The calcium signal in human neutrophils and its relation to exocytosis investigated by patch-clamp capacitance and Fura-2 measurements

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Isolation of mononuclear cells and granulocytes from human blood.

1968 • 9,672 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

INTRACELLULAR CALCIUM HOMEOSTASIS

1987 • 2,183 citations

Rates of diffusional exchange between small cells and a measuring patch pipette

1988 • 712 citations

Patch-clamp techniques for time-resolved capacitance measurements in single cells

1988 • 659 citations

Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration

1986 • 489 citations

Is Cytosolic Ionized Calcium Regulating Neutrophil Activation?

1983 • 471 citations

Polyphosphoinositide phosphodiesterase: regulation by a novel guanine nucleotide binding protein, Gp

1987 • 356 citations

Two roles for guanine nucleotides in the stimulus-secretion sequence of neutrophils

1986 • 339 citations

Protein kinase C activation of physiological processes in human neutrophils at vanishingly small cytosolic Ca2+ levels

1984 • 334 citations

Modulation of cytosolic-free calcium transients by changes in intracellular calcium-buffering capacity: correlation with exocytosis and O2-production in human neutrophils.

1984 • 262 citations

Multiple elevations of cytosolic-free Ca2+ in human neutrophils: initiation by adherence receptors of the integrin family.

1991 • 259 citations

The influence of intracellular calcium concentration on degranulation of dialysed mast cells from rat peritoneum.

1988 • 245 citations

Cytosolic Ca2+, exocytosis, and endocytosis in single melanotrophs of the rat pituitary

1990 • 208 citations

Phorbol myristate acetate stimulates ATP-dependent calcium transport by the plasma membrane of neutrophils.

1984 • 193 citations

IgE-mediated degranulation of mast cells does not require opening of ion channels

1986 • 179 citations

Quantal Ca2+ mobilization stimulated by inositol 1,4,5-trisphosphate in permeabilized hepatocytes

1991 • 127 citations

Conversion of GDP into GTP by nucleoside diphosphate kinase on the GTP-binding proteins.

1990 • 121 citations

Limitations of the whole cell patch clamp technique in the control of intracellular concentrations

1990 • 119 citations

Techniques and concepts in exocytosis: focus on mast cells

1991 • 109 citations

The dynamics of exocytosis in human neutrophils.

1988 • 109 citations

Spontaneous and chemoattractant-induced oscillations of cytosolic free calcium in single adherent human neutrophils.

1988 • 106 citations

Receptor signalling and intracellular calcium in neutrophil activation

1989 • 104 citations

Calculation of time constants for intracellular diffusion in whole cell patch clamp configuration

1988 • 92 citations

Calcium fluxes and calcium buffering in human neutrophils.

1986 • 89 citations

Voltage-dependent and Ca2(+)-activated ion channels in human neutrophils.

1990 • 88 citations

Membrane‐cytoskeleton interactions and the regulation of chemotactic peptide‐induced activation of human granulocytes: The effects of dihydrocytochalasin B

1985 • 84 citations

Two mechanisms for IgG Fc-receptor-mediated phagocytosis by human neutrophils.

1991 • 73 citations

Activation of protein kinase C in human neutrophils attenuates agonist-stimulated rises in cytosolic free Ca2+ concentration by inhibiting bivalent-cation influx and intracellular Ca2+ release in addition to stimulating Ca2+ efflux

1989 • 68 citations

Intracellular application of guanosine-5'-O-(3-thiotriphosphate) induces exocytotic granule fusion in guinea pig eosinophils.

1990 • 66 citations

Washout phenomena in dialyzed mast cells allow discrimination of different steps in stimulus-secretion coupling

1987 • 58 citations

Roles of Ca2+ in human neutrophil responses to receptor agonists

1991 • 50 citations

Localized superoxide release by neutrophils can be provoked by a cytosolic calcium 'cloud'.

1991 • 47 citations

Ca²⁺-storage organelles

1991 • 44 citations

Influence of botulinum C2 toxin on F-actin and N-formyl peptide receptor dynamics in human neutrophils.

1989 • 43 citations

Rapid kinetics of agonist-evoked changes in cytosolic free Ca2+ concentration in fura-2-loaded human neutrophils

1990 • 32 citations

Calcium signals in neutrophils can be divided into three distinct phases

1987 • 30 citations

Intracellular stimulation of mast cells with guanine nucleotides mimic antigenic stimulation

1987 • 29 citations

Analysis of Calcium Homeostasis in Activated Human Polymorphonuclear Leukocytes

1989 • 28 citations

Superoxide responses to formyl-methionyl-leucyl-phenylalanine in primed neutrophils. Role of intracellular and extracellular calcium.

1991 • 26 citations

A quantitative investigation into the dependence of Ca²⁺ mobilisation on changes in inositol 1,4,5‐trisphosphate levels in the stimulated neutrophil

1991 • 21 citations

GTPγS-induced calcium transients and exocytosis in human neutrophils

1990 • 17 citations

Ca²⁺‐independent regulation of neurosecretion by intracellular Na⁺

1991 • 17 citations