway

2004 • 70 citations

Local Delivery of Platelet-Derived Growth Factor Receptor–Specific Tyrphostin Inhibits Neointimal Formation in Rats

2000 • 67 citations

Distinct Mechanisms of Activation of Stat1 and Stat3 by Platelet-Derived Growth Factor Receptor in a Cell-Free System

1999 • 63 citations

Urokinase potentiates PDGF-induced chemotaxis of human airway smooth muscle cells

2003 • 53 citations

c-kit-Immunopositive vascular progenitor cells populate human coronary in-stent restenosis but not primary atherosclerotic lesions

2004 • 52 citations

Molecular structure and transcriptional regulation of the gene for the platelet-derived growth factor alpha receptor in cultured vascular smooth muscle cells.

1995 • 50 citations

Urokinase-induced migration of human vascular smooth muscle cells requires coupling of the small GTPases RhoA and Rac1 to the Tyk2/PI3-K signalling pathway

2003 • 48 citations

Platelet-derived growth factor (PDGF)-induced disulfide-linked dimerization of PDGF receptor in living cells.

1991 • 45 citations

Urokinase Induces Activation and Formation of Stat4 and Stat1-Stat2 Complexes in Human Vascular Smooth Muscle Cells

1999 • 45 citations

Urokinase plasminogen activator induces smooth muscle cell migration: key role of growth factor‐like domain

1997 • 38 citations

Imaging spatiotemporal dynamics of Rac activation in vivo with FLAIR

2000 • 38 citations

LRP1B Attenuates the Migration of Smooth Muscle Cells by Reducing Membrane Localization of Urokinase and PDGF Receptors

2004 • 34 citations

Monocyte-expressed urokinase inhibits vascular smooth muscle cell growth by activating Stat1

2003 • 33 citations

Fibrillar Collagen Regulation of Plasminogen Activator Inhibitor-1 Is Involved in Altered Smooth Muscle Cell Migration

2002 • 25 citations

Regulation of proteolytic enzymes and inhibitors in two smooth muscle cell phenotypes

1999 • 25 citations

Expression and role of PDGF-BB and PDGFR-β during testis morphogenesis in the mouse embryo

2004 • 22 citations

Platelet-Derived Growth Factor (PDGF)-Induced Disulfide-Linked Dimerization of PDGF Receptor in Living Cells

1991 • 16 citations

Native Atherosclerosis and Vein Graft Arterialization: Association with Increased Urokinase Receptor Expression In Vitro and In Vivo

1998 • 14 citations

Mitogen crosstalk accompanying urokinase receptor expression in stimulated vascular smooth muscle cells

1996 • 6 citations