Cultured GABA-immunoreactive neurons are resistant to toxicity induced by β-amyloid

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

1983 • 3,028 citations

The molecular pathology of Alzheimer's disease

1991 • 2,603 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

1991 • 1,191 citations

A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

1991 • 1,121 citations

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.

1992 • 982 citations

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

1993 • 909 citations

Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa

1980 • 866 citations

In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

1991 • 833 citations

Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus ceruleus) in senile dementia

1982 • 677 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

1989 • 549 citations

Neuropeptide-containing neurons of the cerebral cortex are also GABAergic.

1984 • 537 citations

GABAergic neurons containing the Ca2+-binding protein parvalbumin in the rat hippocampus and dentate gyrus

1987 • 536 citations

Two classes of cortical GABA neurons defined by differential calcium binding protein immunoreactivities

1989 • 514 citations

Excitatory amino acids and Alzheimer's disease

1989 • 485 citations

A POST-MORTEM STUDY OF THE CHOLINERGIC AND GABA SYSTEMS IN SENILE DEMENTIA

1982 • 449 citations

Biochemical Assessment of Serotonergic and Cholinergic Dysfunction and Cerebral Atrophy in Alzheimer's Disease

1983 • 440 citations

Reduced amounts of immunoreactive somatostatin in the temporal cortex in senile dementia of Alzheimer type

1980 • 434 citations

Neurochemical characteristics of early and late onset types of Alzheimer's disease.

1984 • 411 citations

Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells.

1989 • 405 citations

Apoptosis mediated neurotoxicity induced by chronic application of β amyloid fragment 25–35

1993 • 343 citations

Aggregation-related toxicity of synthetic β-amyloid protein in hippocampal cultures

1991 • 280 citations

Cortical somatostatin-like immunoreactivity in cases of Alzheimer's disease and senile Dementia of the Alzheimer type

1981 • 274 citations

Loss of pigmented dopamine-β-hydroxylase positive cells from locus coeruleus in senile dementia of alzheimer's type

1983 • 267 citations

Effects of injected Alzheimer beta-amyloid cores in rat brain.

1991 • 255 citations

In vivo neurotoxicity of beta-amyloid [β(1–40)] and the β(25–35) fragment

1992 • 225 citations

Cortical somatostatin, neuropeptide Y, and NADPH diaphorase neurons: Normal anatomy and alterations in alzheimer's disease

1988 • 219 citations

Calretinin is present in non-pyramidal cells of the rat hippocampus—II. Co-existence with other calcium binding proteins and gaba

1992 • 215 citations

Methodological variables in the assessment of beta amyloid neurotoxicity

1992 • 208 citations

Excitatory amino acids

1991 • 194 citations

The noradrenergic system in Alzheimer and multi-infarct dementias.

1982 • 177 citations

Neuropeptides in neurological disease

1986 • 162 citations

Neuropeptide Y immunoreactivity is reduced in cerebral cortex in Alzheimer's disease

1986 • 155 citations

Region-specific loss of glutamate innervation in Alzheimer's disease

1987 • 147 citations

II. Cortical neurons immunoreactive with antisera against neuropeptide Y are altered in Alzheimer's‐type dementia

1985 • 146 citations

A postmortem study of amino acid neurotransmitters in Alzheimer's disease

1986 • 134 citations

β-Amyloid induces neuritic dystrophy in vitro

1992 • 132 citations

GAMMA-AMINOBUTYRIC ACID CONCENTRATION IN BRAIN TISSUE AT TWO STAGES OF ALZHEIMER'S DISEASE

1988 • 130 citations

CORRELATION OF CORTICAL CHOLINERGIC AND GABA DEFICITS WITH QUANTITATIVE NEUROPATHOLOGICAL FINDINGS IN SENILE DEMENTIA

1984 • 129 citations

The acute neurotoxicity and effects upon cholinergic axons of intracerebrally injected β-amyloid in the rat brain

1992 • 127 citations

A disorder of cortical GABAergic innervation in Alzheimer's disease

1987 • 113 citations

B- Amyloid increases neuronal susceptibility to injufy by glucose deprivation

1991 • 111 citations

Galanin immunoreactivity is increased in the nucleus basalis of meynert in Alzheimer's disease

1990 • 108 citations

Alzheimer's disease

1987 • 103 citations

Selective vulnerability of neurones in organic dementia

1977 • 99 citations

Intralaminar Neurochemical Distributions in Human Midtemporal Cortex: Comparison Between Alzheimer's Disease and the Normal

1984 • 91 citations

GABAergic neocortical neurons are resistant to NMDA receptor‐mediated injury

1989 • 87 citations

Somatostatin- and Neuropeptide Y-immunoreactive neurons in the neocortex in senile dementia of alzheimer's type

1986 • 78 citations

Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease

1983 • 77 citations

Decreased somatostatin immunoreactivity but not neuropeptide Y immunoreactivity in cerebral cortex in senile dementia of Alzheimer type

1986 • 76 citations

Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques

1985 • 65 citations

A preliminary study of free amino acids in the postmorten temporal cortex from Alzheimer-type dementia patients

1984 • 63 citations

Decreased somatostatin-like immunoreactivity in cerebral cortex and cerebrospinal fluid in Alzheimer's disease

1987 • 53 citations

Maintenance of peripheral dendrites of GABAergic neurons requires specific input

1991 • 52 citations

Loss of cortical GABA uptake sites in Alzheimer's disease

1988 • 46 citations