Granules of the Human Neutrophilic Polymorphonuclear Leukocyte

ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES

1985 • 4,790 citations

SNAP receptors implicated in vesicle targeting and fusion

1993 • 3,220 citations

The synaptic vesicle cycle: a cascade of protein–protein interactions

1995 • 2,004 citations

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

1993 • 1,893 citations

The lipocalin protein family: structure and function

1996 • 1,658 citations

Defensins. Natural peptide antibiotics of human neutrophils.

1985 • 1,411 citations

Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase

1993 • 1,226 citations

Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25

1993 • 1,200 citations

Protein Sorting by Transport Vesicles

1996 • 1,168 citations

Molecular dissection of the secretory pathway

1992 • 985 citations

Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo.

1991 • 977 citations

Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation.

1983 • 938 citations

THE DEVELOPMENT OF NEUTROPHILIC POLYMORPHONUCLEAR LEUKOCYTES IN HUMAN BONE MARROW

1971 • 870 citations

Biosynthesis of lysosomal enzymes in fibroblasts. Synthesis as precursors of higher molecular weight.

1980 • 809 citations

Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.

1994 • 798 citations

Chlorination of Taurine by Human Neutrophils

1982 • 794 citations

Cathelicidins: a novel protein family with a common proregion and a variable C‐terminal antimicrobial domain

1995 • 714 citations

P-selectin glycoprotein ligand-1 mediates rolling of human neutrophils on P-selectin.

1995 • 712 citations

THE ISOLATION AND PROPERTIES OF THE SPECIFIC CYTOPLASMIC GRANULES OF RABBIT POLYMORPHONUCLEAR LEUCOCYTES

1960 • 708 citations

Plant ‘pathogenesis-related’ proteins and their role in defense against pathogens

1993 • 673 citations

Leukocyte Trafficking Mediated by Selectin-Carbohydrate Interactions

1995 • 648 citations

Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase.

1985 • 625 citations

Sequential contribution of L- and P-selectin to leukocyte rolling in vivo.

1995 • 597 citations

Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein

1995 • 566 citations

The Human Gene FALL39 and Processing of the Cathelin Precursor to the Antibacterial Peptide LL‐37 in Granulocytes

1996 • 556 citations

Identification of the homologous beige and Chediak–Higashi syndrome genes

1996 • 536 citations

ATP-dependent inositide phosphorylation required for Ca2+-activated secretion

1995 • 508 citations

T cell gelatinases mediate basement membrane transmigration in vitro.

1995 • 507 citations

Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein

1993 • 504 citations

FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis.

1995 • 499 citations

ORIGIN OF GRANULES IN POLYMORPHONUCLEAR LEUKOCYTES

1966 • 476 citations

Mannose 6-Phosphate Receptors and Lysosomal Enzyme Targeting

1989 • 473 citations

Oxidative Autoactivation of Latent Collagenase by Human Neutrophils

1985 • 466 citations

Stimulated mobilization of monocyte Mac-1 and p150,95 adhesion proteins from an intracellular vesicular compartment to the cell surface.

1987 • 435 citations

BIOCHEMICAL AND MORPHOLOGICAL CHARACTERIZATION OF AZUROPHIL AND SPECIFIC GRANULES OF HUMAN NEUTROPHILIC POLYMORPHONUCLEAR LEUKOCYTES

1974 • 427 citations

Differential expression of the amv gene in human hematopoietic cells.

1982 • 425 citations

Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease

1996 • 424 citations

Membrane surface antigen expression on neutrophils: a reappraisal of the use of surface markers for neutrophil activation

1991 • 416 citations

Role of gelatinase B and elastase in human polymorphonuclear neutrophil migration across basement membrane.

1996 • 416 citations

A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells

1992 • 413 citations

Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases.

1996 • 411 citations

AML1, AML2, and AML3, the Human Members of the runt domain Gene-Family: cDNA Structure, Expression, and Chromosomal Localization

1994 • 403 citations

Human neutrophils increase expression of C3bi as well as C3b receptors upon activation.

1984 • 391 citations

Membrane fusion machinery: Insights from synaptic proteins

1993 • 380 citations

Structure of the human liver/bone/kidney alkaline phosphatase gene.

1988 • 376 citations

Synaptic Vesicles and Exocytosis

1994 • 371 citations

A Signaling Pathway to Translational Control

1996 • 370 citations

Control of exocytosis in early neutrophil activation.

1993 • 366 citations

Stimulation of 92-kDa Gelatinase B Promoter Activity by ras Is Mitogen-activated Protein Kinase Kinase 1-independent and Requires Multiple Transcription Factor Binding Sites Including Closely Spaced PEA3/ets and AP-1 Sequences

1996 • 351 citations

Amino acid sequence of PR‐39

1991 • 343 citations

Complete structure of the human gene for 92-kDa type IV collagenase. Divergent regulation of expression for the 92- and 72-kilodalton enzyme genes in HT-1080 cells.

1991 • 343 citations

Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability.

1989 • 342 citations

Character of azurophil and specific granules purified from human polymorphonuclear leukocytes.

1974 • 340 citations

hCAP‐18, a cathelin/pro‐bactenecin‐like protein of human neutrophil specific granules

1995 • 339 citations

Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease.

1990 • 337 citations

CR3 (Mac-1, alpha M beta 2, CD11b/CD18) and Fc gamma RIII cooperate in generation of a neutrophil respiratory burst: requirement for Fc gamma RIII and tyrosine phosphorylation.

1994 • 332 citations

The Neutral Proteases of Human Granulocytes

1974 • 316 citations

The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter.

1993 • 315 citations

PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells.

1994 • 315 citations

Constitutive expression of a c-myb cDNA blocks Friend murine erythroleukemia cell differentiation.

1988 • 314 citations

Mobilization of granules and secretory vesicles during in vivo exudation of human neutrophils.

1995 • 313 citations

RESOLUTION OF GRANULES FROM RABBIT HETEROPHIL LEUKOCYTES INTO DISTINCT POPULATIONS BY ZONAL SEDIMENTATION

1969 • 311 citations

Crystallographic refinement of human serum retinol binding protein at 2Å resolution

1990 • 310 citations

Human neutrophil granules and secretory vesicles

1993 • 306 citations

DNA Binding Specificity of the CCAAT/Enhancer-binding Protein Transcription Factor Family

1996 • 300 citations

PU.1 (Spi-1) and C/EBPα Regulate Expression of the Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Gene

1995 • 287 citations

Subcellular localization and dynamics of Mac-1 (alpha m beta 2) in human neutrophils.

1993 • 287 citations

Secretory Responses of Human Neutrophils: Exocytosis of Specific (Secondary) Granules by Human Neutrophils during Adherence in vitro and during Exudation in vivo

1979 • 286 citations

Release of Gelatinase from a Novel Secretory Compartment of Human Neutrophils

1982 • 276 citations

Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types.

1993 • 275 citations

CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter.

1991 • 274 citations

Antibiotic proteins of human polymorphonuclear leukocytes.

1989 • 273 citations

SEQUENTIAL DEGRANULATION OF THE TWO TYPES OF POLYMORPHONUCLEAR LEUKOCYTE GRANULES DURING PHAGOCYTOSIS OF MICROORGANISMS

1973 • 272 citations

Structure and bactericidal activity of an antibiotic dodecapeptide purified from bovine neutrophils.

1988 • 272 citations

Activation of the endogenous metalloproteinase, gelatinase, by triggered human neutrophils.

1986 • 267 citations

Calreticulin Functions as a Molecular Chaperone in the Biosynthesis of Myeloperoxidase

1995 • 260 citations

Leukocyte rolling in vivo is mediated by P-selectin glycoprotein ligand- 1

1995 • 258 citations

Chemoattractant-Regulated Mobilization of a Novel Intracellular Compartment in Human Neutrophils

1987 • 256 citations

Subcellular localization of the large subunit of Mo1 (Mo1 alpha; formerly gp 110), a surface glycoprotein associated with neutrophil adhesion.

1984 • 249 citations

Association of a Ras-related protein with cytochrome b of human neutrophils

1989 • 248 citations

Quantitative analysis of the cytosolic free calcium dependency of exocytosis from three subcellular compartments in intact human neutrophils.

1986 • 246 citations

The timing of synaptic vesicle endocytosis.

1996 • 238 citations

Characterization of gelatinase from pig polymorphonuclear leucocytes. A metalloproteinase resembling tumour type IV collagenase

1989 • 233 citations

An acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms.

1995 • 232 citations

Changes in subcellular localization and surface expression of L-selectin, alkaline phosphatase, and Mac-1 in human neutrophils during stimulation with inflammatory mediators

1994 • 232 citations

Biosynthesis of granule proteins in normal human bone marrow cells. Gelatinase is a marker of terminal neutrophil differentiation

1995 • 232 citations

Leukocyte adhesion receptors are stored in peroxidase-negative granules of human neutrophils.

1987 • 229 citations

L-selectin (CD62L) cross-linking signals neutrophil adhesive functions via the Mac-1 (CD11b/CD18) beta 2-integrin.

1995 • 228 citations

A 25 kDa α₂‐microglobulin‐related protein is a component of the 125 kDa form of human gelatinase

1992 • 226 citations

VAMP-2 and cellubrevin are expressed in pancreatic beta-cells and are essential for Ca(2+)-but not for GTP gamma S-induced insulin secretion.

1995 • 223 citations

Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B

1995 • 222 citations

The Human Cysteine‐Rich Secretory Protein (CRISP) Family

1996 • 218 citations

PU.1 (Spi-1) autoregulates its expression in myeloid cells.

1995 • 213 citations

Partial purification of collagenase and gelatinase from human polymorphonuclear leucocytes. Analysis of their actions on soluble and insoluble collagens

1982 • 203 citations

Isolation and characterization of gelatinase granules from human neutrophils

1994 • 201 citations

Synergistic activation of the chicken mim-1 gene by v-myb and C/EBP transcription factors.

1993 • 198 citations

Granulocyte colony-stimulating factor administration to healthy volunteers: analysis of the immediate activating effects on circulating neutrophils

1994 • 196 citations

Recruitment of CD11b/CD18 to the neutrophil surface and adherence-dependent cell locomotion.

1992 • 193 citations

Activation of human neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin.

1993 • 187 citations

Membrane Dynamics in Endocytosis

1996 • 186 citations

Ca2+ and secretory-vesicle dynamics

1995 • 185 citations

Divergent fates of P- and E-selectins after their expression on the plasma membrane.

1993 • 181 citations

The protein machinery of vesicle budding and fusion

1996 • 181 citations

Posttranslational processing of defensins in immature human myeloid cells

1992 • 180 citations

Steel factor and c-kit regulate cell-matrix adhesion

1994 • 178 citations

Cellular and subcellular localization of the bactericidal/permeability- increasing protein of neutrophils

1987 • 172 citations

Antibiotic proteins of polymorphonuclear leukocytes

1996 • 168 citations

The latent collagenase and gelatinase of human polymorphonuclear neutrophil leucocytes

1980 • 168 citations

Secreted forms of human neutrophil collagenase.

1986 • 167 citations

Activation of the 92-kDa Gelatinase by Stromelysin and 4-Aminophenylmercuric Acetate

1995 • 166 citations

Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway

1995 • 165 citations

Purification and characterization of a human neutrophil lipocalin (HNL) from the secondary granules of human neutrophils

1994 • 164 citations

Potentiation of the oxidative burst of human neutrophils. A signaling role for L-selectin

1994 • 163 citations

Separation and characterization of human neutrophil granules.

1974 • 163 citations

Cloning and mapping of a testis-specific gene with sequence similarity to a sperm-coating glycoprotein gene

1989 • 162 citations

Defensin-rich dense granules of human neutrophils

1987 • 162 citations

Activation of human neutrophils through L-selectin and Mac-1 molecules.

1995 • 159 citations

Identification of a highly mobilizable subset of human neutrophil intracellular vesicles that contains tetranectin and latent alkaline phosphatase.

1990 • 157 citations

Adhesomes: specific granules containing receptors for laminin, C3bi/fibrinogen, fibronectin, and vitronectin in human polymorphonuclear leukocytes and monocytes.

1989 • 157 citations

Targeting of proteins to granule subsets is determined by timing and not by sorting: The specific granule protein NGAL is localized to azurophil granules when expressed in HL-60 cells.

1996 • 157 citations

Cytoplasmic domain of P-selectin (CD62) contains the signal for sorting into the regulated secretory pathway.

1992 • 156 citations

Ultrastructural localization of proteinase 3, the target antigen of anti-cytoplasmic antibodies circulating in Wegener's granulomatosis.

1990 • 156 citations

Developmental regulation of c-myb in normal myeloid progenitor cells.

1985 • 155 citations

Proteolytic cleavage by neutrophil elastase converts inactive storage proforms to antibacterial bactenecins

1992 • 155 citations

Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors.

1992 • 155 citations

Primary structure of a new cysteine proteinase inhibitor from pig leucocytes

1989 • 152 citations

Inhibition of hematopoiesis by competitive binding of transcription factor PU.1.

1994 • 151 citations

SV40-induced expression of mouse gene 24p3 involves a post-transcriptional mechanism.

1989 • 150 citations

Distinct molecular mechanisms for protein sorting within immature secretory granules of pancreatic beta-cells.

1994 • 148 citations

Ultrastructural localization of lactoferrin and myeloperoxidase in human neutrophils by immunogold

1985 • 146 citations

Subcellular localization and translocation of the receptor for N-formylmethionyl-leucyl-phenylalanine in human neutrophils

1994 • 146 citations

Ultrastructural localization of cytochrome b in the membranes of resting and phagocytosing human granulocytes.

1990 • 145 citations

Subcellular distribution of docking/fusion proteins in neutrophils, secretory cells with multiple exocytic compartments.

1995 • 144 citations

Evidence for small intracellular vesicles in human blood phagocytes containing cytochrome b558 and the adhesion molecule CD11b/CD18

1993 • 143 citations

Histamine induces interleukin-8 secretion by endothelial cells

1994 • 143 citations

Structure of the human neutrophil elastase gene.

1988 • 142 citations

The receptor for urokinase-type plasminogen activator and urokinase is translocated from two distinct intracellular compartments to the plasma membrane on stimulation of human neutrophils

1994 • 140 citations

Molecular cloning of the cDNA for androgen‐dependent sperm‐coating glycoproteins secreted by the rat epididymis

1986 • 138 citations

Stimulus-dependent secretion of plasma proteins from human neutrophils.

1992 • 137 citations

Calcium signaling capacity of the integrin on human neutrophils

1991 • 135 citations

The exocytotic fusion pore of small granules has a conductance similar to an ion channel.

1995 • 133 citations

An intriguing member of the lipocalin protein family: α1-microglobulin

1990 • 132 citations

Activation of Proton Pumping in Human Neutrophils Occurs by Exocytosis of Vesicles Bearing Vacuolar-type H+-ATPases

1996 • 131 citations

Association of Lactoferrin with Lysozyme in Granules of Human Polymorphonuclear Leukocytes

1972 • 131 citations

Molecular size-fractionation during endocytosis in macrophages.

1995 • 130 citations

Studies of the release and turnover of a human neutrophil lipocalin

1995 • 129 citations

Cationic defensins arise from charge-neutralized propeptides: a mechanism for avoiding leukocyte autocytotoxicity?

1992 • 128 citations

Sorting within the regulated secretory pathway occurs in the trans-Golgi network.

1990 • 127 citations

Restriction of interferon gamma responsiveness and basal expression of the myeloid human Fc gamma R1b gene is mediated by a functional PU.1 site and a transcription initiator consensus.

1994 • 126 citations

Genomic Organization and Chromosomal Localization of the Human Cathepsin G Gene

1989 • 126 citations

Differential expression and functional role of GATA-2, NF-E2, and GATA-1 in normal adult hematopoiesis.

1995 • 126 citations

Differential expression of CD11b/CD18 (Mo1) and myeloperoxidase genes during myeloid differentiation

1989 • 124 citations

Human neutrophils contain an intracellular pool of putative receptors for the chemoattractant N-formyl-methionyl-leucyl-phenylalanine

1983 • 118 citations

The necrotic venom of the brown recluse spider induces dysregulated endothelial cell-dependent neutrophil activation. Differential induction of GM-CSF, IL-8, and E-selectin expression.

1994 • 118 citations

Secretory vesicles are the intracellular reservoir of complement receptor 1 in human neutrophils.

1994 • 117 citations

The opsonizing ligand on Salmonella typhimurium influences incorporation of specific, but not azurophil, granule constituents into neutrophil phagosomes.

1989 • 116 citations

SNAP‐25 is present in a SNARE complex in adrenal chromaffin cells

1994 • 113 citations

Mouse oncogene protein 24p3 is a member of the Lipocalin protein family

1991 • 110 citations

CCAAT Displacement Protein Competes with Multiple Transcriptional Activators for Binding to Four Sites in the Proximal gp91 Promoter

1996 • 110 citations

The dynamics of exocytosis in human neutrophils.

1988 • 109 citations

The Enzymes of the Granules of Polymorphonuclear Leukocytes and Their Functions

1972 • 109 citations

Subcellular localization and release of human neutrophil gelatinase, confirming the existence of separate gelatinase-containing granules

1992 • 107 citations

Lactoferrin biosynthesis during granulocytopoiesis

1984 • 106 citations

SGP28, a novel matrix glycoprotein in specific granules of human neutrophils with similarity to a human testis‐specific gene product and to a rodent sperm‐coating glycoprotein

1996 • 106 citations

Association of rap1 and rap2 proteins with the specific granules of human neutrophils. Translocation to the plasma membrane during cell activation.

1992 • 106 citations

Structural and functional heterogeneity among peroxidase-negative granules in human neutrophils: identification of a distinct gelatinase- containing granule subset by combined immunocytochemistry and subcellular fractionation

1993 • 105 citations

Ultrastructural localization of the CD68 macrophage-associated antigen in human blood neutrophils and monocytes.

1991 • 104 citations

CD18 (beta 2 leukocyte integrin) promoter requires PU.1 transcription factor for myeloid activity.

1995 • 103 citations

Intracellular location of T200 and Mo1 glycoproteins in human neutrophils.

1988 • 102 citations

Covalent structure of two novel neutrophile leucocyte‐derived proteins of porcine and human origin

1991 • 100 citations

Intracellular and Extracellular Degranulation of Human Polymorphonuclear Azurophil and Specific Granules Induced by Immune Complexes

1974 • 100 citations

Neutrophil Specific Granule Deficiency

1985 • 99 citations

Further characterization of the NB 1 antigen as a variably expressed 56–62 kD GPI‐linked glycoprotein of plasma membranes and specific granules of neutrophils

1992 • 98 citations

The murine myeloperoxidase promoter contains several functional elements, one of which binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1).

1993 • 98 citations

Separation of human neutrophil plasma membrane from intracellular vesicles containing alkaline phosphatase and NADPH oxidase activity by free flow electrophoresis.

1992 • 97 citations

Prophenin‐1, an exceptionally proline‐rich antimicrobial peptide from porcine leukocytes

1995 • 97 citations

Mobilization of sialidase from intracellular stores to the surface of human neutrophils and its role in stimulated adhesion responses of these cells.

1991 • 96 citations

Neutrophil specific granules: a fuse that ignites the inflammatory response.

1984 • 96 citations

Stimulus-induced maturation of probactenecins, precursors of neutrophil antimicrobial polypeptides.

1991 • 95 citations

GABP and PU.1 Compete for Binding, yet Cooperate to Increase CD18 (β2 Leukocyte Integrin) Transcription

1995 • 93 citations

The human beta 2 integrin CD18 promoter consists of two inverted Ets cis elements.

1994 • 92 citations

Intracellular localization of N-formyl chemotactic receptor and Mg2+ dependent ATPase in human granulocytes☆

1982 • 91 citations

The heterogeneity of azurophil granules in neutrophil promyelocytes: immunogold localization of myeloperoxidase, cathepsin G, elastase, proteinase 3, and bactericidal/permeability increasing protein

1994 • 91 citations

The lysosomal membrane glycoproteins Lamp-1 and Lamp-2 are present in mobilizable organelles, but are absent from the azurophil granules of human neutrophils

1995 • 91 citations

Subcellular localization of cytochrome b and ubiquinone in a tertiary granule of resting human neutrophils and evidence for a proton pump ATPase.

1984 • 90 citations

Isolation of lactoferrin cDNA from a human myeloid library and expression of mRNA during normal and leukemic myelopoiesis

1987 • 90 citations

A novel intracellular compartment with unusual secretory properties in human neutrophils.

1991 • 89 citations

Involvement of the transcription factor PU.1/Spi-1 in myeloid cell-restricted expression of an interferon-inducible gene encoding the human high-affinity Fc gamma receptor.

1994 • 89 citations

The pro region of human neutrophil defensin contains a motif that is essential for normal subcellular sorting

1995 • 87 citations

Nuclear oncoprotein expression as a function of lineage, differentiation stage, and proliferative status of normal human hematopoietic cells

1989 • 87 citations

Development of the superoxide-generating system during differentiation of the HL-60 human promyelocytic leukemia cell line.

1984 • 87 citations

Lactoferrin gene promoter: structural integrity and nonexpression in HL60 cells

1992 • 86 citations

Annexin 3 is associated with cytoplasmic granules in neutrophils and monocytes and translocates to the plasma membrane in activated cells

1994 • 86 citations

Association between gelatinase release and increased plasma membrane expression of the Mo1 glycoprotein.

1987 • 86 citations

Subcellular localization of Gi alpha in human neutrophils.

1988 • 85 citations

Subcellular distribution and mobilization of MAC-1 (CD11b/CD18) in neonatal neutrophils

1990 • 84 citations

Expression of C3b receptors on human be cells and myelomonocytic cells but not natural killer cells.

1983 • 83 citations

Subcellular localization of CD66, CD67, and NCA in human neutrophils

1992 • 83 citations

pH- and Ca2+-dependent Aggregation Property of Secretory Vesicle Matrix Proteins and the Potential Role of Chromogranins A and B in Secretory Vesicle Biogenesis

1996 • 83 citations

Identification of the promoter of the myelomonocytic leukocyte integrin CD11b.

1992 • 82 citations

Granulocyte colony-stimulating factor induction of normal human bone marrow progenitors results in neutrophil-specific gene expression

1995 • 82 citations

Carboxyl-terminal Prodomain-deleted Human Leukocyte Elastase and Cathepsin G Are Efficiently Targeted to Granules and Enzymatically Activated in the Rat Basophilic/Mast Cell Line RBL

1995 • 82 citations

Antibody-induced engagement of beta 2 integrins on adherent human neutrophils triggers activation of p21ras through tyrosine phosphorylation of the protooncogene product Vav.

1996 • 81 citations

Biosynthesis and Processing of Proteinase 3 in U937 Cells

1996 • 79 citations

Endotoxin receptors (CD14) are found with CD16 (Fc gamma RIII) in an intracellular compartment of neutrophils that contains alkaline phosphatase.

1995 • 78 citations

Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen.

1992 • 78 citations

Characterization of the myeloid-specific CD11b promoter

1992 • 78 citations

Human neutrophil gelatinase is a component of specific granules.

1989 • 77 citations

Cross-linking of CD18 primes human neutrophils for activation of the respiratory burst in response to specific stimuli: Implications for adhesion-dependent physiological responses in neutrophils

1995 • 77 citations

Identification of Routing Determinants in the Cytosolic Domain of a Secretory Granule-associated Integral Membrane Protein

1996 • 76 citations

Roles of heme insertion and the mannose-6-phosphate receptor in processing of the human myeloid lysosomal enzyme, myeloperoxidase

1992 • 76 citations

Rapid increases in the membrane expression of neutral endopeptidase (CD10), aminopeptidase N (CD13), tyrosine phosphatase (CD45), and Fc gamma-RIII (CD16) upon stimulation of human peripheral leukocytes with human C5a.

1991 • 76 citations

Myeloperoxidase is synthesized as larger phosphorylated precursor.

1984 • 74 citations

Sorting of the Specific Granule Protein, NGAL, During Granulocytic Maturation of HL-60 Cells

1997 • 74 citations

The structure of neutrophil defensin genes

1993 • 74 citations

Amino acid sequence of CAP37, a human neutrophil granule‐derived antibacterial and monocyte‐specific chemotactic glycoprotein structurally similar to neutrophil elastase

1990 • 74 citations

Human neutrophil plasminogen activator is localized in specific granules and is translocated to the cell surface by exocytosis.

1986 • 74 citations

Differential trafficking of soluble and integral membrane secretory granule-associated proteins

1994 • 73 citations

Quantitation of Intracellular Mac-1 (CD11b/CD18) Pools in Human Neutrophils

1988 • 73 citations

Arachidonic acid release from diacylglycerol in human neutrophils. Translocation of diacylglycerol-deacylating enzyme activities from an intracellular pool to plasma membrane upon cell activation

1991 • 72 citations

Granulophysin is located in the membrane of azurophilic granules in human neutrophils and mobilizes to the plasma membrane following cell stimulation.

1994 • 72 citations

Mutations in the promoter region of the gene for gp91-phox in X-linked chronic granulomatous disease with decreased expression of cytochrome b558.

1994 • 72 citations

Increased expression of complement decay-accelerating factor during activation of human neutrophils.

1987 • 70 citations

Interferon Regulatory Factor-2 Directs Transcription from the gp91 Promoter

1996 • 70 citations

Activation of Human Neutrophil Procollagenase by Stromelysin 2

1996 • 70 citations

High resolution of heterogeneity among human neutrophil granules: physical, biochemical, and ultrastructural properties of isolated fractions

1986 • 66 citations

Regulated and constitutive secretion. Differential effects of protein synthesis arrest on transport of glycosaminoglycan chains to the two secretory pathways.

1992 • 66 citations

Early myeloid cell-specific expression of the human cathepsin G gene in transgenic mice.

1994 • 65 citations

Dual granule localization of the dormant NADPH oxidase and cytochrome b₅₅₉ in human neutrophils

1989 • 65 citations

Distribution of Lysosomal Enzymes, Cationic Proteins, and Bactericidal Substances in Subcellular Fractions of Human Polymorphonuclear Leukocytes

1971 • 64 citations

CATIONIC PROTEINS AND ANTIBACTERIAL PROPERTIES OF INFECTED TISSUES AND LEUKOCYTES.

1963 • 63 citations

Low molecular weight GTP-binding proteins in human neutrophil granule membranes.

1991 • 62 citations

Overexpression of neu-related lipocalin (NRL) in neu-initiated but not ras or chemically initiated rat mammary carcinomas.

1995 • 62 citations

Annexin III translocates to the periphagosomal region when neutrophils ingest opsonized yeast.

1991 • 59 citations

Patch-clamp measurements reveal multimodal distribution of granule sizes in rat mast cells.

1990 • 57 citations

Dissection of GLUT4 Recycling Pathway into Exocytosis and Endocytosis in Rat Adipocytes

1995 • 57 citations

Simultaneous mobilization of Mac-1 (CD11b/CD18) and formyl peptide chemoattractant receptors in human neutrophils [published erratum appears in Blood 1993 Mar 15;81(6):1668]

1992 • 55 citations

Genomic structure and mapping of the chromosomal gene for transcobalamin I (TCN1): Comparison to human intrinsic factor

1992 • 53 citations

[44] Human neutrophil degranulation

1988 • 52 citations

Beta 2-microglobulin in neutrophils: an intragranular protein.

1987 • 51 citations

Localization of the low-Mr subunit of cytochrome b558 in human blood phagocytes by immunoelectron microscopy

1990 • 48 citations

Characterization of a gp91-phox Promoter Element That Is Required for Interferon γ-induced Transcription

1995 • 47 citations

Calcium-induced translocation of annexins to subcellular organelles of human neutrophils

1994 • 47 citations

Poisson-distributed active fusion complexes underlie the control of the rate and extent of exocytosis by calcium.

1996 • 46 citations

Regulation of granule size in human and horse eosinophils by number of fusion events among unit granules.

1995 • 45 citations

Mechanisms of granule enzyme secretion from permeabilized guinea pig eosinophils. Dependence on Ca2+ and guanine nucleotides.

1991 • 44 citations

The intracellular transport of glycosaminoglycans (mucopolysaccharides) in human leukocytes

1969 • 44 citations

Identification of a human neutrophil protein ofMr 24 000 that bindsN-formyl peptides: Co-sedimentation with specific granules

1989 • 44 citations

Biosynthesis and processing of cathepsin G and neutrophil elastase in the leukemic myeloid cell line U-937

1990 • 43 citations

The processing and intracellular transport of myeloperoxidase. Modulation by lysosomotropic agents and monensin.

1986 • 43 citations

An N‐terminal hydrophobic peak is the sorting signal of regulated secretory proteins

1995 • 43 citations

Subcellular localization of heparanase in human neutrophils

1992 • 43 citations

Alpha 1-antitrypsin is present within the primary granules of human polymorphonuclear leukocytes.

1991 • 43 citations

Molecular cloning of a putative homolog of proline/arginine‐rich antibacterial peptides from porcine bone marrow

1993 • 43 citations

Cloning of human lysozyme gene and expression in the yeast Saccharomyces cerevisiae

1988 • 42 citations

Intracellular sites for storage and recycling of C3b receptors in human neutrophils.

1991 • 42 citations

Cross-linking of CD11b or CD18 signals release of localized Ca2+ from intracellular stores in neutrophils.

1993 • 42 citations

Bactenecin, a leukocytic antimicrobial peptide, is cytotoxic to neuronal and glial cells

1993 • 41 citations

Processing and intracellular transport of cathepsin G and neutrophil elastase in the leukemic myeloid cell line U-937—modulation by brefeldin A, ammonium chloride, and monensin

1994 • 41 citations

Cloning and expression of the cDNA encoding mouse neutrophil gelatinase: demonstration of coordinate secondary granule protein gene expression during terminal neutrophil maturation

1993 • 40 citations

Current concepts about neutrophil granule physiology

1996 • 40 citations

The effects of interleukin‐8 on neutrophil fMetLeuPhe receptors, CD11b expression and metabolic activity, in comparison and combination with other cytokines

1993 • 39 citations

Immunogold localisation of ubiquitin‐protein conjugates in primary (azurophilic) granules of polymorphonuclear neutrophils

1991 • 39 citations

Lysozyme in human neutrophils and plasma. A parameter of myelopoietic activity.

1995 • 38 citations

The human lysozyme promoter directs reporter gene expression to activated myelomonocytic cells in transgenic mice.

1996 • 38 citations

Myeloperoxidase: expression and modulation in a large panel of human leukemia-lymphoma cell lines

1993 • 37 citations

Human Cathepsin G Lacking Functional Glycosylation Site Is Proteolytically Processed and Targeted for Storage in Granules after Transfection to the Rat Basophilic/Mast Cell Line RBL or the Murine Myeloid Cell Line 32D

1995 • 36 citations

The selectins: Insights into selectin-induced intracellular signaling in leukocytes

1995 • 34 citations

Intracellular localization of platelet-activating factor synthesis in human neutrophils

1988 • 34 citations

Translocation of annexin I to plasma membranes and phagosomes in human neutrophils upon stimulation with opsonized zymosan: possible role in phagosome function

1996 • 32 citations

Internalization of type 1 complement receptors and de novo multivesicular body formation during chemoattractant-induced endocytosis in human neutrophils.

1994 • 32 citations

Ca²⁺‐dependent translocation of cytosolic proteins to isolated granule subpopulations and plasma membrane from human neutrophils

1992 • 31 citations

Subcellular distribution and membrane association of human neutrophil substrates for ADP-ribosylation by pertussis toxin and cholera toxin.

1989 • 29 citations

The subcellular localization of defensins and myeloperoxidase in human neutrophils: immunocytochemical evidence for azurophil granule heterogeneity.

1995 • 29 citations

Identification and characterization of the human myeloperoxidase promoter.

1995 • 29 citations

Human neutrophils contain subpopulations of specific granules exhibiting different sensitivities to changes in cytosolic free calcium

1987 • 29 citations

Mobilizable intracellular pool of p55 (type I) tumor necrosis factor receptors in human neutrophils

1992 • 28 citations

Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils

1994 • 27 citations

Enhancement of human neutrophil functions by a monoclonal antibody directed against a 19-kDa antigen.

1992 • 27 citations

The NADPH oxidase of phagocytic cells is an electron pump that alkalinises the phagocytic vacuole

1995 • 27 citations

Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1

1993 • 26 citations

A 30-base pair element is responsible for the myeloid-specific activity of the human neutrophil elastase promoter.

1994 • 26 citations

Localization of human neutrophil peptide (HNP) and its messenger RNA in neutrophil series

1994 • 26 citations

Activation of cytosolic phospholipase A2 in permeabilized human neutrophils

1996 • 25 citations

Leukocyte integrin CD11b promoter directs expression in lymphocytes and granulocytes in transgenic mice

1995 • 25 citations

Topographic Distribution of CD18 Integrin on Human Neutrophils as Related to Shape Changes and Movement Induced by Chemotactic Peptide and Phorbol Esters

1996 • 24 citations

Evaluation of the expression of the cationic peptide gene in various types of leukocytes

1992 • 23 citations

Cis-elements in the promoter region of the human myeloperoxidase (MPO) gene.

1996 • 23 citations

The CD11b promoter directs high-level expression of reporter genes in macrophages in transgenic mice [published erratum appears in Blood 1995 Apr 1;85(7):1983]

1995 • 23 citations

Chediak-Higashi syndrome.

1994 • 23 citations

Regulation of C1q receptor expression on human polymorphonuclear leukocytes.

1994 • 23 citations

Genomic Structure and Expression of the Human Gene Encoding Cytochrome b561, an Integral Protein of the Chromaffin Granule Membrane

1995 • 23 citations

Migration of polymorphonuclear leukocytes through human amnion membrane--a scanning electron microscopic study.

1992 • 21 citations

Separation of Granule Subpopulations in Human Polymorphonuclear Leukocytes

1990 • 20 citations

Localization of histaminase to the specific granule of the human neutrophil.

1984 • 20 citations

Effects of myeloid cell growth factors on alkaline phosphatase, myeloperoxidase, defensin and granulocyte colony‐stimulating factor receptor mRNA expression in haemopoietic cells of normal individuals and myeloid disorders

1996 • 19 citations

Signal transduction via Fc gamma R and Mac-1 alpha-chain in monocytes and polymorphonuclear leucocytes.

1994 • 19 citations

Development of the phagocytic and cidal capacity during maturation of myeloid cells: studies on cells from patients with chronic myelogenous leukaemia

1987 • 16 citations

Anomalous neutrophil granule distribution in a patient with lactoferrin deficiency: Pertinence to the respiratory burst

1985 • 16 citations

The calcium signal in human neutrophils and its relation to exocytosis investigated by patch-clamp capacitance and Fura-2 measurements

1993 • 16 citations

Human neutrophils are selectively activated by independent ligation of the subunits of the CD11b/CD18 integrin

1994 • 16 citations

Exocytotic Competence and Intergranular Fusion in Cord Blood-Derived Eosinophils During Differentiation

1997 • 15 citations

Diverse effects of different neutrophil organelles on truncation and membrane-binding characteristics of annexin I

1996 • 15 citations

Heterogeneity of peroxidase-positive granules in normal human an Chédiak-Higashi neutrophils.

1993 • 14 citations

Functional, physical, and ultrastructural localization of CD15 antigens to the human polymorphonuclear leukocyte secondary granule

1990 • 13 citations

Isolation by calcium-dependent translation to neutrophil-specific granules of a 42-kD cytosolic protein, identified as being a fragment of annexin XI

1996 • 13 citations

Synthesis and localization of myeloperoxidase protein in transfected BHK cells

1989 • 13 citations

An ELISA for grancalcin, a novel cytosolic calcium-binding protein present in leukocytes

1995 • 12 citations

Constitutive (pro)insulin release from pancreas of transgenic mice expressing monomeric insulin.

1995 • 12 citations

Thrombospondin receptor expression in human neutrophils coincides with the release of a subpopulation of specific granules

1992 • 11 citations

Enhancer Function of a 53-bp Repetitive Element in the 5′ Flanking Region of the Human Neutrophil Elastase Gene

1994 • 11 citations

Exudation induces clustering of CR1 receptors at the surface of human polymorphonuclear leukocytes

1990 • 10 citations

Localization of an abundant myeloid mRNA to individual leukocytes in mixed cell populations.

1987 • 10 citations

Ultrastructural morphology, cytochemistry, and morphometry of eosinophil granules in Chédiak-Higashi syndrome.

1993 • 10 citations

Posttranslational processing and targeting of transgenic human defensin in murine granulocyte, macrophage, fibroblast, and pituitary adenoma cell lines

1993 • 8 citations

Calcium-dependent Vesicular Exocytosis: From Constitutive to Regulated Secretion

1995 • 7 citations

NB4 cells show bilineage potential and an aberrant pattern of neutrophil secondary granule protein gene expression

1994 • 7 citations

Dynamic reorganization of the alkaline phosphatase-containing compartment during chemotactic peptide stimulation of human neutrophils imaged by backscattered electrons

1995 • 7 citations

Subcellular distribution of the Rap1A protein in human neutrophils: colocalization and cotranslocation with cytochrome b559

1992 • 5 citations

Distinct temporal patterns of defensin mRNA regulation during drug- induced differentiation of human myeloid leukemia cells

1996 • 3 citations

Correlation of messenger RNA levels with protein defects in specific granule deficiency

1992 • 2 citations