Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class.

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells

1996 • 3,649 citations

Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative.

1996 • 1,080 citations

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

1999 • 914 citations

Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops.

1992 • 689 citations

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

1999 • 584 citations

Interaction of c-Abl and p73α and their collaboration to induce apoptosis

1999 • 542 citations

CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated.

1996 • 404 citations

Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop

1995 • 298 citations

Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus.

1998 • 290 citations

Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor alpha receptor expression in human malignant gliomas.

1996 • 228 citations

Treatment of pediatric low-grade gliomas with a nitrosourea-based multiagent chemotherapy regimen.

1997 • 199 citations

A tiger behind many doors: multiple genetic pathways to malignant glioma

1995 • 187 citations

Differential expression of platelet-derived growth factor receptors in human malignant glioma cell lines.

1991 • 181 citations

Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance.

1990 • 177 citations

Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells.

1993 • 155 citations

Clinical efficacy and safety of an ABL specific tyrosine kinase inhibitor as targeted therapy for chronic myelogenous leukemia

1999 • 123 citations

Inhibition of glioma cell growth by a truncated platelet-derived growth factor-beta receptor.

1994 • 116 citations

Activated platelet‐derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line

1994 • 105 citations

Detection of activated platelet-derived growth factor receptors in human meningioma.

1997 • 65 citations

Reversion of autocrine transformation by a dominant negative platelet-derived growth factor mutant.

1993 • 52 citations

Platelet-derived growth factor-B/v-sis confers a tumorigenic and metastatic phenotype to human T98G glioblastoma cells.

1996 • 45 citations

Is PDGF really important? Testing the hypotheses

1991 • 41 citations

Structure of Platelet-Derived Growth Factor: Implications for Functional Properties

1993 • 38 citations

Combination of 6-Thioguanine, Procarbazine, Lomustine, and Hydroxyurea for Patients with Recurrent Malignant Gliomas

1996 • 30 citations

Receptors for platelet derived growth factor in human glioma cell lines and influence of suramin on cell proliferation

1991 • 21 citations