Delivery of molecular and cellular medicine to solid tumors

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

1995 • 3,139 citations

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

1995 • 1,682 citations

Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation

1997 • 1,590 citations

Determinants of tumor blood flow: a review.

1988 • 1,362 citations

Transport of molecules in the tumor interstitium: a review.

1987 • 1,360 citations

Barriers to Drug Delivery in Solid Tumors

1994 • 1,064 citations

Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.

1994 • 904 citations

Transport of molecules across tumor vasculature

1987 • 856 citations

Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection

1989 • 836 citations

Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.

1990 • 742 citations

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

1996 • 718 citations

Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure.

1988 • 703 citations

Microvascular permeability of normal and neoplastic tissues

1986 • 601 citations

Delivery of Novel Therapeutic Agents in Tumors: Physiological Barriers and Strategies

1989 • 571 citations

Physiologically Based Pharmacokinetic Modeling: Principles and Applications

1983 • 560 citations

Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions.

1991 • 505 citations

Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse.

1992 • 501 citations

Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows.

1994 • 463 citations

During angiogenesis, vascular endothelial growth factor regulate natural killer cell adhesion to tumor endothelium

1996 • 449 citations

Neovasculature induced by vascular endothelial growth factor is fenestrated.

1997 • 441 citations

Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier.

1992 • 397 citations

Diffusion and convection in normal and neoplastic tissues.

1974 • 395 citations

Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching.

1989 • 391 citations

Animal scale-up

1973 • 389 citations

Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice.

1992 • 368 citations

Transport of fluid and macromolecules in tumors

1991 • 362 citations

Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics

1990 • 345 citations

Hindered diffusion in agarose gels: test of effective medium model

1996 • 320 citations

Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy.

1994 • 315 citations

Delivery of Molecular Medicine to Solid Tumors

1996 • 314 citations

Differential response of normal and tumor microcirculation to hyperthermia.

1984 • 308 citations

Extravascular diffusion in normal and neoplastic tissues.

1984 • 294 citations

Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.

1994 • 272 citations

Role of Tumor Vascular Architecture in Nutrient and Drug Delivery: An Invasion Percolation-Based Network Model

1996 • 271 citations

Time-dependent behavior of interstitial fluid pressure in solid tumors: implications for drug delivery.

1995 • 263 citations

Intussusceptive Microvascular Growth in a Human Colon Adenocarcinoma Xenograft: A Novel Mechanism of Tumor Angiogenesis

1996 • 258 citations

Interstitial hypertension in human breast and colorectal tumors.

1992 • 251 citations

Interstitial hypertension in head and neck tumors in patients: correlation with tumor size.

1992 • 246 citations

Modulation of the Organ Microenvironment for Treatment of Cancer Metastasis

1995 • 244 citations

Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment.

1996 • 235 citations

Tumor Blood Flow-Characterization, Modifications, and Role in Hyperthermia

1984 • 226 citations

Endothelial Adhesiveness for Blood Neutrophils Is Inhibited by Transforming Growth Factor-β

1988 • 224 citations

Scale-Invariant Behavior and Vascular Network Formation in Normal and Tumor Tissue

1995 • 222 citations

Transforming growth factor-beta inhibits E-selectin expression on human endothelial cells.

1993 • 217 citations

Interstitial hypertension in superficial metastatic melanomas in humans.

1991 • 217 citations

Tumor angiogenesis and interstitial hypertension.

1996 • 212 citations

Microvascular Permeability of Albumin, Vascular Surface Area, and Vascular Volume Measured in Human Adenocarcinoma LS174T Using Dorsal Chamber in SCID Mice

1993 • 207 citations

Diffusion and partitioning of proteins in charged agarose gels

1995 • 195 citations

Fluorescence photobleaching with spatial Fourier analysis: measurement of diffusion in light-scattering media

1993 • 190 citations

Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice.

1994 • 189 citations

Interstitial fluid pressure in breast cancer, benign breast conditions, and breast parenchyma

1994 • 186 citations

Interstitial fluid pressure in intracranial tumours in patients and in rodents

1997 • 183 citations

Effect of Transvascular Fluid Exchange on Pressure–Flow Relationship in Tumors: A Proposed Mechanism for Tumor Blood Flow Heterogeneity

1996 • 179 citations

Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response.

1991 • 178 citations

Biodistribution of monoclonal antibodies: scale-up from mouse to human using a physiologically based pharmacokinetic model.

1995 • 177 citations

Geometric resistance to blood flow in solid tumors perfused ex vivo: effects of tumor size and perfusion pressure.

1989 • 173 citations

Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions.

1997 • 168 citations

Fluid and protein fluxes across small and large pores in the microvasculature. Application of two‐pore equations

1987 • 165 citations

Interstitial pressure of subcutaneous nodules in melanoma and lymphoma patients: changes during treatment.

1993 • 164 citations

Tissue Perfusion Inhomogeneity During Early Tumor Growth in Rats<xref ref-type="fn" rid="fn2">2</xref>

1979 • 152 citations

Directin vivomeasurement of targeted binding in a human tumor xenograft

1997 • 143 citations

Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution

1991 • 139 citations

Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity.

1989 • 137 citations

Transport in lymphatic capillaries. I. Macroscopic measurements using residence time distribution theory

1996 • 137 citations

Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays.

1992 • 135 citations

Lateral diffusion of small compounds in human stratum corneum and model lipid bilayer systems

1996 • 133 citations

Interstitial fluid pressure in solid tumors following hyperthermia: possible correlation with therapeutic response.

1992 • 132 citations

Role of erythrocytes in leukocyte-endothelial interactions: mathematical model and experimental validation

1996 • 131 citations

Effect of radiation on interstitial fluid pressure and oxygenation in a human tumor xenograft.

1996 • 128 citations

Tumor necrosis factor alpha-induced leukocyte adhesion in normal and tumor vessels: effect of tumor type, transplantation site, and host strain.

1995 • 127 citations

Endothelial cell adhesiveness for human T lymphocytes is inhibited by transforming growth factor-beta 1.

1991 • 122 citations

Reduction of interstitial fluid pressure after TNF-alpha treatment of three human melanoma xenografts

1996 • 115 citations

Geometric Resistance and Microvascular Network Architecture of Human Colorectal Carcinoma

1997 • 108 citations

Nicotinamide can lower tumor interstitial fluid pressure: mechanistic and therapeutic implications.

1992 • 106 citations

Leukocyte-endothelial adhesion and angiogenesis in tumors

1996 • 105 citations

Analysis of cell flux in the parallel plate flow chamber: implications for cell capture studies

1994 • 102 citations

Dynamics of neovascularization in normal tissue

1981 • 99 citations

Selectin- and integrin-mediated T-lymphocyte rolling and arrest on TNF-alpha-activated endothelium: augmentation by erythrocytes

1995 • 95 citations

Continuous Noninvasive Monitoring of pH and Temperature in Rat Walker 256 Carcinoma During Normoglycemia and Hyperglycemia23

1984 • 94 citations

2H-nuclear magnetic resonance imaging of tumor blood flow: spatial and temporal heterogeneity in a tissue-isolated mammary adenocarcinoma.

1992 • 94 citations

Mice lacking E-selectin show normal numbers of rolling leukocytes but reduced leukocyte stable arrest on cytokine-activated microvascular endothelium.

1998 • 92 citations

A War not Won

1994 • 88 citations

Pharmacologic Modification of Tumor Blood Flow and Interstitial Fluid Pressure in a Human Tumor Xenograft: Network Analysis and Mechanistic Interpretation

1995 • 88 citations

Physiologically based kinetic model of effector cell biodistribution in mammals: implications for adoptive immunotherapy.

1996 • 86 citations

Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients

1996 • 82 citations

Flow velocity in the superficial lymphatic network of the mouse tail

1994 • 80 citations

Measurement of capillary filtration coefficient in a solid tumor.

1991 • 80 citations

Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies.

1991 • 77 citations

Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft.

1993 • 75 citations

Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline

1994 • 73 citations

Preferential Localization of Human Adherent Lymphokine-Activated Killer Cells in Tumor Microcirculation

1991 • 71 citations

Extracellular water measurements: organ tracer kinetics of bromide and sucrose in rats and man

1978 • 71 citations

Imaging of activated natural killer cells in mice by positron emission tomography: preferential uptake in tumors.

1993 • 70 citations

Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data.

1992 • 70 citations

Invited review: Response of tumours to hyperglycaemia: characterization, significance and role in hyperthermia

1988 • 67 citations

Blood flow and venous pH of tissue-isolated Walker 256 carcinoma during hyperglycemia.

1988 • 67 citations

Perfusion of Single Tumor Microvessels: Application to Vascular Permeability Measurement

1996 • 66 citations

Quantification of transport and binding parameters using fluorescence recovery after photobleaching. Potential for in vivo applications

1990 • 62 citations

Lack of General Correlation between Interstitial Fluid Pressure and Oxygen Partial Pressure in Solid Tumors

1995 • 62 citations

Suppression of tumor growth in vivo by local and systemic 90K level increase.

1995 • 62 citations

Interleukin 2 induced leukocyte adhesion to the normal and tumor microvascular endothelium in vivo and its inhibition by dextran sulfate: implications for vascular leak syndrome.

1991 • 62 citations

Effect of angiotensin II induced hypertension on tumor blood flow and interstitial fluid pressure.

1993 • 58 citations

Rolling in P-selectin-deficient mice is reduced but not eliminated in the dorsal skin

1995 • 58 citations

Role of oxygen vs. glucose in energy metabolism in a mammary carcinoma perfused ex vivo: direct measurement by 31P NMR.

1993 • 54 citations

Angiogenesis and growth of isografted bone: quantitative in vivo assay in nude mice.

1994 • 54 citations

Photodynamic therapy-induced alterations in interstitial fluid pressure, volume and water content of an amelanotic melanoma in the hamster

1994 • 52 citations

Effect of red blood cell rigidity on tumor blood flow: increase in viscous resistance during hyperglycemia.

1991 • 51 citations

Low deformability of lymphokine-activated killer cells as a possible determinant of in vivo distribution.

1989 • 48 citations

Spatial heterogeneity in tumor perfusion measured with functional computed tomography at 0.05 microliter resolution.

1994 • 47 citations

A method for labeling cells for positron emission tomography (PET) studies

1994 • 47 citations

Suppressive effect of basic fibroblast growth factor on transendothelial emigration of CD4(+) T-lymphocyte.

1994 • 46 citations

Microcirculatory flow changes during tissue growth

1983 • 46 citations

Measurement of mass transport and reaction parameters in bulk solution using photobleaching. Reaction limited binding regime

1991 • 44 citations

Potential and limitations of radioimmunodetection and radioimmunotherapy with monoclonal antibodies.

1997 • 44 citations

Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: comparison with experimental data

1996 • 43 citations

Tumor pretargeting for radioimmunodetection and radioimmunotherapy.

1998 • 42 citations

Interaction of Activated Natural Killer Cells with Normal and Tumor Vessels in Cranial Windows in Mice

1995 • 39 citations

Effect of hyperthermia on microvascular permeability to macromolecules in normal and tumor tissues.

1985 • 39 citations

Fluorescence Ratio Imaging Measurement of pH Gradients: Calibration and Application in Normal and Tumor Tissues

1993 • 38 citations

Residence Time Distributions of various Tracers in Tumors: Implications for Drug Delivery and Blood Flow Measurement

1994 • 38 citations

Tissue-Isolated Human Tumor Xenografts in Athymic Nude Mice

1994 • 38 citations

Transport Phenomena in Tumors

1994 • 37 citations

Oxygenation in tumors by modified hemoglobins

1996 • 36 citations

Pharmacokinetics of methotrexate in solid tumors

1979 • 35 citations

Effect of glucose and galactose on red blood cell membrane deformability.

1987 • 33 citations

Transient Temperature Distributions in an Infinite, Perfused Medium due to a Time-Dependent, Spherical Heat Source

1979 • 32 citations

Mice Lacking E‐Selection Show Normal Numbers of Rolling Leukocytes but Reduced Leukocyte Stable Arrest on Cytokine‐Activated Microvascular Endothelium

1998 • 29 citations

Intratumor pharmacokinetics, flow resistance, and metabolism during gemcitabine infusion in ex vivo perfused human small cell lung cancer.

1996 • 29 citations

Effect of Hemodilution and Resuscitation on Tumor Interstitial Fluid Pressure, Blood Flow, and Oxygenation

1994 • 26 citations

Effect of Inhomogeneities and Finite Boundaries on Temperature Distributions in a Perfused Medium, With Application to Tumors

1978 • 23 citations

In vitro measurement and screening of monoclonal antibody affinity using fluoroscence photobleaching

1992 • 23 citations

Kinetics of interleukin-2 induced changes in rigidity of human natural killer cells

1992 • 22 citations

Kinetics of adhesion molecule expression and spatial organization using targeted sampling fluorometry.

1995 • 21 citations

Reduction of rigidity in human activated natural killer cells by thioglycollate treatment

1994 • 21 citations

Leukocyte rolling increases with age [letter]

1995 • 17 citations

Effect of tumor necrosis factor alpha on vascular resistance, nitric oxide production, and glucose and oxygen consumption in perfused tissue-isolated human melanoma xenografts.

1997 • 15 citations

Transport in Lymphatic Capillaries: II. Microscopic Velocity Measurement with Fluorescence Recovery After Photobleaching

1996 • 15 citations

Adhesion of activated natural killer cells to tumor necrosis factor-alpha-treated endothelium under physiological flow conditions.

1996 • 14 citations

Are Hospitals Heading for Intensive Care?

1994 • 10 citations