Calreticulin Functions as a Molecular Chaperone in the Biosynthesis of Myeloperoxidase

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

Protein folding in the cell

1992 • 4,138 citations

A C-terminal signal prevents secretion of luminal ER proteins

1987 • 2,189 citations

Fluorographic detection of radioactivity in polyacrylamide gols with the water-soluble fluor, sodium salicylate

1979 • 1,976 citations

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

1988 • 1,292 citations

INHIBITORS OF THE BIOSYNTHESIS AND PROCESSING OF N-LINKED OLIGOSACCHARIDE CHAINS

1987 • 1,122 citations

MOLECULAR CHAPERONES

1991 • 1,089 citations

Peroxidases in chemistry and biology

1990 • 1,039 citations

Protein Oligomerization in the Endoplasmic Reticulum

1989 • 993 citations

Role of N-linked oligosaccharide recognition, glucose trimming, and calnexin in glycoprotein folding and quality control.

1994 • 815 citations

Control of Protein Exit from the Endoplasmic Reticulum

1989 • 794 citations

Association of folding intermediates of glycoproteins with calnexin during protein maturation

1993 • 558 citations

SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane.

1991 • 544 citations

Calnexin: a membrane-bound chaperone of the endoplasmic reticulum

1994 • 533 citations

Calreticulin

1992 • 402 citations

Molecular chaperones in protein folding: the art of avoiding sticky situations

1994 • 402 citations

Modulation of gene expression by calreticulin binding to the glucocorticoid receptor

1994 • 389 citations

Inhibition of nuclear hormone receptor activity by calreticulin

1994 • 372 citations

Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts.

1977 • 371 citations

Myeloperoxidase: Contribution to the Microbicidal Activity of Intact Leukocytes

1970 • 345 citations

Folding of VSV G Protein: Sequential Interaction with BiP and Calnexin

1994 • 316 citations

X-ray crystal structure of canine myeloperoxidase at 3 Å resolution

1992 • 312 citations

Participation of a novel 88-kD protein in the biogenesis of murine class I histocompatibility molecules.

1991 • 312 citations

A set of endoplasmic reticulum proteins possessing properties of molecular chaperones includes Ca(2+)-binding proteins and members of the thioredoxin superfamily.

1994 • 279 citations

Induction of two transformation-sensitive membrane polypeptides in normal fibroblasts by a block in glycoprotein synthesis or glucose deprivation

1977 • 273 citations

Endoplasmic reticulum resident protein of 90 kilodaltons associates with the T- and B-cell antigen receptors and major histocompatibility complex antigens during their assembly.

1992 • 259 citations

The emergence of the chaperone machines

1992 • 249 citations

The Human Neutrophil Respiratory Burst Oxidase

1990 • 225 citations

Interaction with newly synthesized and retained proteins in the endoplasmic reticulum suggests a chaperone function for human integral membrane protein IP90 (calnexin)

1993 • 203 citations

Myeloperoxidase: its structure and expression during myeloid differentiation

1985 • 184 citations

Evidence for role of glycoprotein carbohydrates in membrane transport: specific inhibition by tunicamycin.

1979 • 183 citations

The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes.

1993 • 137 citations

Calreticulin: not just another calcium-binding protein

1994 • 135 citations

Biochemical and Immunologic Analysis of Hereditary Myeloperoxidase Deficiency

1983 • 115 citations

The p88 molecular chaperone is identical to the endoplasmic reticulum membrane protein, calnexin.

1992 • 110 citations

The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters.

1992 • 99 citations

Myeloperoxidase biosynthesis by a human promyelocytic leukemia cell line: insight into myeloperoxidase deficiency

1986 • 98 citations

The integrin chains beta 1 and alpha 6 associate with the chaperone calnexin prior to integrin assembly.

1994 • 97 citations

Chronic Granulomatous Disease

1992 • 84 citations

Identification of the region on the class I histocompatibility molecule that interacts with the molecular chaperone, p88 (calnexin, IP90).

1993 • 77 citations

Roles of heme insertion and the mannose-6-phosphate receptor in processing of the human myeloid lysosomal enzyme, myeloperoxidase

1992 • 76 citations

Biosynthesis, transport and processing of myeloperoxidase in the human leukaemic promyelocytic cell line HL-60 and normal marrow cells

1984 • 69 citations

Posttranslational processing of a human myeloid lysosomal protein, myeloperoxidase

1987 • 66 citations

Chaperone function of calnexin for the folding intermediate of gp80, the major secretory protein in MDCK cells. Regulation by redox state and ATP.

1994 • 65 citations

Processing of a newly identified intermediate of human myeloperoxidase in isolated granules occurs at neutral pH.

1986 • 61 citations

Hsp108, a novel heat shock inducible protein of chicken

1986 • 56 citations

Myeloperoxidase precursors in human myeloid leukemia HL-60 cells.

1982 • 56 citations

Myeloperoxidase precursors incorporate heme.

1987 • 50 citations

Evidence for complex formation between rabbit lung flavin-containing monooxygenase and calreticulin

1991 • 47 citations

The processing and intracellular transport of myeloperoxidase. Modulation by lysosomotropic agents and monensin.

1986 • 43 citations

The Post-translational Processing of Myeloperoxidase Is Regulated by the Availability of Heme

1994 • 38 citations

Chaperones and protein folding

1992 • 35 citations

A glycosylation-deficient endothelial cell mutant with modified responses to transforming growth factor-beta and other growth inhibitory cytokines: evidence for multiple growth inhibitory signal transduction pathways.

1993 • 30 citations

Immunochemical and electrophoretic analyses of phosphorylated native and recombinant neutrophil oxidase component p47-phox

1990 • 27 citations

Isolation and Characterization of an Unprocessed Extracellular Myeloperoxidase in HL-60 Cell Cultures

1989 • 24 citations

Assembly of dimeric myeloperoxidase during posttranslational maturation in human leukemic HL-60 cells

1990 • 24 citations

Biochemical and ultrastructural effects of monensin on the processing, intracellular transport, and packaging of myeloperoxidase into low and high density compartments of human leukemia (HL-60) cells

1987 • 23 citations

Ultrastructural, immunochemical, and cytochemical study of myeloperoxidase in myeloid leukemia HL-60 cells following treatment with succinylacetone, an inhibitor of heme biosynthesis.

1992 • 18 citations

Evidence for the involvement of an acidic compartment in the processing of myeloperoxidase in human promyelocytic leukemia HL-60 cells

1987 • 17 citations

Chronic Granulomatous Disease: An Update and a Paradigm for the Use of Interferon-γ as Adjunct Immunotheraphy in Infectious Diseases

1992 • 12 citations