Making models for Alzheimer's disease

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

1994 • 1,463 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

1994 • 1,085 citations

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

1993 • 1,035 citations

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

1993 • 909 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

1992 • 883 citations

Normal and Abnormal Biology of the beta-Amyloid Precursor Protein

1994 • 813 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1995 • 517 citations

Formation of β-amyloid protein deposits in brains of transgenic mice

1991 • 385 citations

Introduction and expression of the 400 kilobase precursor amyloid protein gene in transgenic mice

1993 • 309 citations

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.

1993 • 223 citations

Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain.

1992 • 150 citations

Deposits of Amyloid β Protein in the Central Nervous System of Transgenic Mice

1991 • 140 citations

Ultrastructural analysis of β-amyloid-induced apoptosis in cultured hippocampal neurons

1994 • 133 citations

CELLULAR AND MOLECULAR BIOLOGY OF ALZHEIMER'S DISEASE AND ANIMAL MODELS

1994 • 130 citations

RETRACTED ARTICLE: Amyloid plaques, neurofibrillary tangles and neuronal loss in brains of transgenic mice overexpressing a C-terminal fragment of human amyloid precursor protein

1991 • 104 citations

Expression of the human beta-amyloid precursor protein gene from a yeast artificial chromosome in transgenic mice.

1993 • 81 citations

Expression of the human beta-amyloid protein of Alzheimer's disease specifically in the brains of transgenic mice.

1991 • 64 citations

Alzheimer's retraction

1992 • 61 citations

Toxicity of synthetic aβ peptides and modeling of alzheimer's disease

1992 • 40 citations

Response : Age-Associated Inclusions in Normal and Transgenic Mouse Brain

1992 • 15 citations