Antibiotic proteins of polymorphonuclear leukocytes

Inflammation. Basic principles and clinical correlates

1989 • 2,424 citations

Peptide Antibiotics and Their Role in Innate Immunity

1995 • 1,602 citations

Diversity of group types, regulation, and function of phospholipase A2.

1994 • 1,444 citations

On a remarkable bacteriolytic element found in tissues and secretions

1922 • 1,128 citations

Defensins: Antimicrobial and Cytotoxic Peptides of Mammalian Cells

1993 • 986 citations

What's new in lysozyme research?

1984 • 911 citations

Killing of gram-negative bacteria by lactoferrin and lysozyme.

1991 • 714 citations

Cathelicidins: a novel protein family with a common proregion and a variable C‐terminal antimicrobial domain

1995 • 714 citations

The respiratory burst oxidase.

1994 • 608 citations

Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein

1995 • 566 citations

hBD‐1: a novel β‐defensin from human plasma

1995 • 547 citations

Paneth cells of the human small intestine express an antimicrobial peptide gene

1992 • 525 citations

Inflammation: Basic Principles and Clinical Correlates

1993 • 518 citations

Antimicrobial actions of calcium binding leucocyte L1 protein, calprotectin

1990 • 515 citations

Crystal Structure of Defensin HNP-3, an Amphiphilic Dimer: Mechanisms of Membrane Permeabilization

1991 • 515 citations

Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA.

1991 • 505 citations

FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis.

1995 • 499 citations

Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins

1993 • 497 citations

Antibacterial activity of lactoferrin and a pepsin-derived lactoferrin peptide fragment

1993 • 494 citations

Monocyte-chemotactic activity of defensins from human neutrophils.

1989 • 486 citations

Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes.

1978 • 466 citations

Epithelial Antibiotics Induced at Sites of Inflammation

1995 • 417 citations

Squalamine: an aminosterol antibiotic from the shark.

1993 • 410 citations

THE EXTRA RESPIRATION OF PHAGOCYTOSIS

1932 • 394 citations

MRP-8 and MRP-14, two abundant Ca2+-binding proteins of neutrophils and monocytes

1993 • 388 citations

Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases.

1995 • 382 citations

Structure of human lactoferrin at 3.2-A resolution.

1987 • 375 citations

Antiviral Effects of Plasma and Milk Proteins: Lactoferrin Shows Potent Activity against Both Human Immunodeficiency Virus and Human Cytomegalovirus Replication In Vitro

1995 • 373 citations

Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds.

1994 • 364 citations

Sequence specificity and transcriptional activation in the binding of lactoferrin to DNA

1995 • 349 citations

Lactoferrin is a lipid A-binding protein

1994 • 341 citations

hCAP‐18, a cathelin/pro‐bactenecin‐like protein of human neutrophil specific granules

1995 • 339 citations

PHAGOCYTIN: A BACTERICIDAL SUBSTANCE FROM POLYMORPHONUCLEAR LEUCOCYTES

1956 • 325 citations

Defensins and other endogenous peptide antibiotics of vertebrates

1995 • 323 citations

Human neutrophil granules and secretory vesicles

1993 • 306 citations

Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells

1989 • 293 citations

Bactericidal/permeability-increasing protein has endotoxin-neutralizing activity.

1990 • 282 citations

Lectures on the Comparative Pathology of Inflammation.

1970 • 276 citations

High-affinity binding of the bactericidal/permeability-increasing protein and a recombinant amino-terminal fragment to the lipid A region of lipopolysaccharide

1992 • 264 citations

Bactericidal properties of murine intestinal phospholipase A2.

1995 • 260 citations

Bactericidal Activity of Human Lactoferrin: Differentiation from the Stasis of Iron Deprivation

1982 • 257 citations

Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium.

1989 • 254 citations

Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains.

1992 • 237 citations

Inhibition of fungal growth by wheat germ agglutinin

1975 • 235 citations

Lactoferrin regulates the release of tumour necrosis factor alpha and interleukin 6 in vivo.

1993 • 233 citations

Biosynthesis of granule proteins in normal human bone marrow cells. Gelatinase is a marker of terminal neutrophil differentiation

1995 • 232 citations

Human bactericidal/permeability-increasing protein and a recombinant NH2-terminal fragment cause killing of serum-resistant gram-negative bacteria in whole blood and inhibit tumor necrosis factor release induced by the bacteria.

1992 • 230 citations

Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations.

1988 • 230 citations

Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties.

1990 • 214 citations

Granulins, a novel class of peptide from leukocytes

1990 • 209 citations

Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis.

1993 • 209 citations

The potent anti-Staphylococcus aureus activity of a sterile rabbit inflammatory fluid is due to a 14-kD phospholipase A2.

1996 • 208 citations

Antibacterial and Enzymic Basic Proteins from Leukocyte Lysosomes: Separation and Identification

1963 • 207 citations

Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I.

1993 • 205 citations

Bactericidal activity of human lysozyme, muramidase-inactive lysozyme, and cationic polypeptides against Streptococcus sanguis and Streptococcus faecalis: inhibition by chitin oligosaccharides

1985 • 203 citations

Rapid membrane permeabilization and inhibition of vital functions of gram-negative bacteria by bactenecins

1990 • 199 citations

Defensins are mitogenic for epithelial cells and fibroblasts

1993 • 199 citations

Cryptdins: antimicrobial defensins of the murine small intestine

1992 • 187 citations

Evidence for reactive nitrogen intermediates in killing of staphylococci by human neutrophil cytoplasts. A new microbicidal pathway for polymorphonuclear leukocytes.

1992 • 186 citations

Natural resistance and nitric oxide

1995 • 181 citations

Epithelins 1 and 2: isolation and characterization of two cysteine-rich growth-modulating proteins.

1990 • 180 citations

The acid‐stable proteinase inhibitor of human mucous secretions (HUSI‐I, antileukoprotease)

1986 • 178 citations

Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter.

1992 • 163 citations

The toxin-agglutinin fold. A new group of small protein structures organized around a four-disulfide core.

1980 • 162 citations

A 25-kDa NH2-terminal fragment carries all the antibacterial activities of the human neutrophil 60-kDa bactericidal/permeability-increasing protein.

1987 • 158 citations

Lipopolysaccharide interaction with lysozyme

1989 • 158 citations

Bactericidal/permeability-increasing protein (BPI) is an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis

1995 • 157 citations

Proteolytic cleavage by neutrophil elastase converts inactive storage proforms to antibacterial bactenecins

1992 • 155 citations

Airway epithelial cells are the site of expression of a mammalian antimicrobial peptide gene.

1993 • 155 citations

Modulation of natural killer and lymphokine-activated killer cell cytotoxicity by lactoferrin

1992 • 152 citations

CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity.

1990 • 151 citations

A novel granulocyte-derived peptide with lipopolysaccharide-neutralizing activity.

1994 • 147 citations

The bactericidal/permeability-increasing protein (BPI), a potent element in host-defense Against gram-negative bacteria and lipopolysaccharide

1993 • 143 citations

The Zinc-Reversible Antimicrobial Activity of Neutrophil Lysates and Abscess Fluid Supernatants

1991 • 142 citations

Antibiotic peptides and serine protease homologs in human polymorphonuclear leukocytes: defensins and azurocidin

1993 • 140 citations

The Effects of Lactoferrin on Gram-Negative Bacteria

1994 • 136 citations

Acidic precursor revealed in human eosinophil granule major basic protein cDNA.

1988 • 133 citations

Enhanced bactericidal action of lysozyme to Escherichia coli by inserting a hydrophobic pentapeptide into its C terminus.

1994 • 131 citations

Human neutrophil defensin and serpins form complexes and inactivate each other.

1995 • 130 citations

Structural determinants of the action against Escherichia coli of a human inflammatory fluid phospholipase A2 in concert with polymorphonuclear leukocytes

1994 • 129 citations

Inhibition of Endotoxin-Induced Cytokine Release and Neutrophil Activation in Humans by Use of Recombinant Bactericidal/Permeability-Increasing Protein

1995 • 125 citations

Structure of the gene for porcine peptide antibiotic PR-39, a cathelin gene family member: comparative mapping of the locus for the human peptide antibiotic FALL-39.

1995 • 123 citations

Separation of sublethal and lethal effects of the bactericidal/permeability increasing protein on Escherichia coli.

1990 • 118 citations

Identification of the primary antimicrobial domains in human neutrophil cathepsin G.

1990 • 117 citations

Phylogenetic Perspectives in Immunity: The Insect Host Defense

1994 • 114 citations

Characterization of the disulfide motif in BNBD-12, an antimicrobial beta-defensin peptide from bovine neutrophils.

1993 • 113 citations

Morphology of defensin-treated Staphylococcus aureus

1995 • 113 citations

Chemical synthesis and biological activity of a novel antibacterial peptide deduced from a pig myeloid cDNA

1994 • 111 citations

Biosynthesis and secretion of complement component (C3) by activated human polymorphonuclear leukocytes.

1992 • 109 citations

An ACTH Receptor on Human Mononuclear Leukocytes

1987 • 106 citations

Cloning the human lysozyme cDNA: inverted Alu repeat in the mRNA and in situ hybridization for macrophages and Paneth cells.

1988 • 99 citations

CAP37, a neutrophil-derived multifunctional inflammatory mediator

1995 • 97 citations

Identification and characterization of a primary antibacterial domain in CAP18, a lipopolysaccharide binding protein from rabbit leukocytes

1994 • 97 citations

Prophenin‐1, an exceptionally proline‐rich antimicrobial peptide from porcine leukocytes

1995 • 97 citations

Relative concentrations of endotoxin-binding proteins in body fluids during infection

1994 • 96 citations

Molecular cloning and chemical synthesis of a novel antibacterial peptide derived from pig myeloid cells.

1994 • 96 citations

Stimulus-induced maturation of probactenecins, precursors of neutrophil antimicrobial polypeptides.

1991 • 95 citations

The role of lipopolysaccharides in the action of the bactericidal/permeability-increasing neutrophil protein on the bacterial envelope.

1984 • 94 citations

Competition between rBPI23, a recombinant fragment of bactericidal/permeability-increasing protein, and lipopolysaccharide (LPS)-binding protein for binding to LPS and gram-negative bacteria

1994 • 93 citations

Antimicrobial activity of rabbit CAP18-derived peptides

1993 • 92 citations

The structure of porcine protegrin genes

1995 • 90 citations

Synthetic bactericidal peptide based on CAP37: a 37-kDa human neutrophil granule-associated cationic antimicrobial protein chemotactic for monocytes.

1993 • 89 citations

Characterization of a rabbit cationic protein (CAP18) with lipopolysaccharide-inhibitory activity

1994 • 89 citations

Individual and synergistic effects of rabbit granulocyte proteins on Escherichia coli.

1994 • 89 citations

The pro region of human neutrophil defensin contains a motif that is essential for normal subcellular sorting

1995 • 87 citations

Human granulocytes express a 55-kDa lipopolysaccharide-binding protein on the cell surface that is identical to the bactericidal/permeability-increasing protein.

1993 • 84 citations

A cDNA Derived from Pig Bone Marrow Cells Predicts a Sequence Identical to the Intestinal Antibacterial Peptide PR-39

1993 • 84 citations

Antibacterial 15-kDa protein isoforms (p15s) are members of a novel family of leukocyte proteins.

1993 • 82 citations

Structures of genes for two cathelin‐associated antimicrobial peptides: prophenin‐2 and PR‐39

1995 • 82 citations

Extracellular accumulation of potently microbicidal bactericidal/permeability-increasing protein and p15s in an evolving sterile rabbit peritoneal inflammatory exudate.

1995 • 82 citations

Lactoferrin Structure and Function

1994 • 79 citations

Complete sequence analysis of cDNA clones encoding rat whey phosphoprotein: homology to a protease inhibitor.

1982 • 74 citations

CDNA cloning of the neutrophil bactericidal peptide indolicidin

1992 • 74 citations

The structure of neutrophil defensin genes

1993 • 74 citations

Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation

1994 • 72 citations

The Control of Neutrophil Chemotaxis by Inhibitors of Cathepsin G and Chymotrypsin

1995 • 71 citations

cDNA sequence analysis of an antibiotic dodecapeptide from neutrophils

1992 • 70 citations

Chemotactic and protease‐inhibiting activities of antibiotic peptide precursors

1993 • 70 citations

How bacteria resist killing by host-defense peptides

1994 • 69 citations

A neutrophil-derived proteolytic inactive elastase homologue (hHBP) mediates reversible contraction of fibroblasts and endothelial cell monolayers and stimulates monocyte survival and thrombospondin secretion

1992 • 69 citations

The solution structure of the active domain of CAP18 — a lipopolysaccharide binding protein from rabbit leukocytes

1995 • 68 citations

Acute phase protein stimulation by alpha 1-antichymotrypsin-cathepsin G complexes. Evidence for the involvement of interleukin-6.

1990 • 68 citations

Synergistic cytolysis mediated by hydrogen peroxide combined with peptide defensins

1988 • 68 citations

Human polymorphonuclear leukocytes store large amounts of terminal complement components C7 and C6, which may be released on stimulation.

1995 • 67 citations

Removal of lactoferrin from plasma is mediated by binding to low density lipoprotein receptor‐related protein/α₂‐macroglobulin receptor and transport to endosomes

1995 • 66 citations

Lipopolysaccharide-inactivating activity of neutrophils is due to lactoferrin

1995 • 66 citations

Bacterial phospholipid hydrolysis enhances the destruction of Escherichia coli ingested by rabbit neutrophils. Role of cellular and extracellular phospholipases.

1990 • 66 citations

Human autoantibody to defensin: disease association with hyperreactive onchocerciasis (sowda).

1995 • 65 citations

Antibacterial proteins of granulocytes differ in interaction with endotoxin. Comparison of bactericidal/permeability-increasing protein, p15s, and defensins.

1995 • 64 citations

Lysozyme: primary bactericidin in human plasma serum active against Bacillus subtilis

1978 • 62 citations

Identification of an Inhibitor of Tissue-type Plasminogen Activator-mediated Fibrinolysis in Human Neutrophils

1995 • 61 citations

Effects of Phagocytosis by Rabbit Granulocytes on Macromolecular Synthesis and Degradation in Different Species of Bacteria

1973 • 61 citations

Lectures on the comparative pathology of inflammation

2008 • 60 citations

Identification of defensin binding to C1 complement

1994 • 59 citations

Corticostatic peptides cause nifedipine-sensitive volume reduction in jejunal villus enterocytes.

1991 • 59 citations

Selective inhibition of microbial serine proteases by eNAP-2, an antimicrobial peptide from equine neutrophils

1993 • 57 citations

Integration of antimicrobial host defenses: role of the bactericidal/permeability-increasing protein

1994 • 55 citations

Heparin protects cathepsin G against inhibition by protein proteinase inhibitors.

1994 • 54 citations

Identification of eNAP-1, an antimicrobial peptide from equine neutrophils

1992 • 54 citations

Identification of the iroA gene product of Neisseria meningitidis as a lactoferrin receptor

1994 • 53 citations

Isolation and mode of action of rabbit corticostatic (antiadrenocorticotropin) peptides.

1992 • 52 citations

Characterization of a myeloid-specific enhancer of the chicken lysozyme gene. Major role for an Ets transcription factor-binding site.

1994 • 51 citations

Lactoferrin acts on I-A and I-E/C antigen+ subpopulations of mouse peritoneal macrophages in the absence of T lymphocytes and other cell types to inhibit production of granulocyte-macrophage colony stimulatory factors in vitro.

1984 • 50 citations

Isolation and primary structure of the three major forms of granulin-like peptides from hematopoietic tissues of a teleost fish (Cyprinus carpio)

1993 • 50 citations

Granule serine proteases are normal nuclear constituents of natural killer cells

1994 • 49 citations

Biosynthesis of Defensins and Other Antimicrobial Peptides

2007 • 47 citations

eNAP-2, a novel cysteine-rich bactericidal peptide from equine leukocytes

1992 • 46 citations

Inhibition of endotoxin-induced activation of the coagulation and fibrinolytic pathways using a recombinant endotoxin-binding protein (rBPI23)

1995 • 45 citations

Isolation and Molecular Cloning of a Novel Bone Phosphoprotein Related in Sequence to the Cystatin Family of Thiol Protease Inhibitors

1995 • 45 citations

Prospects for use of recombinant BPI in the treatment of gram-negative bacterial infections.

1995 • 44 citations

The far upstream chicken lysozyme enhancer at -6.1 kilobase, by interacting with NF-M, mediates lipopolysaccharide-induced expression of the chicken lysozyme gene in chicken myelomonocytic cells.

1994 • 43 citations

Proteinase 3. A neutrophil proteinase with activity on platelets.

1994 • 43 citations

Pig leukocyte cysteine proteinase inhibitor (PLCPI), a new member of the stefin family

1993 • 43 citations

ANCA—pathophysiology revisited

1995 • 42 citations

Biochemical analysis of the epithelin receptor

1993 • 42 citations

Processing and intracellular transport of cathepsin G and neutrophil elastase in the leukemic myeloid cell line U-937—modulation by brefeldin A, ammonium chloride, and monensin

1994 • 41 citations

Isolation of two isoforms of a novel 15-kDa protein from rabbit polymorphonuclear leukocytes that modulate the antibacterial actions of other leukocyte proteins.

1990 • 40 citations

P-selectin-dependent leukocyte recruitment and intestinal mucosal injury induced by lactoferrin

1994 • 39 citations

Protective Effects Of An N-Terminal Fragment Of Bactericidal/Permeability-Increasing Protein In Rodent Models Of Gram-Negative Sepsis: Role Of Bactericidal Properties

1994 • 38 citations

Inhibition of intracellular Histoplasma capsulatum replication by murine macrophages that produce human defensin

1994 • 38 citations

Protease-modulation of neutrophil superoxide response.

1989 • 35 citations

Lipopolysaccharide-Binding Protein and CD14 in the Lipopolysaccharide-Dependent Activation of Cells

1994 • 33 citations

Isolation and mode of action of rabbit corticostatic (antiadrenocorticotropin) peptides

1992 • 33 citations

Defensins Reduce the Barrier Integrity of a Cultured Epithelial Monolayer without Cytotoxicity

1993 • 31 citations

Synergistic activity of rabbit granulocyte peptides against Candida albicans

1986 • 29 citations

Human neutrophil azurocidin synergizes with leukocyte elastase and cathepsin G in the killing of Capnocytophaga sputigena

1992 • 28 citations

Bactericidal Activity of Different Forms of Lactoferrin

1994 • 28 citations

Relation between binding and the action of phospholipases A2 on Escherichia coli exposed to the bactericidal/permeability-increasing protein of neutrophils

1987 • 27 citations

In vitro inhibition of mammary cell growth by lactoferrin: A comparative study

1994 • 26 citations

Biosynthesis and processing of lactoferrin in bone marrow cells, a comparison with processing of myeloperoxidase

1988 • 25 citations

Multiple cDNA sequences of bovine tracheal lysozyme.

1993 • 22 citations

Lysozyme regulates LPS-induced interleukin-6 release in mice.

1994 • 20 citations

Effect of growth conditions on peptidoglycan structure and susceptibility to lytic enzymes in cell walls of Micrococcus sodensis

1972 • 18 citations

Identification, sequence analysis, and characterization of cDNA clones encoding two granzyme‐like serine proteinases from rat duodenum

1993 • 12 citations

Lipopolysaccharide-binding protein and CD14 in the lipopolysaccharide- dependent activation of cells

1994 • 11 citations

O2-Independent Killing of Gram-Negative Bacteria by Intact Granulocytes. The Role of a Potent Bactericidal Membrane-Perturbing Protein

1982 • 4 citations

Localization and measurement of corticostatin-I in nonpregnant and pregnant rabbit tissues during late gestation.

1993 • 4 citations

Localization and measurement of corticostatin-I in nonpregnant and pregnant rabbit tissues during late gestation

1993 • 3 citations