Platelet-derived growth factor receptor-β promotes early endothelial cell differentiation

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Vascular-specific growth factors and blood vessel formation

2000 • 3,667 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

VEGF receptor signalling ? in control of vascular function

2006 • 2,930 citations

Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor

1999 • 2,386 citations

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

1993 • 2,370 citations

Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice

1997 • 2,136 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

Endothelial/Pericyte Interactions

2005 • 1,909 citations

Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse

1999 • 1,618 citations

A common precursor for hematopoietic and endothelial cells

1998 • 1,433 citations

Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors

2000 • 1,372 citations

Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo

2001 • 1,202 citations

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

1994 • 1,123 citations

Lack of Pericytes Leads to Endothelial Hyperplasia and Abnormal Vascular Morphogenesis

2001 • 1,067 citations

The platelet membrane glycoprotein IIb-IIIa complex

1988 • 1,031 citations

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

1994 • 984 citations

Endothelial cells and VEGF in vascular development

2005 • 967 citations

Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

1995 • 961 citations

A Requirement for Flk1 in Primitive and Definitive Hematopoiesis and Vasculogenesis

1997 • 938 citations

VEGF-receptor signal transduction

2003 • 846 citations

The platelet membrane glycoprotein IIb-IIIa complex

1988 • 841 citations

Progressive lineage analysis by cell sorting and culture identifies FLK1+VEcadherin+ cells at a diverging point of endothelial and hemopoietic lineages

1998 • 830 citations

The T Cell Leukemia Oncoprotein SCL/tal-1 Is Essential for Development of All Hematopoietic Lineages

1996 • 746 citations

CD45: An Emerging Role as a Protein Tyrosine Phosphatase Required for Lymphocyte Activation and Development

1994 • 733 citations

Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.

1995 • 582 citations

PDGFRβ+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival

2005 • 538 citations

Flk-1 expression defines a population of early embryonic hematopoietic precursors

1990 • 363 citations

Paracrine PDGF-B/PDGF-Rβ signaling controls mesangial cell development in kidney glomeruli

1998 • 359 citations

Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo

2002 • 356 citations

The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse.

1996 • 343 citations

CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo

2003 • 326 citations

Critical Role of the TIE2 Endothelial Cell Receptor in the Development of Definitive Hematopoiesis

1998 • 314 citations

Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation.

1988 • 288 citations

A transitional stage in the commitment of mesoderm to hematopoiesis requiring the transcription factor SCL/tal-1

2000 • 247 citations

Transcription Profiling of Platelet-Derived Growth Factor-B-Deficient Mouse Embryos Identifies RGS5 as a Novel Marker for Pericytes and Vascular Smooth Muscle Cells

2003 • 230 citations

Expressions ofPDGF receptor alpha, c‐KitandFlk1genes clustering in mouse chromosome 5 define distinct subsets of nascent mesodermal cells

1997 • 224 citations

Pericyte‐specific expression ofRgs5:implications for PDGF and EDG receptor signaling during vascular maturation

2003 • 197 citations

Evidence for Distinct Signaling Properties and Biological Responses Induced by the PDGF Receptor α and β Subtypes

1999 • 197 citations

Spatial and temporal emergence of high proliferative potential hematopoietic precursors during murine embryogenesis

2001 • 184 citations

Novel PDGF family members: PDGF-C and PDGF-D

2003 • 184 citations

Angiogenesis during human extraembryonic development involves the spatiotemporal control of PDGF ligand and receptor gene expression

1991 • 164 citations

PECAM-1: Its Expression and Function as a Cell Adhesion Molecule on Hemopoietic and Endothelial Cells

1995 • 152 citations

The Hemangioblast: A Common Progenitor of Hematopoietic and Endothelial Cells

2002 • 124 citations

Functions of the major tyrosine phosphorylation site of the PDGF receptor beta subunit.

1991 • 96 citations

Platelet-derived growth factor: A key regulator of connective tissue cells in embryogenesis and pathogenesis

1997 • 95 citations

Ligand-induced dimerization of growth factor receptors: Variations on the theme

1996 • 92 citations

Role of KIT and platelet-derived growth factor receptors as oncoproteins

2004 • 87 citations

Cell Fate Decisions in Early Blood Vessel Formation

2003 • 83 citations

Deregulation of Flk-1/vascular endothelial growth factor receptor-2 in fibroblast growth factor receptor-1-deficient vascular stem cell development

2004 • 61 citations

Heparin Amplifies Platelet-derived Growth Factor (PDGF)- BB-induced PDGF α-Receptor but Not PDGF β-Receptor Tyrosine Phosphorylation in Heparan Sulfate-deficient Cells

2002 • 59 citations

Platelet lntegrins

1995 • 51 citations

Paracrine PDGF-B/PDGF-Rβ signaling controls mesangial cell development in kidney glomeruli

1998 • 42 citations

Hematopoietic Commitment during Embryogenesis

1999 • 41 citations

Fibroblast Growth Factor Receptor-1 Expression Is Required for Hematopoietic but not Endothelial Cell Development

2005 • 37 citations

A Gain of Function Mutation in the Activation Loop of Plateletderived Growth Factor β-Receptor Deregulates Its Kinase Activity

2004 • 29 citations

Shb promotes blood vessel formation in embryoid bodies by augmenting vascular endothelial growth factor receptor-2 and platelet-derived growth factor receptor-β signaling

2005 • 22 citations