VAMP-2 and cellubrevin are expressed in pancreatic beta-cells and are essential for Ca(2+)-but not for GTP gamma S-induced insulin secretion.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

SNAP receptors implicated in vesicle targeting and fusion

1993 • 3,220 citations

Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

1992 • 1,792 citations

Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25

1993 • 1,200 citations

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.

1992 • 1,128 citations

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1.

1992 • 880 citations

Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.

1987 • 802 citations

Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.

1994 • 798 citations

Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and β-pancreatic islet cells

1988 • 786 citations

The syntaxin family of vesicular transport receptors

1993 • 656 citations

Vesicle fusion from yeast to man

1994 • 635 citations

Implications of the SNARE hypothesis for intracellular membrane topology and dynamics

1994 • 582 citations

SNAPs, a family of NSF attachment proteins involved in intracellular membrane fusion in animals and yeast

1990 • 578 citations

Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin.

1993 • 540 citations

Mechanism of action of tetanus and botulinum neurotoxins

1994 • 532 citations

Purification of an N-ethylmaleimide-sensitive protein catalyzing vesicular transport.

1988 • 519 citations

Synaptobrevin: an integral membrane protein of 18,000 daltons present in small synaptic vesicles of rat brain.

1989 • 513 citations

Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein

1993 • 504 citations

Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels

1989 • 451 citations

Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets

1993 • 430 citations

Role of an N-ethylmaleimide-sensitive transport component in promoting fusion of transport vesicles with cisternae of the Golgi stack

1988 • 389 citations

GABA and pancreatic beta-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion.

1991 • 382 citations

Membrane fusion machinery: Insights from synaptic proteins

1993 • 380 citations

Two Vesicle-associated Membrane Protein Genes Are Differentially Expressed in the Rat Central Nervous System

1989 • 326 citations

Homologs of the synaptobrevin/VAMP family of synaptic vesicle proteins function on the late secretory pathway in S. cerevisiae

1993 • 316 citations

Possible role for fatty acyl-coenzyme A in intracellular protein transport

1987 • 302 citations

Members of the VAMP family of synaptic vesicle proteins are components of glucose transporter-containing vesicles from rat adipocytes.

1992 • 275 citations

Dissection of a single round of vesicular transport: Sequential intermediates for intercisternal movement in the Golgi stack

1989 • 269 citations

A post-docking role for synaptobrevin in synaptic vesicle fusion

1994 • 255 citations

Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells.

1987 • 244 citations

SNAP-25 is expressed in islets of Langerhans and is involved in insulin release.

1995 • 243 citations

Botulinum neurotoxins are zinc proteins.

1992 • 243 citations

Tetanus and botulism neurotoxins: a new group of zinc proteases

1993 • 233 citations

A guide to the use of pore-forming toxins for controlled permeabilization of cell membranes

1993 • 232 citations

Tetanus toxin-mediated cleavage of cellubrevin impairs exocytosis of transferrin receptor-containing vesicles in CHO cells.

1994 • 227 citations

Kinetic analysis of secretion from permeabilized adrenal chromaffin cells reveals distinct components.

1992 • 208 citations

Identification of synaptic proteins and their isoform mRNAs in compartments of pancreatic endocrine cells.

1994 • 199 citations

Correlation between cytosolic free Ca2+ and insulin release in an insulin-secreting cell line.

1984 • 199 citations

Structural and Functional Considerations of GABA in Islets of Langerhans: β-Cells and Nerves

1991 • 157 citations

Purification of three related peripheral membrane proteins needed for vesicular transport.

1990 • 147 citations

Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2.

1990 • 144 citations

Tetanus toxin light chain cleaves a vesicle-associated membrane protein (VAMP) isoform 2 in rat pancreatic zymogen granules and inhibits enzyme secretion.

1994 • 141 citations

The tetanus toxin light chain inhibits exocytosis

1989 • 129 citations

Cellubrevin and synaptobrevins: similar subcellular localization and biochemical properties in PC12 cells.

1995 • 125 citations

A gamma-aminobutyric acid transporter driven by a proton pump is present in synaptic-like microvesicles of pancreatic beta cells.

1993 • 94 citations

Chains and fragments of tetanus toxin

1989 • 81 citations

Stimulus-response coupling in insulin-secreting HIT cells. Effects of secretagogues on cytosolic Ca2+, diacylglycerol, and protein kinase C activity.

1990 • 76 citations

Identification of a vesicle-associated membrane protein (VAMP)-like membrane protein in zymogen granules of the rat exocrine pancreas.

1994 • 74 citations

[13] Isolation of pancreatic islets and primary culture of the intact microorgans or of dispersed islet cells

1990 • 64 citations

Expression of the synaptic vesicle proteins VAMPs/synaptobrevins 1 and 2 in non-neural tissues.

1994 • 61 citations

Tetanus toxin: Biochemical and pharmacological comparison between its protoxin and some isotoxins obtained by limited proteolysis

1988 • 51 citations

Dynamics of Ca2+ and guanosine 5′-[γ-thio]triphosphate action on insulin secretion from α-toxin-permeabilized HIT-T15 cells

1994 • 49 citations

Stimulation of insulin release from permeabilized HIT‐T15 cells by a synthetic peptide corresponding to the effector domain of the small GTP‐binding protein rab3

1993 • 48 citations

Different requirements for protein kinase C activation and Ca2+-independent insulin secretion in response to guanine nucleotides

1989 • 48 citations

Protein kinase C and clostridial neurotoxins affect discrete and related steps in the secretory pathway

1993 • 38 citations

Coatomers and SNAREs in promoting membrane traffic

1993 • 36 citations