Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Principles and procedures of statistics.

1960 • 22,587 citations

A rapid radiochemical method for the determination of choline acetyltransferase

1975 • 2,406 citations

Principles and Procedures of Statistics.

1961 • 2,074 citations

Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

1981 • 1,701 citations

APRIORITY

1961 • 1,293 citations

NEUROTRANSMITTER-RELATED ENZYMES AND INDICES OF HYPOXIA IN SENILE DEMENTIA AND OTHER ABIOTROPHIES

1976 • 1,272 citations

Huntington's Chorea

1973 • 845 citations

Spectrophotometric measurements of the enzymatic formation of fumaric and cis-aconitic acids

1950 • 818 citations

HUNTINGTON'S CHOREA

1974 • 527 citations

Changes in the Brain Catecholamines in Patients with Dementia of Alzheimer Type

1979 • 445 citations

Oral penicillin in gonorrhoea.

1946 • 348 citations

Cortical somatostatin-like immunoreactivity in cases of Alzheimer's disease and senile Dementia of the Alzheimer type

1981 • 274 citations

Brain dysfunction in mild to moderate hypoxia

1981 • 252 citations

The distribution of glutamate decarboxylase and aspartate transaminase in subcellular fractions of rat and guinea-pig brain

1968 • 249 citations

Coenzyme a-acetylating enzymes in Alzheimer's disease: Possible cholinergic ‘compartment’ of pyruvate dehydrogenase

1980 • 232 citations

TOPOGRAPHICAL AND SUBCELLULAR LOCALIZATION OF CHOLINE ACETYLTRANSFERASE IN RAT HIPPOCAMPAL REGION

1970 • 191 citations

Relationship between plaques, tangles, and dementia in Down syndrome

1980 • 189 citations

Biochemistry of Dementia

1981 • 155 citations

Pyruvate Dehydrogenase Complex Activity in Normal and Deficient Fibroblasts

1981 • 148 citations

Defective activation of the pyruvate dehydrogenase complex in subacute necrotizing encephalomyelopathy (leigh disease)

1979 • 146 citations

The Aging Brain and Senile Dementia

1977 • 135 citations

Mental Function and Cerebral Oxygen Consumption in Organic Dementia

1957 • 117 citations

Glutamate dehydrogenase deficiency in three patients with spinocerebellar syndrome

1980 • 111 citations

A radiochemical method for the estimation of choline acetyltransferase

1966 • 109 citations

When words collide: Orthographic and phonological interference during word processing

1983 • 108 citations

Neurobiology and pharmacology of Huntington's disease

1977 • 96 citations

SUBCELLULAR DISTRIBUTION OF ACETYL‐CoA SYNTHETASE, ATP CITRATE LYASE, CITRATE SYNTHASE, CHOLINE ACETYLTRANSFERASE, FUMARATE HYDRATASE AND LACTATE DEHYDROGENASE IN MAMMALIAN BRAIN TISSUE

1967 • 95 citations

Acetylcholine Synthesis in Neurons

1979 • 70 citations

Brain Pyruvate Dehydrogenase: Phosphorylation and Enzyme Activity Altered by a Training Experience

1981 • 68 citations

Phosphorylation‐Mediated Changes in Pyruvate Dehydrogenase Activity Influence Pyruvate‐Supported Calcium Accumulation by Brain Mitochondria

1981 • 68 citations

Acetyl‐CoA Synthesizing Enzymes in Cholinergic Nerve Terminals

1980 • 64 citations

Evidence that a 41,000 dalton brain phosphoprotein is pyruvate dehydrogenase

1980 • 60 citations

A possible mechanism for selective cerebellar damage in partial pyruvate dehydrogenase deficiency

1976 • 59 citations

Studies on the Pyruvate Dehydrogenase Complex in Brain with the Arylamine Acetyltransferase‐Coupled Assay

1982 • 57 citations

Intermittent ataxia and immunodeficiency with multiple carboxylase deficiencies: A biotin‐responsive disorder

1980 • 55 citations

HUNTINGTON'S CHOREA: POST MORTEM ACTIVITY OF ENZYMES INVOLVED IN CEREBRAL GLUCOSE METABOLISM

1977 • 52 citations

Pyruvate dehydrogenase deficiency restricted to brain

1981 • 38 citations

Mental Symptoms in Huntington's Disease and a Possible Primary Aminergic Neuron Lesion

1980 • 35 citations

BIOCHEMISTRY AND MENTAL DISORDER

1932 • 28 citations

Identification of a Mitochondrial Phosphoprotein in Brain Synaptic Membrane Preparations

1981 • 24 citations

Decreased receptor-binding sites for kainic acid in brains of patients with Huntington's disease.

1981 • 24 citations

Spectrophotometric measurement of pyruvate dehydrogenase complex activity in cultured human fibroblasts

1981 • 23 citations

Choline acetyltransferase and acetylcholinesterase abnormalities in senile dementia: Importance of biochemical measurements in human post-mortem brain specimens

1979 • 8 citations