Evidence for protein kinase C independent activation of phospholipase D by phorbol esters in lymphocytes

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Transphosphatidylation by Phospholipase D

1967 • 563 citations

Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.

1987 • 472 citations

Tumor Promoters and the Mechanism of Tumor Promotion

1980 • 415 citations

Phosphatidylethanol Formation via Transphosphatidylation by Rat Brain Synaptosomal Phospholipase D

1987 • 342 citations

Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes.

1988 • 307 citations

Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases.

1986 • 307 citations

Regulation of Phospholipase D in HL-60 Granulocytes

1989 • 250 citations

Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways.

1987 • 156 citations

Synergistic action of phorbol esters in mitogen-activated bovine lymphocytes

1974 • 145 citations

Activation of phospholipase D by sphingoid bases in NG108-15 neural-derived cells.

1990 • 134 citations

Phospholipase D in homogenates from HL-60 granulocytes: Implications of calcium and G protein control

1989 • 91 citations

Phorbol diesters and dioctanoylglycerol stimulate accumulation of both diacylglycerols and alkylacylglycerols in human neutrophils.

1988 • 79 citations

12-O-tetradecanoylphorbol-13-acetate activates phosphatidylethanol and phosphatidylglycerol synthesis by phospholipase D in cell lysates

1988 • 78 citations

Evidence for a protein kinase C‐directed mechanism in the phorbol diester‐induced phospholipase D pathway of diacylglycerol generation from phosphatidylcholine

1989 • 74 citations

Prevention of the TPA-mediated down-regulation of protein kinase C

1988 • 60 citations

Differentiative action of K252a on protein kinase C and A calcium-unresponsive, phorbol ester/phospholipid-activated protein kinase

1989 • 51 citations

Acyl specificity of hamster heart CDP-choline 1,2-diacylglycerol phosphocholine transferase in phosphatidylcholine biosynthesis

1984 • 50 citations

12-O-Tetradecanoylphorbol-13-acetate activates the synthesis of phosphatidylethanol in animal cells exposed to ethanol

1987 • 50 citations

Protein kinase C inhibition by sphingoid long-chain bases: Effects on secretion in human neutrophils

1987 • 42 citations

The purification and characterization of a phospholipase A in hamster heart cytosol for the hydrolysis of phosphatidylcholine.

1987 • 35 citations

Phorbol esters activate the pathway for phosphatidylethanol synthesis in differentiating HL-60 cells

1987 • 33 citations

Changes in protein kinase C and cAMP‐dependent kinase in lymphocytes after treatment with 12‐O‐tetradecanoylphorbol‐13‐acetate or concanavalin A: Quantitation of activities with an in situ gel assay

1987 • 24 citations

Effect of macrophages on phorbol ester-stimulated comitogenesis in bovine lymphocytes.

1982 • 23 citations

Lectin-induced phosphatidylinositol metabolism in lymphocytes is potentiated by macrophages.

1988 • 16 citations

Glycoprotein biosynthesis in B lymphocytes: Induction of protein N-glycosylation, RNA synthesis, and DNA synthesis by phorbol ester plus ionomycin is blocked by protein kinase inhibitors

1988 • 9 citations