The Role of Oxidative Processes and Metal Ions in Aging and Alzheimer’s Disease

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

Oxidative mechanisms in the toxicity of metal ions

1995 • 4,127 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Protein Oxidation and Aging

1992 • 2,687 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

1988 • 1,806 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Rapid induction of Alzheimer A beta amyloid formation by zinc

1994 • 1,483 citations

Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster

1994 • 1,461 citations

Aging, energy, and oxidative stress in neurodegenerative diseases

1995 • 1,453 citations

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

1993 • 1,329 citations

Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins

1994 • 1,311 citations

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 • 1,290 citations

Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?

1992 • 1,268 citations

Cytochrome oxidase: an endogenous metabolic marker for neuronal activity

1989 • 1,231 citations

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

1994 • 1,085 citations

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

1993 • 1,035 citations

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1994 • 1,020 citations

The biochemistry of programmed cell death

1995 • 997 citations

The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy

1995 • 976 citations

Lipid peroxidation damage to cell components.

1973 • 925 citations

Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum.

1993 • 901 citations

The physiological role of zinc as an antioxidant

1990 • 887 citations

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

1992 • 878 citations

Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons

1987 • 852 citations

Oxygen free radicals and metallothionein

1993 • 848 citations

Brain Aluminum Distribution in Alzheimer's Disease and Experimental Neurofibrillary Degeneration

1973 • 843 citations

Dose‐dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli

1991 • 816 citations

Advanced glycation end products contribute to amyloidosis in Alzheimer disease.

1994 • 791 citations

Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation

1995 • 784 citations

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1990 • 784 citations

Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain

1993 • 759 citations

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

1994 • 749 citations

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

1995 • 741 citations

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1991 • 734 citations

Intramuscular desferrioxamine in patients with Alzheimer's disease

1991 • 723 citations

DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING

1989 • 722 citations

Aging and resistance to oxidative damage in Caenorhabditis elegans.

1993 • 720 citations

Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

1994 • 712 citations

Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency

1995 • 711 citations

Altered Brain Metabolism of Iron as a Cause of Neurodegenerative Diseases?

1994 • 701 citations

The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein

1991 • 689 citations

Reduction of β‐amyloid peptide₄₂ in the cerebrospinal fluid of patients with Alzheimer's disease

1995 • 684 citations

REGIONAL CEREBRAL OXYGEN SUPPLY AND UTILIZATION IN DEMENTIA: A CLINICAL AND PHYSIOLOGICAL STUDY WITH OXYGEN-15 AND POSITRON TOMOGRAPHY A CLINICAL AND PHYSIOLOGICAL STUDY WITH OXYGEN - 15 AND POSITRON TOMOHRAPHY

1981 • 681 citations

The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)

1996 • 657 citations

Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease

1989 • 651 citations

Apolipoprotein E in animal models of CNS injury and in alzheimer's disease

1994 • 651 citations

Regulators of cell death

1995 • 647 citations

Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease

1995 • 641 citations

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.

1992 • 633 citations

Cytochrome oxidase deficiency in Alzheimer's disease

1990 • 581 citations

Positron emission tomography in Alzheimer's disease

1986 • 563 citations

Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress.

1994 • 558 citations

MT-III, a brain-specific member of the metallothionein gene family.

1992 • 558 citations

Brain Cytochrome Oxidase in Alzheimer's Disease

1992 • 526 citations

Dementia of the Alzheimer Type

1980 • 518 citations

The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1995 • 517 citations

Cortical Cytochrome Oxidase Activity Is Reduced in Alzheimer's Disease

1994 • 502 citations

Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species

1993 • 484 citations

Electron transport chain defects in Alzheimer's disease brain

1994 • 483 citations

Apolipoprotein E, Dementia, and Cortical Deposition of β-Amyloid Protein

1995 • 481 citations

Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: A laser microprobe (LAMMA) study

1992 • 474 citations

Radical AGEing in Alzheimer's disease

1995 • 464 citations

Aluminum, Iron, and Zinc Ions Promote Aggregation of Physiological Concentrations of β‐Amyloid Peptide

1993 • 461 citations

Autopsy Samples of Alzheimer's Cortex Show Increased Peroxidation In Vitro

1990 • 456 citations

Memory‐related neural systems in Alzheimer's disease

1990 • 450 citations

A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains

1992 • 450 citations

ALUMINOSILICATES AND SENILE PLAQUE FORMATION IN ALZHEIMER'S DISEASE

1986 • 449 citations

Mitochondrial DNA Variants Observed in Alzheimer Disease and Parkinson Disease Patients

1993 • 449 citations

Mitochondrial DNA and Disease

1995 • 444 citations

Natural Antioxidants in Human Health and Disease

1994 • 422 citations

Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease.

1994 • 420 citations

Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain

1992 • 416 citations

Intravesicular localization of zinc in rat telencephalic boutons. A histochemical study

1985 • 410 citations

β-Amyloid Peptide Free Radical Fragments Initiate Synaptosomal Lipoperoxidation in a Sequence-Specific Fashion: Implications to Alzheimer′s Disease

1994 • 406 citations

Clinical and pathological correlates of apolipoprotein E ε4 in Alzheimer's disease

1996 • 384 citations

A potential role for apoptosis in neurodegeneration and Alzheimer's disease

1995 • 382 citations

Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative.

1994 • 373 citations

Amyloid peptides are toxic via a common oxidative mechanism.

1995 • 372 citations

BCL2 translocation frequency rises with age in humans.

1994 • 372 citations

Regional distribution of iron and iron‐regulatory proteins in the brain in aging and Alzheimer's disease

1992 • 367 citations

Bioenergetic and oxidative stress in neurodegenerative diseases

1995 • 365 citations

Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease.

1992 • 362 citations

Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain

1983 • 355 citations

Alzheimer disease: depiction of increased cerebral myo-inositol with proton MR spectroscopy.

1993 • 354 citations

Expression of heme oxygenase‐1 in the senescent and alzheimer‐diseased brain

1995 • 352 citations

Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments.

1995 • 347 citations

RETRACTED: Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease

1997 • 345 citations

Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation.

1992 • 344 citations

Direct evidence of oxidative injury produced by the Alzheimer's β-Amyloid peptide (1–40) in cultured hippocampal neurons

1995 • 333 citations

Transferrin and Iron in Normal, Alzheimer's Disease, and Parkinson's Disease Brain Regions

1995 • 333 citations

Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: Effect of ageing

1992 • 329 citations

Modulation of A beta adhesiveness and secretase site cleavage by zinc.

1994 • 327 citations

Decline with age of the respiratory chain activity in human skeletal muscle

1994 • 325 citations

Hypoxemia Is Associated With Mitochondrial DNA Damage and Gene Induction

1991 • 325 citations

Liver mitochondrial respiratory functions decline with age

1989 • 322 citations

Functions of trace elements in brain metabolism.

1987 • 297 citations

Hydrogen peroxide release by mitochondria increases during aging

1991 • 292 citations

Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons.

1994 • 291 citations

A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease

1993 • 289 citations

Zinc deficiency causes oxidative damage to proteins, lipids and DNA in rat testes.

1995 • 282 citations

Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: An age-related alteration

1990 • 276 citations

Cellular reducing equivalents and oxidative stress

1994 • 275 citations

Neocortical Metabolic Abnormalities Precede Nonmemory Cognitive Defects in Early Alzheimer's-Type Dementia

1986 • 274 citations

Mitochondrial oxidative damage, hydrogen peroxide release, and aging

1994 • 273 citations

Hypothesis

1985 • 272 citations

Glutamate as a Neurotransmitter

2018 • 271 citations

ALZHEIMERʼS DISEASE

1953 • 267 citations

Age‐Dependent Impairment of Mitochondrial Function in Primate Brain

1993 • 265 citations

Apolipoprotein E genotyping in the differential diagnosis, not prediction, of Alzheimer's disease

1995 • 253 citations

Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing

1994 • 253 citations

Lipid Peroxidation and Free Radical Scavengers in Alzheimer’s Disease

1989 • 250 citations

Ageing-associated 5 kb deletion in human liver mitochondrial DNA

1991 • 247 citations

Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia

1990 • 243 citations

Diffuse prolonged depression of cerebral oxidative metabolism following concussive brain injury in the rat: a cytochrome oxidase histochemistry study

1991 • 241 citations

An autosomal locus predisposing to deletions of mitochondrial DNA

1995 • 240 citations

Ultrastructural Studies of the Cells Forming Amyloid Fibers in Classical Plaques

1989 • 238 citations

Sequence analysis of cDNAs for the human and bovine ATP synthase ? subunit: mitochondrial DNA genes sustain seventeen times more mutations

1987 • 237 citations

Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR

1992 • 237 citations

Reactive oxygen and DNA damage in mitochondria

1992 • 234 citations

Superoxide dismutase, aging, and degenerative disease

1994 • 234 citations

Risk for neuropathologically confirmed Alzheimer's disease and residual aluminum in municipal drinking water employing weighted residential histories

1996 • 233 citations

Altered cerebral energy metabolism in Alzheimer's disease: a PET study.

1994 • 229 citations

Increased Cerebral Glucose‐6‐Phosphate Dehydrogenase Activity in Alzheimer's Disease May Reflect Oxidative Stress

1986 • 226 citations

Mitochondrial DNA mutations in human degenerative diseases and aging

1995 • 224 citations

Carbonyl‐Related Posttranslational Modification of Neurofilament Protein in the Neurofibrillary Pathology of Alzheimer's Disease

1995 • 224 citations

Glucose metabolism as the site of the primary abnormality in early-onset dementia of Alzheimer type?

1988 • 223 citations

Amyloid β peptide induces necrosis rather than apoptosis

1994 • 221 citations

Natural antioxidants in human health and disease

1995 • 218 citations

Evidence that Glyceraldehyde‐3‐Phosphate Dehydrogenase Is Involved in Age‐Induced Apoptosis in Mature Cerebellar Neurons in Culture

1996 • 215 citations

Multiple mitochondrial DNA deletions in an elderly human individual

1992 • 214 citations

Deleterious mitochondrial DNA mutations accumulate in aging human tissues

1992 • 212 citations

Theories of biological aging

1985 • 212 citations

Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease

1994 • 203 citations

Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm

1991 • 203 citations

Cellular management of iron in the brain

1995 • 202 citations

Plasma Concentrations of Vitamins A and E and Carotenoids in Alzheimer's Disease

1992 • 201 citations

Basic FGF, NGF, and IGFs Protect Hippocampal and Cortical Neurons against Iron-Induced Degeneration

1993 • 199 citations

Mitochondrial DNA copy number and mitochondrial DNA deletion in adult and senescent rats

1992 • 196 citations

Evidence of an oxidative challenge in the Alzheimer's brain

1994 • 194 citations

Brain trace elements in Alzheimer's disease.

1986 • 194 citations

Superoxide dismutase activity in Alzheimer's disease: possible mechanism for paired helical filament formation

1989 • 193 citations

Involvement of free radicals in dementia of the Alzheimer type: A hypothesis

1990 • 191 citations

Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease.

1992 • 191 citations

A mitochondrial DNA clone is associated with increased risk for Alzheimer disease.

1995 • 188 citations

[54] In Vivo Oxidative DNA damage: Measurement of 8-Hydroxy-2′-deoxyguanosine in DNA and urine by high-performance liquid chromatography with electrochemical detection

1990 • 186 citations

Alzheimer’s and Parkinson’s disease

1991 • 186 citations

Trace element imbalances in isolated subcellular fractions of Alzheimer's disease brains

1990 • 186 citations

Mitochondrial function in brain tissue in primary degenerative dementia

1987 • 177 citations

ELECTRON MICROSCOPIC DEMONSTRATION OF ZINC IN THE HIPPOCAMPAL FORMATION USING TIMM'S SULFIDE-SILVER TECHNIQUE

1969 • 177 citations

Evolution of Protein Metabolism in Mammals

1969 • 175 citations

Brain α‐Ketoglutarate Dehydrotenase Complex Activity in Alzheimer's Disease

1993 • 174 citations

Multiple mitochondrial DNA deletions exist in cardiomyocytes of patients with hypertrophic or dilated cardiomyopathy

1990 • 174 citations

Increased Immunoreactivity for Jun- and Fos-Related Proteins in Alzheimer's Disease: Association with Pathology

1994 • 173 citations

TRACE ELEMENT CONCENTRATION IN HUMAN BRAIN

1975 • 172 citations

Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF)

1994 • 170 citations

Decreased Catalase Activity but Unchanged Superoxide Dismutase Activity in Brains of Patients with Dementia of Alzheimer Type

1995 • 168 citations

Selective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer's disease

1994 • 166 citations

Short‐term dichloroacetate treatment improves indices of cerebral metabolism in patients with mitochondrial disorders

1995 • 165 citations

Mitochondrial DNA alterations as ageing-associated molecular events

1992 • 163 citations

Bioactivity of Metallothionein-3 Correlates with Its Novel .beta. Domain Sequence Rather Than Metal Binding Properties

1995 • 163 citations

Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease

1990 • 160 citations

In vivo ³¹ P NMR profiles of Alzheimer's disease and multiple subcortical infarct dementia

1989 • 156 citations

Amyloidogenicity of rodent and human βA4 sequences

1993 • 155 citations

Localization of superoxide dismutases in Alzheimer's disease and Down's syndrome neocortex and hippocampus.

1995 • 150 citations

d-Cycloserine enhances implicit memory in Alzheimer patients

1996 • 150 citations

Ferritin immunohistochemistry as a marker for microglia

1989 • 148 citations

Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease

1995 • 146 citations

Aging, cytochrome oxidase activity, and hydrogen peroxide release by mitochondria

1993 • 138 citations

Mitochondrial production of pro-oxidants and cellular senescence

1992 • 137 citations

An update on the mitochondrial-DNA mutation hypothesis of cell aging

1992 • 135 citations

Damage to dopamine systems differs between parkinson's disease and alzheimer's disease with parkinsonism

1995 • 134 citations

Ultrastructural analysis of β-amyloid-induced apoptosis in cultured hippocampal neurons

1994 • 133 citations

E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures.

1996 • 132 citations

GAMMA-AMINOBUTYRIC ACID CONCENTRATION IN BRAIN TISSUE AT TWO STAGES OF ALZHEIMER'S DISEASE

1988 • 130 citations

The Biology of Aging

1971 • 130 citations

Immunologic theory of aging: current status.

1974 • 129 citations

A POSSIBLE ROLE OF ZINC IN THE PATHOLOGY OF DEMENTIA

1981 • 129 citations

Mitochondrial DNA mutation and the ageing process: bioenergy and pharmacological intervention

1992 • 128 citations

Peripheral antioxidant enzyme activities and selenium in elderly subjects and in dementia of Alzheimer's type—Place of the extracellular glutathione peroxidase

1996 • 127 citations

Familial and sporadic Alzheimer's disease

1996 • 125 citations

Protein Oxidation in Aging Braina

1992 • 123 citations

Fiber systems in the olfactory bulb and cortex: A study in adult and developing rats, Using the Timm method with the light and electron microscope

1984 • 122 citations

Laser microprobe analysis of brain aluminum in Alzheimer' disease

1993 • 121 citations

Cerebrospinal fluid trace element content in dementia

1983 • 120 citations

Amino acids, glutathione, and glutathione transferase activity in the brains of patients with Alzheimer's disease

1987 • 119 citations

Iron and aluminium in relation to brain ferritin in normal individuals and Alzheimer's-disease and chronic renal-dialysis patients

1992 • 117 citations

Methylmercury Induces Apoptosis of Rat Cerebellar Neurons in Primary Culture

1994 • 115 citations

Brain Protein Kinase PK40erk Converts TAU into a PHF-like Form as Found in Alzheimer′s Disease

1993 • 113 citations

[25] Role of oxidized amino acids in protein breakdown and stability

1995 • 110 citations

Superoxide dismutase isoenzymes in normal brains and in brains from patients with dementia of Alzheimer type

1985 • 110 citations

Quantitative analysis of age-associated accumulation of mitochondrial DNA with deletion in human hearts

1991 • 110 citations

The Spin-Trap N-tert-α-Phenylbutylnitrone Prolongs the Life Span of the Senescence-Accelerated Mouse

1995 • 110 citations

Merritt's Textbook of Neurology

1990 • 108 citations

Retinoic acid induced differentiated neuroblastoma cells show increased expression of the βA4 amyloid gene of Alzheimer's disease and an altered splicing pattern

1990 • 107 citations

Abnormality of the α‐ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease

1994 • 99 citations

Mitochondrial DNA sequence analysis of four Alzheimer's and Parkinson's disease patients

1996 • 99 citations

Human Aging is Associated with Various Point Mutations in tRNA Genes of Mitochondrial DNA

1993 • 96 citations

Ceruloplasmin levels in the human superior temporal gyrus in aging and Alzheimer's disease

1993 • 95 citations

Brain membrane fluidity and lipid peroxidation in Alzheimer's disease

1990 • 95 citations

Temporal Sequence of Plaque Formation in the Cerebral Cortex of Non-Demented Individuals

1993 • 94 citations

Regional Cerebral Blood Flow in Patients With Leuko-Araiosis and Atherosclerotic Carotid Artery Disease

1990 • 93 citations

Crosslinking of Apolipoprotein E by Products of Lipid Peroxidation

1996 • 93 citations

Aluminum and Alzheimerʼs Disease

1983 • 92 citations

No evidence for systemic oxidant stress in Parkinson's or Alzheimer's disease

1995 • 91 citations

Entorhinal cortex of the human, monkey, and rat: Metabolic map as revealed by cytochrome oxidase

1992 • 91 citations

Interaction between the zinc(II) and the heparin binding site of the Alzheimer's disease βA4 amyloid precursor protein (APP)

1994 • 89 citations

Age-dependent increase of mitochondrial DNA deletions together with lipid peroxides and superoxide dismutase in human liver mitochondria

1994 • 89 citations

Functional Alterations in Alzheimerʼs Disease

1993 • 88 citations

Transferrin receptors of rat and human brain and cerebral microvessels and their status in Alzheimer's disease

1992 • 87 citations

In vitro polymerization of oxidized tau into filaments

1993 • 84 citations

Iron Levels Modulate α‐Secretase Cleavage of Amyloid Precursor Protein

1995 • 82 citations

Food additives as a source of behavioral disturbances in children.

1986 • 81 citations

Implications of alterations in trace element levels in brain in Parkinson's disease and other neurological disorders affecting the basal ganglia.

1993 • 81 citations

Cultured GABA-immunoreactive neurons are resistant to toxicity induced by β-amyloid

1993 • 80 citations

Aspects of Aluminum Toxicity

1990 • 80 citations

Decreased adhesiveness of alzheimer's disease fibroblasts: Is amyloid β‐protein precursor involved?

1989 • 79 citations

Brain aluminum in Alzheimer's disease using an improved GFAAS method.

1992 • 77 citations

Selective MAO-A and B inhibitors, radical scavengers and nitric oxide synthase inhibitors in Parkinson's desease

1994 • 75 citations

Metal ion-induced conformational changes of phosphorylated fragments of human neurofilament (NF-M) protein

1992 • 75 citations

Cytochrome Oxidase Inhibition: A Novel Animal Model of Alzheimer's Disease

1992 • 74 citations

Mitochondria from Alzheimer's fibroblasts show decreased uptake of calcium and increased sensitivity to free radicals

1994 • 69 citations

Involvement of free oxygen radicals in β-amyloidosis: An hypothesis

1994 • 67 citations

Age-dependent accumulation of advanced glycosylation end products in human neurons

1995 • 66 citations

Lipid peroxidation and mtDNA degeneration. A hypothesis

1992 • 66 citations

Absence of aluminium in Alzheimer's disease brain tissue: Electron microprobe and ion microprobe studie

1991 • 65 citations

Free radical theory of aging: A hypothesis on pathogenesis of senile dementia of the Alzheimer’s type

1993 • 64 citations

Zinc Uptake into Synaptosomes

1988 • 64 citations

Spin Trapping of Azidyl and Hydroxyl Radicals in Azide-Inhibited Rat Brain Submitochondrial Particles

1994 • 64 citations

Copper-zinc superoxide dismutase activity in red blood cells and serum in demented patients and in aging

1993 • 63 citations

Isolation, primary structures and metal binding properties of neuronal growth inhibitory factor (GIF) from bovine and equine brain

1994 • 62 citations

Studies in Ageing of the Brain

1972 • 61 citations

Disturbances of the neuronal calcium homeostasis in the aging nervous system

1994 • 60 citations

Regional Brain Activity of Free Radical Defense Enzymes in Autopsy Samples from Patients with Alzheimer's Disease and from Nondemented Controls

1994 • 60 citations

Aluminum-induced nonenzymatic phospho-incorporation into human tau and other proteins

1993 • 60 citations

Mitochondrial function in neurodegeneration and ageing

1992 • 59 citations

Brain glutathione peroxidase in neurodegenerative disorders

1986 • 57 citations

Chronic lead poisoning

1959 • 56 citations

Mitochondrial abnormalities in cortical dendrites from patients with Alzheimer's disease.

1985 • 56 citations

Age-dependent increases of DNA adducts (I-compounds) in human and rat brain DNA

1993 • 55 citations

Gallium‐67 as a Potential Marker for Aluminium Transport in Rat Brain: Implications for Alzheimer's Disease

1990 • 52 citations

Aluminium detected in senile plaques and neurofibrillary tangles is contained in lipofuscin granules with silicon, probably as aluminosilicate

1995 • 52 citations

Mitochondrial DNA: does more lead to less?

1994 • 50 citations

Analyses of energy metabolism and mitochondrial genome in post-mortem brain from patients with Alzheimer's disease

1993 • 50 citations

Increased glutathione peroxidase activity in erythrocytes in patients with Alzheimer's disease/senile dementia of Alzheimer's type

1986 • 50 citations

Synuclein proteins and Alzheimer's disease

1994 • 47 citations

Frontal lobe phosphorus metabolism and neuropsychological function in aging and in alzheimer's disease

1995 • 46 citations

(-)Deprenyl-Medication: A Strategy To Modulate the Age-Related Decline of the Striatal Dopaminergic System

1992 • 46 citations

Response : Zinc and Alzheimer's Disease

1995 • 45 citations

Neurodegenerative diseases and risk factors: A literature review

1995 • 45 citations

Ceruloplasmin inhibits carbonyl formation in indogenous cell proteins

1993 • 44 citations

No association found between Alzheimer's disease and a mitochondrial tRNA glutamine gene variant

1995 • 44 citations

Role of protein oxidation in aging and in age-associated neurodegenerative diseases

1994 • 44 citations

Prevalence of dementia in adult patients with trisomy 21

2005 • 44 citations

L-Deprenyl Therapy Improves Verbal Memory in Amnesic Alzheimer Patients

1991 • 44 citations

Mitochondrial free Ca2+ concentration in living cells

1994 • 43 citations

Aluminum Neurotoxicity — Potential Role in the Pathogenesis of Neurofibrillary Tangle Formation

1986 • 40 citations

Energy, oxidative damage, and Alzheimer's disease: Clues to the underlying puzzle

1994 • 39 citations

Metals and the Liver in Alzheimer's Disease An Investigation of Hepatic Zinc, Copper, Cadmium, and Metallothionein

1990 • 39 citations

Histochemistry of Zinc and Copper

1984 • 38 citations

On the Possible Role of Iron‐Induced Free Radical Peroxidation in Neural Degeneration in Alzheimer's Disease^a

1992 • 36 citations

Isolation and Expression of an Arrestin cDNA from the Horseshoe Crab Lateral Eye

1995 • 35 citations

Proving the worth of neurologists?

1996 • 34 citations

No evidence for reduced thrombocyte cytochrome oxidase activity in Alzheimer's disease

1992 • 34 citations

τ Self‐Association: Stabilization with a Chemical Cross‐Linker and Modulation by Phosphorylation and Oxidation State

1995 • 33 citations

Making models for Alzheimer's disease

1995 • 32 citations

Alterations of intracellular calcium regulation during aging and Alzheimer's disease in nonneuronal cells

1994 • 31 citations

Localization of cytochrome oxidase (COX) activity and COX mRNA in the hippocampus and entorhinal cortex of the monkey brain: correlation with specific neuronal pathways

1992 • 31 citations

[Alzheimer's disease and the zinc theory].

1990 • 31 citations

Studies in Ageing of the Brain.

1973 • 30 citations

Clinically-Silent Mutation in the Putative Iron-Responsive Element in Exon 17 of the β-Amyloid Precursor Protein Gene

1992 • 30 citations

Essential Fatty Acids in Alzheimer's Diseasea

1991 • 30 citations

CBF and cognitive evaluation of Alzheimer type patients before and after IMAO-B treatment: a pilot study

1992 • 29 citations

Erythrocyte glutathione peroxidase and superoxide dismutase in Alzheimer's disease and other dementias

1986 • 28 citations

Platelet membrane fluidity and plasma malondialdehyde levels in Alzheimer's demented patients with and without family history of dementia

1994 • 26 citations

Copper-zinc superoxide dismutase activity in red blood cells in probable Alzheimer's patients and their first-degree relatives

1994 • 26 citations

Genetic basis of limited cell proliferation

1991 • 26 citations

Molecular Biology of Aging Part II: A Synopsis of Current Research

1991 • 26 citations

Age Dependent Changes in Mitochondria

1985 • 23 citations

Changes in intraneuronal lipopigment in alzheimer's disease

1992 • 22 citations

Evidence for and against the causal involvement of mitochondrial DNA mutation in mammalian ageing

1992 • 22 citations

Spinal fluid aluminum levels in patients with alzheimer disease

1979 • 20 citations

Changes in the rat liver mitochondrial DNA upon aging

1991 • 18 citations

CRC handbook of physiology in aging

1981 • 17 citations

Mammalian protein metabolism. Volume 4.

1964 • 17 citations

Constellation of Risks and Processes Seen in Search for Alzheimer's Clues

1994 • 16 citations

Amyloid Protein Precursor in Development, Aging and Alzheimer’s Disease

1994 • 16 citations

Microanalysis of Senile Plaques Using Nuclear Microscopy

1993 • 16 citations

Ultrastructural localization of heme oxygenase-1 to the neurofibrillary pathology of Alzheimer disease

1995 • 14 citations

Oxidants and Mitochondrial Decay in Aging

1994 • 14 citations

Isolation of a cytochrome oxidase gene overexpressed in Alzheimer's disease brain

1992 • 14 citations

Structural dynamics of the mitochondrial compartment

1992 • 13 citations

Drastic reduction of the zinc‐ and magnesium‐stimulated protein tyrosine kinase activities in Alzheimer's disease hippocampus

1993 • 13 citations

[Chronic lead poisoning (author's transl)].

1974 • 12 citations

Zinc and Alzheimer's Disease

1995 • 11 citations

Alterations in trace elements during brain aging and in Alzheimer's dementia.

1993 • 10 citations

Glutathione peroxidase in human cerebrospinal fluid

1982 • 9 citations

Neurochemical aspects of aging in primates

1993 • 8 citations

Amyloidogenesis in Alzheimer's disease

1993 • 8 citations

Behavioral interactions in cocaine-treated rats

1979 • 6 citations

Re: design

1995 • 5 citations

Technical Aspects of Quantification of Aluminum

1990 • 5 citations

Recent trends in analytical approaches for trace element determinations in biomedical investigations.

1993 • 3 citations