Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Phosphorus Assay in Column Chromatography

1959 • 12,895 citations

Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

1989 • 1,251 citations

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.

1991 • 627 citations

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1992 • 428 citations

Intracellular Calcium Release Mediated by Sphingosine Derivatives Generated in Cells

1990 • 391 citations

Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst.

1986 • 294 citations

Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds

1989 • 247 citations

Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.

1990 • 230 citations

Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide.

1993 • 213 citations

Phospholipase D in cell signalling and its relationship to phospholipase C

1991 • 172 citations

Suppression of nerve growth factor-directed neurite outgrowth in PC12 cells by sphingosine, an inhibitor of protein kinase C.

1988 • 172 citations

Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation

1992 • 154 citations

Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells.

1988 • 151 citations

Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver

1991 • 142 citations

Phorbol Ester Stimulates the Hydrolysis of Phosphatidylethanolamine in Leukemic HL-60, NIH 3T3, and Baby Hamster Kidney Cells

1989 • 140 citations

Activation of phospholipase D by sphingoid bases in NG108-15 neural-derived cells.

1990 • 134 citations

Existence of cytosolic phospholipase D. Identification and comparison with membrane-bound enzyme

1991 • 120 citations

Identification of phosphatidylcholine-selective and phosphatidylinositol-selective phospholipases D in Madin-Darby canine kidney cells.

1992 • 103 citations

Sphingosine inhibits phosphatidate phosphohydrolase in human neutrophils by a protein kinase C-independent mechanism

1991 • 97 citations

Sphingosine activation of protein kinases in Jurkat T cells. In vitro phosphorylation of endogenous protein substrates and specificity of action.

1992 • 80 citations

4-hydroxynonenal, a metabolite of lipid peroxidation, activates phospholipase D in vascular endothelial cells

1993 • 75 citations

Thrombin stimulation of human endothelial cell phospholipase D activity. Regulation by phospholipase C, protein kinase C, and cyclic adenosine 3'5'-monophosphate.

1992 • 71 citations

Activation of casein kinase II by sphingosine.

1991 • 70 citations

Sphingosine Kinase in Blood Platelets

1973 • 66 citations

Phosphatidylinositol-specific phospholipase D: A pathway for generation of a second messenger

1988 • 58 citations

[55] Characterization and assay of phosphatidate phosphatase

1991 • 57 citations

A facile enzymatic synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate.

1989 • 55 citations

Phosphatidic Acid Directly Activates Endothelial Cell Protein Kinase C

1993 • 47 citations

Protein kinase C inhibition by sphingoid long-chain bases: Effects on secretion in human neutrophils

1987 • 42 citations

Agonist-induced activation of phospholipase D in bovine pulmonary artery endothelial cells: regulation by protein kinase C and calcium.

1993 • 41 citations

Regulation of phospholipase D by sphingosine involves both protein kinase C-dependent and -independent mechanisms in NIH 3T3 fibroblasts

1992 • 37 citations

Modifications of phospholipid metabolism induced by chlorpromazine, desmethylimipramine and propranolol in C6 glioma cells

1987 • 37 citations

Sphingosine enhances platelet aggregation through an increase in phospholipase C activity by a protein kinase C-independent mechanism

1992 • 22 citations

Signal Transduction in Pulmonary Endothelium

1992 • 19 citations