Phospholipase D Activity in PC12 Cells

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

1993 • 900 citations

Human ADP-ribosylation Factor-activated Phosphatidylcholine-specific Phospholipase D Defines a New and Highly Conserved Gene Family

1995 • 663 citations

Phospholipase D: a Downstream Effector of ARF in Granulocytes

1994 • 636 citations

Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger

1995 • 592 citations

Characterization of Two Alternately Spliced Forms of Phospholipase D1

1997 • 547 citations

Central Hypotensive Effects of the α _2a -Adrenergic Receptor Subtype

1996 • 484 citations

Cardiovascular Regulation in Mice Lacking α ₂ -Adrenergic Receptor Subtypes b and c

1996 • 463 citations

Gα12 and Gα13 Stimulate Rho-dependent Stress Fiber Formation and Focal Adhesion Assembly

1995 • 443 citations

Raf-1 Kinase Possesses Distinct Binding Domains for Phosphatidylserine and Phosphatidic Acid

1996 • 402 citations

Regulation of Phospholipase D by Protein Kinase C Is Synergistic with ADP-ribosylation Factor and Independent of Protein Kinase Activity

1996 • 251 citations

Activation of rat brain phospholipase D by ADP-ribosylation factors 1,5, and 6: separation of ADP-ribosylation factor-dependent and oleate-dependent enzymes.

1994 • 250 citations

Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation-independent mechanism.

1992 • 237 citations

Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts.

1993 • 234 citations

Neutrophil phospholipase D is activated by a membrane-associated Rho family small molecular weight GTP-binding protein.

1993 • 229 citations

Phospholipase D signaling is essential for meiosis.

1995 • 208 citations

Structure and regulation of phospholipase D

1996 • 176 citations

Gα12 Stimulates c-Jun NH2-terminal Kinase through the Small G Proteins Ras and Rac

1996 • 152 citations

Identification and Characterization of a Gene Encoding Phospholipase D Activity in Yeast

1996 • 150 citations

Phosphatidate-dependent protein phosphorylation.

1991 • 149 citations

Determinants of alpha 2-adrenergic receptor activation of G proteins: evidence for a precoupled receptor/G protein state.

1994 • 149 citations

Evidence for Rho-mediated Agonist Stimulation of Phospholipase D in Rat1 Fibroblasts

1996 • 149 citations

Existence of cytosolic phospholipase D. Identification and comparison with membrane-bound enzyme

1991 • 120 citations

Regulation of Membrane-bound Phospholipase D by Protein Kinase C in HL60 Cells

1996 • 118 citations

Expression of a mutant Gi2 alpha subunit inhibits ATP and thrombin stimulation of cytoplasmic phospholipase A2-mediated arachidonic acid release independent of Ca2+ and mitogen-activated protein kinase regulation.

1994 • 112 citations

Rapid protein kinase C-dependent activation of phospholipase D leads to delayed 1,2-diglyceride accumulation.

1990 • 110 citations

The biologically active phospholipid, lysophosphatidic acid, induces phosphatidylcholine breakdown in fibroblasts via activation of phospholipase D. Comparison with the response to endothelin

1992 • 107 citations

Role of Rho Family Proteins in Phospholipase D Activation by Growth Factors

1997 • 83 citations

Characterization of Saccharomyces cerevisiae deficient in expression of phospholipase D

1996 • 74 citations

Extracellular signal-regulated kinases 2 autophosphorylates on a subset of peptides phosphorylated in intact cells in response to insulin and nerve growth factor: analysis by peptide mapping.

1992 • 71 citations

Factors Determining Specificity of Signal Transduction by G-protein-coupled Receptors

1995 • 65 citations

v-Src activates a unique phospholipase D activity that can be distinguished from the phospholipase D activity activated by phorbol esters

1993 • 60 citations

Characterization of a regulated form of phospholipase D in the yeast Saccharomyces cerevisiae

1995 • 51 citations

Signal-dependent activation of phosphatidylcholine hydrolysis: role of phospholipase D

1991 • 48 citations

Activations of mitogen-activated protein kinases and phospholipase D in A7r5 vascular smooth muscle cells.

1994 • 42 citations

Phospholipase D hydrolysis of choline phosphoglycerides is selective for the alkyl-linked subclass of Madin-Darby canine kidney cells.

1993 • 36 citations

Interplay between Ras‐related and heterotrimeric GTP binding proteins: lifestyles of the BIG and little ¹

1996 • 35 citations

A Fluorescent Assay for Agonist-Activated Phospholipase D in Mammalian Cell Extracts

1994 • 31 citations

The Active Site Specificity of the Yersinia Protein-tyrosine Phosphatase

1996 • 26 citations

Effects of phorbol ester on phospholipase D and mitogen-activated protein kinase activities in T-lymphocyte cell lines

1996 • 24 citations

Synergistic Effects of Insulin and Phorbol Ester on Mitogen-activated Protein Kinase in Rat-1 HIR Cells

1996 • 18 citations

Precoupling of alpha-2B adrenergic receptors and G-proteins in transfected PC-12 cell membranes: influence of pertussis toxin and a lysine-directed cross-linker.

1994 • 11 citations