New Members of the Platelet-Derived Growth Factor Family of Mitogens

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor

1999 • 2,386 citations

Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice

1997 • 2,136 citations

Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

1994 • 1,211 citations

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

1994 • 1,123 citations

Inhibition of Neointimal Smooth Muscle Accumulation After Angioplasty by an Antibody to PDGF

1991 • 1,081 citations

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

1994 • 984 citations

PDGF-A Signaling Is a Critical Event in Lung Alveolar Myofibroblast Development and Alveogenesis

1996 • 867 citations

The PDGFα receptor is required for neural crest cell development and for normal patterning of the somites

1997 • 706 citations

Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops.

1992 • 689 citations

PDGF-C is a new protease-activated ligand for the PDGF α-receptor

2000 • 612 citations

PDGF-D is a specific, protease-activated ligand for the PDGF β-receptor

2001 • 542 citations

Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney.

1993 • 525 citations

Deregulation of the platelet-derived growth factor β-chain gene via fusion with collagen gene COL1A1 in dermatof ibrosarcoma protuberans and giant-cell fibroblastoma

1997 • 518 citations

Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors.

2001 • 444 citations

Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development

1997 • 420 citations

PDGF-D, a new protease-activated growth factor

2001 • 389 citations

Platelet-derived growth factor BB for the treatment of chronic pressure ulcers

1992 • 389 citations

Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor.

1992 • 345 citations

Effects of platelet-derived growth factor and transforming growth factor-beta 1 on the synthesis of a large versican-like chondroitin sulfate proteoglycan by arterial smooth muscle cells.

1991 • 331 citations

Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class.

2000 • 312 citations

Abnormal gastrointestinal development in PDGF-A and PDGFR-α deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis

2000 • 300 citations

Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts

1989 • 298 citations

The TEL/platelet-derived growth factor β receptor (PDGFβR) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGFβR kinase-dependent signaling pathways

1996 • 285 citations

The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB.

1999 • 284 citations

Platelet-derived Growth Factor C (PDGF-C), a Novel Growth Factor That Binds to PDGF α and β Receptor

2001 • 278 citations

Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis.

2001 • 276 citations

Infusion of platelet-derived growth factor or basic fibroblast growth factor induces selective glomerular mesangial cell proliferation and matrix accumulation in rats.

1993 • 254 citations

Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB.

1993 • 238 citations

Tumorigenic conversion of immortal human keratinocytes through stromal cell activation

1998 • 236 citations

Novel Approach to Specific Growth Factor Inhibition in Vivo

1999 • 233 citations

Crystal structure of human platelet-derived growth factor BB.

1992 • 232 citations

Platelet-derived growth factor-BB induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis.

1996 • 224 citations

A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFRbeta oncoprotein

1997 • 220 citations

Human breast carcinoma desmoplasia is PDGF initiated

2000 • 214 citations

Involvement of platelet-derived growth factor in disease: development of specific antagonists

2001 • 210 citations

Induction of fibronectin gene transcription and mRNA is a primary response to growth-factor stimulation of AKR-2B cells.

1988 • 193 citations

PDGF-Receptor Tyrosine Kinase Blocker AG1295 Selectively Attenuates Smooth Muscle Cell Growth In Vitro and Reduces Neointimal Formation After Balloon Angioplasty in Swine

1998 • 171 citations

Antisense Oligonucleotide Inhibition of PDGFR-β Receptor Subunit Expression Directs Suppression of Intimal Thickening

1997 • 152 citations

Specific Inhibitors of Platelet-Derived Growth Factor or Epidermal Growth Factor Receptor Tyrosine Kinase Reduce Pulmonary Fibrosis in Rats

1999 • 144 citations

A novel physiological function for platelet‐derived growth factor‐BB in rat dermis.

1996 • 135 citations

Emphysematous Lesions, Inflammation, and Fibrosis in the Lungs of Transgenic Mice Overexpressing Platelet-Derived Growth Factor

1999 • 132 citations

PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors

2001 • 128 citations

Effect of platelet-derived growth factor on DNA and protein synthesis in cultured rat calvaria

1981 • 127 citations

PDGF signal transduction inhibition ameliorates experimental mesangial proliferative glomerulonephritis

2001 • 120 citations

Chimaeric analysis reveals role of Pdgf receptors in all muscle lineages

1998 • 117 citations

Growth-inhibitory effect of STI571 on cells transformed by theCOL1A1/PDGFB rearrangement

2001 • 116 citations

The mouse Pdgfc gene: dynamic expression in embryonic tissues during organogenesis

2000 • 114 citations

Transforming activity of the chimeric sequence formed by the fusion of collagen gene COL1A1 and the platelet derived growth factor b-chain gene in dermatofibrosarcoma protuberans

1998 • 114 citations

Preclinical promise of becaplermin (rhPDGF-BB) in wound healing

1998 • 95 citations

Expression of platelet-derived growth factor and its receptors in proliferative disorders of fibroblastic origin.

1992 • 94 citations

Restenosis Following Angioplasty in the Swine Coronary Artery Is Inhibited By an Orally Active PDGF-Receptor Tyrosine Kinase Inhibitor, RPR101511A

1999 • 87 citations

Intimal Hyperplasia Recurs After Removal of PDGF-AB and -BB Inhibition in the Rat Carotid Artery Injury Model

2000 • 83 citations

The Role of Alpha and Beta Platelet-Derived Growth Factor Receptor in the Vascular Response to Injury in Nonhuman Primates

1999 • 80 citations

Platelet-derived growth factor causes pulmonary cell proliferation and collagen deposition in vivo.

1996 • 74 citations

Selective tyrosine kinase inhibitor for the platelet-derived growth factor receptor in vitro inhibits smooth muscle cell proliferation after reinjury of arterial intima in vivo.

1999 • 72 citations

Increased mitogenicity of an αβ heterodimeric PDGF receptor complex correlates with lack of RasGAP binding

1999 • 67 citations

Weekly Dosing With the Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitor SU9518 Significantly Inhibits Arterial Stenosis

2001 • 54 citations

Role of Platelet-derived Growth Factor in Obliterative Bronchiolitis (Chronic Rejection) in the Rat

1999 • 52 citations

Targeting endogenous platelet-derived growth factor B-chain by adenovirus-mediated gene transfer potently inhibits in vivo smooth muscle proliferation after arterial injury

1999 • 51 citations

Chimera Analysis Reveals That Fibroblasts and Endothelial Cells Require Platelet-Derived Growth Factor Receptorβ Expression for Participation in Reactive Connective Tissue Formation in Adults but Not during Development

1999 • 44 citations

Platelet-derived growth factor is involved in the augmentation of airway responsiveness through remodeling of airways in diesel exhaust particulate–treated mice

2001 • 43 citations

Characterization of the chronic myelomonocytic leukemia associated TEL-PDGFβR fusion protein

1999 • 37 citations

In Vivo Gene Transfer of an Extracellular Domain of Platelet-Derived Growth Factor β Receptor by the HVJ-Liposome Method Ameliorates Bleomycin-Induced Pulmonary Fibrosis

1999 • 33 citations

Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract

2000 • 26 citations

Beneficial Effects of a Novel Inhibitor of Platelet-Derived Growth Factor Receptor Autophosphorylation in the Rat with Mesangial Proliferative Glomerulonephritis

1998 • 23 citations

Molecular Cloning of SCDGF-B, a Novel Growth Factor Homologous to SCDGF/PDGF-C/fallotein

2001 • 15 citations