Differential trafficking of soluble and integral membrane secretory granule-associated proteins

Constitutive and Regulated Secretion of Proteins

1987 • 1,021 citations

Pre- and post-golgi vacuoles operate in the transport of semliki forest virus membrane glycoproteins to the cell surface

1984 • 523 citations

Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi network.

1991 • 457 citations

Hepatoma secretory proteins migrate from rough endoplasmic reticulum to Golgi at characteristic rates

1983 • 436 citations

Exit of newly synthesized membrane proteins from the trans cisterna of the Golgi complex to the plasma membrane.

1985 • 415 citations

Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation

1983 • 329 citations

Induction of specific storage organelles by von Willebrand factor propolypeptide

1991 • 276 citations

The trans-most cisternae of the Golgi complex: A compartment for sorting of secretory and plasma membrane proteins

1987 • 275 citations

Peptidylglycine α‐amidating monooxygenase: A multifunctional protein with catalytic, processing, and routing domains

1993 • 263 citations

Characterization of the immature secretory granule, an intermediate in granule biogenesis.

1991 • 231 citations

Protein targeting via the "constitutive-like" secretory pathway in isolated pancreatic islets: passive sorting in the immature granule compartment.

1992 • 188 citations

Newly synthesized synaptophysin is transported to synaptic-like microvesicles via constitutive secretory vesicles and the plasma membrane.

1991 • 176 citations

Cytoplasmic domain of P-selectin (CD62) contains the signal for sorting into the regulated secretory pathway.

1992 • 156 citations

Protein discharge from immature secretory granules displays both regulated and constitutive characteristics

1991 • 139 citations

Sorting within the regulated secretory pathway occurs in the trans-Golgi network.

1990 • 127 citations

P-selectin, a granule membrane protein of platelets and endothelial cells, follows the regulated secretory pathway in AtT-20 cells.

1992 • 120 citations

Protein sorting among two distinct export pathways occurs from the content of maturing exocrine storage granules.

1987 • 119 citations

Expression of individual forms of peptidylglycine alpha-amidating monooxygenase in AtT-20 cells: endoproteolytic processing and routing to secretory granules

1992 • 113 citations

Protein sorting and secretion granule formation in regulated secretory cells

1992 • 109 citations

Amino-terminal sequences of prosomatostatin direct intracellular targeting but not processing specificity

1989 • 108 citations

Constitutive and basal secretion from the endocrine cell line, AtT-20.

1991 • 95 citations

Identification of molecular aggregates containing glycoproteins III, J, K (carboxypeptidase H), and H (Kex2-related proteases) in the soluble and membrane fractions of adrenal medullary chromaffin granules.

1992 • 87 citations

Biogenesis of secretory granules Implications arising from the immature secretory granule in the regulated pathway of secretion

1991 • 84 citations

COOH-terminal signals mediate the trafficking of a peptide processing enzyme in endocrine cells.

1993 • 82 citations

Intermediates in the constitutive and regulated secretory pathways released in vitro from semi-intact cells.

1992 • 73 citations

Efficient targeting to storage granules of human proinsulins with altered propeptide domain.

1988 • 64 citations

A Targeting Sequence for Dense Secretory Granules Resides in the Active Renin Protein Moiety of Human Preprorenin

1990 • 62 citations

In vitro mutagenesis of trypsinogen: role of the amino terminus in intracellular protein targeting to secretory granules.

1987 • 54 citations

Expression of a peptide processing enzyme in cultured cells: truncation mutants reveal a routing domain.

1992 • 50 citations

Use of endoproteases to identify catalytic domains, linker regions, and functional interactions in soluble peptidylglycine alpha-amidating monooxygenase

1993 • 49 citations

Topological Switching of the COOH-Terminal Domain of Peptidylglycine α-Amidating Monooxygenase by Alternative RNA Splicing

1993 • 36 citations

Expression of porcine cholecystokinin cDNA in a murine neuroendocrine cell line. Proteolytic processing, sulfation, and regulated secretion of cholecystokinin peptides.

1988 • 36 citations

Is a sorting signal necessary to package proteins into secretory granules?

1991 • 23 citations

Maturation, internalization, and turnover of soluble and membrane proteins associated with atrial myocyte secretory granules.

1993 • 22 citations

Expression of porcine pro-opiomelanocortin in mouse neuroblastoma (Neuro2A) cells: Targeting of the foreign neuropeptide to dense-core vesicles

1991 • 21 citations

Protein targeting to dense‐core secretory granules

1993 • 18 citations

Expression and Posttranslational Processing of Preprodynorphin Complementary DNA in the Mouse Anterior Pituitary Cell Line AtT-20

1989 • 16 citations

Effects of propeptide deletion on human renin secretion from mouse pituitary AtT‐20 cells

1990 • 14 citations